Talpa occidentalis (Iberian mole): 119247121
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Entry
119247121 CDS
T07495
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod05012
Parkinson disease
tod05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
119247121 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
119247121 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tod01001
]
119247121 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
tod04131
]
119247121 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
tod04147
]
119247121 (LRRK2)
Enzymes [BR:
tod01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
119247121 (LRRK2)
Protein kinases [BR:
tod01001
]
Serine/threonine kinases: TKL group
LRRK family
119247121 (LRRK2)
Membrane trafficking [BR:
tod04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
119247121 (LRRK2)
Exosome [BR:
tod04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
119247121 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_4
LRR_8
Roc
COR-B
COR-A
Ras
LRR_14
LRR_9
AAA_16
ARM_CUL7_CUL9
Arf
NACHT
LRR_6
AAA_22
nSTAND_NTPase5
Kdo
T2SSE
MMR_HSR1
Beta-prop_RSE1_2nd
AAA_30
nSTAND3
TsaE
G-alpha
AAA_33
Viral_helicase1
ARM_LIN_2nd
cobW
MobB
Beta-prop_EML_2
Motif
Other DBs
NCBI-GeneID:
119247121
NCBI-ProteinID:
XP_054552771
LinkDB
All DBs
Position
Unknown
AA seq
2533 aa
AA seq
DB search
MTQAQAPPRQSPLDVELPAVHTGGCWGSTGRGHCGRFPVQSQPRQLPAGPPAGAGNTVSL
GPPSAELFRGRDAHGPLLALLDAHLGAARVQQVGWSLLCRLLEVCPSSTEGLTAPPDIGP
DWEVLGAHQLVLKMLAVHGASADLCTVGLKALDLLLAASGRIALLILEEESDVFLLVLSA
MRSFAARSEVQQLGCRALHVLLERVSEEQLAEFVENKDHEVLLEALRLFGGDVEVVLPAL
LCLHALAVPCSNVEVLMSGSVRCYNVVVTAMVEFPGHEGVQEVSCSLLHRLSLGNFLNIL
VLNKVHTFVVAAVGRFPGNAALQVAALSCLALLTETIFLNQDLEEKSEAPGATAAAEDER
LFWLEACHRALAGHRKDKHVQEAACWALDSLLTHQRSLHRRIGDEDGQFPVHREVMLSML
MHSSCPGVCQAATSALSSLLQQNTNFRKVLLSKGIHLNVLELMQRHAGTAEVAASSCRLM
NRLFQGSDASLDTVMAVVPKIIAVMRSHEAELPVQLEATQAILHFLDPGVPAESGGGPRQ
LDAAREQCWRSGLHKLVLAALSRFPGHPGLQRGGLRVLSTLALLPEAVEVLRLDGAVDTV
LPNLQGHPHDAEIQHLGLSLIGHLATSTSLSTGKGPLLAAVLVSSLRRFEGLADVQIGGL
RTALRTLELWAPFAGLLLRHNFDEVLSRRLSACAPELMDPQLLDLGCKCLARLAAEDEAR
GALLRRACERDDGVLAECLLLLGADINHAQAPGAPALICQVCEEARSPALVELLLRQGPR
EQDVRSALALSVSRGDGAAIGLLLRRLALDPAHGSACLGGLGLRRVEPAWLAPLFADPTP
