KEGG   Trichechus manatus latirostris (Florida manatee): 101359658
Entry
101359658         CDS       T05135                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu00562  Inositol phosphate metabolism
tmu01100  Metabolic pathways
tmu01521  EGFR tyrosine kinase inhibitor resistance
tmu01522  Endocrine resistance
tmu01524  Platinum drug resistance
tmu04012  ErbB signaling pathway
tmu04014  Ras signaling pathway
tmu04015  Rap1 signaling pathway
tmu04024  cAMP signaling pathway
tmu04062  Chemokine signaling pathway
tmu04066  HIF-1 signaling pathway
tmu04068  FoxO signaling pathway
tmu04070  Phosphatidylinositol signaling system
tmu04071  Sphingolipid signaling pathway
tmu04072  Phospholipase D signaling pathway
tmu04081  Hormone signaling
tmu04140  Autophagy - animal
tmu04150  mTOR signaling pathway
tmu04151  PI3K-Akt signaling pathway
tmu04152  AMPK signaling pathway
tmu04210  Apoptosis
tmu04211  Longevity regulating pathway
tmu04213  Longevity regulating pathway - multiple species
tmu04218  Cellular senescence
tmu04360  Axon guidance
tmu04370  VEGF signaling pathway
tmu04380  Osteoclast differentiation
tmu04510  Focal adhesion
tmu04517  IgSF CAM signaling
tmu04518  Integrin signaling
tmu04550  Signaling pathways regulating pluripotency of stem cells
tmu04611  Platelet activation
tmu04613  Neutrophil extracellular trap formation
tmu04620  Toll-like receptor signaling pathway
tmu04625  C-type lectin receptor signaling pathway
tmu04630  JAK-STAT signaling pathway
tmu04650  Natural killer cell mediated cytotoxicity
tmu04660  T cell receptor signaling pathway
tmu04662  B cell receptor signaling pathway
tmu04664  Fc epsilon RI signaling pathway
tmu04666  Fc gamma R-mediated phagosome formation
tmu04668  TNF signaling pathway
tmu04670  Leukocyte transendothelial migration
tmu04722  Neurotrophin signaling pathway
tmu04725  Cholinergic synapse
tmu04750  Inflammatory mediator regulation of TRP channels
tmu04810  Regulation of actin cytoskeleton
tmu04910  Insulin signaling pathway
tmu04914  Progesterone-mediated oocyte maturation
tmu04915  Estrogen signaling pathway
tmu04917  Prolactin signaling pathway
tmu04919  Thyroid hormone signaling pathway
tmu04923  Regulation of lipolysis in adipocytes
tmu04926  Relaxin signaling pathway
tmu04929  GnRH secretion
tmu04930  Type II diabetes mellitus
tmu04931  Insulin resistance
tmu04932  Non-alcoholic fatty liver disease
tmu04933  AGE-RAGE signaling pathway in diabetic complications
tmu04935  Growth hormone synthesis, secretion and action
tmu04960  Aldosterone-regulated sodium reabsorption
tmu04973  Carbohydrate digestion and absorption
tmu05010  Alzheimer disease
tmu05017  Spinocerebellar ataxia
tmu05020  Prion disease
tmu05100  Bacterial invasion of epithelial cells
tmu05132  Salmonella infection
tmu05135  Yersinia infection
tmu05142  Chagas disease
tmu05146  Amoebiasis
tmu05160  Hepatitis C
tmu05161  Hepatitis B
tmu05162  Measles
tmu05163  Human cytomegalovirus infection
tmu05164  Influenza A
tmu05165  Human papillomavirus infection
tmu05166  Human T-cell leukemia virus 1 infection
tmu05167  Kaposi sarcoma-associated herpesvirus infection
tmu05168  Herpes simplex virus 1 infection
tmu05169  Epstein-Barr virus infection
tmu05170  Human immunodeficiency virus 1 infection
tmu05171  Coronavirus disease - COVID-19
tmu05200  Pathways in cancer
tmu05203  Viral carcinogenesis
tmu05205  Proteoglycans in cancer
tmu05206  MicroRNAs in cancer
tmu05207  Chemical carcinogenesis - receptor activation
tmu05208  Chemical carcinogenesis - reactive oxygen species
tmu05210  Colorectal cancer
