Theropithecus gelada (gelada): 112634420 Help Entry 112634420         CDS       T08041                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism tge  Theropithecus gelada (gelada) Pathway tge04020   Calcium signaling pathway tge04024   cAMP signaling pathway tge04260   Cardiac muscle contraction tge04261   Adrenergic signaling in cardiomyocytes tge04371   Apelin signaling pathway tge04713   Circadian entrainment tge04911   Insulin secretion tge04921   Oxytocin signaling pathway tge04972   Pancreatic secretion tge05020   Prion disease tge05022   Pathways of neurodegeneration - multiple diseases tge05410   Hypertrophic cardiomyopathy tge05412   Arrhythmogenic right ventricular cardiomyopathy tge05414   Dilated cardiomyopathy tge05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:tge00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112634420 (RYR2)    04020 Calcium signaling pathway     112634420 (RYR2)    04024 cAMP signaling pathway     112634420 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112634420 (RYR2)    04921 Oxytocin signaling pathway     112634420 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     112634420 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     112634420 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     112634420 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     112634420 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     112634420 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     112634420 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     112634420 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     112634420 (RYR2)    05414 Dilated cardiomyopathy     112634420 (RYR2)    05415 Diabetic cardiomyopathy     112634420 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tge04040]     112634420 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:tge04990]     112634420 (RYR2) Ion channels [BR:tge04040]  Voltage-gated cation channels   Ryanodine receptor    112634420 (RYR2) Domain-containing proteins not elsewhere classified [BR:tge04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112634420 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  112634420 NCBI-ProteinID:  XP_025257659 Ensembl:  ENSTGEG00000015328 LinkDB All DBs Position 1:210946584..211581256 Genome browser AA seq 5098 aa AA seqDB search MAQEGSKATGSTTRVLQELWEEYDSKRQKLAHWEAKFQPFWTSVLAPRAPAAVCRTWKCQ GYRELPGPPGRRYVIEGENSLVLGHKNSGKRMCDFSSVNQKLYRHTADLSDQSIGQFTHQ KFEEQDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQ SLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLC CLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERY LHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGE HGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMED KNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLW LTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIR GLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQE EGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQF SGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVL DVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYK KWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLH LWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPV VSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLL GPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDN KRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQ LTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPR LVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAE KTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEH YGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQ VGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVT RIDGTIDSSPCLKVTQKSFGSQNSHTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPK NDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLR RTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFH QYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVV DAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLF KSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLH IPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIEN KYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGI GLSTSLRPRMQFSSPSFVSVSNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVG GTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVD DAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDD FVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEE IRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESD SKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGV SVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETV MEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLAS PAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQLLVSKGYPDIGWN PVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAI KIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHA GKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLF LDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRC APLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRR LVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDA LSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNI TIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIY RWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNV TLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQD ILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKG EHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKL GVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKT MENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCY RILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRE RAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWE HGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVK PQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYP LLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFL ITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIAL AKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERV LDIANVLFHLEQKSKRVGRRHYCLGSTVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEDEGTKRVDPLHQLI LLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEHDIIKDLRNKFAS LGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGG NSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKV LQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFY WYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSC AETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYF QPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELF VNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVKSALFALR YNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRII CSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEAALPSEDLTDLKEL TEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEK EEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQ KLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDS GSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISEL LGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMS VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15297 nt NT seq  +upstreamnt  +downstreamnt atggctcaggaagggtcgaaggctaccgggtccaccacgagagtgctccaggagctctgg gaagaatatgactccaagaggcagaagctggctcactgggaggccaagttccagcctttc tggaccagcgtgttggctcccagggctccagccgcagtctgcaggacctggaagtgccag gggtaccgtgagctgccaggacccccaggaaggagatatgtaatagagggagagaactca ctagtcctgggccataaaaactctgggaaaaggatgtgtgacttttcttctgtcaaccag aaattatatcgccacaccgcagatttgtctgaccagtctatcgggcagtttacacatcag aaatttgaagagcaggatgatgaggtggttctgcagtgcaccgcaaccatccacaaagaa caacagaaactatgcttggcagcagaaggatttggcaacagactttgtttcttggagtcc acttccaattccaagaatgtgcccccagacctctccatctgcacctttgtgctggagcag tccctctctgtccgggccctgcaggagatgctggctaacaccgtggagaaatcagaaggg caagttgatgtggaaaaatggaaattcatgatgaagactgctcagggtggtggtcatcga acactcctctacggacatgccatattgctgcgccattcctacagtggcatgtatctgtgc tgcctgtccacctcccggtcttcaactgataagctggcttttgatgttggcttgcaagag gacaccacaggggaggcttgttggtggaccatacaccctgcctctaagcagcgatcagaa ggagaaaaagtacgagttggagatgacctcatcttagttagcgtgtcctctgaaaggtac ttgcacttgtcttacggcaatggcagcttacacgtggatgccgctttccagcagactctc tggagcgtggccccaatcagctcaggaagtgaggcagcccaagggtatctcattggtggt gatgtcctcaggttgctgcatggacacatggacgagtgtctcactgtcccttcaggagaa catggtgaagagcagcggagaactgttcattacgaaggtggcgctgtgtctgttcatgca cgttccctttggagactagagacactaagagttgcgtggagtggaagccacataagatgg ggccagccattccgactacgccatgtcacaacaggaaaatacttgagtctcatggaagac aaaaaccttctactcatggacaaagagaaagctgatgtaaaatcaacagcatttaccttc cggtcttccaaggaaaaattggatgtaggggtgagaaaagaagtcgacggcatgggaaca tctgaaataaaatacggtgactcagtatgctatatacaacatgtggacacgggcctatgg cttacttaccagtctgtggatgtgaagtctgtgagaatgggatctatacaacgtaaggct attatgcaccatgaaggccacatggatgatggcataagtttatcgagatcccagcatgaa gaatcacgcacagcacgagttatccggagcacagtcttccttttcaatagatttataagg ggcctcgatgcgctcagcaagaaagcgaaggcttccaccgtcgatttgccgatagaatcc gtgagtctaagtctgcaggatctcattggctactttcacccgcccgatgagcatttagaa catgaagacaaacagaacagactacgagccctgaagaatcggcaaaatctcttccaggaa gagggaatgatcaacctcgtgctcgagtgcatagaccgattgcacgtctacagcagtgca gcacactttgctgatgttgctgggcgagaagcaggggagtcttggaaatccattctgaat tctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgctcagttt tccggctcccttgactggttgatcagcagattggaaagactggaagcttcttcgggcatt ctggaagttttacactgtgttttagtagaaagtccagaagctctaaatattattaaagaa ggacatattaaatccattatctcacttttagacaagcatggaagaaatcacaaggtcctg gacgtgttgtgctcactctgtgtttgccatggggttgcagtccgttctaaccagcacctc atctgtgacaatctcttaccaggaagagatctgttactgcagacacgtcttgtgaaccac gtcagcagcatgagacccaatatttttctgggcgtcagtgaaggttctgctcagtataag aaatggtactatgagttgatggtggaccacacagagccctttgtgacagctgaagcaacg cacctgcgagtgggctgggcttccactgaagggtattctccctaccctggagggggcgaa gagtggggtggaaatggtgttggagatgatctcttctcctatggatttgatggccttcat ctctggtcaggttgtattgctcgtactgtaagctcaccaaaccaacatctgttaagaact gatgatgtcatcagttgctgtttagatctaagtgccccaagcatctcgttccggattaat