Thermotoga maritima MSB8: TM0236
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Entry
TM0236 CDS
T00022
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
tma
Thermotoga maritima MSB8
Pathway
tma00300
Lysine biosynthesis
tma00550
Peptidoglycan biosynthesis
tma01100
Metabolic pathways
tma01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
tma00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
TM0236
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
TM0236
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
TM0236
Enzymes [BR:
tma01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
TM0236
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
AAD35327
UniProt:
Q9WY78
Structure
PDB
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Position
complement(250621..251901)
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AA seq
426 aa
AA seq
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MKDLLTRRFVLNSKEVREGDVFVAVKGKRFDGHDFIDEALRNGAYAIIAERKTVNSDRIF
LVESSVDTLAKLAREKLGNFSGTVVGVTGSSGKTTTKEILYNLLKNKRSVFKTPGNMNTE
YGLPLSILNDYKGEEILVLEMAASRPGDIAHLCKIAPPDVAVLLNVGSAHLEFFGTRERI
METKMEIIKHSKENAIAVTLFDDPDLRKEVPRYRNTLFFGKEGGDSVLKDWWYYEGSTIA
EFEAFDSLFTVKLSGYWNGGQLLNIAASLCVMRTLGETVDIFDLASLKTVPGRFNVREKK
GVLIVDDTYNASPEAFQTSIEALLRFPGKKFAVVGAMKELGERSKEFHEELGERLNVLDG
VYVFLSEPEAEWIKSKKIILKSDDPEKIAKDLATRVKKGDVVLFKASRAVRIERVLEMFE
KELEKR
NT seq
1281 nt
NT seq
+upstream
nt +downstream
nt
atgaaagatctactcacaaggcgtttcgttctgaattcgaaagaagtgagagaaggtgac
gtgttcgtcgccgtgaaagggaaaagattcgatggtcacgattttatagatgaagccctc
aggaacggcgcttatgcgatcattgccgagagaaaaacggtgaattctgatagaatcttt
ctcgtagaaagttccgttgacacgcttgctaagctggcccgagaaaagctcgggaatttt
tccggtacagtcgttggtgtaacaggttcatcgggaaaaaccaccacgaaagaaatattg
tacaaccttctcaaaaacaagagaagtgtcttcaaaacaccgggaaacatgaacacggag
tacgggttgccactctccattctcaacgactacaaaggagaagaaatcctggttctcgaa
atggccgcgagcaggcccggtgatatcgctcacctgtgtaaaatcgctcctccggatgtc
gccgttctcctcaacgttggaagcgctcacctcgagttttttggaacacgagaaagaatc
atggaaaccaagatggagatcatcaagcactcgaaagaaaatgcgatagccgtaacactc
tttgacgatcctgatctgagaaaagaagtgcctcgctacagaaatacactgttcttcggc
aaagaaggcggtgactcggttctaaaggattggtggtactatgagggttccacgatcgca
gagttcgaagcttttgattctcttttcacagtgaaactctccggatactggaatggaggg
caacttctgaacatcgccgcttctctgtgtgtcatgagaactttgggcgaaactgtggat
atcttcgatcttgccagcctgaaaacagttcccggccgtttcaacgtgagagaaaaaaaa
ggtgtgctgatcgtggatgatacgtacaacgcaagccctgaagcgtttcaaacttccata
gaggcgcttcttcgtttccccggaaagaaattcgctgttgtgggagcgatgaaagagctc
ggggagaggtcgaaggagtttcacgaagaactgggagagagattgaacgttctggatggg
gtgtatgttttcttgtcagaacccgaagcagaatggatcaagtccaaaaagatcatcctg
aagtcagacgatcccgaaaagatagcgaaagatctcgccaccagggtaaaaaaaggggat
gtggttctcttcaaagcttcaagagcggtgagaatagaaagagttctggaaatgtttgaa
aaggagctggagaaaagatga
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