Talpa occidentalis (Iberian mole): 119244119 Help Entry 119244119         CDS       T07495                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism tod  Talpa occidentalis (Iberian mole) Pathway tod04020   Calcium signaling pathway tod04024   cAMP signaling pathway tod04260   Cardiac muscle contraction tod04261   Adrenergic signaling in cardiomyocytes tod04371   Apelin signaling pathway tod04713   Circadian entrainment tod04911   Insulin secretion tod04921   Oxytocin signaling pathway tod04972   Pancreatic secretion tod05020   Prion disease tod05022   Pathways of neurodegeneration - multiple diseases tod05410   Hypertrophic cardiomyopathy tod05412   Arrhythmogenic right ventricular cardiomyopathy tod05414   Dilated cardiomyopathy tod05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:tod00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     119244119 (RYR2)    04020 Calcium signaling pathway     119244119 (RYR2)    04024 cAMP signaling pathway     119244119 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     119244119 (RYR2)    04921 Oxytocin signaling pathway     119244119 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     119244119 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     119244119 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     119244119 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     119244119 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     119244119 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     119244119 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     119244119 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     119244119 (RYR2)    05414 Dilated cardiomyopathy     119244119 (RYR2)    05415 Diabetic cardiomyopathy     119244119 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tod04040]     119244119 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:tod04990]     119244119 (RYR2) Ion channels [BR:tod04040]  Voltage-gated cation channels   Ryanodine receptor    119244119 (RYR2) Domain-containing proteins not elsewhere classified [BR:tod04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    119244119 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  119244119 NCBI-ProteinID:  XP_054550871 LinkDB All DBs Position Unknown AA seq 4948 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGKFMMKTAQGSGHRTLLYGHAILLRHSYSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LLEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSMCYIQHVN TGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYKKWYYELMVDHTVPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT RDLLGPTVPLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGMSDEHAEEKVKKMKLP KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSSTGERFRI FRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQ GNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTIDSSPCLKITQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAGGLPGAGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEI GCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQF MSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLY AIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPGENKKHG LPGIGLSTSLRPRMQFSSPSFVSINHECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHAR DPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILRLIEPSVFKEAASPEEESEVLEKE LGMDDAKLEGAGEEEIKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVA FSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECP CPEEIRDQLLDFHEDLMAHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKP VESDSQKSSTLQQLISDTMVRWAQESVIEDPELVRAMFMLLHRQYDGIGGLVRALPKTYT INGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKIAEDPSRDGPSPTSGSSKTLDLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMH LIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAA MVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVD TSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKE KEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAID MSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDRE KAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGS RSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLETVKSALRAFLDNAAED LEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQ VSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNVYSIYNTK SSRERTALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVVLPMLCSYMS RWWEHGPENNPERAEMCCTALDSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII NKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQE LIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKT VERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNL FLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEK CKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEM VLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQS CSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLR TKTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNT LTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMV VMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDG KGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDISFNVA VLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKE ESEKEKPEEQGPKMGFFSILTVKSALFALKYNILALMRMLSLKSLKKQMKKVKKMTMKDM VTAFFSSYWSIFMSLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQ DEVRGDGEEGERKPMEAALPSEDLADLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPN AGLSDLISNPVPIPEVQEKFQEQKAKEEEKEEKEENKSEPEKAEGEDGEKEEKPKEDKGK QKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLF YKVSTSSVVEGKELPSRSSSENAKVSTVDSDSQRIIAVHYVLEESSGYMEPTLRILAILH TVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQS FPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLAAVLN SIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYV GVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14847 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggatgaaatccagtttctgcgaactgatgatgaagtg gttctgcagtgcacagcaaccatccacaaagaacaacagaagctatgcttggcagcggaa ggctttggcaacagactttgtttcttggagtccacatcaaattccaagaatgtcccccca gacctctctatttgcacctttgttttggaacagtccctctccgtccgtgccctgcaggag atgctggccaacacaatggagaagtcagaagggaaattcatgatgaagactgctcaaggg agtgggcataggacgctgctctatggtcatgccatattgctacgccactcctacagtggc atgtatctgtgctgcttgtccacttcccgatcttcaactgataaactggcttttgatgtt ggcttgcaagaggacacaacaggtgaagcttgttggtggactattcatcctgcctcaaag cagcgatcagaaggagaaaaggttcgagtcggagatgacctcatcttagtcagtgtgtcc tctgaaaggtatttgcacttgtcctatggcaatggcagcttgcacgtggatgccgctttc cagcaaaccctctggagtgtggctccaatcagctcaggaagtgaagcagcccaagggtat ctgattggtggcgacgtcctcaggttgctgcacggacacatggacgagtgcctcactgtc ccttctggagaacacggcgaagagcaacggagaactgttcactatgaaggtggtgctgtg tctgttcatgcacgttctctgtggagactggagactctaagagttgcgtggagtggaagc cacataagatggggccagcctttccgactacgccatgtcacaacaggaaaatacttgagt ctcttggaagacaaaaaccttttactcatggacaaagagaaagctgatgtaaaatcaaca gcatttgcttttcgatcttccaaggaaaaattggatgtaggggtgagaaaagaagttgat ggcatgggaacatcagaaataaaatatggagactcaatgtgttatatacaacatgtaaat acaggcctgtggctgacttaccagtctgtggatgtgaaatctgtgagaatgggatccata