ggacaacctgttcaaggaatgtttgagaatttcaacatcgatggcctcttctttccagtc gttagtttctctgcgggaataaaagtacgctttctgcttggggggcgacatggagaattc aaatttcttcctccacccgggtacgctccttgttatgaagctgttctgccaaaagaaaag ttgaaagtggaacacagccgagagtacaagcaagaaagaacttacacacgcgacctgctg ggccccacggtttccctgacacaagctgccttcacaccgatccctgtggataccagccag attgtgttgcctcctcatctagaaagaataagagaaaaactggcagagaatatccatgaa ctctgggttatgaataaaattgagcttggctggcagtatggaccggttagagatgacaac aagagacagcacccatgccttgtggagttctccaagctgcctgaacaggagcgcaattac aacttacaaatgtcacttgagaccctgaagactttgttggcattaggatgtcatgtgggt atatcagatgaacatgctgaagacaaggtgaaaaaaatgaagctacccaagaattaccag ctgacaagtggatacaagcctgcccctatggacctgagctttatcaaactcaccccgtct caagaagcaatggtggacaagttggcagaaaatgcacacaatgtgtgggcgcgggatcga atccggcagggctggacttacggcatccagcaggacgtaaagaacagaagaaatcctcgc cttgttccctacactcttctggatgaccgaaccaagaaatccaacaaggacagcctccgc gaggccgtgcgcacgctgctggggtacggttacaacttggaagcaccagatcaagaccat gcagccagagccgaagtgtgcagcggcactggggaaaggttccgaatcttccgtgctgag aagacttacgcagtgaaggcgggacggtggtattttgaatttgagacggtcactgctgga gacatgagagttggttggagtcggcctggttgtcaaccggatcaggagctcggctcggat gaacgtgcctttgcctttgatggcttcaaggcccagcggtggcatcagggcaacgaacac tatgggcgctcttggcaagcaggcgatgtcgtgggctgtatggttgacatgaacgaacac accatgatgttcacactgaatggtgaaatccttcttgatgattcaggttcagaactggct ttcaaggactttgatgttggcgatggattcatacctgtgtgtagccttggagtggctcaa gtgggcaggatgaactttggaaaggatgtcagcaccttgaaatacttcaccatctgtggc ttacaagagggctatgaaccatttgccgttaatacaaacagggatattactatgtggctg agcaagaggcttcctcagtttctccaagttccatcaaaccatgaacatatagaggtgacc agaatagacggcaccatagacagttccccatgtttaaaggtcactcagaagtcttttggt tctcagaacagccacactgatatcatgttctatcgcctgagcatgccgatcgagtgcgcg gaggtcttctccaagactgtggctggagggctccctggggctggcctttttgggcccaag aatgatttggaagattatgatgctgattctgactttgaggttctgatgaagacagctcat ggccatctagtgcccgatcgtgttgacaaagacaaagaagctaccaagccagagtttaat aaccacaaagattatgcccaggaaaagccctctcgtctgaaacaaagatttttgcttaga agaacaaagccagattacagcacgagccattctgcaagactcaccgaagatgtccttgct gatgatcgggatgattatgatttcttgatgcaaacgtccacgtactattactcagtgaga atcttccctggacaagaacctgctaatgtctgggtgggctggattacgtcggatttccat cagtatgacacaggctttgacttggacagagttcgcacagtaacagttactctaggagat gaaaaaggaaaagtgcatgaaagcatcaaacgcagcaactgctatatggtatgtgcgggt gagagcatgagccccgggcaaggacgcaacaataatggactggagatcggctgtgtggtg gatgctgccagcgggctgctcacgttcattgccaatggcaaggaactgagcacatactat caggtggagccgagtacaaaattatttcctgcggtttttgcacaagctacaagtcccaat gttttccagtttgagttgggaagaataaagaatgtgatgcctctctcggcgggattattc aagagtgagcacaaaaaccccgtgccgcagtgccccccgcgcctccacgtgcagttcctg tcacacgtgctgtggagcagaatgcccaaccagtttttgaaggtagatgtgtctcgaata agtgaacgccaaggctggttggtgcagtgtttggatcctctgcagttcatgtctcttcat atccctgaggaaaacagatctgttgacatcttagagttgacagagcaggaggagttgctg aaatttcactatcacactctgcggctctactcagccgtctgtgctcttgggaaccaccgg gtggcccacgccctgtgcagccacgtggatgaacctcagctcctctacgccattgagaac aagtacatgcctggcttgctgcgtgctggctactatgacctgctgatcgacatccacctg agctcctatgccactgccaggctcatgatgaacaacgagtacattgtccccatgacggag gagacgaagagcatcaccctgttccctgatgagaacaaaaagcatggccttccagggatc ggcctcagcacctccctcaggccacggatgcagttttcctcccctagttttgtaagtgtt agtaatgaatgttaccagtacagtccagagttcccactggatatcctcaaggccaagacc atacagatgctgacggaagctgttaaagagggcagtcttcatgcgcgggacccagttgga gggactactgaattcctctttgtgcctctcatcaagcttttctataccctgctaatcatg