Tenebrio molitor (yellow mealworm): 138133633 Help Entry 138133633         CDS       T10686                                  Symbol RyR Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism tmol  Tenebrio molitor (yellow mealworm) Brite KEGG Orthology (KO) [BR:tmol00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tmol04040]     138133633 (RyR)    04990 Domain-containing proteins not elsewhere classified [BR:tmol04990]     138133633 (RyR) Ion channels [BR:tmol04040]  Voltage-gated cation channels   Ryanodine receptor    138133633 (RyR) Domain-containing proteins not elsewhere classified [BR:tmol04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    138133633 (RyR) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  138133633 NCBI-ProteinID:  XP_068907667 LinkDB All DBs Position 1:complement(29753943..29794480) Genome browser AA seq 5099 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGNETGQESLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENEISIVNASFHVTHWSVQPYGTGTSRMKYVGYVFGGDVLRFFHGGDECLTIPSTW SIDANIVIYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHITTGRYLAVNENNE LYLVSRDEANTATTAFCLRQEKDDQKTVLEDKDLEVIGSPIIKYGDSTVIVQHSETGLWL SYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQFIN GLETLQMNKRHSVFFLAVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQDLF QEEGILNLILEAIDKINVITSQGFLAGLAGDQNWEMISGYLYQLLAAIIKGNHTNCAQFA NSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDP KVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVASVRPNIFVGRVEGSA IYQKWYFEVTVDHIEQTTHMMPHLRIGWANSKGYVPYPGGGEKWGGNGVGDDLYSYGFDG VHLWSGGRSTQVVTHFSHPFIKKNDVVGCALDLTIPIITFTFNGVPIKGSFRNFNLDGMF FPVISCSSKLSCRFLLGGDHGRLKYIPPEEFSPLIESLLPQQVLNLEPCFYFGNMNKNVI AGPLAVEDDTAFVPNPVDTSMVSLASYIESIRDKLAENIHEMWAMNKIEAGWQWGEYRDD LRHVHPCLVPFDKLPPAEKKYDSQLAVQTLKTIIALGYYITMDKPPSRIKTVRLPNEPFM QSNGYKPAPLDLSAITLTPKLEELVDQLAENTHNLWAKERIQQGWTYGLNEDPDMFRSPH LVPYAKVDEAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEANRSRHTAFRTYR VEKNYAVSSGKWYFEFEILTAGPMRVGWAKADCAPGCMLGSDENTWAFDGYNEEKVYSNS AESFGKQWQVGDVVGVFLDLIDHTISFSLNGELLMDALGGETTFADVQGDNFVPAFTFSV GQKARLCFGQDVTQLKYFTTCGLQEGYEPFCVNMNRPVTYWYTKDQPIFENTDDMLDTKI DVTRILAGSDSPPCLKISHNTFETMEKANWEFLRLSLPVICHSTFISEEEKMRHWQEIKI RQHRLKAEAESQNTPAHIEQMMMKSGFSMSDIKGLQRNYSEDAVESDEVMKHHTKSTKSM PARPPRKGSLSRNVNGFEDNLLNVNSGRGVHRSSSELDLNRYHDMAPTNQEKLDDKKKRG RSPFRFFSRKKAGNSPGTESIKADKSKTPEPDRDRMATVKAPARSVGLSSSMLTRSPTVK QSQTDLMQAPSVPIGQQKQLSVPHTSGVEAVGDELYDAECLKLINEYFYGVRIYPGQDPT HVYVGWVTTQYHLHTKDFNQNQVRKSSIVITDEYDRLLDCVDRHSCYMVRADELYNEVTQ DASGKGASQGMFIGCFLDAATGVITFTCEGKATSHAFRMEPETKLFPAIFVEATSKEILQ IELGRTPTSLPLSAAVLQNSAKHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDI RGWSMLCEDPISMLALHIPEEDRCIDVLELIEMDKLLSFHAHTLTLYAALCYQSNYKAAH VLCKHVNQRQLLYAIKSEYMSGPLRQGFYDLLIAVHIESAATTMEVCQNEYVIPLGQELK