Taeniopygia guttata (zebra finch): 100225109 Help Entry 100225109         CDS       T01082                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism tgu  Taeniopygia guttata (zebra finch) Pathway tgu04020   Calcium signaling pathway tgu04260   Cardiac muscle contraction tgu04261   Adrenergic signaling in cardiomyocytes tgu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tgu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100225109 (RYR2)    04020 Calcium signaling pathway     100225109 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     100225109 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     100225109 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tgu04040]     100225109 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:tgu04990]     100225109 (RYR2) Ion channels [BR:tgu04040]  Voltage-gated cation channels   Ryanodine receptor    100225109 (RYR2) Domain-containing proteins not elsewhere classified [BR:tgu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100225109 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  100225109 NCBI-ProteinID:  XP_030124087 Ensembl:  ENSTGUG00000010491 LinkDB All DBs Position 3:complement(66905642..67273009) Genome browser AA seq 4978 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWSAQGGGHRTLLYGHAILLRHSY SGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECL TVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKY LSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQH VDTGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFL FNRFIRGLDVLSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHENKQNRLRALKNR QNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISE GSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSY GFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNID GLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVENSREYKQDRS YTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYG PVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMK LPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVK NRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCSGIMEKF RIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRW HQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADGFLPVC SLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNH EHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGS GLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLK QRFMLRRTKPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGW ITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGL EIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMP LSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPL QFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQL LYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKK HGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLH VRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFKEAMSQEDEIDFSE KEFSSDELKSEEGEEETRGEQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIV AFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDC PCPEEIRDQLLDFHEDLMTHCGIELDEDGALDGNSDSTIRGRLLYLMEKVTYLKKKQDEK TVDEDDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTY TINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA MEEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFCPDHKA AMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQ HLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFW GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPV DTSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYKLLSEK EKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAI DMSNVTLSRDVHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLVPYDTLTAKEKAKD REKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG GSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVT SLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRTFLDNAA EDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILED VQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYN TKNARDRAVLNLPTSVEEVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPMLCSY MSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQP IISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARD LYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEI NNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGD QELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPE KTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAV NLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALT EKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKHDIIKDLRNKFASL GENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGN STVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVM QDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYW YYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHV FAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNV EMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHRAMESHKHYTQSETEFLLSCA ETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQ PFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFV NFCEDTIFEMQLAAQISESDLNERSANKEENDKDNPEEEDPRMGFFSLVTMKSALVALKY NLMTLMKMLSMKSLKKQMKKMKKMTMKDMVLALFSSYWSILVGLLHFACSVVRGFFRIIC SLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEEEEGERKPTEAALPAEDLTDLQTLT EESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEKVKEDEK EEKEETKSEPEKAEGEDGEKEEKTKEDKGKQKLRQLHTHRYGEPEVQESVFWKNIIAYQQ KLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKELPVVSDGESTKLNILES DDERVIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISEL LGMDKAALDFSDAREKKKPKKDSSFSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMS VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaagagcaacaaaaattgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatctaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggctaacacggaagaaaaggcagaagggctagttgatgtggaaaaatggtctgca caaggtggtggacatagaactctgctctacgggcatgcgatcttgctgcgccattcctac agcggcatgtacctatgctgtctttctacatctcgatcgtcaatggataagctggcattt gatgtaggattgcaagaggacacaacaggtgaggcttgctggtggaccatacatcctgct tctaaacaacgatcagaaggagaaaaagtgcgcgttggagatgatctgattttagtcagt gtctcttcagaaagatatttgcatctctcttatggcaatggtagcttacacgttgatgca gccttccagcagacactctggagtgtagcaccaatcagttcaggaagtgaagttgcccaa ggataccttataggaggggatgttctgaggttattgcatggtcacatggatgaatgtttg acggtcccttcaggtgaacacggagaagaacaaagaagaactgtccattatgaaggtggt gctgtgtccattcatgctcgttccctttggcgactagagactctaagagttgcgtggagt ggaagccacattagatggggacagccattcaggctaagacatataacaacaggaaaatat ttaagtctcctggatgacaagagtcttcttcttacagacaaagagaaggcagatgtaaaa tctacagcattctgttttcggtcttccaaggaaaagttggatatagggacaagaaaggag gtggatgggatgggagcacctgaaataaagtatggggattcaatatgcttcatacaacat gtagatacaggcttgtggctcacataccagtctgctgatgcaaagtctgtaaggatgggc tctctgcagcgaaaggcaataatgcaccatgaagggcatatggatgatggtttaacacta tccagatctcagaatgaagaatcccgcacagcacgtgtcatccgtagtacagtcttcctt ttcaacaggttcataaggggccttgatgttctcagcaagaaagtgaagtcttccaccatc gatttgcctatcgagtcagtcagtctgagcctgcaggacttgattggctactttcacccc cctgatgaacatttggagcatgaaaacaaacaaaacaggctcagagcactgaaaaatcgc