SPGGQSSVGAALARMVLGHQRSSPGAGAEAPRGEGSLAGDAQDRCEEWTLVTEFLVDGVF
SQSDDPDSEGSEGSDPAGKLARSGSPGGSGHLLASPRPCYLPRPLRPALPQGPIGDQEDS
REGRRSVLSPEDPPRPWGSLSPPPPETGRITSLDLSANELQDIDALAQRGGLSAHLEHLE
RLELHQNALSGLPAQLCQVLRRLTHLDLHSNKLTSFPAHVLSLSRLAFLDVSRNDIGPRV
LLDPALSCPALRQLSLAHNRLSSVPEGLGAVASGLQQLALEGNEIAGTCPCLCLTELRAL
NLSKNHISDLAGGFLEACPRLESFSASMNLLATLPTLPPSLTSVKLAQNRFACVPDALLS
LPHLRSLDMSSNEIQSLPGPAHWKSQNLRELLFSHNHIRVLDLGDKACAWARLEKLHLAH
NRLRELPPEIGCLQNLASLDVSGNAELRSFPNEMGKLSKMWDLPLDDLRLDFDFKRVGCR
AKDIIRFLQQRLRKAVPYSRLKLLVVGNAGSGKTTLLRQLMRARKAEAAAPGPTVGIDVR
DWPVPVRGKGKRDLVLSVWDFAGREEFYSAHAHFMTPRALYLAVFDLSKGPAEVEAMKPW
LFNIKARASASPVVLVGTHLDICEEGQLQACAASVAQELLGRRGFPAVRGCHFVNATQDS
DALAKLRTAIIRESLGFKIRAEPVVGQLVPACYVELERLVLAERKSMPAEFPVVSRQRLL
QLVREQQLQLDESELPQAVHFLSESGTLLHFQDPALQLDDLYFVDPKWLCKAVAQILTVR
TEGYPKHPQGIVSRRDVEKFLTKRRRFPKKHLPQYFSLLEKFQLALPLGEDLLLVPSSLP
GHTPVIELPHCENSEVTVRLYETPCFPMGFWPRLINRVLEISPYMLSGRERALRPNRMYW
RQGVYLSWSSEAYCLVGAEAPDGRPESCLRITVPSCRKGRILLGQAVDHIDSLLEEWFPG
LLETDVCGDGETLLKKWALYSFRDGEEPQRILLDDLAREAEQGDLLVSPDEPRLTVPIAQ
IAPDLMLADLPRSIVLRREALELQQAPELLLGDGSFGSVYRARYDGEEVAVKIFNKHTSL
RLLRQELAVLCRLHHPSLVSLLAAGIRPRMLVMELAGRGSLDRLLEQGPAGLPRTLQHRI
ALHVADGLRYLHSAMIIYRDLKPHNVLLFTLHPSAAVIAKIADYGIAQYCCRMGIKTSEG
TPGFRAPEVAKGNVVYNQRADVYSLGLLLYDVLTAGRRIAEGLKFPNEFDELAVQGKLPD
PVREYGCAPWPLVEQLIKKCLKENPQDRPTSAQVFDSLTAAELVCLARHVPLPGDPQAEC
AAAWSLGGGRVGVWLGCGRASSGHLASLDLHTEALTSQEVADSQVLCLALVPLPADQDVW
VVCGTQSGALLAVNAQDGERRHALGRMTDAVTCMCCKAFCGQRQSSFLLVGTADGTLVVF
EDRAVKSPGAAPLQTVTLGDASTPLLCLSESANSAERNLVWGGCGTRVFSLGQDLSVQTL
IETRTRQLFSYGAFGEANVTAVVGDMVLYVAKQSSPFVEVWDQKTRKLCQLVDCAHWLRE
EAAPGSKDCRPSATYVGRVKALCLQKNTALWVGTGGGCILLLDLSTHRLIRLIRGFYDSV
RVMVTAQLGKSPGFLPGPSLFLKITCLLVFVFLHSRSFLYSDWFLPQVRPPRFFYHHSPP
TVTLSLELIPPVF
NT seq
7602 nt
NT seq
+upstream
nt +downstream
nt
atgactcaggcccaggcgcccccacgacagagcccgctggatgtggagctcccagctgtc
cacactggtggctgctggggcagcactggccgcggacactgtggccgcttccccgtccag
tctcagccccgacagctgcctgctgggccgccggctggagcaggaaacaccgtgtccctg
gggccgccctccgccgagctgttccggggccgcgacgcgcacgggccgctgctggcgctg
ctggacgcccacctgggcgcggcgcgggtgcagcaggtgggctggtcgctgctctgcagg
ctgctcgaggtctgtccaagctccacggaaggcctgacggcgccccccgacatcggcccc
gactgggaggtgctcggggcccaccagctggttctgaagatgctcgcggtccacggcgcc