tmu05211  Renal cell carcinoma
tmu05212  Pancreatic cancer
tmu05213  Endometrial cancer
tmu05214  Glioma
tmu05215  Prostate cancer
tmu05218  Melanoma
tmu05220  Chronic myeloid leukemia
tmu05221  Acute myeloid leukemia
tmu05222  Small cell lung cancer
tmu05223  Non-small cell lung cancer
tmu05224  Breast cancer
tmu05225  Hepatocellular carcinoma
tmu05226  Gastric cancer
tmu05230  Central carbon metabolism in cancer
tmu05231  Choline metabolism in cancer
tmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tmu05415  Diabetic cardiomyopathy
tmu05417  Lipid and atherosclerosis
tmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101359658
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101359658
   04014 Ras signaling pathway
    101359658
   04015 Rap1 signaling pathway
    101359658
   04370 VEGF signaling pathway
    101359658
   04630 JAK-STAT signaling pathway
    101359658
   04668 TNF signaling pathway
    101359658
   04066 HIF-1 signaling pathway
    101359658
   04068 FoxO signaling pathway
    101359658
   04070 Phosphatidylinositol signaling system
    101359658
   04072 Phospholipase D signaling pathway
    101359658
   04071 Sphingolipid signaling pathway
    101359658
   04024 cAMP signaling pathway
    101359658
   04151 PI3K-Akt signaling pathway
    101359658
   04152 AMPK signaling pathway
    101359658
   04150 mTOR signaling pathway
    101359658
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101359658
   04517 IgSF CAM signaling
    101359658
   04518 Integrin signaling
    101359658
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101359658
  09143 Cell growth and death
   04210 Apoptosis
    101359658
   04218 Cellular senescence
    101359658
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101359658
   04550 Signaling pathways regulating pluripotency of stem cells
    101359658
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101359658
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101359658
   04613 Neutrophil extracellular trap formation
    101359658
   04620 Toll-like receptor signaling pathway
    101359658
   04625 C-type lectin receptor signaling pathway
    101359658
   04650 Natural killer cell mediated cytotoxicity
    101359658
   04660 T cell receptor signaling pathway
    101359658
   04662 B cell receptor signaling pathway
    101359658
   04664 Fc epsilon RI signaling pathway
    101359658
   04666 Fc gamma R-mediated phagosome formation
    101359658
   04670 Leukocyte transendothelial migration
    101359658
   04062 Chemokine signaling pathway
    101359658
  09152 Endocrine system
   04910 Insulin signaling pathway
    101359658
   04923 Regulation of lipolysis in adipocytes
    101359658
   04929 GnRH secretion
    101359658
   04915 Estrogen signaling pathway
    101359658
   04914 Progesterone-mediated oocyte maturation
    101359658
   04917 Prolactin signaling pathway
    101359658
   04926 Relaxin signaling pathway
    101359658
   04935 Growth hormone synthesis, secretion and action
    101359658
   04919 Thyroid hormone signaling pathway
    101359658
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101359658
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101359658
  09156 Nervous system
   04725 Cholinergic synapse
    101359658
   04722 Neurotrophin signaling pathway
    101359658
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101359658
  09158 Development and regeneration
   04360 Axon guidance
    101359658
   04380 Osteoclast differentiation
    101359658
  09149 Aging
   04211 Longevity regulating pathway
    101359658