DMYENPEMGHSLRALKMESVQPQMNMSEITDTIDNIKNLYSPYFPLDIVRNYVMTALAEA VETNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRDEDVEKLLIMVCPETWDPSFQKD GKDEHRKGLLSMKMAEGAKLQMCYLLQHLCDIQLRHRVESVIAFSHAFVGDVQADQLRRY IEIKQSDLPSAVAAKKTREFRCPPREQMNAILWFKNLEEEDKENCPLGDELCEKLNEFHT RLMSHVSLQALQAPAEEENNDVQKPGPFKRLYNFINAVKELEEEPKEEPEPEKKTPEEVF RKVLISTIVKWASEESIESPNLVQEMFSLLVRQYDSVGELIRALQKTYIINAKTKQDVAE MWVGLSKIRALLPVQMSQEEEELMRERLWKLVNNHTFFQHPDLIRVLRIHENVMAVMINT LGRRSQAQSDAQVQAQATEGEPIVKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFEHFD FLLDNSNILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSE LIEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEG EGLLRAIVDANKMSERISDRRKMMDEAEGTVNIAQFSHPLPESDDDEDYIDTGAAILNFY CTLVDLLGRCAPDATVIDLGKNESLRARAILRSLVPLEDLQGVLSLRFTLQNPAAGEERP KSDMPSGLIPGHKQSVVLFLERVYGIETQELFFRLLEEAFLPDLRCATMLDRNDGSESDM ALSMNRYIGNSILPLLIQHSKFYSEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSALQPSMLLKLLRKLTVDVSNLSEYTTVALRLLTLHYDRCAKYYGSSSGQGLYGA ASDEEKRLTMMLFSNIFDSLSKMDYDPELFGKALPCLSAIGCALPPDYSLSKNYDDEWYA NKSSKTGPDGPYNPQPINTSSVALNNDLNSIVQQFSEHYHDAWASRKLENGWQYGETWSD SNKTHPRLKPYTMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSNNRNSIHRQST DGSSPYNYNPHPVDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELNTCGGGIHPQLVP YDLLTDKEKRKDRERSQEFLKYLQYQGYKLHRPNRGGQGEAEQSTAGPSIELRFAYSLLE KLIQYADRATINMKLLKPSSTFSRRPSYKTSSRDIKFFSKVVLPLMEKYFSTHRNYFIAI ATATNNVGAASLKEKEMVASLFCKLASLLRSRLTAFGADVRITVRCLQVLVKGIDAKSLV KNCPEFIRTSMLTFFNNTADDLGHTIINLQEGKYSHLRGTHLKTSTSLFYVNTVIIPILT AMFDHLANCEYGSDLLLDEIQVASYKILQALYTLGTDPNLTHERKYLKTEIEKYKPALGS CLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMARMEGSMPTLETILSEVDQ FVESEKTYSDAPYIIDVIMPMLCSYLPFWWSQGPDNVSPTGGAHVSMVTAEHMNHLLKNV LKLIKKNIGNETSPWMTRIAAYTQQIIINSSEELLKDPFLPLAERVKKRTEAMFHKEESL RGFIKSSSDDTSQIETQIQEDWHLLVRDIYAFYPLLIKYVDLQRNHWLRHNIAEAEDLYN HVADIFNIWSKSQYFLREEQNFISANEIDNMVLIMPTASRRTVVPDGTQPTGGKKKKKHR DKKRDKDKEIQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMPEYDIIDFAKT QLTLPDKIDPADEMSWQHYLYSQLGSKKSAAVGVVDSNGKNVLEETVDRIVAMSKVLYGL HMIDHPQQQQKGVYHSVVSTQRKRAVLSCFRQASLHSLPRHRAINIFIRSYYELWLQDEN VGQEVMIEDLTQSFEDSELKKKEAEEEEAKPDPLTQLVTTFCRGAMTERSGALQEDPLYM SYAEIIAKSCGEEEEEGEEEESGEGEEGGASIHEQEMEKQKLLFNQARLANRGVAEMVLL HISACKGVPSEMVMKTLELGISILRGGNFDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSV LDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQA GNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTE VIQGPCPLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMM LSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSSPSFLEIDINSDGW VYPKDFKEKMEQQKSYTSEEIDFLLACCEVNHDGKIDYMGFIDRFHEPAKEIGFNLAVLL TNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGGSKRIERVYFEIKESNIEQWEK PQIKESKRAFFYSIVTEGGDKEKLEAFINFCEDAIFEMQHASGLMAVEDSGGGGPTRAAS