KEGG   Trichechus manatus latirostris (Florida manatee): 101346209
Entry
101346209         CDS       T05135                                 
Name
(RefSeq) ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu04020  Calcium signaling pathway
tmu04024  cAMP signaling pathway
tmu04260  Cardiac muscle contraction
tmu04261  Adrenergic signaling in cardiomyocytes
tmu04371  Apelin signaling pathway
tmu04713  Circadian entrainment
tmu04911  Insulin secretion
tmu04921  Oxytocin signaling pathway
tmu04972  Pancreatic secretion
tmu05020  Prion disease
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05410  Hypertrophic cardiomyopathy
tmu05412  Arrhythmogenic right ventricular cardiomyopathy
tmu05414  Dilated cardiomyopathy
tmu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    101346209
   04020 Calcium signaling pathway
    101346209
   04024 cAMP signaling pathway
    101346209
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    101346209
   04921 Oxytocin signaling pathway
    101346209
  09153 Circulatory system
   04260 Cardiac muscle contraction
    101346209
   04261 Adrenergic signaling in cardiomyocytes
    101346209
  09154 Digestive system
   04972 Pancreatic secretion
    101346209
  09159 Environmental adaptation
   04713 Circadian entrainment
    101346209
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    101346209
   05022 Pathways of neurodegeneration - multiple diseases
    101346209
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    101346209
   05412 Arrhythmogenic right ventricular cardiomyopathy
    101346209
   05414 Dilated cardiomyopathy
    101346209
   05415 Diabetic cardiomyopathy
    101346209
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:tmu04040]
    101346209
   04990 Domain-containing proteins not elsewhere classified [BR:tmu04990]
    101346209
Ion channels [BR:tmu04040]
 Voltage-gated cation channels
  Ryanodine receptor
   101346209
Domain-containing proteins not elsewhere classified [BR:tmu04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   101346209
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase
Other DBs
NCBI-GeneID: 101346209
NCBI-ProteinID: XP_023583920
UniProt: A0A2Y9QKD8
LinkDB
Position
Unknown
AA seq 5041 aa
MEVLYFTVIRAGCLLRSDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKXXP
PDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGSHRTLLYGHAI
LLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGD
DLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHG
HMDECLTVPAGDHGEEQRRNVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRH
VTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGIRKEVDGMGTSEIKYGDS
VCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVI
RSTVFLFNRFIRGLDALSKKVKASSVDLPIESVSLSLQDLISYFHPPDEHLEHEDKQNRL
RALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYKLLAA
LIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIIS
LLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNI
FLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVG
DDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMF
ENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSRE
YKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIE
LGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGILDEHADE
KVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYG
IQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCS
GTGERFRIFRAEKTYAVKAGKWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDG
FKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEAGD
GFIPACSLGVAQVGRMNFGKDVSTLKYFTVCGLQEGYEPFAVNTNRDITMWLSKRLPQFL
QVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAA
GGLPGASLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKEKEATKSEFNNHKDYAQE
KPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRVFPGQEPA
NVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQG
RNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR
IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV
QCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSH
VDEPQLLYAIENKYMPGLLRAGFYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF
PDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAV
KESSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNDDLKHILQLIEPSVFKEAATPEE
DSVVLEKELSMEDSKLEGAGEEEAKGGKRPKEGLLHMKLPEPVKLQMCLLLQYLCDCQVR
HRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNF
KDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNNDLTIRGRLLSLVEKVTYL
KKKQAEKPIQSNSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLV
RALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHP
NLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLS
YLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQM
LVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEG
GNGLLAVMEEAIKIAEDPSRDGPSPTSGSSKTPDTEEEEDDTIHMGNAIMTFYAALIDLL
GRCAPEMHLIHAGKGEAIRIRSILRSLIPLADLVGVISIAFQMPAIAKDGNVVEPDMSAG
FCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRY
LCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQ
LRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELH
LSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEG
NFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEVYSDSSKIQPLMKP
YKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDTAH
GYSPRAIDMSNVTLSRDLHAMAEMMAENYHNTWAKKKKMELESKGGGNHPLLVPYDTLTA
KEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQY
ILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNK
EKEMVTSLFCKLGVLVRHRISLFGNDASSIVNCLHILGQTLDARTVMKTGLESVKSALRA
FLDNAAEDLEKTMQNLQQGQFTHTRNQPRGVTQIINYTTVALLPMLSSLFEHIGQHQFGE
DLILEDVQVSCYRILTSLYALGTSKSIYVERQRSSLGECLAAFAGAFPVAFLETHLNKHN
IYSIYNTKSSRERAALNLPSNVEDVCPNIPSLEKLMDEIVELAESGIRYTQMPHVMEVIL
PMLCSYMSRWWEHGPENNLERAEMCCTAVNSEHMNTLLGNILKIIYNNLGIDEGAWMKRL
AVFSQPIINKVKPQLLKTHFLPLMEKLKKKAALVVSEEDHMKAEARGDMSEAELLILDEF
TTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNF
VVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLN
ICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTE
DTSDPEKTVERVLDIANVLFHLEQKSTCVGWRYYNLVEHPQRSKKAVWHKLLSKQRKRAV
VACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTK
RVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGS
QRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNS
TVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQ
DDEFTCDLFRFLQLLCEGHSSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWY
YSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVF
AHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVE
MILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAE
TDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQP
FLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVN
FCEDTIFEMQLAAQISESDLNERSTNKEESEKEKPEEQEPRMGFFSVLTVKSALFALRYN
ILTLMRTLSLKSLKKQMKKVKKMTMKDMITAFFSSYWSIFLSLLHFVASVFRGFFRIVCS
LLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEDGERKSVEVALPSEDLTDLKELAE
ESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKVKEEEKEE
KEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKITAYQQKL
LNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELHPRSSGENAKVSNLDSGS
QRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLE
FDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGGFYGRDRISELLG
MDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNKFLFSLLQSVIEKK
KDVFHSNYHYKNGIVFVRNVNYLKRLNLVQMEKVFNVVSTAKYLDDGKMSININLNMKLN
HNLCSGSVYLLESSPPTLMSNMPIKCLVPLTHVQCHIALQLVLTVGLLAVVVYLYTVVAF
NFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIF
DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFE
THTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQL
N
NT seq 15126 nt   +upstreamnt  +downstreamnt
atggaagtcctgtattttactgttatccgtgcaggctgcctcctgagatcagatgatgaa
gtggttctgcagtgtaccgcaaccatccacaaagagcaacagaaactatgcttggcggca
gaaggatttggaaacagactttgcttcttggagtccacttccaattccaagnnnnnncca
ccagatctctccatctgcaccttcgtgttggaacagtccctgtccgtccgggccctgcag
gagatgctggctaacacggtggagaaatccgaagggcaagttgatgtggaaaaatggaaa
ttcatgatgaagacggctcaaggaggtagccatcgaaccctcctctacggacatgccata
ttgctgcgtcattcctatagcggcatgtatctatgctgtctatccacctcccggtcttca
actgataaactggcctttgatgttggcttgcaagaagacacaacaggtgaggcttgttgg
tggacgatacaccctgcctctaagcagcgatcagaaggagagaaagtccgagtgggagat
gaccttatcttagttagtgtgtcctctgaaaggtacttgcacttgtcctatggcaatggc
agcttgcacgtggacgccgccttccagcagaccctctggagcgtggccccaatcagctca
ggaagtgaagccgcccaagggtatctgattggtggtgatgttctccggctgctgcatgga
catatggacgaatgcctcaccgttcccgcgggggaccacggggaagagcagcggagaaat
gttcattatgaaggtggtgccgtatctgttcatgcacgttccctgtggagactagagaca
ctaagagttgcatggagtggaagccatataagatggggccagcccttccgactacgccat
gtgacaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaag
gaaaaagctgatgtaaaatcgacagcatttaccttccggtcttccaaggaaaaattggat
gtagggataagaaaagaagtcgatggcatgggcacatctgaaataaaatatggtgactca
gtgtgctatatacaacatgtagatacaggcctgtggcttacttaccagtccgtggacgtg
aaatctgtgagaatggggtctatacaacgtaaggctattatgcaccatgaaggccacatg
gatgatggtttaaatttatctaggtctcagcatgaagaatctcgtacagcacgagtaatt
cgtagcacagtcttccttttcaatagatttataaggggccttgatgctctcagcaagaaa
gtgaaggcttcttccgtagacttgcctatagagtctgtaagtctaagtctgcaggatctg
attagctacttccaccctccagatgagcatttagagcatgaggacaagcagaacagactc
cgagctctgaagaaccgccagaatctcttccaggaagagggaatgatcaacctcgtactc
gagtgcatagatcggctgcatgtctacagtagtgcggcccacttcgccgatgttgctggg
agggaagcaggagaatcttggaaatcgatcctaaattctctgtacaaattgcttgcggct
ctaattaggggaaatcgtaaaaactgtgctcagttttccggctcccttgactggttgatc
agcagattggaaagactggaagcttcttctggcattcttgaagttttacactgtgtgtta
gtggaaagtccagaagctctgaatattatcaaagaaggacatattaaatccattatctca
ctcttggacaagcatggaagaaatcacaaggttctggacgtcttgtgttctctctgtgtt
tgccacggagttgcagtccgttctaaccagcatctcatttgtgacaatctcctaccagga
agagatctgttattgcagacgcgtcttgtaaatcatgtcagcagcatgaggcctaatatt
tttctgggcgtcagcgaagggtctgctcaatataaaaaatggtactatgaactgatggtg
gaccacactgaaccatttgtgacagctgaagcgacacaccttcgagtgggctgggcttcc
actgaagggtactctccctaccccggaggtggtgaagagtggggtggaaatggtgttgga
gacgacctgttctcttatggatttgatggactacacctctggtcaggttgcattgctcgt
actgtaagttccccaaaccaacacctgttgagaactgatgatgttatcagttgctgttta
