Talpa occidentalis (Iberian mole): 119231615
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Entry
119231615 CDS
T07495
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod04140
Autophagy - animal
tod04141
Protein processing in endoplasmic reticulum
tod04210
Apoptosis
tod04932
Non-alcoholic fatty liver disease
tod05010
Alzheimer disease
tod05012
Parkinson disease
tod05014
Amyotrophic lateral sclerosis
tod05016
Huntington disease
tod05017
Spinocerebellar ataxia
tod05022
Pathways of neurodegeneration - multiple diseases
tod05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
119231615 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
119231615 (ERN1)
09143 Cell growth and death
04210 Apoptosis
119231615 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
119231615 (ERN1)
05012 Parkinson disease
119231615 (ERN1)
05014 Amyotrophic lateral sclerosis
119231615 (ERN1)
05016 Huntington disease
119231615 (ERN1)
05017 Spinocerebellar ataxia
119231615 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
119231615 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
119231615 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
119231615 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tod01001
]
119231615 (ERN1)
Enzymes [BR:
tod01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
119231615 (ERN1)
Protein kinases [BR:
tod01001
]
Serine/threonine kinases: Other
IRE family
119231615 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
119231615
NCBI-ProteinID:
XP_054544887
LinkDB
All DBs
Position
Unknown
AA seq
973 aa
AA seq
DB search
MPARLLLLLLALLPPGPGAFASPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDMDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVIDLVGQTSENTPTTVSQ
DVEEKFSHAPAKPEAPVDSMLKDIATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQLPFHPPGDLAQDAELLDSSGLYSESSATSSPSTSPRASNHSLHSSSS
ASRVGASLEQDDEDEETSMVLVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPE
CFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLE
PITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHS
FSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQAN
ILLGAYGLDCLHPEKHEDVIARELIERMIATDPQKRPSAKHVLKHPFFWSLEKQLQFFQD
VSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAM
RNKKHHYRELPVEVRETLGSLPDDFVRYFTSRFPHLLAHTYRAMELCAHERLFQPYYCHE
PPEPQPPMAPDAL
NT seq
2922 nt
NT seq
+upstream
nt +downstream
nt
atgccggcccggctgctgctgctgctgctggcgctgctgccgcccgggcccggggcgttt
gcaagtcccagcaccgtgacacttccggaaaccttgttgttcgtgtcaaccctggatggc
agtttgcatgctgtgagcaagaggacaggctccatcaaatggactttaaaagaagatcca
gtcctgcaggtcccaacacacgttgaagagcccgccttcctccctgatcccaacgatggc
agcctttacacactcggaggcaagaataacgaaggcctgacgaaacttcccttcaccatc
ccggagctggtacaggcatctccgtgccggagttcagatggaattctctacatgggtaaa
aaacaggacatctggtatgtcatcgacctgctgacgggggagaagcagcagactctgtcg
tcggcctttgcagacagtctctgcccgtccacctctcttctgtatcttgggcgaacagag
tacaccatcaccatgtatgacaccaaaacccgagagctccgctggaacgccacctacttc
gactacgctgcctcgctgccggaggatgacatggactacaagatgtcccactttgtgtcc
aatggcgatgggctggtggtgacggtggacagtgaatctggggacgtcctgtggatccag
aactatgcctcccccgtggtggccttttacgtctggcagcgggagggtctgcggaaggtg
atgcacatcaacgtggctgtggagaccctgcgctacctgaccttcatgtccggggaggtg
gggcgcatcaccaaatggaagtaccccttccccaaggagacggaggccaagagcaagctg
acgcccaccctgtatgttgggaagtactccaccagtctctacgcctccccctccatggtt
cacgagggggtcgccgttgtgccccgaggcagcacccttcctttgctggaaggcccccag
accgacggtgtcaccattggggacaaaggcgagtgtgtgatcacgcccagcacggaccta
aagtttgaccctggtctcaaagggaagaacaaactcaactacttgaggaactactggctt
ctgataggtcaccatgagaccccgctgtctgcatccaccaagatgctggagagattcccc
aacaacctgcccaagcatcgggaaaacgtgattccagccgactcggagaaaaagagcttt
gaggaggtcatcgacctggttggccagacctcagagaacacacccaccaccgtttctcaa
gatgtggaggagaaattctctcatgcccccgccaagcccgaggcccccgtggactccatg
ctcaaggacatcgccaccatcatcctgagcaccttcctgctcatcggctgggtggccttc
atcatcacctaccccctgagcatgcatcagcagcagcagctccagcaccagcagttccag
aaggaattggagaaaattcagctcctgcaacagcagcagctgcccttccacccacctgga
gacttggctcaggacgctgagctcctggactcatctggcctctactcagagagctcagcc
accagcagccccagcacgtcacccagagcctccaaccactcgctgcactccagcagctct
gcctccagagtgggcgcctccctggagcaggacgatgaggatgaagaaaccagcatggtg
ctggttgggaaaatttcattctgtcccaaggacgtcctgggccatggagctgagggcaca
attgtgtaccggggcatgtttgataaccgagacgtggccgtcaagaggatcctccccgag
tgtttcagtttcgccgaccgtgaggtccagctgctgcgagagtcggacgagcacccgaac
gtgatccggtacttctgcaccgagaaggaccgacagttccagtacatcgccatcgagctg
tgcgcagccaccctgcaggagtacgtggagcagaaggactttgcccacctgggcttggag
cccatcaccctgctgcagcagaccacctcgggcctggcccacctgcactccctcaacatc
gttcacagagacctgaagcctcacaacatcctcttatccatgcccaatgcacacggtcgc
atcaaggccatgatctccgactttggcctctgcaagaagctggcggtgggcagacacagc
ttcagccgccgttccggggtgcccggcacagaaggctggattgctcccgagatgctgagc
gaagactgcaaggaaaaccctacctacactgtggacatcttctccgcgggctgcgtcttt
tactacgtgatatccgagggcaaccaccctttcggcaagtccctgcagcggcaagccaac
atcctcctgggcgcttacggtctcgactgcttgcaccctgagaagcacgaagacgtcatc
gcccgggagctgatcgagaggatgatcgccacggaccctcagaagcgcccctccgcgaag
cacgtgctgaaacaccccttcttctggagcctggaaaagcagctgcagttcttccaggac
gtgagtgaccgaatagaaaaggagtccctagacggcccgatagtgaagcagctggagcga
ggcgggcgagccgtggtgaagatggactggagggagaacatcactgtccccctgcagaca
gatcttcgtaaatttagaacctataaaggcggctccgtcagagacctcctccgagccatg
agaaataagaagcaccactaccgagagctccccgtggaggtgcgggagacactgggctcc
ctcccggacgacttcgtgcgctacttcacctcgcgcttcccgcacctcctcgcccacacc
taccgggccatggagctgtgcgcccacgagagactcttccagccctactactgccacgag
ccgccggagccacagcccccaatggctccagatgccctctga
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