cagaacctcttccaagaagagggtatgatcaaccttgttcttgaatgtattgatcgcttg aatgtatacagcagtgcagctcactttgcagatgtagctgggaaggaggccggagaagca tggaaatctattctgaattctttgtatgaattactagcggctctgattcgaggaaatcgt aaaaactgtgctcaattttctggatctcttgattggttaatcagcagattagaaagactg gaagcctcttctggaattctagaggttttacattgtgtgttggtagaaagcccagaagct ctaaacattattaaggaaggacatattaaatcaatcatctgtcttttggacaagcatgga agaaaccataaggttttggatgttttgtgttctctctgtgtttgtcatggagtagctgtg cggtctaatcaacatctaatctgtgataatctcctgccaggaagagatctgctcttacag acacgccttgtcaaccatgtgagcagcatgcgacccaacatcttcttggggattagtgaa ggttcggctcaataccgaaaatggtactatgaacttatggtggaccatctagagcccttt gtgactgcagaatcaactcacctacgagtgggctgggcttcaacagaaggctactcacct tacccagggggaggagcagaatggggaggaaatggtgttggtgatgacttatattcctat ggctttgatggtctacatctgtggtcaggttgtgtagcacgaacagtaaattctcccaac caacatctattaagaactgatgatgttattagctgctgtttggacctgagtgcccccagc atctctttccgaataaatggtcagccagttcaaggaatgtttgaaaacttcaacatagat ggcctcttcttcccagttgtcagcttctctgcaggaataaaggttcgtttcttgcttgga ggtcgccatggagagttcaagttccttcctccacctggatatgctccatgctttgaagct gtcctaccaaaagagaagctgaaagtggagaacagccgagagtacaaacaagatcgtagc tacacaagagacctgctgggtcccactgtctccctgtcacaagcagctttcactccagtt cctgtagatactagccagattgttttgcctccccacctggaaagaattagagaaaaatta gcagagaacatccatgaactttgggttatgaataagattgaacttggctggcaatatgga ccagttagagatgacaacaaaagacaacacccatgcttagtggagttctcaaaattgccg gagcaggaaagaaattataacttgcaaatgtcacttgaaacactgaaaaccctgctggca ttaggttgccacgttggaattgctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaa cttccaaagaactatcagttgttgagtggatataagccagcacccatggatctgagtttt atcaaactgaccccctctcaagaagctatggtggataaactagcagagaatgctcacaat gtatgggcaagggaccgtataaggcaaggctggacatatggcatccagcaggatgtgaaa aaccgacgaaatcctcgccttgtaccgtatgctcttttggatgatcgcacaaagaagtcc aacaaagacagtcttcgggaagcagtccgcacccttctaggctatggctacaatctggaa gctcctgatcaagaccatgcaacaagactggatgtgtgcagtgggataatggaaaagttc aggatcttccgcacagaaaagacttacgcagtgaaggctgggaagtggtactttgagttt gaggcagttactgcaggagacatgagagttggctggaccaggccaggttgtctgccagat caggaacttggctcagatgaagaagcttttgtttttgatggctttaaggcacagcggtgg catcaaggtaatgagcattttggccgctcttggttggcaggagatgttgttggatgtatg gttgacatgaatgagcacacaatgatgttcaccttaaatggtgaaatcctgcttgatgac tcaggctcagaacttgcgttcaaggactttgaggttgctgatggatttctacctgtgtgc agcctgggcccatctcaagtgggaagaatgaactttggaaaagatgtcagcactctgaaa tatttcactatatgtggcttacaggaagggtatgaaccctttgctgttaatacaaacaga gacatcaccatttggctgagtaaaaggcttcctcagtttctaccagtgccacaaaaccat gaacatattgaggtgatgagaattgatgggaccatagacagctgcccctgtctgaaggtc acacagaagtcctttggttcacagaacagtaaaacagatgtcatgttttttcgattaagt atgcccattgaatgtgctgaggtgttctccagatcagctgcaggagggttaccaggctct ggtctttttggcccaaaaaatgacttggaagattatgacgctgattctgattttgaggtt ctaatgaaaactgctcatggtcatttagttcctgaccggacagaaagagaaaaagatgcc acaaaaccagagctcaataaccataaagattatgttcaagaaaagccctcacgtcttaag caaagatttatgctcaggaggacaaagccagattatagcatgagtcactctgcacggctt actgaggatgtactagcagatgatagggatgactatgattacttgatgcaaacttccacg tactactattctgtgagaatatttcctggtcaagaacctgctaatgtctgggtgggctgg attacatcagactttcaccagtatgacacaagctttgacttggacagagtgcgtactgtc acagttacactgggagacgaaaaagggaaggttcatgagagtataaaacgcagcaactgc tacatggtgtgtgcaggagagagcttgagccctggacaaggacgtaataataatggtctg gagattggttgcttggttgatgctgccagtggcctgctgaccttcacagctaatggcaag gaattaggcacatactatcaggttgaaccaagtacaaagttgtttcctgctgtatttgct caagctacaagtcccaatgttttccagtttgaattgggaagaataaagaatgtaatgcca ttatctgctggattattcaaaagtgagcacaaaaacccagtctctcaatgtcccccacgt ctccatgtccagtttctgactcatgtgctttggagcagagtaccaaaccatttcttaaag