   04213 Longevity regulating pathway - multiple species
    101359658
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101359658
   05206 MicroRNAs in cancer
    101359658
   05205 Proteoglycans in cancer
    101359658
   05207 Chemical carcinogenesis - receptor activation
    101359658
   05208 Chemical carcinogenesis - reactive oxygen species
    101359658
   05203 Viral carcinogenesis
    101359658
   05230 Central carbon metabolism in cancer
    101359658
   05231 Choline metabolism in cancer
    101359658
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101359658
  09162 Cancer: specific types
   05210 Colorectal cancer
    101359658
   05212 Pancreatic cancer
    101359658
   05225 Hepatocellular carcinoma
    101359658
   05226 Gastric cancer
    101359658
   05214 Glioma
    101359658
   05221 Acute myeloid leukemia
    101359658
   05220 Chronic myeloid leukemia
    101359658
   05218 Melanoma
    101359658
   05211 Renal cell carcinoma
    101359658
   05215 Prostate cancer
    101359658
   05213 Endometrial cancer
    101359658
   05224 Breast cancer
    101359658
   05222 Small cell lung cancer
    101359658
   05223 Non-small cell lung cancer
    101359658
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101359658
   05170 Human immunodeficiency virus 1 infection
    101359658
   05161 Hepatitis B
    101359658
   05160 Hepatitis C
    101359658
   05171 Coronavirus disease - COVID-19
    101359658
   05164 Influenza A
    101359658
   05162 Measles
    101359658
   05168 Herpes simplex virus 1 infection
    101359658
   05163 Human cytomegalovirus infection
    101359658
   05167 Kaposi sarcoma-associated herpesvirus infection
    101359658
   05169 Epstein-Barr virus infection
    101359658
   05165 Human papillomavirus infection
    101359658
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101359658
   05135 Yersinia infection
    101359658
   05100 Bacterial invasion of epithelial cells
    101359658
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101359658
   05142 Chagas disease
    101359658
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101359658
   05017 Spinocerebellar ataxia
    101359658
   05020 Prion disease
    101359658
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101359658
   05418 Fluid shear stress and atherosclerosis
    101359658
   05415 Diabetic cardiomyopathy
    101359658
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101359658
   04932 Non-alcoholic fatty liver disease
    101359658
   04931 Insulin resistance
    101359658
   04933 AGE-RAGE signaling pathway in diabetic complications
    101359658
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101359658
   01524 Platinum drug resistance
    101359658
   01522 Endocrine resistance
    101359658
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tmu04131]
    101359658
Enzymes [BR:tmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101359658
Membrane trafficking [BR:tmu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101359658
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 101359658
NCBI-ProteinID: XP_004385197
UniProt: A0A2Y9E158
LinkDB
Position
Unknown
AA seq 1044 aa
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLV
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWEAWLQYSFPLQLEPAARGWGT
GTLRVPNRVLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEDYA
LQVNGKYEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPTPQVQKLR
TKPPPIPVKKPSSASLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNEMLCKMVSS
SEVSVCSGPVWNQRLEFDINICDLPRMARLCLALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGEQCLYMWPFVPDEKGELLNPTGTVRSNPNTESAAALVICLPEVAP
HPVYYPALEKILELGRHGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
YFPEALARLLLVTKWNKHEDVAQMLCLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHVCMR
QETYLEALSHLQSPLDPSTLLADVCVEQCTFMDSKMKPLWIMYSNEEAGSEGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNNEKFERFRGYC
EKAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccccggggttgactgccctatggaattctggaccaaggaggagaaccagagcgtg
gcggttgacttcttgctgcccacgggtgtctatctgaacttccctgtgtcccgcaatgcc
aacctcagtaccatcaagcaggtgttgtggcaccgcgcccagtatgagcccttcttccac
atgctcagcgaccccgaggcctatgtgttcacctgcgtcaaccagacagcggaacagcag
gagctggaggacgagcagcgtcgactctgtgacatccaacccttcctgccagtcctgcgc
ctggtggcccgtgagggcgaccgtgtgaagaagctcatcaattcacagatcagccttgtc
atcggcaaaggcctccatgagttcgactccttgcgagacccggaggtgaacgacttccgc
accaagatgcgccagttctgcgaggaggcagccgcgcaccggcagcagctgggctgggag
gcctggctgcagtacagcttccctctgcagctggagcctgcggcgcggggctggggcact
ggcaccctgcgcgtccccaaccgggtcctcctagtcaatgtcaagttcgagggcagtgag
gagagcttcaccttccaggtatccaccaaggacatgcccctggcgctgatggcctgtgcc
ctccggaagaaggctaccgtgttccggcagccgctggtggagcggccggaggactatgcg
ctgcaggtgaatgggaagtacgagtacctctacggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgacccctcacctgaccatggtgcactcctcc
tccatcttggccatgcgggatgagcagagcaaccccacgccccaggtccagaagctgcgc
accaagccgccccccattcctgtgaagaagccctcctctgcatccctgtggtccctggag
cagccgttttgcatcgagctgatccagggcagcaaagtgaatgccgatgagcgtatgaag
ctggtggtgcaggctgggctcttccacggcaacgagatgctgtgcaaaatggtgtccagc
tcagaggtgagcgtgtgctcagggcccgtgtggaaccagcggctggagttcgacatcaac
atctgtgacctgccccgaatggcccggctctgcctcgcgctttacgctgtgattgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgtttgactataaggaccagctcaagaccggggagcagtgcctctac
atgtggccctttgtcccagacgagaaaggggagctgctgaaccccacagggactgtgcgg
agtaatcctaacacagagagtgccgctgccctggtcatctgcctccccgaggtggcccct
catcccgtgtactaccctgccctggagaagatcctggagctggggcggcacggggagcac
gggcgcttcaccgaggaggagcagctgcagttgcgggaaatcctggagcggcgcggctcg
ggggagctgtacgagcacgagaaggacctggtgtggaagatgcgccatgaggtccaggag
tacttccctgaggctctggcccggctgctgctggtcactaagtggaacaagcacgaggac
gtggcccagatgctctgcctgctgtgttcatggcccgagctgcccgtcctgagtgccctg
gagctgctggacttcagtttcccggaccgccacgtgggctcctttgccatcaagtccctg
cgcaagctgacggacgatgagcttttccagtacctgctgcagctggtgcaggtactcaag
tatgagtcctacctggactgtgagctgaccaagtttctgctggaccgggcactggccaac
cgcaagatcggtcacttcctcttctggcacctccgctccgagatgcatgttccatcggtg
gccctgcgcttcggcctcatcatggaggcctactgcaggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagcactgagcaagctgaaggccctgaatgattttgtcaaa
gtgagctcccagaagaccaccaagccgcaaaccaaggagatgatgcatgtgtgcatgcgt
caggagacctacctggaggctctctcccacctgcagtccccactcgaccccagcacgctg
ctggctgacgtctgtgtggagcagtgcaccttcatggactccaagatgaagcccctatgg
atcatgtacagcaatgaggaggcgggcagtgagggcagcgtgggcatcatcttcaagaat
ggggatgatctccgccaggacatgctgactctgcaaatgatccagctcatggacgttctg
tggaagcaggaggggctggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacaggcctcatcgaagtagtgctccactcagacaccatcgccaacatccagctaaac
aagagcaacatggcagccacagctgcctttaacaaggatgccctgctcaactggctcaag
tccaagaacccaggggaggccctggaccgagccatcgaggagttcaccctttcctgtgct
ggctactgtgtggccacctatgtgctgggcatcggcgatcggcacagtgacaacatcatg
atccgtgaaagtgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgtgaacgagtcccattcatcctcacctatgactttgtccat
gtgattcagcaggggaagacgaacaacaatgagaagtttgaaaggttccgaggctactgt
gagaaagcctacaccatcctgcggcgccacgggctgctctttctccacctctttgctctc
atgagggcagcaggcctgcctgaactcagctgctcaaaagacatccagtatctcaaggac
tccctggcattggggaaaacggaggaggaagcactcaagcacttccgggtcaagtttaat
gaagccctgcgggagagctggaaaaccaaagtgaactggttggcccacaatgtgtctaaa
gacaacaggcagtag

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