agcgccgacctctgcacggtggggctgaaggccctcgacctcctgctggcggcttcaggg
aggattgcgctgctgattctggaggaggaaagtgacgtcttcctgctggtcctcagcgcc
atgcgcagcttcgcggcccgcagtgaggtccagcagttgggctgccgcgccctgcacgtg
ctgctcgagcgagtctccgaggagcagctggcggagttcgtagagaacaaggaccacgag
gtgctgctggaggcgctgcggctctttggcggtgatgtggaggtggtgctgcccgccctg
ctgtgcctgcacgccctcgccgtgccctgcagcaacgtggaggtgctcatgagcggcagc
gtccggtgctacaacgttgtggtgacggccatggtggagttccctggccatgagggcgtc
caggaagtgagctgcagcctgctgcaccggctctcgctgggcaacttcctcaacatcctg
gtgctgaacaaggtgcacacgtttgtggtggcagccgtggggcgcttcccggggaacgcc
gccctgcaggtggccgcactcagctgcctggccctgctcaccgagaccattttcttgaac
caagacttagaggaaaagagtgaggccccaggcgccacagcagcagcggaggacgagcgg
ctcttctggctggaggcctgtcaccgcgccctggccggccaccgcaaggacaagcacgtg
caggaggccgcatgctgggcgctggacagcctgctcacgcaccagcgcagcctgcaccgg
aggatcggcgacgaggacggccagttccctgtgcaccgggaggtgatgctgtccatgctg
atgcactcgtcctgcccgggggtctgccaggccgccaccagcgccctgtcatcgctgctg
cagcagaacaccaatttcaggaaggtcctgctgtccaaagggatccacctgaacgtgctg
gagctgatgcagaggcacgcgggcaccgcggaggtggcggcgagcagctgccgcctgatg
aaccggcttttccaaggaagcgacgcctccctggacacggtgatggccgtggtccccaag
ataatcgcggtcatgcgcagccacgaggccgagctgccggtgcagctggaggccacccag
gccatcctgcacttcctggacccaggcgtgcccgcggagagcgggggaggcccgcgccag
ctggacgcggccagagagcagtgctggagaagcggcctgcacaagctggtcctggcggct
ctgagccggttcccggggcaccctgggctccagcggggcggcctgcgggtgctgtccacg
ctggcactgctgcccgaggctgtggaggtgctgcgcctggacggcgctgtggacacggtg
ctgcccaacctgcaggggcacccccatgacgcagaaatccagcatctgggtttaagtctg
ataggacatctggccacgagcaccagcctgagcaccggaaagggccccctgctggccgca
gtcctggtgtccagcctgcggcggttcgagggcctggcggacgtgcagatcgggggcctc
cggacggcgctgaggacgctggagctgtgggcgcccttcgcggggctgctgctgcggcac
aacttcgacgaggtgctctcccggcggctgagcgcctgcgcccccgagctgatggacccg
cagctcctggacctcggctgcaagtgcctggccaggctggctgcggaggacgaggcgcgg
ggcgcgctgctgcgacgggcctgcgagcgcgacgacggcgtcctggccgagtgtctgctg
ctgctgggggctgacatcaaccacgcgcaggccccgggcgcgcccgccctcatctgccag
gtgtgcgaggaggcacgcagccctgcgctggtggagctgctgctgcgccaggggccccgc
gagcaggacgtgcgctccgcactggccctcagcgtgtcccggggcgacggggcggccatc
gggctgctgctgcggagactcgcgctggacccggcccacggcagcgcgtgcctgggcggc
ctcggcctgcggagggtggagcccgcctggctggccccgctgttcgctgacccgacgccg
agccccgggggacagtcgagtgtcggggccgccctggccaggatggtgctggggcaccag