YSYMNVDDEERGKDPIRRGYQSVKEGIAYGLSALSPSNIKHKIAEMQQMTIPELFIGFFR MIMYAFYYSGFGVAIIFKYIFGVLLSLMRGPVEEPVVEIKEEEEKVGLTRVLPALPSTEE QNTQMQAFGLDITKEDNGQYKMAAHESPTTSQPSSAEGEGETTPEEDGEHAEVEAPEVPL SLSDLLGGEQAKRAAQEKVEAQAAQQAAMQAIESESKQPVITEPSAVSQINFGAYSHRAV SFLARNFYNLKYVALVLAFCINFMLLFYRVSTLNDDAEGSGSKGIPDIIEGSAEGSSAGS GESGEDEEDPLELVHVDEDFYYMAHVMRLAAILHSVVSLAMLIAYYNLKVPLAIFKREKE IARRLEFEGLYIAEQPEDDDLKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDS ISNLLGMEKTSFQQQESDEGKSFIYFIINIDWRYQIWKSGVTITDNSFLYSLWYFIFSIL GNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRK FYVQEEDEEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIEPPDGDDYEVYRIMFDITFFF FVIVILLAIIQGLIIDAFGELRDQLESVKEDMESNCFICGMGKEYFDKVPHGFDTHVQQE HNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQYEEELGSGGG NT seq 15300 nt NT seq  +upstreamnt  +downstreamnt atggccgaggccgaagggggatccgaacaggatgatgtttcattcttacgaacggaagat atggtgtgtctctcctgcacggccacaggagagcgcgtgtgtttggctgctgaaggcttt ggtaatcgacactgtttcttggaaaatatagcagataagaacatacctccagatttgtca caatgtgtgttcgttattgaacaggcattgtctgttcgagctttacaagaattggttact gcagctggaaatgaaactggccaggaaagtttagggaaaggtacgggatctggacatcgc acactgttgtacggtaatgcgattcttcttcgccatcagaacagtgatatgtatttagct tgcctttctacaagttcaagtaacgataaacttgcttttgatgttggtttgcaagagcat agtcaaggtgaagcttgttggtggaccgttcatcctgccagcaaacagagatctgaaggt gaaaaagtgcgtgtaggtgacgatttaatcttagtatcagttgccactgaaagatatttg cacactacaaaagagaatgaaatttctatagtgaatgcaagttttcacgtaactcattgg tctgtacaaccatatggtactggtacttcgcgtatgaagtatgttggttacgtttttggt ggtgatgtacttagatttttccatggcggtgacgaatgtttgacaattccatcaacatgg agtatagatgcgaacattgtaatatatgagggcggtagcgttatgtctcaagcccgttcg ttatggcgtttggaattggcaagaacaaagtgggcaggcggtttcattaactggtcacac ccaatgagaatacgacatattacaactgggagatatcttgcagtaaacgaaaataatgag ttgtatttggttagcagagacgaagctaacactgcaactacagctttttgcctgagacaa gaaaaagatgatcaaaaaacggttttagaagataaagatttagaagttattgggtcacca attatcaaatatggtgattccacagtcattgtgcagcattctgaaactggtttgtggctt tcttataagtcatacgaaacgaagaaaaaaggtgtcggaaaagtagaagaaaagcaagct gtacttcacgaagaaggaaaaatggatgacggtttagatttcagtaggagtcaagaagaa gaatcaagaactgcaagagttattcgcaaatgcagttcactatttactcaattcatcaat gggttagaaacgcttcaaatgaataaacgtcactctgtattctttttggctgtcaattta aatgaaatggtgatgtgtcttgaagatttaataaattattttgctcaacctgaagatgat atggaacacgaagaaaaacaaaatcggtttagggcattaagaaacagacaagatttattc caagaagaaggcattttaaacttaatcttggaagccattgataaaataaatgtaattact tcacaaggctttttagctggacttgcgggtgatcaaaattgggaaatgatttctggttat ctttatcagttgctagctgcaattattaaaggcaaccatactaattgtgctcaatttgcc aattctaacaggctgaattggttattttcgcgacttggttctcaagcatctagcgaagga actggtatgttagatgtacttcactgtgttcttattgattccccagaggcgttaaacatg atgagggatgaacacattaaagttattatttctcttcttgaaaagcacggaagagatccg aaggtcttggatgtactttgttcactctgtgtcggtaacggtgtagccgtgcgcagttct