ggcatcttccacaacgaggacttgaagcacatcttgcagctgatcgagcccagtgtgttt aaagaagcggccactccagaggaggagagtgatacgctggagaaagagctcagtgtggat gacgcaaagctgcaaggagctggtgaggaagaagccaagggtggcaagcggcccaaggaa ggcctgctccaaatgaaactgccagagccagttaaattgcagatgtgcctactgcttcaa tacctctgtgactgccaggtccggcaccggatagaagccattgtagccttttcagacgat tttgtagctaagctccaagacaatcaacgtttccgatacaacgaagttatgcaagcctta aacatgtcagctgcactcacagccaggaaaacaaaggaatttagatcaccacctcaagag cagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtccgtgtccagaagaa attcgtgaccaactattggatttccatgaagatttgatgacgcattgtggaattgagctg gatgaagatgggtctctggatggaaacagtgatttaacaattagagggcgtctgctatcc ctggtagaaaaggtgacatacctgaagaagaagcaagcagaaaaaccagttgagagtgac tccaaaaagtcctccactctgcagcagctgatctctgagaccatggtccgatgggctcag gagtctgtcattgaagaccccgagcttgtgagggccatgtttgtgttgctccatcggcag tatgatggcattgggggtcttgttcgggccctgccaaagacgtacacaataaatggtgtg tctgtggaggacaccatcaacctgctggcgtcccttggtcagattcggtccctgctgagt gtgagaatgggcaaagaagaagagaagcttatgattcgtggattaggggatattatgaat aacaaggtgttttaccagcaccctaatctcatgagggcactggggatgcatgagactgtg atggaggtcatggtgaacgtccttggaggtggagagtccaaggaaatcacctttcccaag atggtggccaactgttgccgttttctctgttacttctgtcgtataagtaggcagaatcaa aaagctatgtttgatcatctcagttatttactggaaaacagcagtgttggtcttgcctcc ccagctatgagaggttcaacaccactggatgtggctgcagcttcggtgatggataataat gaactagcattagctctgcgtgagccggatctagaaaaggtagttcgttacttggctggt tgtggactgcagagttgccagttgctggtgtctaagggttatccagacattgggtggaat ccagttgaaggagagagatatcttgactttctcagatttgctgtcttctgtaatggggag agtgtggaggagaatgcaaatgtcgtggtgagattgctcattcggaggcctgagtgtttt ggtcctgctttgagaggagaaggtgggaatgggcttcttgcagcaatggaagaagccatc aaaatcgccgaggatccttctcgagatggtccctcaccaaatagcggatccagtaaaaca cttgatacagaggaggaggaagatgacactatccacatggggaacgcgatcatgaccttc tatgcagctttgattgacctcttgggacgctgtgcgcctgagatgcatttgattcatgct ggtaagggagaagccatcagaattaggtctattttgagatccctaattcccttgggagat ttggtgggcgttatcagcatcgcttttcagatgccaacaatagccaaagatgggaatgtg gtggaacctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttattc cttgacagggtctatggaattgaggttcaagacttcctcctccatcttcttgaggttggc tttctgccagatctccgggcggctgcttctttagatacggcggctttgagtgctacagac atggccttggccctcaatcggtacctttgcacggccgtcttgccgttgctaacaagatgt gctcctctctttgctggcacagagcaccatgcttctctcattgactcattgcttcatact gtgtatagactttctaagggctgttcacttaccaaagctcagcgggattctatagaagtt tgtttgctctctatttgtggacaactgagaccttctatgatgcagcacttactcagaaga ttagtatttgatgttccattattaaatgaacatgcaaagatgcctcttaaactgctgaca aatcattatgaaagatgctggaaatattactgcctgcctggagggtggggaaactttggt gctgcctcagaagaagaacttcatttatcaagaaagttgttctggggcatttttgatgcc ctgtctcaaaagaaatatgaacaagagcttttcaaactggcactgccttgcctgagtgca gttgcgggagctttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaa cagtcatcaatggattctgaagggaactttaacccacaacctgttgatacctcaaatatt acaattcctgagaagttggaatacttcattaacaaatatgcagaacactcgcatgacaaa tggtcaatggacaagttggcaaatggatggatttatggagaaatatattcagactcttct aaagttcaaccattaatgaagccatataagctattgtctgaaaaggaaaaagaaatttat cgctggccaatcaaagaatctttaaaaactatgctggcttggggctggagaattgaaaga actcgagagggagacagcatggccctttacaaccggactcgtcgtatttctcagacaagc caggtttctgtagacgctgcccatggttacagtccccgggccattgacatgagcaatgtt acgctatctagagacctgcatgctatggcagaaatgatggctgaaaactaccataatata tgggcaaagaaaaagaaaatggagttggagtccaaaggaggaggtaaccaccctctgctg gtgccctatgatacactgacagccaaagagaaagccaaggatagagaaaaagcacaggac