gatctaagtgccccaagcatctccttccgaattaatggtcaacctgttcaaggaatgttt
gagaatttcaacatcgatgggctcttctttccagttgttagtttctctgcagggataaag
gtacgctttctgcttggggggagacatggagaatttaaattccttcctccacctgggtat
gctccttgttatgaagctgttctgccaaaagaaaagttgaaagtggaacacagccgggag
tacaagcaagaaagaacatatacccgggacctactgggtcccacagtttccctgacacaa
gcagccttcacaccaattcctgtggataccagccagattgtgttgccgcctcacctggaa
aggataagagaaaaacttgcagagaatatccatgaactctgggttatgaataaaattgaa
cttggctggcagtatggtccggttagagatgacaacaagagacaacacccgtgtctggtg
gagttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcactggagact
ctgaagactttgttggcattgggatgccatgtgggtatattggatgaacatgctgatgaa
aaggtgaaaaaaatgaagctacccaagaattaccagctgaccagtggatacaagcctgct
ccgatggacctaagttttataaaactcaccccttcccaggaagcaatggtggacaagtta
gctgaaaatgcccataatgtgtgggctcgagatcgaatcaggcagggctggacttatgga
atccaacaggatgtaaagaacagaagaaacccccgccttgttccctatgctcttctagat
gaccgaaccaagaaatcaaataaggacagcctacgagaggctgtgcggacccttctggga
tatggctacaacctggaagctcctgatcaagatcatgctgccagagctgaagtgtgtagt
ggcacaggggaacggttccgaatcttccgggctgagaagacctatgctgtgaaggcagga
aagtggtattttgaatttgaggctgtcactgctggagacatgagagttggctggagcagg
ccaggttgtcagcctgatcaggaacttggttccgatgaacgtgcttttgcttttgatggc
tttaaggcccagcggtggcaccagggcaatgagcattatgggcgctcttggcaagcaggc
gatgtggtggggtgcatggttgacatgaatgagcacaccatgatgttcacactgaatggg
gaaatccttctcgatgattctggctcagaactggctttcaaggactttgaggctggtgat
ggattcatacctgcatgtagccttggtgtggctcaggtgggcaggatgaactttggaaag
gatgtcagcaccttgaaatatttcactgtctgtggcttacaagagggctatgaaccattt
gcagtgaatacaaatagggatattaccatgtggctaagcaagaggcttcctcaatttctt
caagttccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagacagt
tccccatgtttaaaggtgactcagaagtcttttgggtcacagaacagcagcactgatatc
atgttttatcgtctgagcatgccaatcgagtgtgcagaggtcttctccaagactgctgca
ggaggactacccggggccagcctctttgggcccaagaatgacctggaagattatgatgca
gattctgactttgaggttctaatgaagacagctcatggccatctggtgccagatcgggtt
gacaaagaaaaagaagctacaaaatcggagtttaataaccacaaagattatgctcaagaa
aagccctctcgtctgaaacaaagatttttgcttagaagaacaaaaccagattacagtaca
agccattctgcaagacttactgaagatgtccttgcagatgatcgggatgactatgattac
ttgatgcaaacgtccacgtactattactctgtgagagtctttcctggacaagaacctgct
aacgtctgggtgggctggattacgtcagatttccatcagtatgatacaggctttgacttg
gacagagttcgtacagtaaccgttactctaggagatgaaaaaggaaaagtgcatgaaagc
atcaaacgcagcaactgctatatggtgtgtgcgggtgagagtatgagccctgggcaggga
cggaacaataatggattggagattggctgtgtggtggatgctgccagtgggttgctcacg
ttcacggctaatggcaaggaattgagcacatattaccaggtggagccaagtacaaaacta
tttcctgcagtttttgcacaggctacaagtcccaatgttttccagtttgagttgggaaga
ataaagaatgtaatgcctctgtcagctggattattcaagagtgagcataaaaaccctgtg
ccacagtgtcctccacgtctccatgtgcagtttttatcacacgttctttggagcagaatg
ccaaatcagtttctgaaggtagatgtctctcgaatcagtgaacgccaaggctggctggtg
cagtgtttggatcctctgcagttcatgtctcttcatatcccagaggagaacagatctgtg
gacatattagaattgacggagcaagaggaactgctgaagttccactatcacactctccgc
ctctactcagcggtctgtgctctggggaaccaccgggtggcccacgccctgtgcagccac
gtggatgagcctcagctcctctacgccatcgagaacaagtacatgcctggcttgctgcgt
gcaggcttctatgacctgctgatcgacatccaccttagctcctacgccactgccaggctt
atgatgaacaatgaattcatcgttcccatgacggaagaaaccaagagtattaccctcttc
cctgatgagaacaaaaagcacggtctcccagggatcggccttagcacctccctcaggccg
cggatgcagttttcctcccctagttttgtgagcattagtaatgaatgctaccagtatagt
ccagagttccccctagatatcctaaaggccaaaaccatccagatgctgacagaagcagtg
aaagagagcagccttcatgcccgggacccggttggggggaccactgaattcctctttgta
cctctcatcaagcttttctataccctgctcatcatgggcatcttccacaatgacgacttg