caaaataatatctgtgattatctccttccgggaaaaaatttacttttacaaactcagtta gtagatcacgtagcaagtgtgcgccccaatatttttgtgggtcgagtggaaggtagcgca atttatcaaaaatggtattttgaagttactgtagatcacatagaacaaacaactcacatg atgcctcacttgcgaattggttgggcaaactctaagggatacgttccttacccaggcggt ggtgaaaagtggggtggcaatggagtaggtgatgatttgtattcttacggttttgatggt gtacatctttggtcgggaggacgttccacacaagtggttacccatttttcacacccattt ataaagaagaatgacgtggttggttgtgccttagatttaactattccgattattacattt acatttaatggagtgccaattaaggggagttttagaaattttaatttagacggcatgttc tttccggtgatcagttgttcgtccaaacttagttgtcgatttttactgggcggggatcat ggtcgcctaaagtatatccctccagaagaattttcacctctaattgaaagtcttcttccc caacaagttttaaatttagaaccgtgtttttactttggtaatatgaataaaaatgtcata gctggtcctttggcggtcgaggatgatactgcatttgttccgaacccagtagacacctct atggtgagtttggctagttacattgagtccatcagagataaactagccgaaaacattcac gaaatgtgggcaatgaacaaaattgaagccggatggcagtggggagaatacagagatgat ttaaggcacgttcatccttgtttagtgccgttcgataaacttccgccagcagaaaaaaaa tatgactctcaactcgcagtacaaacattaaaaacaattattgcattaggttattatata accatggataagccaccatcaaggataaaaactgtacgtcttccaaacgaaccgttcatg cagtcaaatggatataaaccagcacctcttgacttgagtgctataactttaacgccaaaa ctagaagaactcgtcgatcaattagctgaaaatacgcacaacctttgggccaaagaaaga attcaacaaggttggacttatggtcttaatgaggatcctgacatgtttagaagtccccat cttgtgccttacgcaaaagtagatgaagctattaaaaaagccaacagagacactgcctca gaaacagttcgcactcttttagtgtacggttataatttggatcccccaactggagagcag cacgaagctttacttgctgaagcaaatagatcaaggcacacagcgtttaggacgtacaga gttgagaaaaattatgccgttagttcggggaagtggtattttgaattcgaaattttgaca gccggaccaatgagagtgggatgggcgaaggctgattgtgctccaggatgtatgttgggt tctgatgaaaatacttgggccttcgacggttacaatgaagaaaaagtgtatagcaattcg gccgagtctttcggaaaacagtggcaagttggggatgttgtgggtgtattccttgaccta atcgatcacacaattagtttttctttaaatggggaattgttaatggatgcattaggaggt gaaaccactttcgcggatgtgcaaggcgacaattttgttccagcgtttactttcagcgta ggccaaaaagcgcggctttgttttggtcaagacgttacccaattaaagtactttacaaca tgtggtttgcaagaaggttatgagcctttttgtgtaaatatgaaccgtcccgttacatat tggtatactaaagaccagccgatatttgaaaacactgatgacatgctcgacactaagatt gacgttactagaattttagccggttcggatagtccaccgtgcctgaaaatcagtcataat actttcgagactatggagaaagctaactgggaatttttacgattaagtttaccagtcatc tgtcattcaacatttatttcggaagaagagaaaatgcgacattggcaggaaataaaaatt agacaacataggttaaaggctgaagctgagtcacaaaacacaccagcacatatcgagcaa atgatgatgaaaagcggattttcgatgagtgatatcaaaggtttgcaacgtaattattct gaggacgctgtagaatccgatgaagttatgaaacaccacaccaaatctactaaaagtatg cctgcaagacctccaagaaaaggttccctttctagaaatgtcaacggttttgaagataat ctgttaaacgtgaattccggtaggggcgttcatcgatccagcagcgaattagacttaaac agatatcatgatatggctccaacgaaccaagaaaaactagatgacaagaaaaaacgaggc agatcacctttcagatttttttcgagaaagaaagctggtaattctcccgggaccgaatcc atcaaagcggacaaatcaaaaacaccagaaccggatagagaccgaatggcaacagtaaaa gcgccggctcgatcagttggtttatcttcatcgatgttgacaagaagtcctacagtcaag cagtcacagaccgatttaatgcaagcaccgtccgttcctattggacaacaaaaacaactg