atcctcaagttcttgcagatcaatggatatgctgtatccagaggatttaaggacctggaa ctggacacgccttctattgagaaacgatttgcctacagtttcctccaacaactcattcgc tatgtggatgaagcccatcagtatatcctggagtttgatggtggcagcagaggcaaagga gagcatttcccttatgaacaagaaatcaagttctttgcaaaagtcgttcttcctttaatt gatcagtatttcaaaaaccatcgtttatacttcttatctgcagccagcagacctctctgc tctggaggacatgcttccaacaaagagaaagagatggtgactagcctattctgcaaactt ggagttcttgtcaggcataggatttcactatttggcaatgatgcaacatcaattgtcaac tgtcttcatattttgggtcagactttggatgcaaggacagtgatgaagactggcctggag agtgttaaaagtgcactcagagcttttctggacaatgccgcagaggatctggagaagacc atggaaaacctcaagcagggccagttcactcacacccgaaaccagcccaaaggggttact cagattatcaattacaccacagtggccctgcttccaatgctgtcgtcattatttgagcat attggccagcatcagttcggagaagacctcatattggaagatgtccaggtgtcttgttat agaattctgactagcttatatgctttgggaaccagcaagagtatttatgtggagaggcaa cgttctgcgttaggagaatgtcttgctgcgtttgctggtgcctttcctgtagcatttttg gaaactcatctggacaaacataatatttactccatctacaataccaagtcttcacgagaa agagcagctctcagtttgccaactaatgtggaagatgtttgtccaaatataccgtctttg gagaaactcatggaagaaatcgtggaattagctgagtccggcattcgctacactcaaatg ccacatgtgatggaagtcatactgcccatgctttgcagctacatgtctcgttggtgggag catgggcctgagaacaatccagaacgggccgagatgtgctgcacagccctgaactcagag cacatgaacacacttctagggaacatattgaaaatcatatataataacttggggattgat gagggagcctggatgaagaggctagcagtgttttcccagcctataataaataaagtgaaa cctcagctcttgaaaactcatttcttgccgttaatggagaaactcaagaaaaaggcagcc atggtggtgtctgaggaagaccacctgaaagccgaggccaggggggacatgtcagaggct gaactcctcatcctagatgagttcaccacgctggccagagatctctatgccttctaccct ctcttgattagatttgtggactataacagggcaaagtggctgaaggagcctaacccggaa gcagaggagctcttccgcatggtggcagaagtgtttatctactggtcgaaatcccataat ttcaaaagagaagagcagaacttcgttgtacagaatgaaatcaacaatatgtctttcctt attactgataccaagtccaagatgtccaaggcagctgtttctgatcaggaaaggaagaaa atgaagcgcaaaggagatcggtattccatgcagacctctctgattgtagcagctctgaag cgcttactgcccattgggttgaacatctgtgccccaggggaccaggagctcattgctcta gccaaaaatcgatttagcctgaaagatactgaggatgaagtacgagatataatccgcagc aatattcatttacaaggcaagttggaggatcctgctattagatggcaaatggctctttac aaagacttaccaaacaggactgatgatacctcagatccagagaagacggtagaaagagta ttggatatagcaaatgtgctttttcatcttgaacagaagtctaaacgtgtgggtcggaga cattactgtctgggaagtactgtggaacatcctcagagatctaaaaaggctgtatggcat aaactactctctaagcagaggaaaagggctgttgtcgcctgcttccggatggccccctta tataatctgccaaggcatcgggctgtcaatctctttcttcagggatatgaaaagtcttgg attgaaacagaagaacattactttgaagataaactgatagaagatttagcaaaacctggg gctgaccctccagaagaagacgaaggcactaaaagagttgatcctctacatcagctgatc cttctgtttagtcggacagctttaacagagaaatgcaaactggaggaagattttttatat atggcctatgcagatattatggcaaagagttgtcatgatgaggaagatgatgacggtgaa gaggaagtgaagagttttgaacacgatattatcaaagatttaagaaacaaatttgccagc ctcggcgagaactctctggaaaaagaaatggaaaagcaaaagcttctataccagcaagcc cgactccacgaccgtggtgcggctgagatggtgctgcagaccatcagtgccagcaaaggt gaaactggaccaatggtagcagctactttgaaacttggaattgctattttaaatggtggg aactccacagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttc tttcagagcctggccggcctgatgcagtcatgtagtgtccttgacctaaatgcatttgag cgacaaaacaaagctgaaggtcttgggatggtgacagaggaaggatcaggagaaaaggtt ctacaggacgatgagtttacctgtgacctcttccgattcctgcagctactctgtgaggga cacaactcagattttcagaattatctgagaactcagactggcaataatacaactgtcaac ataatcatctccactgtagactacctactgagagttcaggaatcaattagtgacttttac tggtattactctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagct attcaagtggcaaaacaagtctttaacactcttacagagtatattcagggtccttgcact