KEGG   Trichechus manatus latirostris (Florida manatee): 101357635
Entry
101357635         CDS       T05135                                 
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu04217  Necroptosis
tmu04380  Osteoclast differentiation
tmu04620  Toll-like receptor signaling pathway
tmu04621  NOD-like receptor signaling pathway
tmu04630  JAK-STAT signaling pathway
tmu04658  Th1 and Th2 cell differentiation
tmu04659  Th17 cell differentiation
tmu05145  Toxoplasmosis
tmu05160  Hepatitis C
tmu05161  Hepatitis B
tmu05162  Measles
tmu05164  Influenza A
tmu05165  Human papillomavirus infection
tmu05167  Kaposi sarcoma-associated herpesvirus infection
tmu05168  Herpes simplex virus 1 infection
tmu05169  Epstein-Barr virus infection
tmu05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    101357635
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    101357635
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101357635
   04621 NOD-like receptor signaling pathway
    101357635
   04658 Th1 and Th2 cell differentiation
    101357635
   04659 Th17 cell differentiation
    101357635
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101357635
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    101357635
   05160 Hepatitis C
    101357635
   05171 Coronavirus disease - COVID-19
    101357635
   05164 Influenza A
    101357635
   05162 Measles
    101357635
   05168 Herpes simplex virus 1 infection
    101357635
   05167 Kaposi sarcoma-associated herpesvirus infection
    101357635
   05169 Epstein-Barr virus infection
    101357635
   05165 Human papillomavirus infection
    101357635
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101357635
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tmu01001]
    101357635
Enzymes [BR:tmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101357635
Protein kinases [BR:tmu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   101357635
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 SH2_1 Kdo Kinase-like RA_2 APH FERM_C_FAK1 ABC1
Other DBs
NCBI-GeneID: 101357635
NCBI-ProteinID: XP_023588974
UniProt: A0A2Y9R049
LinkDB
Position
Unknown
AA seq 1183 aa
MPLCQWGGTARGSKPNGDGAQSMVTGEGLRVHLHWAGPGGGEPWVTFNEASLTAEEVCIH
IAHKIGITPLCFNLFALFDTQAQVWLPPNHILEVPRESSLILHFRMRFYFRNWHGMNPQE
PTVYRCGPPGAEAPSGQAEHGLQFLDPASFEYIFEQGKHEFVNDVASLWELSSEEEIHHF
KNESLGMAFLHLCHLALHRGVPLEEVAKKISFKDCIPRSFRSQIRQHNALTRLRLRSIFY
KFLRAFQPSHLSQQLVMVKYLATLERLAPRFATEHMPVCHLELLAQAEGEPSYIQDRGQA
PLDPGPESVPGPPTHEVLVTGTRGIQWRPVQAEGSGGSGGGSRNPPASPSGKKAQAQEAD
VQPAGRPKGLPWASFCNFQDISHLVVKEHRVSIHRQDNKCLELTLPSRAAALSLVSLVDG
YFRLTVDSSHYLCHEVAPPRLVMSIQDGIHGPLLDPFVLAKLQPEDGHYLIHWSTSHLYR
LILTVAQRDQAPGSQSLRLRKFTIKQQAGTFTLEGWGRSFPSVGALRAALQDCSLRVGED
CFPLRRCCLPLPRELSNLIIMRGPRASPRPLNLSQLSFHRVCRDEITQLSHLGQGTRTNV
YEGLLRVEGEGPEEDKEDSGDPPVPSRGRGQELRVVLKVLDPSHHDIALAFYEVASLMSQ
VSHVHLAFVHGVCVHGSENILVTEYVEHGPLDVWLRREKGHVPVAWKVAVAQQLASALSY
LEDKNLVHGNVCGRNILLARPGLAEGTSPFIKLSDPGVGLGTLSREERVERIPWMAPECL
PGGANSLSTAADKWGFGATLLEICFDGEAPLQGRGPSEKERFYQKQHQLPEPSYPELATL
TSQCLTYEPAQRPSFRTILRDLTRLQPHNLVDVSAVSPDSPASDPTVFHKRYLKKIRDLG
EGHFGKVSLYCYDPTNDCTGEMVAVKSLKAGCSPQLHSGWRREIDILRTLYHEHIIKYKG
CCEDAGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQHYIHRDL
AARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVCEDGDSPVFWYAPECLKECKFYYASDV
WSFGVTLYELLTRCDSSQSPPTKFIELIGLTQGQMTVLRLTELLEQGERLPRPEACPCEI
YHLMKNCWEAEASFRPTFQNLIPILKTVHEKYQGQAPSVFSVC
NT seq 3552 nt   +upstreamnt  +downstreamnt
atgccactgtgccagtggggtggcaccgcccggggcagcaagcctaatggggacggagct
cagtccatggtcaccggggaaggcctgagggtgcatctgcactgggctggcccaggcggc