tctgtaccccatacttcaggtgtggaagcagtgggcgatgaattgtatgatgcagaatgc cttaaacttattaatgaatatttttatggtgttcgaatatatcctgggcaagatcctact cacgtttacgtaggctgggtcaccactcagtatcatctgcatactaaagattttaatcag aatcaagtgaggaaaagttcaattgttattaccgatgagtatgacagattgcttgattgt gttgatagacattcttgttatatggtacgtgcagatgaattatataatgaggtaacacag gacgcatcaggaaaaggagcatcacaaggaatgttcatcggttgtttcctggacgcagca actggtgttattacattcacctgtgaaggaaaagcaacttctcatgcgtttaggatggaa ccagaaactaaattattcccagcaatcttcgtagaagcaacgagcaaagagattcttcaa attgaacttggcagaacgccaactagtttacctttatcagcagctgtattgcaaaacagc gcaaaacacgtgataccacagtttcctcccagattaaaagtacaatgtcttaaaccgcat cagtgggctagagtacctaaccagagtttgcaagttcatgccctaaaactatctgacatt aggggttggtcaatgttgtgtgaagatcctatttcaatgttggctcttcatattcccgag gaagaccgttgcattgatgtgttagaattgatagagatggacaagttattaagcttccac gcacatactttgactctgtatgcagctttgtgttaccaaagtaattataaagctgctcat gttttatgcaaacatgtaaatcaaaggcagctgttatatgccatcaaatctgaatatatg agcggtcctttaagacaaggattttatgatttgcttattgccgtacatattgaatcagct gcaactacaatggaggtatgtcaaaatgaatacgtgattcccctgggtcaagaattgaaa gatatgtatgaaaatccagaaatgggtcacagtttaagagctttaaaaatggaatctgta caacctcaaatgaatatgtcagaaataactgatacaattgacaatattaagaatttgtat tctccgtacttccctcttgacattgtaagaaattatgtgatgacagctttggctgaggcg gtcgagaccaatcaagttcacaatcgtgacccaatcggaggttcaaatgaaaatctattt cttccattactgaaattagttgatcgtttgttgcttgtcggcatgttgcgagatgaagac gtagagaaattattaattatggtctgtccagaaacttgggatccctcatttcaaaaagat ggcaaagatgaacatcgaaagggccttctttcaatgaaaatggctgaaggggctaaacta caaatgtgttacttattgcaacatctttgtgatattcagttacggcacagagttgaatca gttattgcctttagtcatgcttttgttggagatgtacaagccgaccaacttcgtcgttat attgaaattaaacaatctgatttaccatcagctgttgccgccaaaaaaaccagagagttt aggtgtccacctcgtgaacagatgaatgcaattttgtggtttaaaaatctcgaagaagaa gacaaagagaactgtccattaggagacgaattatgtgaaaaattaaacgaatttcatact agattaatgtcgcatgtgtcattgcaagcactgcaggctcctgcagaagaagaaaataat gacgttcaaaaaccgggaccgttcaagcgtttgtataactttattaatgccgtaaaagaa ttagaagaagaaccaaaagaagaaccagaaccagaaaaaaagacaccagaagaagtattc agaaaggttttaataagtacaattgtaaaatgggcttcagaggaatcaatagaaagtcca aacctcgttcaagagatgtttagtttacttgtgaggcaatatgattccgtgggcgagtta atcagagctttacaaaaaacttacatcattaacgctaaaaccaaacaagatgttgcggaa atgtgggtcggtttgagcaaaattagagcacttttgccagtacaaatgtctcaagaagaa gaagaactaatgagagaacgcttgtggaaattagtaaataatcatacattcttccagcat cccgatttaattcgtgttttgcgcattcacgaaaacgtaatggctgttatgataaataca cttggtagaagatcacaagcacaatctgacgctcaagtacaagctcaagctacagaagga gaaccaattgtaaaagaaaaagatacatcccatgaaatggtcgtagcgtgttgtcgcttt ttatgttacttttgcagaactggtcgtcaaaatcaaaaagcaatgttcgaacactttgac ttcttattggataacagtaacattttattagcgagacctagtttaagaggttcaacacct ttagacgtagcttattcatctctgatggaaaatacagaacttgcattggcattacgagaa cactacttagaaaaaattgctatatatttatcgcgatgcgggcttcagtcaaattctgaa ctaatcgaaaaaggttatcctgatttagggtgggacccggtagaaggagaacgttacctt