gtggatgtgtctcggatcagtgaacgtcaaggctggatgatacagtgcctgaatcctttg cagttcatggcccttcatattcctgaggaaaacagaacaattgatattttagagctgaca gaacaggaagaattgctgaaatttcactaccacaccctccgattgtattcagctgtgtgt gctttaggcaacaacagagtggcccatgctctgtgtagccatgtggatgaatctcagctt ctctatgctattgagaataaatacatgccaggattattacgtgcgggatattatgactta ctcattgacatccatctcaatacctatgcaactgccaggctgatgatgaataatgaattt atagttccaatgacagatgagaccaagagtattactttgtttcctgatgaaaacaaaaaa cacggccttcctggtattggacttagtacttcattaaggccaagaatgcagttttcctct ccgagttttgtaagcattagcagtgaatgctttcagttcagtcctgaattccctctggaa attttgaaggccaaaaccatagagatgctgactgaagctgttcaggagggaagcctccat gtcagagatccagttggaggttctacagaatttctgtttgttcctctcatcaagctcttt tataccctcctaattatgggaatcttccacaatgaggatctgaaacacatcctgcagttg attgagcctcgagttttcaaagaagcaatgagccaggaggatgaaattgatttctcagag aaggagttcagttcagatgagctcaagtcagaagaaggagaggaagaaaccagaggagag caaatgccaaaggaaggactccttcagatgaaacttccagaacctgttaaattacagatg tgtcacctactccagtacctgtgtgattgtcaagtgcgacaccgaatagaagccattgta gcattttctgatgattttgtggccaagcttcaggagaatcagcgcttccggtacaatgag gtgatgcaggccttgaacatgtctgctgccctgacagctaggaaaacaaaagaatttcga tcccctcctcaggaacagattaatatgctgctgaactttaaagatgataaaaatgattgt ccttgccctgaagaaattcgggatcaactcttggatttccatgaagacctaatgacacat tgtggaattgaactagatgaagatggagccttggatggcaacagtgattcaaccattagg ggtcgcctcctataccttatggaaaaagttacgtatctgaagaagaaacaagatgagaag acagttgatgaggatgataagacatcctctactctccagcagttgatttcagacacgatg gtgcgttgggcccaggagtcagtgatagaagacccggagttagtgagagccatgtttgtg ctgctgcatcgccagtatgatggcattggtggtctggttcgagccctaccaaagacctac accataaatagcgtgtctgtggaagacaccatcaaccttctggcatcccttggccaaatc cgttccttgcttagtgtcagaatggggaaggaagaggagaagcttatgattcgtggatta ggagacatcatgaataataaagtattttaccaacatccaaatctcatgagagctttaggc atgcatgaaactgtcatggaagtgatggtgaatgtgcttggtggaggagaatccaaggaa atcactttcccaaagatggtggcaaactgctgtcgttttctatgttatttttgccgcatc agcagacagaatcaaaaagctatgtttgatcatcttagctatttattggaaaatagcagt gttggccttgcctctccttctatgcgagggtcaactcctttagatgttgctgcagcatcc gtaatggataacaatgaacttgctctggcgttaagggagcctgatctggagaaggtggtt cgctacttggctggatgtgggttgcagagttgtcctttgttgatttgtaaaggctaccca gacatcggatggaatccagttgaaggagaaagatatttggattttcttcgttttgctgtc ttttgcaatggagagagtgtggaggagaatgctaatgttgtagtcagactgcttattcgc cggcctgagtgttttggtcctgctctaagaggagaaggaggcaatgggttgcttgctgcc atggaggaggcaatacaaatatcagaagatagaacaagagatggaccttccccgagtaat ggatctagtaaaacccttgaaatagaagaacaagaagatgacactattcacatgggaaat gcaataatgaccttttatgctgccttgattgatctcttaggacgttgtgcccctgaaatg catctaatccatgctggtaaaggggaagccattagaatcagatcaattctacggtctttg attccacttgaagatttggtgggagttatcagtattgctttccacatgccaaccatagca aaagatggtactgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggca gccatggttttgttccttgacagggtctatggaattgaggaccaggattttcttctacat cttcttgaagttggctttctgccagaccttcgtgctgctgcctcattagatacggctgct ttaagtgctacagatatggctttggctctgaatcgatacctttgcacagcagtcttgcct ctcttgaccagatgtgctcctctgtttgctggcacggagcaccatgcttccctcatcgat tccctattacacactgtgtacagactctcaaagggatgctctcttaccaaagctcagcga gattctattgaagagtgtttgctgtccatctgtgggcagttgcggccttccatgatgcag catttgctgaggagattagtatttgatgtacctctgttaaatgaacatgcaaagatgcct ctcaagttgctgacaaatcattatgaaagatgctggaagtattattgtttgccaagtgga tggggtaactttggtgcagcgtcagaagaagaacttcatttatccagaaaattgttctgg ggtatttttgatgctttatctcaaaagaagtatgaacaagaactgttcaaattggccttg ccttgtctgagtgcagttgcaggagccttacctccagattatatggaatcaaattatgtc aatatgatggaaaagcagtcttcaatggattcagatgggaactttaatcctcaacctgtt gatacctcaaacattacaatccctgaaaagctagaatatttcattaacaaatatgcagaa catgctcatgacaagtggtcaatggaaaagtttgccaatggatggacctatggtgaaaca