KEGG   Talpa occidentalis (Iberian mole): 119232527
Entry
119232527         CDS       T07495                                 
Symbol
RPS6KB1
Name
(RefSeq) ribosomal protein S6 kinase beta-1 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod04012  ErbB signaling pathway
tod04066  HIF-1 signaling pathway
tod04140  Autophagy - animal
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04152  AMPK signaling pathway
tod04211  Longevity regulating pathway
tod04213  Longevity regulating pathway - multiple species
tod04350  TGF-beta signaling pathway
tod04371  Apelin signaling pathway
tod04666  Fc gamma R-mediated phagocytosis
tod04714  Thermogenesis
tod04910  Insulin signaling pathway
tod04931  Insulin resistance
tod05163  Human cytomegalovirus infection
tod05165  Human papillomavirus infection
tod05170  Human immunodeficiency virus 1 infection
tod05200  Pathways in cancer
tod05205  Proteoglycans in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05210  Colorectal cancer
tod05212  Pancreatic cancer
tod05221  Acute myeloid leukemia
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    119232527 (RPS6KB1)
   04350 TGF-beta signaling pathway
    119232527 (RPS6KB1)
   04371 Apelin signaling pathway
    119232527 (RPS6KB1)
   04066 HIF-1 signaling pathway
    119232527 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    119232527 (RPS6KB1)
   04152 AMPK signaling pathway
    119232527 (RPS6KB1)
   04150 mTOR signaling pathway
    119232527 (RPS6KB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119232527 (RPS6KB1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    119232527 (RPS6KB1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119232527 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    119232527 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    119232527 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    119232527 (RPS6KB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119232527 (RPS6KB1)
   05205 Proteoglycans in cancer
    119232527 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    119232527 (RPS6KB1)
   05231 Choline metabolism in cancer
    119232527 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119232527 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119232527 (RPS6KB1)
   05212 Pancreatic cancer
    119232527 (RPS6KB1)
   05225 Hepatocellular carcinoma
    119232527 (RPS6KB1)
   05226 Gastric cancer
    119232527 (RPS6KB1)
   05221 Acute myeloid leukemia
    119232527 (RPS6KB1)
   05224 Breast cancer
    119232527 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    119232527 (RPS6KB1)
   05163 Human cytomegalovirus infection
    119232527 (RPS6KB1)
   05165 Human papillomavirus infection
    119232527 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    119232527 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119232527 (RPS6KB1)
   01522 Endocrine resistance
    119232527 (RPS6KB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119232527 (RPS6KB1)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     119232527 (RPS6KB1)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   119232527 (RPS6KB1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015
Other DBs
NCBI-GeneID: 119232527
NCBI-ProteinID: XP_037350463
LinkDB
Position
Unknown
AA seq 557 aa
MRRRRRRDGFYPAPDFRDGEAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSAGVWEVHPQGIANLVSGLIRMLTLTTSEPQSFL
TAYLISCLLALMSTMNTSVLCLLSSSWWVQWSEGTDDDTVAKLVSPGSTLTGIFELLWSC
GVFCLWKFQRVRNSEMA
NT seq 1674 nt   +upstreamnt  +downstreamnt
atgaggcgacgacggaggcgggacggcttttacccggcgccggacttccgagacggggaa
gctgaggacatggcgggagtgtttgacatagacctggaccagccagaggacgcgggctct
gaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaac
agagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactgggaaaatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca
aaagcagaacggaatattctcgaggaagtaaagcatcccttcattgtggatttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagtggaggagaacta
tttatgcagttagaaagagagggaatatttatggaagacacagcctgcttttacttggca
gaaatctccatggctttggggcatttacatcaaaaagggatcatctacagagacctgaag
ccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagattttggactatgc
aaagaatctattcatgacggaacagtcacacacacattttgtggaacaatagaatacatg
gcccctgaaattttgatgagaagtgggcataatcgagctgtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcacccccattcacaggggagaatagaaagaaa
acgattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttcccgtcttggagctggtcct
ggggatgctggagaagttcaagctcatccatttttcagacatattaactgggaagaactg
ctggctcgaaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtgagt
cagtttgattccaagtttacacgtcagacacctgttgacagcccagatgactcaactctc
agtgaaagtgccaaccaggtctttctgggttttacatatgtggctccatctgtacttgaa
agtgtgaaagaaaaattttcctttgaaccaaaaattcgatcccctagaagatttattggc
agcccacgaacacctgtcagtgcaggtgtctgggaagtccaccctcaaggcatagcaaat
ttggtgtctggtctgatcaggatgttgaccttgactacatcagagccacagagcttcctc
accgcctatttaatctcgtgcttgttggccttgatgtccaccatgaatacaagtgtgctg
tgtcttctgtcttcttcatggtgggttcagtggtcagagggaactgatgatgacacagtg
gctaagcttgtttctcctgggagcacccttactggaatatttgagttgctatggagctgc
ggtgttttttgcctctggaagtttcagagggtcaggaattctgaaatggcttag

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