gatttccttaggttttgcgtttgggtaaacggtgagagcgttgaagaaaacgccaattta gttattcggttacttataagaagaccagaatgtttgggtcctgctttaagaggagaaggt gagggtctcttgcgcgccattgttgatgccaataaaatgtctgaacgtatatccgataga agaaaaatgatggacgaagctgaaggcactgtaaacatcgctcaattcagtcatccttta ccagaaagtgatgacgacgaagactatattgacacaggagcagctattttgaacttttac tgtactttggtcgatcttctaggcagatgtgcaccagatgccaccgtcatagatctgggt aaaaatgaatcgctgcgtgcacgcgccattcttcgatcattggtaccactggaggacctt caaggagtactaagtttaaggtttactcttcaaaatcctgcggctggtgaagaaagaccc aagtcagatatgccttcaggtttaataccgggccacaaacaatcagtggttcttttccta gaaagagtttatggtattgaaactcaagaacttttcttcagacttttggaagaagcattt ttaccagatttaagatgtgcaactatgttagataggaacgatggcagtgagtctgacatg gcgttaagtatgaaccgatacattggaaactcaatccttccactgttaattcagcacagt aaattttacagcgaagctgaaaattatgcgtctcttctcgatgcaacgttacatacagtt tatcggctctcaaagaatcgtatgcttaccaagggccaaagagaagctgtttccgatttc ttggtagctttgacaagtgctcttcaaccgtccatgttacttaaactacttcgaaaactc actgttgatgtttccaacttatccgaatacaccactgtagctttacgattactgacttta cattacgatagatgtgccaagtattacggttcgagcagtggacaaggactttatggtgct gctagcgatgaagaaaagagacttacgatgatgctgttctccaatattttcgattctttg agtaaaatggactatgatcccgaattgtttggaaaagctctaccgtgtttaagtgcaatc ggttgtgccttaccaccagattactctttgtcaaagaattacgatgatgagtggtatgca aataaatcttctaaaactggcccggacggaccatataatcctcaacccatcaatacatct tcagtagcacttaataacgatttaaacagtattgtacaacagttttctgaacattatcac gatgcttgggcatcacgtaaattagaaaatggatggcaatatggcgagacttggtcagat tcaaacaagacacatccaaggcttaagccatacacaatgttaaatgattatgaaaaagaa aggtacaaggagcctgttcgtgaatctttaaaagccctgttagctattggttggtcagta gaacattctgaagtagatattccatcgaacaaccgaaattccattcatcgtcaatcgact gatgggtcatcaccatataattataatccacatcccgtggatatgacaaatttaactctt tcgagagaaatgcaaaacatggcagagcgcctggctgaaaatgctcacgatatttgggct aaaaagaagaaagaagaattgaacacttgcggtggaggtatacatccccagttagttccg tacgatctcttgacagataaagaaaaacggaaagatagagaacgttcacaagaatttctc aaatatttacagtatcaaggttataaattgcatcggcctaatcggggcggacaaggagaa gcagagcaatccaccgctgggccgtcgattgaattacgttttgcatacagtttattggaa aaacttattcagtatgctgaccgtgcaactattaatatgaaattgttgaagccgtcttct acgttcagtcgaagaccttcttataagacatcgtctcgagacattaaattcttttcaaaa gttgtcctgccgttaatggagaaatatttctctacccatcgcaattattttattgccatt gcaactgctacaaataatgttggagcagctagtctgaaagaaaaagaaatggttgcctct ttattctgcaaattggcaagcttgttaaggtctcgtcttactgctttcggagcagatgtt agaattacagtaaggtgtttgcaagttttggtaaaaggcattgacgccaaatcgttggtt aaaaattgcccagaatttattcgcacctccatgttaacgttcttcaacaataccgctgat gacctaggacacactataattaacttacaagaaggaaaatacagtcatttgcgtgggact cacttgaaaacttctacatctttattttatgttaatactgtaataatacctattctgact gcaatgtttgatcacctcgccaattgcgaatatggaagtgatttgttgttggatgaaatt caagtcgcttcttacaaaattttgcaagcgttatatactttaggtactgatccaaatctt acccatgagagaaaatacttgaaaacggaaatagaaaaatacaaacctgctttaggttcg tgtttaggtgctttcagttcaacgtttccagttgctttcctggaaccacatcttaacaag