aagcacattctgcagttaattgagcccagtgtatttaaggaagctgccacgccagaggag
gacagtgtggtgctggagaaggagctcagcatggaagactcgaagctggaaggagctggg
gaggaagaagccaaaggcggtaaaaggccgaaggaaggcctgctccacatgaaactgcca
gagccagttaaactgcagatgtgcctgctgcttcagtacctttgtgactgccaggtccgg
caccggatagaagccattgtagccttttcagatgactttgtagctaagcttcaagacaat
caacgcttccgatataatgaagttatgcaagccttaaacatgtcagctgcgctcacagcc
aggaaaaccaaggaatttagatccccacctcaagagcagatcaatatgcttctcaatttt
aaggatgacaaaagtgaatgtccatgtcctgaagaaatcagagaccaactcttggatttt
catgaagatctgatgacacattgtggaattgagctggatgaagatggttctttagatgga
aacaatgatctaacaattagagggcgcctgctgtccctggtagaaaaggtgacctacctg
aagaagaaacaagcagaaaaaccaattcagagtaactccaagaagtcctccactcttcag
cagttgatttctgagactatggtccgatgggctcaggagtctgtcattgaagaccctgag
ttggtgagggccatgtttgtgctgctccatcgacagtacgatggcattgggggtctggtc
cgggctctgccaaagacctacaccataaacagtgtctctgtggaggataccatcaacctg
ctggcatctcttggtcagattcgctctttgctgagtgtcaggatgggcaaagaagaagag
aagcttatgattcgtggattgggggatatcatgaataataaagtgttttaccagcatcct
aatctgatgagggcccttgggatgcatgagacggtaatggaagtcatggtgaatgtcctt
ggtggtggtgagtccaaggaaatcacctttcccaagatggtggccaactgttgccgtttt
ctgtgttatttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatcttagt
tatttactggaaaacagcagtgttggtcttgcctcaccagctatgagagggtccacaccg
ctggatgtggctgcagcctcggtgatggataataatgaacttgccttagctttgcgtgag
ccagatctagaaaaggtagttcgatatttggctggttgtggactgcaaagttgccagatg
ctggtatctaagggttatccagacattgggtggaatcctgtcgaaggagagagatatctt
gactttctccgatttgctgtcttctgtaatggggagagtgtggaagagaatgcaaatgtt
gtggtcagattgcttattcggaggcctgagtgttttggtcctgctttgcgaggggaaggt
ggaaatggtcttcttgcagtcatggaagaagccattaaaatagccgaggatccttccaga
gatggtccatcacccacgagtggatctagtaaaacacctgatacagaagaagaggaagat
gataccatccacatggggaatgcaatcatgaccttttatgcagctttgattgacctgttg
ggacgctgtgcgcctgagatgcacttgattcatgctggtaagggagaagccattaggatc
agatctattttgagatccttaattccactggcagatttggtgggcgtaatcagcatcgct
tttcagatgccagcgatagccaaagatgggaatgtggtggagcctgacatgtctgcgggg
ttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgag
gttcaagatttccttctccatcttcttgaggttggctttctgccagatctccgggctgct
gcctctttagatacggctgctttgagtgctacagacatggccttggccctcaatcggtac
ctgtgcacagctgtcttgcctttgttaacgaggtgtgctcccctttttgctggcacagag
caccacgcttccctcattgactcattacttcacactgtgtacagactgtctaaaggctgc
tcacttaccaaagctcaacgggattccatagaagtgtgtttactctccatttgtggtcaa
ctgagaccttctatgatgcagcacttactcagaagattagtatttgatgtcccgttatta
aatgaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaa
tattactgcctgccaggaggatggggaaactttggtgctgcatcagaagaagaacttcat
ttatcaagaaaattgttctggggcatttttgatgccctgtcccagaagaaatatgaacaa
gaacttttcaaactggctctgccttgcctgagtgcagttgcgggagctttgcctccagac
tacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaaggg
aactttaacccacaacctgttgatacctcaaatattacaattcctgaaaagttggaatac
ttcattaacaaatatgcagaacattcccatgacaaatggtcaatggacaagttggcaaat
ggatggatttatggagaagtatattcagactcttctaagattcaaccattaatgaaacca
tataaattattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatcttta
aaaactatgctggcttggggctggagaattgaaagaacccgggagggagacagtatggct
ctttataaccggactcgtcgcatttctcaaacaagccaggtttccatagatactgcccat
ggctatagcccccgagccattgacatgagcaatgttacgctctccagagatctgcatgcc
atggcagaaatgatggctgagaactaccataatacatgggccaagaaaaagaaaatggag
ctggagtccaaaggcggtggaaaccatcccctgctggtgccctatgatacgttgacagcc
aaagaaaaagccaaggacagggaaaaagcccaggatattctcaagttcttgcagatcaat
ggatatgctgtatccagaggattcaaggacctggaactggacacaccttctatcgagaaa