cagcgtaaggctatcatgcatcatgaaggccatatggatgatggcttaaatttatctaga tctcagcatgaagagtcgaggaccgcacgagtcatccgaagcaccgtcttccttttcaat aggtttataaggggtcttgatgctctcagcaaaaaagtgaagagttctacaatagactta ccaatagagtctgtaagtctgagtctgcaggacctgattggctacttccacccaccagat gaacatttagaacatgaagacaagcagaacagattacgagctctaaagaatcgtcagaat ctcttccaggaagagggaatgatcaacctcgtgctggaatgcatagacaggcttcacgtc tacagcagtgctgcacactttgctgatgtggctgggagagaagcaggggagtcttggaaa tccattctgaattctctgtatgaattgctggcggctctaattagaggaaatcgtaaaaac tgtgctcaattttctggctccctcgactggttgattagccgattagaaagattagaagct tcttctggtattcttgaagttttacactgtgtgttagtagaaagtccagaagctctaaat attattaaagaaggacatattaaatccattatctcacttttagataagcatggacgaaat cacaaggtcctggatgttttatgctctctctgtgtttgccatggagtagcagtgcgttct aaccagcatctcatctgtgacaatctcttgcctggaagggacctattattgcagacgcgc cttgtgaatcatgtcagcagcatgagacccaatattttcctgggtgtcagtgaaggttct gctcagtataagaagtggtactatgagttgatggtggaccacacagtgccatttgtgaca gctgaagcaactcatctgcgagtgggctgggcttcaacagaagggtattctccctaccct ggaggaggtgaagagtggggtggcaatggtgttggagatgacctcttttcctatggattt gatggtcttcatctttggtcaggttgtattgctcgtactgtaagttcaccaaaccaacat ctgttgcgaactgatgatgtcatcagttgctgtttagatctcagtgccccaagcatctca ttccgaattaatggacaacccgttcaaggaatgtttgaaaatttcaacatcgatggcctc ttctttccagttgtgagtttctctgcaggaataaaggtacgctttctgcttggggggaga catggagaatttaaattccttcctccacctggatatgctccttgttatgaagctgttctg ccaaaagaaaagttgaaagtggaacatagccgagagtacaagcaagaaagaacttacaca cgggacctgctgggccccacagttccgctgacacaagccgccttcacaccaatcccagtg gatacaagccagattgtgctacctcctcacctcgagaggataagagaaaaactggcagag aatatccatgaactctgggttatgaataaaatagaacttggctggcagtatggtccggtt agagatgacaataagagacaacacccatgcctggtggaattctccaagctgcctgagcag gaacgcaattacaatttacaaatgtcccttgaaactctgaagactttgctagccttagga tgtcatgtgggtatgtcagatgagcatgctgaagaaaaggtgaaaaaaatgaagctaccc aagaattaccagctgacaagtggatataagcctgccccaatggacctgagcttcatcaaa ctcaccccatcccaggaggcaatggtggacaaactggcagaaaatgctcataatgtgtgg gcccgggatcgaatccggcagggctggacttacggcatccagcaggatgtaaagaacaga agaaaccctcgtcttgttccctatgcccttctagatgaccgaaccaagaaatcaaataag gacagcctccgtgaggccgtgcgcacgctgctgggatacggctacaacctggaggcacca gatcaagatcatgctgccagagctgaagtgtgtagcagcacaggggaacggttccgaatc ttccgtgctgagaagacctatgctgtgaaagcaggaaggtggtattttgaatttgaggct gtcactgctggggacatgagagttggttggagcaggccaggttgtcaacctgatcaggag cttggctctgatgaacgtgcctttgcttttgatggcttcaaggcccagcggtggcaccag ggcaatgaacactatgggcgctcttggcaagcaggcgatgttgtggggtgcatggttgac atgacggaacataccatgatgttcacactgaatggtgaaatccttcttgatgattcaggt tcagaactggctttcaaggactttgatgttggcgatggattcatacctgtatgtagcctt ggagtggctcaagtgggcaggatgaactttggaaaggatgtcagcactttgaaatatttt accatctgtggcttgcaagagggctatgaaccatttgctgttaatacaaacagggatatt accatgtggctaagcaagaggcttcctcagtttctccaagttccatcaaaccacgaacat attgaggtgaccagaatagacggcaccatagatagttctccatgtttaaagatcacgcag aagtcttttggctctcagaacagcagcacggacatcatgttctatcgtctaagcatgccc atcgagtgtgcagaggtcttctccaagactgcagcaggaggcctccctggtgctggtctt tttgggcccaagaatgatttggaagattatgatgcagattctgactttgaggttctaatg aaaacagctcatggtcatcttgtacctgatcgagttgacaaagacaaagaagctacaaaa ccggagtttaataaccacaaagattatgctcaggaaaagccttcgcgtctcaaacaaaga tttttgcttagaagaacaaaaccagattatagcacaagccattctgcaagactcacggaa gatgtccttgctgatgatcgggatgactatgattacttgatgcaaacgtccacgtactat tactcagtgagaatctttccggggcaagaacctgctaatgtctgggtgggctggattacc tcagatttccatcaatatgacacaggctttgacttggacagagttcgaacagtaaccgtt actctaggagatgaaaaaggaaaagttcacgaaagcatcaaacgcagcaactgctacatg gtgtgtgcaggcgagagcatgagcccggggcaaggacgcaacaataacgggctggagatc ggctgcgtggtggacgccgccagcgggctgctcacattcactgccaatggcaaggaactg agcacgtactatcaggtggaaccaagtacaaaattgtttcctgcagtttttgcacaagct