cataatcagttttcacttttaaaccgaattgcggatcactcattagaagctcaagatata atggctagaatggagggttctatgccgacccttgaaacaattttatcggaagttgatcag tttgttgaaagtgaaaagacatactcagatgccccttatattattgacgttataatgccc atgctttgttcttatttaccattctggtggtctcaaggacccgacaatgttagtcctaca ggcggagcacacgtctcaatggtaacagcagaacatatgaatcacttgttgaaaaatgtt ttaaagttgattaagaaaaatattggtaacgaaacctccccatggatgactcgcatcgca gcgtatacacaacaaattattatcaatagcagtgaagagcttcttaaagatccgttttta cctttggctgagcgggtaaagaaacgaacagaggctatgttccacaaagaagaaagcttg cgaggtttcatcaagagttcttcagatgacacatctcagattgaaacccaaattcaagaa gactggcatcttttagttagagatatttacgcattttatcctcttctcatcaaatacgtt gatctacaaagaaaccactggttgcgtcacaacatcgccgaagctgaagatctctacaac catgtggctgatattttcaacatttggtcgaagtcccaatatttcctacgtgaagaacaa aacttcatttcagcaaatgaaattgataatatggtgttaattatgccaacagctagcaga agaacagttgttcctgatggaactcaaccgactggtggcaagaagaagaaaaagcatcgt gacaagaagagggacaaagacaaggaaattcaagcatctttaatggtagcttgtttaaaa cgtttgttacctgtaggtttaaatcttttcgcgggaagagagcaagaattggtacagcac tgcaaagatcgtttcctaaagaaaatgcctgaatatgatattattgattttgctaagact cagttaactttgccagataaaatagatcctgcagatgagatgtcctggcagcattattta tacagtcagctcggtagtaagaagagcgctgctgtaggagtggtggacagcaatggaaaa aatgtgttggaagaaaccgtcgataggattgttgcgatgagtaaagttctttatggctta catatgatcgatcaccctcaacaacagcaaaaaggtgtttaccatagcgtggtctctact cagaggaagcgtgctgtactgtcttgcttccgacaagcttctttgcacagtttaccaaga catcgagcaataaacattttcattcgatcatattacgaactttggctgcaagatgaaaac gtggggcaagaggtgatgattgaagatttaactcagagctttgaagactcagaactcaaa aagaaggaggccgaagaagaagaggctaaaccagatcctttaactcagcttgtgactact ttctgcagaggtgctatgacagaacgttctggcgctctacaggaagatcctttatatatg tcctacgctgagatcattgcaaaatcatgtggagaagaagaagaagaaggcgaagaagaa gaaagtggggagggggaagaaggaggagcttcaattcatgaacaagaaatggaaaaacag aagttgctgttcaatcaggcaagactcgctaatcgaggtgtagcagaaatggtgctcttg cacatatctgcatgcaaaggtgttccatctgagatggtcatgaaaacacttgaattaggt atttctattcttcgcggtggtaattttgatatccaaatgggcatgttaaatcacttgaaa gagaagaaggacgtaggctttttcacaagcatagctggattaatgaatagctgcagtgtg ttggatttagatgcatttgaacgtaatactaaggctgaaggtcttggtgtaggatcagaa ggtgccgcgggcgaaaagaacatgcacgatgctgaatttacttgtgcattattccgattc attcaactaacctgtgaagggcacaatttagaatggcagaattatttacgtacccaagct ggtaataccactacagtaaatgtcgtaatctgcacggtagattacctacttcgtcttcaa gaatcgataatggacttctattggcactattctagcaaagaacttattgatccggcgggt aaagctaactttttcaaagccatcggagttgctagtcaagtattcaacacgctcactgaa gtcattcaaggtccttgccctcttaatcaacaagctttggcacattctagattgtgggac gccgttggtggtttccttttcttgttttctcacatgcaagataaattatcaaaacattct agtcaagttgatttacttaaagaattactgaatttacaaaaagatatgattactatgatg ctttcaatgcttgaaggtaacgttgttaatggcactatcggaaaacagatggttgacacg ctggtggagagtgcatctaatgtagaactaattcttaaatactttgatatgttcttgaaa ctgaaagatctgacttcttctcctagcttcctcgaaattgatattaatagtgacggatgg gtatatcccaaagattttaaagaaaaaatggaacagcagaaaagctacacttcggaagaa