Talpa occidentalis (Iberian mole): 119235485 Help Entry 119235485         CDS       T07495                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism tod  Talpa occidentalis (Iberian mole) Pathway tod01521   EGFR tyrosine kinase inhibitor resistance tod04151   PI3K-Akt signaling pathway tod04217   Necroptosis tod04380   Osteoclast differentiation tod04550   Signaling pathways regulating pluripotency of stem cells tod04620   Toll-like receptor signaling pathway tod04621   NOD-like receptor signaling pathway tod04630   JAK-STAT signaling pathway tod04658   Th1 and Th2 cell differentiation tod04659   Th17 cell differentiation tod05140   Leishmaniasis tod05145   Toxoplasmosis tod05152   Tuberculosis tod05160   Hepatitis C tod05161   Hepatitis B tod05162   Measles tod05163   Human cytomegalovirus infection tod05164   Influenza A tod05165   Human papillomavirus infection tod05166   Human T-cell leukemia virus 1 infection tod05167   Kaposi sarcoma-associated herpesvirus infection tod05168   Herpes simplex virus 1 infection tod05169   Epstein-Barr virus infection tod05171   Coronavirus disease - COVID-19 tod05200   Pathways in cancer tod05203   Viral carcinogenesis tod05212   Pancreatic cancer tod05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:tod00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     119235485 (JAK1)    04151 PI3K-Akt signaling pathway     119235485 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     119235485 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     119235485 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     119235485 (JAK1)    04621 NOD-like receptor signaling pathway     119235485 (JAK1)    04658 Th1 and Th2 cell differentiation     119235485 (JAK1)    04659 Th17 cell differentiation     119235485 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     119235485 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     119235485 (JAK1)    05203 Viral carcinogenesis     119235485 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     119235485 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     119235485 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     119235485 (JAK1)    05161 Hepatitis B     119235485 (JAK1)    05160 Hepatitis C     119235485 (JAK1)    05171 Coronavirus disease - COVID-19     119235485 (JAK1)    05164 Influenza A     119235485 (JAK1)    05162 Measles     119235485 (JAK1)    05168 Herpes simplex virus 1 infection     119235485 (JAK1)    05163 Human cytomegalovirus infection     119235485 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     119235485 (JAK1)    05169 Epstein-Barr virus infection     119235485 (JAK1)    05165 Human papillomavirus infection     119235485 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     119235485 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     119235485 (JAK1)    05140 Leishmaniasis     119235485 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     119235485 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tod01001]     119235485 (JAK1) Enzymes [BR:tod01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      119235485 (JAK1) Protein kinases [BR:tod01001]  Non-receptor tyrosine kinases   JAK family [OT]    119235485 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 zf-C2H2_6 Motif Other DBs NCBI-GeneID:  119235485 NCBI-ProteinID:  XP_037354773 LinkDB All DBs Position Unknown AA seq 1156 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEPNPEAPEPGVEVLFYLSDREPLRLGSGEYTAEDL CIRAAQKCSISPLCHNLFALYDDNTKLWYAPNRSITVDDKTWLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHANDSGNIVYYEVMVTGNLGIQWRQKPIVVPVEKEKNKLKRKKLESKHKKDEEKNRIR EEWNNFSYFPEITHIVIKESLVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPISTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGCYSLYGSDSSFPSLKDLMGHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGMAEEKRVKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDIFMHRRSDILTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKSKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKDGKRLPCPPNCPDELYQLMRKCWELQPSNRTT