ttttctgaatctgcaaaggtgcaaccattaatgaaacaatataagttgctgtctgaaaag gagaaagaaatttatcgatggccaatcaaagaatcactcaaaaccatgctagcatgggga tggcgaattgaaagaacacgggaaggagattccatggcactgtataatcggacgcgtcgc atatctcaaaccagtcaaatctctgtagatacagcccatggttacactcctcgagcaatt gacatgagcaatgtcaccctctccagagatgtacatgctatggctgagatgatggctgaa aactaccataacatatgggcaaagaaaaagaaactggagcttgaagcaaaagtaggagga ggcaaccatccccttcttgttccttatgatacactcacagccaaagaaaaagccaaggac agagaaaaagcacaggatattctgaaatttctacagattaatggatatgttgtctccaga ggacttaaggacctggaattagacacaccttcgattgagaaacgctttgcctatagtttc cttcaacagcttataagatatgtggatgaagcccatcagtacattttggagtttgatggt ggcagcagaggcaaaggagagcaattcccatatgaacaggaaatcaagttttttgccaaa gttgtgctccctttgattgatcagtattttaaaaatcatcgcctgtatttcttatcttca gcaagtaggcctctcagcagtgggggccatgcctctaataaagagaaagaaatggtgaca agcctgttctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaacgat gcaacatcaatagtcaactgtcttcacatactgggacagaccctggatgcaaggactgtg atgaaaactggtctggaatctgttagaatggcactgagaacatttttggacaatgctgct gaggatctggagaaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaac cagccaaaaggagttacacaaatcattaattataccacagttgctctcctgccagtccta tcttcattatttgagcatattggacagcaccagtttggggaagatttgatattggaagat gttcaggtctcttgttacagaatattggccagtttatatgctctgggaaccagcaagagt atctatgtagagaggcaacgatcagcactgggagaatgcttggctgctttctcaggggcc tttccagtggcttttttggaaactcatttgaacaaacataatatctactcaatctacaat accaagaatgcaagagatagagcagttctcaatttgccaactagtgtagaagaggtttgc ccaaatattccttccttgatgaagctaatggaagaaatagtggaactggcagaatccggt attcgttacacacaaatgccacatatcatggaagtcatactgcctatgctgtgtagttac atgtcacactggtgggagcatgggccggagaacaatcctgacaaggctgaaatgtgttgc acagccttgacgtcagagcacatgaacactctgttgggtaacatattgaaaatcatctat aacaaccttggtattgatgaaggagcctggatgaagagattagcagtgttttcccagccc atcataagtaaagcgaagccacagctcttaaagacacacttccttccactgatggataaa ctaaagaaaaaggcagcagtggttgtatcggatgaagaacatctaagagcagaaggcaga ggtgacatgtcggaggctgaactgctcatcctagatgagttcaccactttggcacgggac ctctatgccttctaccctttgttgattagatttgtggactataacagggcaaaatggctg aaagagcctaatcctgaagcagaagagttgttccgcatggtggctgaggttttcatttac tggtcaaagtctcacaatttcaaaagggaagagcagaactttgtggtacaaaatgaaatc aacaacatgtctttccttatcagtgacaccaaatctaagatgtctaaggcagcagtttct gaccaggaaaggaagaaaatgaagcgaaaaggtgaccgctactctatgcagacctctctc attgtggcagcactgaagagactgcttccaataggcctaaacatttgtgctcctggagac caagagctgattgcactggccaaaaatcgttttagcatgaaagacacggaagatgaagta cgagatgtcatccgcagtaatcttcaccttcagggcaagctcgaggatcccgccattaga tggcagatggcactttacaaagatttgccaaacaggactgaagattcctcagatccagag aagacggtggaaagggtccttgatatagctaatgtgctatttcacctggaacaggttgag catccgcagcggtccaagaaggcagtgtggcataagctgctgtctaaacagaggaaaaga gcagtggtggcctgctttagaatggcaccgttgtataatctgccaagacaccgagccgtc aatctctttcttcaaggctatgataaatcttggattgaaacagaagaacactattttgaa gacaaactgatagaagacttagcaaaacccggagaggaaccaccagaagaagatgaaagc cttaaaagagttgatcctttacatcaacttattctgctattcagtcgaacagccttgact gaaaaatgcaaattggaagaagatttcctgtatatggcttatgctgacattatggcaaag agctgccatgatgaagaagatgatgatggtgaagaagaagtgaagagttttgaagtgaca ggatcacaacgcagcaagcacgatattatcaaagatttaagaaacaaatttgccagcctc ggcgagaactctctggaaaaagaaatggaaaagcaaaaacttctgtatcaacaagccagg ctgcatgatcggggtgctgctgagatggttctgcagacaatcagtgcaagtaaaggtgag atggggccaatggttgcagcaaccctaaagctaggaattgccatcctaaatggaggaaac tctactgttcaacagaaaatgcttgactacctcaaggataaaaaggatgtggggttcttt cagagccttgctggtcttatgcagtcctgtagtgttcttgacctaaatgcgtttgaacgt cagaacaaagcagaaggccttggcatggtgactgaagagggatcaggagaaaaggtgatg caggatgatgagttcacctgtgacctcttccgcttccttcagttgctttgtgaaggacac