KEGG   Trichechus manatus latirostris (Florida manatee): 101352466
Entry
101352466         CDS       T05135                                 
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu01522  Endocrine resistance
tmu04010  MAPK signaling pathway
tmu04015  Rap1 signaling pathway
tmu04068  FoxO signaling pathway
tmu04071  Sphingolipid signaling pathway
tmu04114  Oocyte meiosis
tmu04148  Efferocytosis
tmu04218  Cellular senescence
tmu04261  Adrenergic signaling in cardiomyocytes
tmu04370  VEGF signaling pathway
tmu04380  Osteoclast differentiation
tmu04550  Signaling pathways regulating pluripotency of stem cells
tmu04611  Platelet activation
tmu04613  Neutrophil extracellular trap formation
tmu04620  Toll-like receptor signaling pathway
tmu04621  NOD-like receptor signaling pathway
tmu04622  RIG-I-like receptor signaling pathway
tmu04625  C-type lectin receptor signaling pathway
tmu04657  IL-17 signaling pathway
tmu04658  Th1 and Th2 cell differentiation
tmu04659  Th17 cell differentiation
tmu04660  T cell receptor signaling pathway
tmu04664  Fc epsilon RI signaling pathway
tmu04668  TNF signaling pathway
tmu04670  Leukocyte transendothelial migration
tmu04714  Thermogenesis
tmu04722  Neurotrophin signaling pathway
tmu04723  Retrograde endocannabinoid signaling
tmu04728  Dopaminergic synapse
tmu04750  Inflammatory mediator regulation of TRP channels
tmu04912  GnRH signaling pathway
tmu04914  Progesterone-mediated oocyte maturation
tmu04917  Prolactin signaling pathway
tmu04926  Relaxin signaling pathway
tmu04932  Non-alcoholic fatty liver disease
tmu04933  AGE-RAGE signaling pathway in diabetic complications
tmu04935  Growth hormone synthesis, secretion and action
tmu04936  Alcoholic liver disease
tmu05014  Amyotrophic lateral sclerosis
tmu05020  Prion disease
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05132  Salmonella infection
tmu05133  Pertussis
tmu05135  Yersinia infection
tmu05140  Leishmaniasis
tmu05142  Chagas disease
tmu05145  Toxoplasmosis
tmu05152  Tuberculosis
tmu05161  Hepatitis B
tmu05163  Human cytomegalovirus infection
tmu05167  Kaposi sarcoma-associated herpesvirus infection
tmu05169  Epstein-Barr virus infection
tmu05170  Human immunodeficiency virus 1 infection
tmu05171  Coronavirus disease - COVID-19
tmu05205  Proteoglycans in cancer
tmu05208  Chemical carcinogenesis - reactive oxygen species
tmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tmu05415  Diabetic cardiomyopathy
tmu05417  Lipid and atherosclerosis
tmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101352466
   04015 Rap1 signaling pathway
    101352466
   04370 VEGF signaling pathway
    101352466
   04668 TNF signaling pathway
    101352466
   04068 FoxO signaling pathway
    101352466
   04071 Sphingolipid signaling pathway
    101352466
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    101352466
  09143 Cell growth and death
   04114 Oocyte meiosis
    101352466
   04218 Cellular senescence
    101352466
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101352466
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101352466
   04613 Neutrophil extracellular trap formation
    101352466
   04620 Toll-like receptor signaling pathway
    101352466
   04621 NOD-like receptor signaling pathway
    101352466
   04622 RIG-I-like receptor signaling pathway
    101352466
   04625 C-type lectin receptor signaling pathway
    101352466
   04660 T cell receptor signaling pathway
    101352466
   04658 Th1 and Th2 cell differentiation
    101352466
   04659 Th17 cell differentiation
    101352466
   04657 IL-17 signaling pathway
    101352466
   04664 Fc epsilon RI signaling pathway
    101352466
   04670 Leukocyte transendothelial migration
    101352466
  09152 Endocrine system
   04912 GnRH signaling pathway
    101352466
   04914 Progesterone-mediated oocyte maturation
    101352466
   04917 Prolactin signaling pathway
    101352466
   04926 Relaxin signaling pathway
    101352466
   04935 Growth hormone synthesis, secretion and action
    101352466
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101352466
  09156 Nervous system
   04728 Dopaminergic synapse
    101352466
   04723 Retrograde endocannabinoid signaling
    101352466
   04722 Neurotrophin signaling pathway
    101352466
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101352466
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101352466
  09159 Environmental adaptation
   04714 Thermogenesis