acaagtcccaatgtttttcagtttgagttgggaagaataaagaacgtgatgcctctctca gcaggattattcaagagcgagcataaaaacccagtgccacagtgtcccccacgcctccat gtgcagtttctatcacatgtcctgtggagcagaatgcccaaccagttcctgaaggtggat gtctctcggatcagtgaacgccaaggctggctggtgcagtgtttggatcctctgcaattc atgtctctccatatcccggaggagaacagatctgttgacatactagaattgacagagcaa gaagaactgctgaaattccactaccacacactccggctctactcagctgtctgtgctctt gggaaccaccgggtggcccacgccctgtgcagccacgtggatgaaccccagctcctctac gccatcgagaataagtacatgcccggtttgctgcgggctggctactacgacctactgatt gacatccacctgagctcttatgccactgccagacttatgatgaacaatgaattcatcgtc cccatgacagaggagacaaagagcatcacccttttccctggtgagaacaaaaagcatggt ctcccagggattggcctcagtacctccctcaggccacggatgcagttttcctcccccagt tttgtaagcattaatcatgaatgttaccagtatagtccagagttcccgctggacatccta aaggccaaaaccatacagatgctgacagaagctgttaaagagggcagcctccatgcccgg gacccggttggggggaccactgaattcctcttcgtgcctctcatcaagcttttctatact ctcctcatcatggggatctttcacaacgaggacctgaaacacatcctgcggttgattgag cccagtgtgttcaaggaggctgccagtcccgaggaggagagtgaggtgctggagaaagag ttgggcatggacgatgccaaactagaaggagctggggaggaagaaatcaaagggggtaag aggcccaaggaaggcctgcttcagatgaaactgcctgagccggtgaaactgcagatgtgc ctgctgctccagtacctctgtgattgccaggtccggcaccggatagaagccattgtggcc ttttcagatgactttgtggctaagctccaagacaatcaacgcttccgatataatgaagtt atgcaagccttaaatatgtcagctgcactcacagccaggaaaacaaaggaatttaggtca ccacctcaagaacagatcaatatgcttctgaattttaaggatgacaaaagtgaatgtcca tgtcctgaagaaatccgagaccaactcttggattttcatgaagatttgatggcacattgt ggaattgagctagatgaagatgggtccctggatggaaacagtgatttaacaatcagagga cgcctgctttccctggtagaaaaggtgacatacctgaagaagaaacaagctgaaaaacca gttgagagtgactcccagaagtcctctactcttcagcagttgatttctgatacaatggtc cgatgggctcaagagtctgtcattgaagaccctgaattggtgagggccatgtttatgttg ctccatcgacagtatgatggcattgggggtctggtccgagctctgccaaagacctacacc atcaatggtgtttctgtggaggacaccataaacctgctggcatctcttggtcagattcgt tctctgctaagtgtgagaatgggcaaagaagaggagaagctgatgattcgtggattaggg gacatcatgaataataaagtattttaccagcaccccaatctcatgagggcacttgggatg catgagacagtgatggaggtcatggtgaatgtccttggtggtggagagtccaaggaaatc actttccccaagatggtggccaactgttgccgattcctctgttatttctgtcgtataagt aggcagaatcaaaaagctatgttcgatcatctcagttatctattggaaaatagcagtgtt ggtctcgcctcaccagctatgagaggttcaacaccgctggatgtggcagcagcctcagtg atggataataatgaactggccttagctttgcgagagccagatctggaaaaggtagttcga tatttggctggttgtggactgcagagttgtcagatgctagtatccaagggttatccagac attgggtggaacccagttgaaggagaaagataccttgactttctcagatttgcggtcttc tgtaatggggagagtgtggaagagaatgcaaatgttgtggtgagattgctcatcaggcga cctgagtgttttggtcctgctttgagaggagaaggtgggaatggccttcttgcagccatg gaagaagccataaagatagccgaggacccctctcgagatggtccttcaccaactagtgga tccagtaaaacacttgacctagaagaggaggaagatgacactatccacatggggaatgct atcatgaccttttatgcagctttgatcgacctattaggacgctgtgctcctgaaatgcat ttgattcatgctggtaagggagaagccatcagaatcaggtctattttgagatctctgatt ccactgggagatttggtgggagtcatcagcattgcttttcaaatgccgacaatagccaaa gatggaaatgtggtggagcctgacatgtctgcgggattttgcccagatcacaaggcagcc atggttttgttccttgacagggtctatggaattgaggttcaagatttcctcctccatctt cttgaggttggctttctgccagatctccgggctgctgcttcgttagatacggctgcgttg agtgctacagatatggctttggccctcaatcggtacctttgcacagccgtgttgcctttg ttaactagatgtgctcctctgttcgctggcactgaacaccatgcttccctcatagactcg ttgcttcatactgtgtacagactttcaaagggctgctcccttaccaaagctcaacgggat tccatagaagtttgtttactttctatttgtggccagttgagaccttcgatgatgcagcac ctactcagaagactggtgtttgatgtgcccttattaaatgaacatgcaaagatgcctctt aagctactgacaaatcactatgaaagatgttggaaatattactgtctgcctggagggtgg ggaaactttggtgctgcctcagaagaagaactccatttatcaagaaagttgttctggggc atttttgacgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgcct tgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagt atgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaaccagttgat acctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcagaacac tcccatgacaaatggtcaatggacaagttggcaaatggatggatttatggagaaatatat tcagattcttctaaagttcaaccattaatgaagccatataaactattatctgaaaaggaa aaagaaatttatcgctggccaatcaaagaatccttaaaaacaatgctggcttggggctgg agaattgaaagaacacgggagggagacagcatggccctttacaatcggacccggcgcatt tctcaaacaagccaggtttctgtagatgctgcccatggctacagcccccgagccattgac atgagcaacgtcacactctccagagatcttcatgctatggcagaaatgatggctgaaaac taccataatatatgggcaaagaaaaagaaaatggaacttgaatctaaaggaggtggaaac catccactgctggtaccctatgatacattaacagccaaagagaaagccaaggatagagaa aaagctcaggacattctcaagttcttgcagatcaatggatatgctgtatccagaggattc aaggacctagaattggatacaccttccattgaaaaacgattcgcctatagtttccttcag caactcattcgctatgtggatgaagcccatcagtatatactggagtttgatggtggcagc agaagcaaaggagaacatttcccttatgaacaagaaatcaagttctttgctaaagtggtc cttcctttaattgatcagtatttcaaaaaccatcgtctatacttcttatctgcagcaagc agacctctctgttctggaggacatgcatcaaacaaagagaaagaaatggttactagccta ttctgcaaacttggagttcttgtcaggcataggatttcactatttggaaatgatgcaaca tcaattgtcaactgtctccatattttgggtcagactttggatgcaaggactgtaatgaag actggcctggagactgtcaaaagtgcactcagggcatttctggacaatgctgcggaggac ctggagaagacgatggagaaccttaagcagggccagttcacccacaccagaaaccaaccc aaaggtgttactcagattatcaattataccacggtggcactgttgccaatgctgtcatca ttatttgagcatattggccagcatcagttcggagaagatctaatattggaagatgtacaa gtgtcatgctacagaattttgactagcttatatgctttgggaaccagcaaaagtatttat gtggaaaggcaacgttctgcattaggagaatgtctggctgcttttgctggtgcctttcct gtagcatttttggaaactcatcttgacaaacataatgtttattccatttataatactaag tcttcacgcgagagaacagctctcaatttgccaactaatgtggaagatgtttgtccaaat ataccatctttggagaaactcatggaagaaattgtagaattagctgagtctggtatacgc tacacacaaatgccacatgtgatggaagttgtcctgcccatgctctgcagctacatgtcc cggtggtgggagcatgggcctgaaaacaacccagaaagggctgaaatgtgctgtacagct ctggactcagagcacatgaacacgcttctggggaatatattgaaaatcatatataataac ttggggattgatgaaggagcctggatgaagaggttagcagtattttcccagcctattata aataaagtaaaacctcagctcttgaaaactcatttcttgccattaatggagaaactcaag aaaaaggcagcgatggtggtgtctgaggaagaccatctgaaagccgaagccaggggggat atgtccgaggctgaacttctcattctagatgagtttaccacactggccagagatctctat gccttctaccctctcttaattagatttgtggactataacagggcaaagtggttaaaagag cctaacccagaagcagaggatcttttccgtatggtggcagaagtgtttatctactggtca aaatcccataatttcaagagagaagaacagaacttcgtagtacagaatgaaatcaacaac atgtcttttcttattactgacaccaagtcaaagatgtcaaaggcagctgtttctgatcag gaaaggaagaaaatgaagcgcaaaggagatcggtattccatgcagacctctctgattgtg gcagccctgaaacgattactgcccattggattgaatatctgtgcccctggagaccaagag ctcattgctctggccaaaaatagatttagtatgaaagacactgaggatgaagtacgagat ataatccgcagtaatatacatctacaaggcaagttggaagatcctgctattagatggcaa atggctctctacaaagacttaccaaacaggactgaagacacttcagaccctgagaagaca gtagaaagagtattggatatagcaaatgtgctttttcatcttgaacaggtggaacaccct cagagatctaaaaaggcagtgtggcacaaactgctttctaagcagaggaaaagggcagtg gtggcctgcttccgaatggctcctttatataatctgccaaggcatcgggctgtcaatctc tttcttcagggatatgaaaaatcttggattgaaacagaagaacattactttgaagataaa ctgatagaagacttagcaaaacctggagccgaacctccagaagaagatgaaggcactaag agagttgatccgctacatcagctgatccttctgtttagtcgaacggctttgacagagaaa tgcaaactggaggaagattttttatatatggcgtatgcagatattatggcaaagagttgt catgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagaaaaagaaatg gaaaagcaaaagcttctataccagcaagccaggctccacgaccgcggtgctgctgaaatg gtgctgcagaccatcagcgccagcaaaggtgaaactggaccaatggtagctgctactttg aaacttggaattgctatattaaatggcggcaactctacagtacagcagaaaatgcttgac tacctcaaggagaagaaggatgtgggcttctttcagagccttgctggcctgatgcagtcg tgtagtgtccttgacctaaatgcatttgaacgacaaaacaaagctgaaggacttggaatg gtgacagaggaaggatcaggagaaaaggttctacaggatgacgagttcacttgtgacctc