KEGG   Talpa occidentalis (Iberian mole): 119244519
Entry
119244519         CDS       T07495                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X3
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod01524  Platinum drug resistance
tod04010  MAPK signaling pathway
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04015  Rap1 signaling pathway
tod04022  cGMP-PKG signaling pathway
tod04024  cAMP signaling pathway
tod04062  Chemokine signaling pathway
tod04066  HIF-1 signaling pathway
tod04068  FoxO signaling pathway
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04140  Autophagy - animal
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04152  AMPK signaling pathway
tod04210  Apoptosis
tod04211  Longevity regulating pathway
tod04213  Longevity regulating pathway - multiple species
tod04218  Cellular senescence
tod04261  Adrenergic signaling in cardiomyocytes
tod04370  VEGF signaling pathway
tod04371  Apelin signaling pathway
tod04380  Osteoclast differentiation
tod04510  Focal adhesion
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04611  Platelet activation
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04625  C-type lectin receptor signaling pathway
tod04630  JAK-STAT signaling pathway
tod04660  T cell receptor signaling pathway
tod04662  B cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04666  Fc gamma R-mediated phagocytosis
tod04668  TNF signaling pathway
tod04722  Neurotrophin signaling pathway
tod04725  Cholinergic synapse
tod04728  Dopaminergic synapse
tod04810  Regulation of actin cytoskeleton
tod04910  Insulin signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04915  Estrogen signaling pathway
tod04917  Prolactin signaling pathway
tod04919  Thyroid hormone signaling pathway
tod04920  Adipocytokine signaling pathway
tod04922  Glucagon signaling pathway
tod04923  Regulation of lipolysis in adipocytes
tod04926  Relaxin signaling pathway
tod04929  GnRH secretion
tod04931  Insulin resistance
tod04932  Non-alcoholic fatty liver disease
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04935  Growth hormone synthesis, secretion and action
tod04936  Alcoholic liver disease
tod04973  Carbohydrate digestion and absorption
tod05010  Alzheimer disease
tod05017  Spinocerebellar ataxia
tod05132  Salmonella infection
tod05135  Yersinia infection
tod05142  Chagas disease
tod05145  Toxoplasmosis
tod05152  Tuberculosis
tod05160  Hepatitis C
tod05161  Hepatitis B
tod05162  Measles
tod05163  Human cytomegalovirus infection
tod05164  Influenza A
tod05165  Human papillomavirus infection
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05168  Herpes simplex virus 1 infection
tod05169  Epstein-Barr virus infection
tod05170  Human immunodeficiency virus 1 infection
tod05200  Pathways in cancer
tod05205  Proteoglycans in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05211  Renal cell carcinoma
tod05212  Pancreatic cancer
tod05213  Endometrial cancer
tod05214  Glioma
tod05215  Prostate cancer
tod05218  Melanoma
tod05220  Chronic myeloid leukemia
tod05221  Acute myeloid leukemia
tod05222  Small cell lung cancer
tod05223  Non-small cell lung cancer
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05230  Central carbon metabolism in cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
tod05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119244519 (AKT3)
   04012 ErbB signaling pathway
    119244519 (AKT3)
   04014 Ras signaling pathway
    119244519 (AKT3)
   04015 Rap1 signaling pathway
    119244519 (AKT3)
   04370 VEGF signaling pathway
    119244519 (AKT3)
   04371 Apelin signaling pathway
    119244519 (AKT3)
   04630 JAK-STAT signaling pathway
    119244519 (AKT3)
   04668 TNF signaling pathway
    119244519 (AKT3)
   04066 HIF-1 signaling pathway
    119244519 (AKT3)
   04068 FoxO signaling pathway
    119244519 (AKT3)
   04072 Phospholipase D signaling pathway
    119244519 (AKT3)
   04071 Sphingolipid signaling pathway
    119244519 (AKT3)
   04024 cAMP signaling pathway
    119244519 (AKT3)
   04022 cGMP-PKG signaling pathway
    119244519 (AKT3)
   04151 PI3K-Akt signaling pathway
    119244519 (AKT3)
   04152 AMPK signaling pathway
    119244519 (AKT3)
   04150 mTOR signaling pathway
    119244519 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119244519 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    119244519 (AKT3)
   04218 Cellular senescence
    119244519 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119244519 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    119244519 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119244519 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119244519 (AKT3)
   04613 Neutrophil extracellular trap formation
    119244519 (AKT3)
   04620 Toll-like receptor signaling pathway
    119244519 (AKT3)
   04625 C-type lectin receptor signaling pathway
    119244519 (AKT3)
   04660 T cell receptor signaling pathway
    119244519 (AKT3)
   04662 B cell receptor signaling pathway
    119244519 (AKT3)
   04664 Fc epsilon RI signaling pathway
    119244519 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    119244519 (AKT3)
   04062 Chemokine signaling pathway
    119244519 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119244519 (AKT3)
   04922 Glucagon signaling pathway
    119244519 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    119244519 (AKT3)
   04920 Adipocytokine signaling pathway
    119244519 (AKT3)
   04929 GnRH secretion
    119244519 (AKT3)
   04915 Estrogen signaling pathway
    119244519 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    119244519 (AKT3)
   04917 Prolactin signaling pathway
    119244519 (AKT3)
   04926 Relaxin signaling pathway