gggaatcaacagagtttggcacacagcaggctgtgggatgctgtggtcggctttcttcat gtatttgcccatatgcagatgaagctgtcgcaggattccagtcaaattgaacttttaaaa gaattaatggatctgcagaaggatatggtggtcatgttgctgtccatgctagaaggtaat gttgttaacggaacgattggcaaacagatggtggatatgcttgtggaatcttccaacaat gtggagatgattctcaaattttttgacatgttcttaaaactgaaagatttgacgtcgtct gatacttttaaagaatatgaccccgatggcaagggagtcatttccaagagggacttccac aaagcgatggagagtcataagcactacacgcagtcagaaacggaatttcttttgtcttgt gcggagacggatgagaatgaaacccttgactatgaggagttcgtcaaacgcttccacgaa cctgcaaaggacatcggcttcaatgtcgccgtccttctgacaaacctctctgagcacatg cccaacgatacccgacttcagactttcctagaattagccgagagtgtcctgaattatttc cagccctttctgggccgcatcgaaatcatgggaagcgccaaacgcatcgagagagtctat tttgaaatcagtgagtctagccgaacccagtgggagaagccccaggtcaaggagtccaaa cgacagttcatctttgatgtggtcaatgaaggaggagaaaaagagaagatggaactcttt gtgaacttctgcgaggacaccatcttcgaaatgcagctggcggctcagatctcagagtcg gatttgaacgagaggtcagcgaataaggaagaaagtgagaaggagaggccggaagagcag gggccgagaatggctttcttctccattctgacggtcaagtcggccctgtttgcgctcagg tacaatatcttgacccttatgcgaatgctcagtctgaagagcctgaagaagcagatgaaa aaagtcaaaaagatgaccgtgaaggacatggtcacggccttcttttcatcctactggagt atttttatgaccctcttgcacttcgtggccagcgttttcagaggctttttccgcatcatt tgcagcctgctgcttgggggaagcctcgtcgaaggtgctaaaaagatcaaagttgcagaa ctcttagccaacatgccagaccccactcaggatgaggttagaggagatggggaggaggga gagaggaaaaccctggaagccgccctgccctctgaggatctgaccgacttaaaggagctg acagaagagagtgaccttctttcggacatctttggcctggatctgaagagagaaggagga cagtacaaactaatccctcataatccaaatgctgggctcagtgacctcatgagcaaccca gtccccatgcctgaggtgcaagaaaaatttcaggaacagaaggcaaaagaagaagaaaag gaagaaaaagaagaaaccaaatctgaacctgaaaaagccgagggagaagatggagaaaaa gaagagaaagccaaggaagacaagggcaaacaaaagttgaggcagcttcacacacacaga tacggagaaccggaagtgcccgagtcagcgttctggaagaaaatcatagcataccaacag aaacttctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtc gcatttgctatcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaa ggaaaggagctccccactagaagttcaagtgaaaatgccaaagtgaccagcctggacagc ggctcccatagaatcatcgcagttcactatgtactggaggagagcagcggctacatggag cccacgttgcgtatcttagctattctccacacggtcatttctttcttctgcatcattgga tactactgcttgaaagtcccattggttatttttaagcgagaaaaggaagtagcacggaaa ttggaatttgatgggctttatattacagaacagccttcagaagatgatattaaaggccag tgggatagactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgtt aaaagaaaggtaatggataagtatggagagttctacggccgagacagaattagtgaatta cttggcatggacaaggcagctctggacttcagtgatgccagagaaaagaagaagccaaag aaagacagctccttatcagctgtactgaactctattgatgtgaagtatcagatgtggaaa ctaggagtcgttttcactgacaactccttcctctacctagcctggtatatgacgatgtct gttcttggacactataacaactttttttttgctgctcaccttctcgacattgctatggga ttcaagacattaagaaccatcttgtcctcagtaactcacaatggcaaacagctcgtatta actgttggcttgttagctgttgttgtgtacctgtacactgtggtggcattcaattttttc cgaaaattctacaataaaagtgaagacggtgatacaccagatatgaaatgtgatgatatg ctaacgtgctatatgttccacatgtatgttggagttcgtgctggaggagggatcggggat gaaatcgaagacccagcaggagatgaatatgagatctatcgaatcatctttgacatcact ttcttcttctttgttattgtcattctcttggccataatacaaggtctaattatcgatgct tttggagaactaagagaccaacaggaacaagtcaaagaagacatggagaccaagtgcttc atctgtgggataggcaatgattacttcgacacggtgccacatggctttgaaacccacact ttacaggagcacaacttggctaattacttgttttttctgatgtatcttataaacaaagac gaaacagaacacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgctgg gaatttttcccagcaggggattgtttccggaaacagtatgaggaccagctaaattaa

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