ttccgcttcctacaactgctttgtgaaggacacaactcagattttcaaaattatctgaga actaagactggcaataatacaactgtcaacataatcatctctactgtagactacctactg agagttcaggaatcaatcagtgatttctattggtattattctggaaaagatgttattgat gaacaaggacaacggaatttctccaaagcaattcaagtagcaaaacaagtctttaacact ctcacagaatatattcagggtccttgcactgggaatcagcagagtctggcccacagcagg ctatgggacgcggtggtgggttttcttcatgtatttgctcacatgcagatgaagctgtct caggattccagtcaaattgaactattaaaagaattaatggatctccagaaggatatggtg gtcatgctgctgtccatgttagaaggtaatgttgtcaatggaaccattggcaaacagatg gtagatatgcttgtggaatcttccaacaacgtggagatgattctcaaattttttgacatg ttcttaaagctgaaggatttgacatcctctgatacatttaaagaatatgatcctgatggc aagggtgtcatttccaagagggacttccataaagccatggagagccacaaacactacaca caatcagaaactgagtttcttctgtcctgtgcagagacagatgaaaatgaaactctcgac tatgaagagtttgttaaacgtttccacgaacctgcgaaggacatcagcttcaatgttgct gtccttctgacaaatctctctgagcacatgcccaatgacacccgactgcagacttttctg gaattagcagaaagtgtgctgaattacttccagccctttctcggtcgcattgagattatg ggaagtgccaagcgcattgagagggtttattttgaaatcagcgagtccagccgcacccag tgggagaaaccccaggtcaaggagtccaaaagacagttcatatttgatgtggtcaatgaa gggggagaaaaggagaagatggaactctttgttaacttctgtgaggacaccatatttgaa atgcagctggcagctcagatctcagagtcggatttgaacgaaaggtcagcaaataaggaa gaaagtgagaaggagaaacctgaagagcaggggcctaaaatgggctttttttcgattctg acagtcaaatcagccctgtttgctctcaagtataatatcttggcccttatgcgaatgctc agtctaaagagcctgaagaaacagatgaaaaaagtaaagaagatgaccatgaaggacatg gtcacagccttcttttcatcctattggagtatatttatgagcctcctgcactttgtagcc agcgtgttcaggggctttttccgcatcatttgcagcctcctgctgggaggaagcctagta gaaggtgctaaaaagatcaaagtcgcagagctcttagccaacatgccagatcctactcag gatgaggtgagaggggatggagaggaaggagagaggaaacccatggaagctgccctgccc tcagaagatctggctgacttaaaggaactgacagaagaaagtgaccttctttcagacata tttggtttggacctgaagagagaaggagggcagtacaagcttattcctcataatccaaac gctggcctcagtgacctaattagcaacccagtccccatccctgaggtgcaagaaaaattt caggaacagaaggcaaaggaagaagaaaaggaagaaaaagaggaaaacaaatctgaacct gaaaaagcagagggagaagatggagaaaaagaagaaaaacccaaagaagacaagggtaaa cagaaattgaggcagctccacacacatcgatatggagagccagaggttcccgaatcagca ttctggaagaaaatcatagcatatcaacaaaaacttctaaattattttgctcgcaacttt tacaacatgagaatgttagccttatttgtcgcatttgcaatcaatttcatcttgctcttt tataaggtctccacttcttctgtggttgaaggaaaggagctcccctctcgcagttcaagt gaaaatgccaaagttagcaccgtggacagtgactcacaaagaatcattgccgttcactat gtactggaggagagcagtggctacatggagcccaccttgcgtatcttagctattctgcac acagtcatttctttcttctgcatcattggatactactgcttgaaagtcccattggttatt tttaagcgagaaaaggaagtagcacggaaattggaatttgatgggctttatattacagaa cagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtca tttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatatggagaa ttctatggacgagatagaatcagtgagttacttgggatggacaaagctgccttggacttc agtgacgcacgggaaaagaaaaagccaaagaaagacagctccctggcggcagtactcaat tctattgatgtgaagtatcagatgtggaagctaggagttgttttcaccgacaattccttc ctctacctagcctggtatatgactatgtccgttcttggacactataacaacttttttttt gctgctcatcttcttgacattgctatgggattcaagaccttaagaaccatcttgtcatca gtaactcacaatggcaaacagcttgtgttaactgttggcttgctggctgttgttgtttac ttatatactgttgtggcattcaattttttccggaaattctacaataaaagtgaagatggt gatacaccagatatgaaatgtgatgatatgctgacatgttacatgttccacatgtatgtt ggagtacgtgccggaggagggattggtgatgaaattgaggatccagcaggtgatgaatac gagatctatcgaatcatctttgatatcactttcttcttctttgtcatcgtcattctcttg gccataatacaaggtttaattattgatgcttttggagagctaagagaccaacaggaacaa gtaaaagaagacatggagaccaagtgtttcatctgtgggataggcaacgattacttcgac acagtgccacatggctttgaaacccacactttacaggaacacaacttggccaattacctg ttttttctgatgtatcttataaacaaagatgaaacagagcacacaggacaggaatcttat gtctggaagatgtatcaggaaagatgttgggagtttttcccagcaggggattgtttccgg aaacagtatgaagaccagctaaattaa

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