Talpa occidentalis (Iberian mole): 119246187
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Entry
119246187 CDS
T07495
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod01521
EGFR tyrosine kinase inhibitor resistance
tod01522
Endocrine resistance
tod04010
MAPK signaling pathway
tod04012
ErbB signaling pathway
tod04068
FoxO signaling pathway
tod04270
Vascular smooth muscle contraction
tod04650
Natural killer cell mediated cytotoxicity
tod04720
Long-term potentiation
tod04726
Serotonergic synapse
tod04730
Long-term depression
tod04810
Regulation of actin cytoskeleton
tod04910
Insulin signaling pathway
tod04914
Progesterone-mediated oocyte maturation
tod04928
Parathyroid hormone synthesis, secretion and action
tod05010
Alzheimer disease
tod05022
Pathways of neurodegeneration - multiple diseases
tod05034
Alcoholism
tod05160
Hepatitis C
tod05161
Hepatitis B
tod05200
Pathways in cancer
tod05205
Proteoglycans in cancer
tod05208
Chemical carcinogenesis - reactive oxygen species
tod05210
Colorectal cancer
tod05211
Renal cell carcinoma
tod05212
Pancreatic cancer
tod05213
Endometrial cancer
tod05214
Glioma
tod05215
Prostate cancer
tod05218
Melanoma
tod05219
Bladder cancer
tod05220
Chronic myeloid leukemia
tod05221
Acute myeloid leukemia
tod05223
Non-small cell lung cancer
tod05224
Breast cancer
tod05225
Hepatocellular carcinoma
tod05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
119246187 (ARAF)
04012 ErbB signaling pathway
119246187 (ARAF)
04068 FoxO signaling pathway
119246187 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
119246187 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
119246187 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
119246187 (ARAF)
04914 Progesterone-mediated oocyte maturation
119246187 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
119246187 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
119246187 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
119246187 (ARAF)
04720 Long-term potentiation
119246187 (ARAF)
04730 Long-term depression
119246187 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
119246187 (ARAF)
05205 Proteoglycans in cancer
119246187 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
119246187 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
119246187 (ARAF)
05212 Pancreatic cancer
119246187 (ARAF)
05225 Hepatocellular carcinoma
119246187 (ARAF)
05226 Gastric cancer
119246187 (ARAF)
05214 Glioma
119246187 (ARAF)
05221 Acute myeloid leukemia
119246187 (ARAF)
05220 Chronic myeloid leukemia
119246187 (ARAF)
05218 Melanoma
119246187 (ARAF)
05211 Renal cell carcinoma
119246187 (ARAF)
05219 Bladder cancer
119246187 (ARAF)
05215 Prostate cancer
119246187 (ARAF)
05213 Endometrial cancer
119246187 (ARAF)
05224 Breast cancer
119246187 (ARAF)
05223 Non-small cell lung cancer
119246187 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
119246187 (ARAF)
05160 Hepatitis C
119246187 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
119246187 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
119246187 (ARAF)
09165 Substance dependence
05034 Alcoholism
119246187 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
119246187 (ARAF)
01522 Endocrine resistance
119246187 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tod01001
]
119246187 (ARAF)
Enzymes [BR:
tod01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
119246187 (ARAF)
Protein kinases [BR:
tod01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
119246187 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
119246187
NCBI-ProteinID:
XP_037368356
LinkDB
All DBs
Position
Unknown
AA seq
606 aa
AA seq
DB search
MEPPRGPPSNGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQETPSSQPLNEPL
TPQGPSPCTQHCGPEHFPFPAPTNAPLQRIRSTSTPNVHMVSTTAPMDSSLLQLTAQSFS
NDAAGGRGGGDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSLSEEKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggacccccttccaacggggcggagccatcccgggcagtgggcact
gtcaaagtgtacctgcccaataagcagcgaacagtggtgactgtccgggatggcatgagt
gtctatgactcgctagataaggccctcaaagtgcggggtctcaaccaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagactgtcacagcctgggacacggccattgccccc
ttggatggtgaggagctcattgtggaggtcctcgaagatgtcccactgactatgcacaat
tttgtacggaagacattcttcagcctggccttctgtgacttctgccttaagtttctcttc
catggtttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtg
cctacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtatccaggat
ttgtccggaggctccagacagcaagagactccctccagccaacccctgaatgagccacta
acccctcagggacccagcccctgcacccagcactgtggccctgagcactttcccttccct
gccccgaccaatgcccccctccagcgcattcgctccacgtccacccccaacgtccatatg
gtcagcaccacggcccccatggattccagcctcctccagcttactgcccagagtttcagc
aatgatgctgctggtggtagaggtggtggcgatggagtcccccgggggagccccagcccg
gccagtgtgtcctcagggaggaaatccccacattccaagtccccatcagagcagagggag
cggaagtccttgtctgaggagaagaagaaagtgaaaaatctggggtaccgggactcaggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggattgggacgggctcc
ttcggcacggtgtttcgcgggcgctggcatggtgacgtggccgtgaaggtgctcaaggtg
gcccagcccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgccacgtcaacatcttgctattcatgggcttcatgaccaggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccaccaccttcacgtggctgacacacgc
tttgacatggtccagctcatcgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccacagagatctcaagtctaataacatcttcctacacgagggg
ctcacagtgaagattggtgacttcggcctggccacagtgaagacgcggtggagcggagcc
cagcccttggagcagccctcgggttctgtgctatggatggcggctgaggtgatccgtatg
caggacccgaacccctatagcttccagtcagatgtctacgcctatggggtcgtgctctat
gaactcatgaccggctcgctgccctacagccatattggcagccgtgaccagataatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagaggagt
gcctcggaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctgctcagc
gcagcccgccttgtgccttag
DBGET
integrated database retrieval system