attgacttcttgttggcttgttgtgaagttaatcacgatggtaaaatagattatatggga ttcatcgatcggttccacgaaccagctaaggaaatcggttttaatttggcagttttactg acaaatctttcagaacacatgccaaatgaaccaagattggcaagatttttagagacggct ggatccgtattaaattatttcgaaccattcttaggacgcattgaaattctaggaggcagt aaacgcattgaaagagtctatttcgaaattaaggaatcaaatatagaacagtgggagaaa ccccaaattaaggagtcaaaacgcgcattcttctattcaattgtgacagaaggtggtgac aaagaaaagttagaagcatttatcaacttttgcgaggatgctatttttgaaatgcagcat gctagtggcttgatggcggttgaagattctggagggggaggtcctactcgtgctgccagt tacagctacatgaatgtcgatgacgaagaacgaggaaaagatccaattcgtagaggatat caatccgtaaaagagggcatcgcgtacggtctttcggctctcagtccttccaatatcaag cataaaattgccgaaatgcaacaaatgactattccagaattatttattggtttctttaga atgattatgtacgcgttttactattccggatttggcgtagcaattatcttcaagtacatt ttcggcgttttattatctttgatgagaggccctgttgaagaacctgttgtggaaattaaa gaagaagaagagaaagttggcttgactagggtgttaccggcattaccgtccacggaagag cagaatacgcaaatgcaggcatttggattagatataacaaaagaagataatggacaatat aaaatggctgctcacgaatcgcctacaacgagccaaccatcttcagccgaaggtgaaggt gaaactacacctgaagaagacggtgaacacgctgaagtggaagctccagaagtaccatta tctttatctgaccttttgggtggggaacaagccaaaagagctgctcaagaaaaagttgaa gcgcaagctgcacagcaagcagcaatgcaagctattgaatcggaatcgaaacaacctgtc atcactgaaccatcagccgtttcacaaattaatttcggagcttatagccatcgtgccgtg tcgttcttagccagaaacttttataatctgaaatacgtcgcactggttctcgccttctgt atcaatttcatgcttctcttttacagggtttcaacactaaatgacgacgcagagggcagt ggaagtaaaggaatacctgatataattgaaggttccgcagaaggtagtagtgccggttct ggtgaatctggtgaagacgaagaagatcctttagaattggttcacgtggatgaggacttt tattacatggcacacgttatgcggttagctgcaattttacattcagtagtttctctggcc atgttaattgcttattacaacttgaaagtacctctagctatatttaaaagagaaaaagaa attgcaagacgactagaatttgaaggtttgtacattgctgagcagccagaggatgacgat ctaaaatcgcactgggataaattagtgatttctgctaaatcatttcctgtaaattattgg gataaatttgtaaagaagaaagtacgccaaaaatatagcgaaacttacgacttcgattcg atcagtaatctgcttggtatggaaaaaacatcattccagcagcaagaatctgatgaagga aagagttttatttacttcattattaatattgactggcgatatcaaatttggaaatctggt gtaactattacagataattcattcttgtattctctgtggtactttattttttcgatactg ggcaactttaataatttcttcttcgctgctcatttactagacgttgctgttggttttaaa actttacgtacgattttacagtcagtaacgcacaatggcaagcaattagttttaactgtg atgttgctcaccatcattgtgtatatttacacagtaatcgcatttaacttcttcaggaag ttttatgtgcaagaagaagacgaagaagtagataaaaagtgtcacgatatgttaacatgt ttcgtattccatctgtataaaggagtaagagctggtggtggtataggtgatgaaatcgag ccacctgatggtgacgattacgaagtatatcgtataatgtttgatatcactttcttcttc tttgtcatcgtcattttgttggctatcattcagggtttgatcatcgatgcttttggtgaa ctccgtgatcaattagaaagtgttaaagaagatatggaatctaattgttttatatgtgga atgggaaaagagtattttgataaagtgcctcacggatttgacactcatgttcagcaggaa cacaatttagccaattacatgtttttccttatgcatctgatcaacaaaccagacacagaa tacacaggtcaagaaacttacgtatggaatatgtaccaacaacgatgttgggactttttc cccgttggtgattgtttccgtaaacagtatgaagaagaattgggaagcggaggcggttaa

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