    119244519 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    119244519 (AKT3)
   04919 Thyroid hormone signaling pathway
    119244519 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119244519 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119244519 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    119244519 (AKT3)
   04728 Dopaminergic synapse
    119244519 (AKT3)
   04722 Neurotrophin signaling pathway
    119244519 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119244519 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    119244519 (AKT3)
   04213 Longevity regulating pathway - multiple species
    119244519 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119244519 (AKT3)
   05205 Proteoglycans in cancer
    119244519 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    119244519 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    119244519 (AKT3)
   05230 Central carbon metabolism in cancer
    119244519 (AKT3)
   05231 Choline metabolism in cancer
    119244519 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119244519 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119244519 (AKT3)
   05212 Pancreatic cancer
    119244519 (AKT3)
   05225 Hepatocellular carcinoma
    119244519 (AKT3)
   05226 Gastric cancer
    119244519 (AKT3)
   05214 Glioma
    119244519 (AKT3)
   05221 Acute myeloid leukemia
    119244519 (AKT3)
   05220 Chronic myeloid leukemia
    119244519 (AKT3)
   05218 Melanoma
    119244519 (AKT3)
   05211 Renal cell carcinoma
    119244519 (AKT3)
   05215 Prostate cancer
    119244519 (AKT3)
   05213 Endometrial cancer
    119244519 (AKT3)
   05224 Breast cancer
    119244519 (AKT3)
   05222 Small cell lung cancer
    119244519 (AKT3)
   05223 Non-small cell lung cancer
    119244519 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119244519 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    119244519 (AKT3)
   05161 Hepatitis B
    119244519 (AKT3)
   05160 Hepatitis C
    119244519 (AKT3)
   05164 Influenza A
    119244519 (AKT3)
   05162 Measles
    119244519 (AKT3)
   05168 Herpes simplex virus 1 infection
    119244519 (AKT3)
   05163 Human cytomegalovirus infection
    119244519 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119244519 (AKT3)
   05169 Epstein-Barr virus infection
    119244519 (AKT3)
   05165 Human papillomavirus infection
    119244519 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119244519 (AKT3)
   05135 Yersinia infection
    119244519 (AKT3)
   05152 Tuberculosis
    119244519 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119244519 (AKT3)
   05142 Chagas disease
    119244519 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119244519 (AKT3)
   05017 Spinocerebellar ataxia
    119244519 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119244519 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    119244519 (AKT3)
   05415 Diabetic cardiomyopathy
    119244519 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    119244519 (AKT3)
   04932 Non-alcoholic fatty liver disease
    119244519 (AKT3)
   04931 Insulin resistance
    119244519 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119244519 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119244519 (AKT3)
   01524 Platinum drug resistance
    119244519 (AKT3)
   01522 Endocrine resistance
    119244519 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119244519 (AKT3)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     119244519 (AKT3)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   119244519 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like ABC1 DUF6932
Other DBs
NCBI-GeneID: 119244519
NCBI-ProteinID: XP_037366197
LinkDB
Position
Unknown
AA seq 478 aa
MIKLEMVEALGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE
RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI
DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII
AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE
DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT
FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF
PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLIPPFKPQ
VTSETDTRYFDEEFTAQTITITPPEKCMSFPCSRNSMVFSCVSSRHLQSLSHFHSERP
NT seq 1437 nt   +upstreamnt  +downstreamnt
atgattaaactggaaatggtagaggcattaggagaatatataaaaaactggaggccaaga
tatttccttttgaagacagatggctcattcataggatataaagagaaacctcaagatgtg
gatttaccttatcccctcaacaacttttcagtggcaaaatgccagttaatgaaaacagaa
cgaccaaagccaaacacatttattataagatgtcttcagtggaccactgttatagagaga
acatttcatgtagatactccagaggaaagggaagaatggacagaagccatccaggctgta
gcagacagacttcagaggcaagaagaggagagaatgaattgtagtccaacttcacaaatt
gataatataggggaggaagagatggatgcttctacaactcatcataaaagaaagacaatg
aatgattttgactatttgaaactgctaggtaaaggcacttttggaaaagttattttggtt
cgagaaaaagcaagtgggaaatattatgctatgaagattctgaagaaagaagttattatt
gcaaaggatgaagtggcacacactctaactgaaagcagggtattaaagaacactagacat
ccctttttaacatccttgaaatattccttccagacaaaagaccgtttgtgttttgtgatg
gaatatgttaatgggggagagctgtttttccatttgtcgagagagcgggtgttctctgag
gaccgcacacgtttctatggtgcagaaattgtgtctgctttggactatctacattctgga
aagattgtgtaccgtgatctcaagttggagaacctgatgctggataaagatggccacata
aaaattacagattttggactttgcaaagaagggatcacagatgcagccaccatgaaaacg
ttctgtggtacaccagaatatctggccccagaggtgttagaagataatgactatggtcga
gccgtggattggtggggcctaggggttgtcatgtatgaaatgatgtgtgggaggttacct
ttctacaatcaggatcatgagaaactttttgaacttatactaatggaagacattaaattt
cctcgaacactctcttcagatgcaaaatcattgctttcagggctcttgataaaagatcca
aataaacgccttggtggaggaccagatgatgcaaaagaaattatgagacacagtttcttt
tctggagttaactggcaagatgtatatgataaaaagcttatacctccttttaagcctcaa
gtaacatctgaaacagatactagatattttgatgaagaatttacagctcaaactattaca
ataacaccacctgaaaaatgcatgagctttccatgctcgagaaactcgatggtcttttca
tgcgtgtcatcccgccacctccaaagcctaagccacttccattctgagaggccatga

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