cgatttgcctatagtttcctccaacagctcattcgctatgtggatgaagcccatcagtat
atcctggagtttgatggtggcagcagaagcaaaggagagcatttcccctacgaacaagaa
atcaagttctttgctaaagtcgtgcttcctttaattgaccaatatttcaaaaatcatcgc
ttatacttcttatctgcagcaagcaggcctctgtgttctggaggacatgcatcgaacaaa
gagaaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatt
tcactgtttggaaatgatgcatcatcaattgtcaactgtcttcatattttgggtcagact
ttggatgcaaggaccgtgatgaagactggcctggagagtgttaaaagtgccctccgagca
ttcctggacaatgcagcagaagacctggagaagacgatgcaaaaccttcagcagggccag
ttcacacacactcggaaccaacccagaggtgtcactcagattatcaattataccacagtg
gcactgttgccaatgctgtcatcattgtttgaacatattggccagcatcagtttggagaa
gatctaatattggaagacgtgcaggtctcctgttatagaatcctgactagcttatatgct
ttgggaaccagcaagagtatctatgtggagaggcaacgttcttcgttaggagaatgtctg
gctgcctttgctggtgcctttccggtagcatttctggaaacccatctcaacaaacataat
atttactctatctacaacactaagtcttcacgagagagagcagctctcaatttgccatct
aatgtggaagacgtttgtcctaacataccatctttggagaaactcatggatgagattgtg
gaattagccgagtctggcattcgctatacacaaatgccacatgtcatggaagttatactg
cccatgctttgcagttacatgtctcgttggtgggagcatggacctgagaacaatctggaa
agggctgaaatgtgctgcacagctgtgaactcagagcacatgaacacacttcttgggaat
atattgaaaattatatacaataacttgggaattgacgaaggggcctggatgaagaggtta
gcagtgttttctcagcctattataaataaagtgaaacctcagctcttgaaaactcacttc
ttgccattaatggagaaactcaagaaaaaggcagcattggtggtatccgaggaagatcac
atgaaagcagaggccagaggcgatatgtctgaggctgagctccttattctagatgagttt
actacactggccagagacctctatgctttctatcctctcctgattagattcgtggactac
aacagggcaaagtggctaaaagagcctaacccggaagcagaggaactcttccgtatggtg
gccgaagtgtttatctactggtcaaaatcccataatttcaaaagagaagagcagaacttc
gtggtacagaatgaaatcaacaatatgtctttccttattactgataccaagtcaaagatg
tcaaaggcagctgtttctgatcaggaaaggaagaaaatgaaacgtaaaggagaccggtat
tctatgcagacctctcttatcgtagcagctctgaagcgcctgctgcccattggattgaac
atctgtgcccctggcgaccaggagctcatcgctctggccaagaatcgatttagtctgaaa
gacaccgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagtta
gaggatcctgctattaggtggcaaatggctctttacaaagacttaccaaacaggactgaa
gatacttcagatccagagaagacagtagaaagagtattggatattgcaaatgtccttttc
catcttgaacagaaatctacatgtgtgggctggagatattacaatctggtggaacatcct
cagagatctaaaaaggctgtgtggcacaaactgctgtctaagcagaggaaaagggcagtg
gtagcctgcttccgaatggctcccttatacaatctcccaaggcatcgagctgtcaatctc
tttcttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataaa
ctgatagaagatttagcaaaacctggagcagaacctccagaagaagatgaaggcactaag
agggttgatcctctacaccagctgatccttctgttcagtcgaacagctttaacagagaaa
tgcaaactggaggaagattttttatatatggcttacgcagatattatggcaaagagttgt
catgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcc
caacgcagcaaggaaaaagaaatggaaaagcaaaagcttctctaccagcaagccagactc
cacgatcgaggcgctgctgagatggtactacagacaatcagtgccagcaaaggtgaaatg
gggccaatggtagctgctactttgaaacttggaattgccatcttaaatggtgggaactca
acagtacagcagaaaatgctagactacctcaaggagaagaaggatgtgggcttctttcaa
agccttgctggcctgatgcagtcatgtagtgtccttgacctaaatgcatttgagcgacaa
aacaaagctgaaggactgggaatggtgacagaggaaggatcaggagagaaggtgctgcag
gacgacgagttcacctgcgacctcttccgcttcctccaacttctctgtgagggacacagt
tcagattttcaaaattatctaagaactcagactggcaataacacaactgtcaatataatc
atctctactgtggactacctactgagagttcaggaatcaattagtgatttctattggtat
tactctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagcaattcaa
gtagcaaaacaagtctttaacacccttacagagtatattcagggtccctgcactgggaat
cagcagagtttggcacacagcaggctatgggacgctgtggtgggttttcttcacgtcttt
gcacacatgcaaatgaagctatctcaggattccagtcaaattgagctattaaaagaatta
