KEGG   Talpa occidentalis (Iberian mole): 119234816
Entry
119234816         CDS       T07495                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01522  Endocrine resistance
tod04010  MAPK signaling pathway
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04024  cAMP signaling pathway
tod04068  FoxO signaling pathway
tod04071  Sphingolipid signaling pathway
tod04137  Mitophagy - animal
tod04140  Autophagy - animal
tod04141  Protein processing in endoplasmic reticulum
tod04210  Apoptosis
tod04215  Apoptosis - multiple species
tod04217  Necroptosis
tod04310  Wnt signaling pathway
tod04380  Osteoclast differentiation
tod04510  Focal adhesion
tod04530  Tight junction
tod04620  Toll-like receptor signaling pathway
tod04621  NOD-like receptor signaling pathway
tod04622  RIG-I-like receptor signaling pathway
tod04625  C-type lectin receptor signaling pathway
tod04657  IL-17 signaling pathway
tod04658  Th1 and Th2 cell differentiation
tod04659  Th17 cell differentiation
tod04660  T cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04668  TNF signaling pathway
tod04722  Neurotrophin signaling pathway
tod04723  Retrograde endocannabinoid signaling
tod04728  Dopaminergic synapse
tod04750  Inflammatory mediator regulation of TRP channels
tod04910  Insulin signaling pathway
tod04912  GnRH signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04917  Prolactin signaling pathway
tod04920  Adipocytokine signaling pathway
tod04926  Relaxin signaling pathway
tod04930  Type II diabetes mellitus
tod04931  Insulin resistance
tod04932  Non-alcoholic fatty liver disease
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04935  Growth hormone synthesis, secretion and action
tod04936  Alcoholic liver disease
tod05010  Alzheimer disease
tod05012  Parkinson disease
tod05016  Huntington disease
tod05017  Spinocerebellar ataxia
tod05020  Prion disease
tod05022  Pathways of neurodegeneration - multiple diseases
tod05132  Salmonella infection
tod05133  Pertussis
tod05135  Yersinia infection
tod05142  Chagas disease
tod05145  Toxoplasmosis
tod05152  Tuberculosis
tod05161  Hepatitis B
tod05162  Measles
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05169  Epstein-Barr virus infection
tod05170  Human immunodeficiency virus 1 infection
tod05171  Coronavirus disease - COVID-19
tod05200  Pathways in cancer
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05212  Pancreatic cancer
tod05231  Choline metabolism in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
tod05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tod00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    119234816 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119234816 (MAPK8)
   04012 ErbB signaling pathway
    119234816 (MAPK8)
   04014 Ras signaling pathway
    119234816 (MAPK8)
   04310 Wnt signaling pathway
    119234816 (MAPK8)
   04668 TNF signaling pathway
    119234816 (MAPK8)
   04068 FoxO signaling pathway
    119234816 (MAPK8)
   04071 Sphingolipid signaling pathway
    119234816 (MAPK8)
   04024 cAMP signaling pathway
    119234816 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119234816 (MAPK8)
   04137 Mitophagy - animal
    119234816 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    119234816 (MAPK8)
   04215 Apoptosis - multiple species
    119234816 (MAPK8)
   04217 Necroptosis
    119234816 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119234816 (MAPK8)
   04530 Tight junction
    119234816 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    119234816 (MAPK8)
   04621 NOD-like receptor signaling pathway
    119234816 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    119234816 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    119234816 (MAPK8)
   04660 T cell receptor signaling pathway
    119234816 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    119234816 (MAPK8)
   04659 Th17 cell differentiation
    119234816 (MAPK8)
   04657 IL-17 signaling pathway
    119234816 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    119234816 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119234816 (MAPK8)
   04920 Adipocytokine signaling pathway
    119234816 (MAPK8)
   04912 GnRH signaling pathway
    119234816 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    119234816 (MAPK8)
   04917 Prolactin signaling pathway
    119234816 (MAPK8)
   04926 Relaxin signaling pathway
    119234816 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    119234816 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    119234816 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    119234816 (MAPK8)
   04722 Neurotrophin signaling pathway
    119234816 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119234816 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119234816 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119234816 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    119234816 (MAPK8)
   05231 Choline metabolism in cancer
    119234816 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119234816 (MAPK8)
   05212 Pancreatic cancer
    119234816 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119234816 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    119234816 (MAPK8)
   05161 Hepatitis B
    119234816 (MAPK8)
   05171 Coronavirus disease - COVID-19
    119234816 (MAPK8)
   05162 Measles
    119234816 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119234816 (MAPK8)
   05169 Epstein-Barr virus infection
    119234816 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119234816 (MAPK8)
   05135 Yersinia infection
    119234816 (MAPK8)
   05133 Pertussis
    119234816 (MAPK8)
   05152 Tuberculosis
    119234816 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119234816 (MAPK8)
   05142 Chagas disease
    119234816 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119234816 (MAPK8)
   05012 Parkinson disease
    119234816 (MAPK8)
   05016 Huntington disease
    119234816 (MAPK8)
   05017 Spinocerebellar ataxia
    119234816 (MAPK8)
   05020 Prion disease
    119234816 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    119234816 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119234816 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    119234816 (MAPK8)
   05415 Diabetic cardiomyopathy
    119234816 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119234816 (MAPK8)
   04936 Alcoholic liver disease
    119234816 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    119234816 (MAPK8)
   04931 Insulin resistance
    119234816 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119234816 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    119234816 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119234816 (MAPK8)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     119234816 (MAPK8)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   119234816 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 119234816
NCBI-ProteinID: XP_037353748
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVISGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagtagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattc
acagtcctgaaacgatatcaaaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagtcggcca
tttcagaatcagactcatgctaagcgggcttacagagaactagttcttatgaaatgtgtt
aatcacaaaaatattattggcctgttgaatgttttcacgccacagaaatccctagaagaa
tttcaggatgtttacattgtcatggagctcatggatgcaaatctttgccaagtgattcaa
atggaactagatcatgaaagaatgtcataccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttatgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgaaaagcttttccccgatgtacttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaagaatctctgtagatgaagctcttcagcacccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaaaatacctgataaa
cagttagatgaaagggaacacacaatagaagaatggaaagaattaatatacaaggaagtt
atggacttggaggagcgaaccaagaatggagttatacgggggcaaccttctcctttaggt
gcagcagtgatcagtggctctcagcatccttcgtcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcttcggatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

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