aattcagattttcagaattacctgagaactcaaactggtaacaacacaactgttaatatt atcatttctactgtggattacttattgagagttcaggaatctatcagtgatttctactgg tattattctgggaaggatgttattgatgaacaaggacaacgaaatttttccaaagccatc caggttgcaaaacaagttttcaatactctcacagaatatatccaggggccatgtactggt aatcagcaaagtctggcacacagcaggctgtgggatgctgtagttggtttccttcatgtg tttgcccacatgcagatgaagctctctcaggattccagtcaaattgaactattgaaagaa ttaatggatcttcagaaagatatggttgtcatgttgctgtctatgctggaaggtaatgtt gtgaatggaactattggaaagcagatggtcgatatgcttgtggaatcatcaaacaatgtg gagatgattctaaagttttttgatatgttcttaaaactgaaagatttgacttcctctgat gcattcaaagaatatgaccctgatggtaaagggataatttcaaagagggattttcacagg gcaatggaaagccataagcattacactcagtctgaaactgagtttctgctgtcatgtgct gaaacagatgagaatgagactttggactacgaggagtttgtgaaacgatttcatgagcct gcaaaagacattggtttcaatgtcgctgttctcctgaccaacctgtcagagcacatgccc catgatacacgcttgcaaactttcctggagctctcagagagcgtgctgaattactttcag cctttccttggacgtatagaaatcatgggcagtgcaaagcgcattgaacgagtttatttt gaaataagtgagtcaagtcggactcagtgggaaaagcctcaggtaaaagagtcaaagaga caatttatatttgatgttgttaatgagggtggggaaaaagaaaagatggagctttttgtt aacttctgtgaggataccatctttgaaatgcaactggctgcccagatctccgagtcagat ctgaatgaaaggtcagctaacaaagaagagaatgataaagataatcctgaggaagaagat cctagaatgggtttcttctctctcgtaacgatgaagtctgctctagtagctctcaagtat aatttaatgactcttatgaaaatgctcagcatgaaaagtctaaagaaacaaatgaagaaa atgaagaaaatgacgatgaaggacatggtcttggctctgttttcttcctactggagcatt ttggtgggcttactgcattttgcttgtagtgttgtccggggcttttttcgcatcatatgc agtttgcttcttggaggaagcctagtagaaggagccaagaaaatcaaggtggctgaactg ttggctaatatgccagatcccactcaggatgaagtgcgtggggaagaagaggaaggggag aggaaaccaacagaagctgcattgcctgcagaagacttgacagatctgcagactttaaca gaagagagtgatctactttcagatatatttggtttggatttgaaacgagaaggtggacag tataaattaatccctcacaatccaaatgctggtttgagtgatttactgagcactccctcc ttagccccaatgccagaggtacaggaaaaaatccaggagaaggtgaaagaagatgaaaag gaagagaaagaagaaacaaaatcagaacctgaaaaagctgaaggagaagatggagaaaaa gaagagaaaaccaaggaggacaaagggaaacagaaattaagacaactgcacacgcacaga tatggagaaccagaagttcaagaatcagttttctggaagaatatcattgcataccagcag aagcttcttaattattttgctcgaaacttttacaacatgaggatgttggcattatttgtt gcttttgccatcaacttcatccttcttttctataaggtctccacatctgctgtgacagaa gaaaaggagcttcctgtggtatctgatggtgaaagtacaaagttgaacatcctggaaagt gatgatgagagggtcattgcagtgcattatgtcctggaagaaagcagtggctacatggag cccacgttgaggattttggccatcctacatacagtcatctcattcttctgcatcataggg tattattgtttgaaagttccactcgttatttttaagagagaaaaggaagtagcaaggaaa ttggaatttgatgggctatatataactgagcagccatcagaagatgatattaagggacag tgggatagacttgtaatcaacacacagtcttttccaaataactattgggacaagtttgtg aaaagaaaggtaatggataaatatggtgagttctatggccgtgacaggatcagtgaatta ctaggaatggacaaagctgctcttgattttagtgatgctcgagaaaagaagaaaccaaag aaggatagctccttttctgctgtgctaaattccattgatgttaagtatcagatgtggaaa ttaggtgttgttttcaccgataattctttcctttacctagcgtggtacatgaccatgtcg gtccttggccattacaacaactttttctttgctgctcatctccttgacattgcaatggga ttcaagacattgcgaactatcctgtcatcagttacccacaatggcaaacagcttgtccta acagtgggattactggcagtagtggtatacttgtatacagtagtggcattcaattttttc cgcaagttctacaacaagagtgaagacggtgacatgccagacatgaaatgtgatgatatg ctaacatgctacatgtttcatatgtatgttggagtacgtgcaggaggaggcattggtgat gaaatagaagatccagcaggagacgaatatgaaatctatcggattatctttgacatcact ttcttcttctttgtgattgtcatcctgcttgcaattatccaaggtttaattattgatgct tttggtgagttaagagatcagcaagagcaagttaaggaagacatggagactaagtgtttt atctgcggaataggaaatgactactttgatacagtgcctcacggctttgaaacacacaca ctacaggagcacaacttggccaattatttgttttttctgatgtatcttattaacaaagat gaaaccgagcatacaggacaggaatcatatgtatggaaaatgtatcaagaacggtgctgg gagtttttccctgctggtgattgcttccgaaaacaatatgaagaccagctcaactaa

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