ggggagccctgggtcaccttcaatgaagcctcactgacggccgaggaggtctgcatccac
atcgcacacaaaattggcatcactccactctgcttcaatctgtttgccctcttcgatacc
caggcccaagtctggctgcccccaaaccacatcctggaggtccccagagagtccagcctg
attctgcacttccgcatgaggttttatttccggaactggcatggcatgaatcctcaggag
ccaactgtgtaccgctgtgggccccctggggccgaggctccctcaggtcaagcagagcat
gggctgcaattcctagacccagcctcctttgagtacatctttgagcagggcaagcatgag
tttgtgaatgacgtggcctcactgtgggagctgtcgagtgaggaggagatccaccacttt
aagaacgagagcctgggcatggcttttctgcatctctgccacctcgctctccaccgtggt
gtccccctggaggaggtggccaagaagatcagcttcaaggactgcatcccgcgctccttc
cggagccagatccggcagcacaatgcactgacgcggctgcgcctgcgcagcatcttctac
aagttcctgcgagccttccagcccagccacctctcccagcagctcgtcatggtcaaatac
ctggccacgctcgagcggctggcgccccgctttgccactgagcacatgcccgtgtgccat
ctggagctactggcccaggctgagggggagcccagctacatccaggaccgcgggcaggct
cctctggacccaggaccggagtctgtccctggaccgcccacccacgaggtgctggtgaca
ggcaccaggggcatccagtggcggccagtacaggcagagggttctggtggcagtggtggt
ggcagcaggaatcctccagctagcccttctgggaagaaagcccaggctcaagaggcggac
gtccagccagcgggcaggccgaaggggctgccatgggcctctttctgcaacttccaggac
atcagccacctggtggtgaaagaacaccgcgtcagcatccaccgtcaggacaacaagtgc
ctggagctgactctgccctcccgggctgcagccctgtccttggtgtcactggtggatggc
tatttccgcctgacagtcgactcgagccactacctgtgccacgaggtggctcccccacgg
ctggtgatgagtatccaggatggtatccatggacccctgctggatccatttgtgctggcc
aagctccagcccgaggacggtcactacctcatccactggagcaccagccacctctaccgc
ctgatcctcacggtggcccagcgtgaccaggcacccggctcacagagcttgcgcttacgg
aagttcaccatcaagcagcaggctgggacctttacactggagggctggggccggtccttt
cccagcgtgggggcactgcgggccgccctgcaggactgctcactgcgcgtcggggaagac
tgcttccctctgcgtcgctgctgcctgccactgccaagagagctctccaacctcatcatc
atgcgggggcctcgggccagccccaggccactcaacctcagccagctcagcttccaccgg
gtctgccgggatgagatcacccagctgtcccacttgggccagggcacaaggaccaatgta
tatgagggcctccttcgtgtggagggtgagggccccgaagaggacaaggaggacagcggg
gaccctccagtgcccagcaggggacgtgggcaggagctccgagtggtgctcaaggtgctg
gaccccagtcaccacgacattgccctggccttctatgaggttgccagcctcatgagccag
gtctcccatgtgcacctggccttcgtgcacggcgtctgtgtgcatggctccgagaacatc
ctggtgacggaatatgtggagcacgggcccctagacgtgtggctgcggcgggagaagggc
catgtgcctgtggcctggaaggtggcagtggcccagcagctggccagcgccctcagctac
ctggaggacaagaacctggttcatggcaacgtgtgtggccggaacatcctgctggcccgg
ccaggcctggcagagggcactagccccttcatcaagctgagtgaccccggcgtgggcctg
ggcaccctctccagggaggagcgggtggagcggatcccctggatggcccctgagtgccta
cccggtggggccaacagcctgagcacggcagctgacaagtggggcttcggtgccaccctc
ctggagatctgctttgatggtgaggcccctctgcagggccgcggcccctccgagaaggag
cgtttctaccagaagcagcatcagctgcccgagccctcgtacccagagctggccaccctc
accagccagtgcttgacctatgagccggcccagcggccgtccttccgcaccatcctgcgt
gacctcactcggctgcagccccacaatcttgttgatgtctcagctgtgagcccggactcc
ccggcgtcagaccccacggttttccacaagcgctatttgaaaaagattcgggatctgggc
gagggtcacttcggcaaggtcagcttgtactgctacgacccgactaacgactgcactggc
gagatggtggccgtgaagtccctcaaggcaggctgcagcccccagctccattcgggttgg
aggcgcgagatcgacatcctgcgcacgctctaccacgagcacatcatcaagtacaagggc
tgctgcgaggacgcaggcgagaagtcggtgcagctggtcatggagtacgtgcccctgggc
agcctccgagactacctgccccggcacagtgtggggctggctcagctgctgctcttcgcc
cagcagatctgcgagggcatggcttacctgcacgcgcagcactatatccaccgagacttg
gctgcccgcaacgtgctcctggacaatgacaggctggtcaagatcggggactttggcctg
gccaaggccgtgcctgaaggccacgagtactaccgcgtgtgcgaggacggggacagcccc
gtgttctggtacgccccagagtgcctgaaggagtgcaagttctactatgcgtctgacgtc
tggtctttcggggtcaccctgtatgagctgctgacccgctgcgactccagccagagcccc
cccacgaaattcatcgagctcataggtctcacccagggacagatgacggtgctgaggctc
actgagttgctggaacaaggggagaggctgccacggcccgaggcatgtccctgtgagatc
tatcacctcatgaagaactgctgggaggcagaggcctccttccgcccgaccttccagaac
ctcatccccatcctcaagacagtccatgagaaataccaaggccaagccccctcggtgttc
agcgtgtgctga

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