    101352466
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    101352466
   05208 Chemical carcinogenesis - reactive oxygen species
    101352466
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101352466
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101352466
   05161 Hepatitis B
    101352466
   05171 Coronavirus disease - COVID-19
    101352466
   05163 Human cytomegalovirus infection
    101352466
   05167 Kaposi sarcoma-associated herpesvirus infection
    101352466
   05169 Epstein-Barr virus infection
    101352466
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101352466
   05135 Yersinia infection
    101352466
   05133 Pertussis
    101352466
   05152 Tuberculosis
    101352466
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101352466
   05140 Leishmaniasis
    101352466
   05142 Chagas disease
    101352466
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    101352466
   05020 Prion disease
    101352466
   05022 Pathways of neurodegeneration - multiple diseases
    101352466
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101352466
   05418 Fluid shear stress and atherosclerosis
    101352466
   05415 Diabetic cardiomyopathy
    101352466
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101352466
   04932 Non-alcoholic fatty liver disease
    101352466
   04933 AGE-RAGE signaling pathway in diabetic complications
    101352466
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101352466
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tmu01001]
    101352466
Enzymes [BR:tmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101352466
Protein kinases [BR:tmu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101352466
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Kinase-like
Other DBs
NCBI-GeneID: 101352466
NCBI-ProteinID: XP_004380080
UniProt: A0A2Y9DT27
LinkDB
Position
Unknown
AA seq 595 aa
MSSPPPARKGFYRQEVTKTVWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGARVAIKKLYR
PFQSELFAKRAYRELRLLKHMHHENVIGLLDVFTPDETLDDFTDFYLVMPFMGADLGKLM
KHDKLSEDRVQFLVYQMLKGLKYIHGAGIIHRDLKPSNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWRHYTQTVDVWSVGCIMAEMISGKTLFKGNDHLDQLKEILK
VTGTPPAEFVQGLQSTDAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAEALAHPYFEALHEAEDEPKAQKYDNSFDDVKRTLDEWKRVTYKEVLSFKPPQQLGSR
DLSGGLGPNLGLHSRHQSPQAKKFLGREGDTLDALRLLWARPSGTGAHAWAPQAALAPLH
LIPRATRLDGEGAEHELCRASGTSPAPPLHSGPAPFPAPEISKTANENSRGGRRVGAGGG
VGTFLEPVPALALRDGVLHSSHRGIILAQLALTGETGLGGIRVNQGSGHPVGQAVQSRPK
TRASGPPPPEMYSRDPRSQKHTACDYLGLNPRRPRLAPLLPRPRIQRAIPRTPPP
NT seq 1788 nt   +upstreamnt  +downstreamnt
atgagctccccgccgcccgcccgcaagggcttttaccgccaggaggtgaccaagacggtg
tgggaggtgcgcgtcgtgtaccaggacctgcagcctgtgggctcgggcgcctatggcgcc
gtgtgctcggccgtggacagccgcaccggcgccagagtggccatcaagaagctgtatcgg
cccttccagtccgagctgttcgctaagcgcgcctaccgcgagctgcgactcctgaagcac
atgcaccacgagaacgtgattgggctgcttgacgtgtttactcccgacgagaccctggat
gacttcacagacttttacctggtgatgccgttcatgggcgctgacctgggcaagctcatg
aagcacgacaagctgagtgaggaccgcgtccagttccttgtgtaccagatgctgaaaggg
ctcaagtacatccatggtgctggcatcatccacagggacctgaagcccagcaacctggcg
gtgaatgaagactgcgagctgaagatcctggactttggcctggccaggcaggcggacagc
gagatgaccgggtacgtggtgacccggtggtaccgagcaccggaagtcatcctgaactgg
agacactacacgcagacggtcgacgtttggtcggtgggctgcatcatggccgagatgatc
tcggggaagacgctgtttaagggcaatgaccacctggatcagctgaaagagatcctgaag
gtgacggggacgcccccggccgaatttgtgcaggggctgcagagtaccgatgccaagaac
tacatgaaaggccttcctgaactggagaagaaggactttgcatccatcctgaccaacgcc
agtcccctggctgtgaacctcctggagaagatgctggtgctggacgcggagcagcgggtg
acagcggccgaggcgctggcccacccctactttgaggccctgcacgaggcggaagatgag
cccaaggcccagaagtacgacaactcctttgatgacgtgaagcgcactctggacgagtgg
aagcgtgtcacctataaagaggtgctcagcttcaagcctccccagcagctggggtccagg
gacctgagcgggggtttaggacccaacctggggctccattcccgccatcagagtccccag
gccaagaagttcttggggagggagggggacacgctagacgccctcaggctcctctgggcc
aggcccagcgggaccggagcccacgcgtgggcccctcaggcagccctcgcgcctctccac
ctgatcccacgagcaactcggctggacggagaaggtgccgaacacgagctctgccgcgcc
tccgggacaagccccgccccgccgctccacagcggccccgcccccttccccgcccccgag
atatccaagacggccaatgagaactctcgaggcgggcggagggtgggcgccggcgggggt
gtcgggacctttctagagcccgtgccggccctggcgctgagggacggagttctgcattcg
tcccaccgtgggatcatccttgcgcagctagcactgaccggagaaacgggactagggggc
ataagggtcaatcaggggtcagggcacccagtggggcaggcggtacagtcccgccccaag
acccgtgcctccgggcctccgcccccagagatgtactcacgggacccccgctcgcagaaa
cacactgcctgtgactacctagggctcaacccacggagaccgcgcctagctcccctgctt
ccaaggccccgaatccagagggccattcccaggaccccgcctccatag

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