atggatcttcagaaggacatggtggtcatgttgctgtccatgttagaaggtaatgttgtc
aacggaacgataggcaaacagatggttgatatgcttgtggaatcgtccaacaacgtagag
atgattctcaaattttttgacatgttcttaaaactaaaggatttgacatcttctgataca
tttaaagaatatgaccctgatggcaagggagtcatttccaagagggacttccataaagca
atggagagccataagcactacacacaatcagaaacggagtttcttttgtcctgcgcagag
acagatgaaaatgaaaccctggactatgaggagtttgtaaaacggttccatgaacctgca
aaggacatcggcttcaacgttgccgtcctcctgacaaatctttcagagcacatgcccaac
gatacccgattgcaaactttccttgaattagcagagagtgtgctgaattatttccagccc
tttctgggccgcattgagatcatgggaagtgctaaacgcattgagagggtttattttgaa
atcagtgaatctagtcggacccagtgggagaagccgcaggtcaaagaatccaaaaggcag
ttcatatttgacgtggtcaacgaaggaggagaaaaagagaagatggaactttttgtgaac
ttttgtgaggacaccatatttgaaatgcagctggcagctcagatctcagaatcagacttg
aatgagaggtccacaaataaagaagaaagtgagaaagagaagcccgaagagcaggagcca
agaatgggtttcttttctgttctgacggtcaagtcggccctgtttgccctcaggtataat
atcttgacccttatgagaacgctcagcttgaaaagcctgaagaaacagatgaagaaagtg
aagaagatgaccatgaaggacatgatcacggccttcttttcatcctattggagtattttt
ttgagcctcttgcactttgtagccagtgttttcagaggctttttccgcatcgtttgtagc
ctgctgctgggaggaagcctagtagaaggtgctaaaaagatcaaagttgcagaactctta
gccaatatgccagaccccactcaggatgaggtgagaggagatggagaggatggagagagg
aaatctgtggaagttgccctgccctctgaagacctgacagacttaaaggaactggcagag
gaaagtgaccttctttcggacatatttggcttggatctgaagagagaaggaggacagtac
aaacttattcctcataacccaaatgctggccttagtgacctaatgagcaacccagtgccc
atccctgaggtgcaagaaaaatttcaggaacagaaggtaaaagaagaagaaaaggaagaa
aaagaagaaaccaaatctgaacctgagaaagccgagggagaagacggagaaaaagaagaa
aaagccaaagaagacaagggtaaacaaaagctgaggcagcttcacacacatagatatgga
gagccagaagttccagagtcagcattctggaagaaaatcacagcatatcaacagaagctt
ctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcattt
gcaatcaatttcatcttgctcttttataaggtctccacctcttctgtggttgaaggaaag
gagctgcaccctcgaagttctggtgaaaatgccaaagtgagcaacctggacagtggctcc
cagagaatcattgctgttcactatgtcctggaggagagcagtggctacatggagcccacg
ctgcgcattttagctattctccacacggtcatttctttcttctgcatcattggatactac
tgcttgaaagtcccattggttatttttaagcgagaaaaggaagtagcacgaaaattggaa
tttgatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggat
agactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaaga
aaggttatggataaatacggagggttctatggccgagatagaatcagcgaattattaggc
atggacaaagcagctctggatttcagcgatgccagagaaaagaagaagccaaagaaagac
agttccttatcggctgtactgaactctattgatgtgaagtatcagatgtggaaactagga
gttgttttcactgacaataaatttctatttagtctcttgcagtcagtgattgaaaagaaa
aaagatgttttccactcaaactatcattacaaaaatgggatcgtatttgttaggaatgta
aattatttgaagagattaaaccttgtacaaatggagaaagtatttaatgtagtatctact
gccaaatatttagatgatggaaaaatgagcattaatatcaatttgaatatgaaactgaat
cataacttatgttctggctcggtgtacttgctggagagttcccctcccacactgatgtca
aacatgccaatcaaatgtcttgtacctctaacacacgttcaatgtcacattgctttacag
cttgtcttaactgttggcttattagccgttgttgtatacctatatactgttgtggcattc
aattttttccgaaaattctacaataagagtgaagatggtgatacaccagatatgaaatgt
gatgatatgttaacgtgctatatgttccacatgtatgttggggtacgtgctggcgggggc
atcggtgatgagatcgaagacccagcaggagatgaatatgagatctatcgcatcattttt
gacatcaccttcttcttctttgtcattgtcattctgttggccataatacaaggtttaatt
attgacgcttttggagaattaagagaccaacaggaacaagtcaaggaggacatggagacc
aaatgcttcatctgtgggataggcaatgattacttcgacacagtgccacacggctttgaa
acgcacactttacaggaacacaacttggccaattacctgtttttcctgatgtatctcata
aataaggatgaaacagagcacacaggacaggaatcttatgtctggaagatgtatcaagaa
aggtgctgggaatttttcccagcaggggattgtttccggaaacagtatgaagaccagcta
aactga

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