FQSLIEGFEALLKQLP NT seq 3471 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaggaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgagccaaatccggaggcccctgagccaggggtggaagtgctcttc tatctctctgatagggagcccctccgactgggcagtggagagtacacagcggaggacctg tgcatcagggccgcacagaaatgcagtatttctcctttgtgtcacaacctctttgctctg tatgatgataacaccaagctctggtacgctccaaatcgctccatcactgttgatgacaaa acgtggctccggcttcactatcggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtcagtatggcgacattctccaaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgctacccctctccttgatgccagctccctggagtatctgtttgct cagggacaatatgacttggtcaaatgcttggctcccattcgagaccctaagactgaacag gatggacatgatattgagaatgagtgtctgggaatggctgtcctggccatctcacactat gccatgatgaagaagatgcagttgccagaacttcccaaggacatcagttacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttcttaccagaatgcggata aataatgttttcaaggatttcctaaaggaatttaacaataagaccatctgtgacagcagt gtgtccacacatgacctgaaggtgaaatacctggctacattggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgttattgatttcatcagaaaatgagatgaat cgctttcatgcaaatgacagtggtaacattgtctactatgaagttatggtgactggaaat cttggaatccaatggaggcagaaaccaattgttgttcctgttgaaaaggaaaaaaataaa ctgaaacggaaaaaactggaaagtaaacataagaaggatgaagaaaaaaacagaatccgg gaagagtggaataatttctcttacttccctgaaatcactcacattgtaataaaggaatct ttggtcagcattaataagcaggacaacaaaaaaatggagctgaaactctcttcccacgag gaggccttgtcctttgtgtccctggtggatggctatttccgactcacagcagatgcccat cattacctctgcaccgatgtggctcccccattgatcgtccacaacatacagaatggctgt catggtccaattagcacagaatatgccatcaataaattacggcaagaaggaagtgaggag gggatgtacgtgttgcggtggagctgcactgactttgacaacatcctcatgaccgtcacc tgctttgaaaagtcagaggtgctgggtggccagaaacagttcaagaactttcagattgag gttcaaaagggctgctatagcctgtacggctcagacagcagcttccccagcctgaaggat ctcatgggccacctcaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgtcagcccaagccccgagaaatctccaatctgctggtggctactaagaaagcc caggagtggcagcctgtctaccccatgagccagttgagtttcgatcggatcctcaagaag gacattgtgcaaggcgaacaccttgggagaggcacacggacacacatctactcgggaacc cttgtggattacaaagatgacgaagggatggctgaagagaagagagtaaaagtgatcctg aaagtcttagaccccagccatagggacatttctctggccttctttgaggcagccagcatg atgagacaagtctcccacaaacacattgtgtacctctatggtgtctgtgtgcgagatgtg gagaatatcatggtagaagagtttgtggaggggggccctctggatatcttcatgcaccgg agaagtgacattctcaccacaccatggaagttcaaagttgctaaacagctagccagtgcc ctgagttacttggaggataaggacctggtccatggaaacgtgtgcactaaaaacctcctc cttgcccgggagggcattgacagcgagtgtggtccattcatcaagctcagcgatcctggc attcccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcct gagtgtgttgaagactctaagaatttgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggcgagatccccctgaaagacaagacactgattgag aaagagagattctatgaaagccgctgcaggccagtgacgccatcttgtaaggaactggct gaccttatgacccgctgcatgaactatgatcccaatcagagacccttctttcgagccatc atgagagacatcaacaagctggaggaacagaatccagacattgtttcagaaaagaagcca gcaactgaagtggatcccacacactttgaaaagcggttcttaaagaggatccgtgatttg ggagagggccacttcgggaaggttgagctctgcaggtatgaccctgagggggacaataca ggggagcaggtggctgtcaagtccctgaagcctgagagcggaggtaaccacatagcggat ctgaagaaggaaatagaaatcttaaggaacctgtatcatgagaacattgtgaagtacaaa ggcatctgtacagaagacggaggaaatggtattaagctcatcatggaatttctgccttct ggaagcctcaaggagtatcttccaaaaaataagagcaaaatcaacctcaaacagcagtta aaatatgcagttcagatttgtaagggaatggactacctggggtctcggcaatacgttcac cgggatttagcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattggagac tttggcttaaccaaagcaattgaaactgataaggagtactacacggtcaaggacgatcgg gacagccctgtgttttggtatgctccagaatgtttaatacagtgtaaattttatattgcc tcagacgtctggtcttttggagtcactctgcatgagctgcttacttactgtgattcagat tccagtcccatggcattgttcctgaaaatgataggcccaactcatggccagatgacagta acaagacttgtgaatacattaaaagatggaaaacgtttgccttgtccaccgaactgtcca gatgagttataccaacttatgagaaaatgctgggaactccaaccgtctaatcggacaact tttcagagccttattgaaggatttgaagcacttttaaaacaactaccatga

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