aggagcagccccggggcgggggcagaggccccccggggcgagggcagcctggctggagac
gcgcaggacaggtgcgaggagtggacccttgtcaccgagttccttgtggacggcgtgttt
tcccagagtgacgaccccgacagtgaaggcagcgaaggctccgatccggcgggaaagctc
gcacgctcgggcagcccgggcgggtctggccacctcctcgcctcgccgcgcccctgctac
ttgccccggcccctgcgccccgccctgccgcagggccccatcggggatcaggaggactcc
agggaggggagaaggagcgtcttgtcccccgaggaccccccgcggccctggggcagcctg
tcccccccgcccccggagacggggcgcatcacgtccttggacttgtcggccaacgagctg
caggacattgacgccctggcccagaggggcgggctcagcgctcacctggagcacctggaa
aggctggagctgcaccaaaacgcgctctcgggcctcccggcccagctgtgccaggtcctg
aggcgcctgacgcacctggacttgcacagcaacaaactcacgtccttcccggcccacgtg
ctgagcctgagccgcctggccttcctcgacgtgtccaggaacgacattggcccccgtgtg
ctgctggacccggcgttgtcctgcccggcactgcggcagctgagcctggcccacaaccgg
ctgagcagcgtgcccgagggcctgggcgccgtggccagcgggctgcagcagctggccctg
gaggggaacgagatagctgggacatgcccctgcctgtgcttgacggagctgagggcctta
aacctgagtaaaaaccacatctcggacctggcgggcggcttcctggaggcctgccccagg
ctggagagcttcagcgccagcatgaacctcctggccaccttgcccaccctgcccccctcc
ttgacgagcgtgaagctggcccagaacaggttcgcctgcgtcccggacgccctgctcagc
ctcccgcacctgcggtccttggacatgagcagcaacgagatccagagcctgccgggcccg
gcgcactggaagtcccagaacctgcgggagctgctgtttagccacaaccacatcagggtc
ctggacctgggcgacaaggcctgtgcctgggcccggctggagaagctgcacctggcccac
aacaggctgagggagctgccccccgagatcggctgtctgcagaacctggcctcgctggac
gtcagcggcaacgcggagctgcggtccttccccaacgagatggggaagctgagcaagatg
tgggacctgcccctggacgacctgcgcctggattttgatttcaagcgcgtcggctgcaga
gccaaggacatcatcaggttcctgcagcagcggctgaggaaagccgtgccctacagccgg
ctgaagctgctggtcgtggggaacgcgggcagcggcaagaccaccctgctgcggcagctg
atgagggcccggaaggccgaggccgcggcgcccggccccacggtgggcatcgacgtccgg
gactggccggtgcctgtgcgtggcaaggggaagcgcgacctggtgctcagcgtctgggac
ttcgcaggccgggaggagttctacagcgcccacgcccacttcatgaccccccgcgccctc
tacctggccgtgttcgacctcagcaaagggccggccgaggtggaggccatgaagccctgg
ctcttcaacataaaggcccgcgcctcggcgtcccccgtggtactcgtgggtactcacctg
gacatctgcgaggagggccagctgcaggcctgtgcagccagcgtggcccaggagctgctg
gggcggcggggcttcccggccgtgcggggctgccacttcgtcaacgccacgcaggactcg
gacgccctggccaagctgcgcacggccatcatcagggagagcctcggcttcaagatccgg
gccgagcccgtggtggggcagctggtccctgcctgctacgtggagctggagaggctcgtc
ctggcggagcgcaagagcatgccggccgagttccccgtggtcagccggcagcggctgctg
cagctcgtgagggagcagcagctgcagctggacgagagcgagctgccccaggccgtccac
ttcctcagcgagtcagggaccctccttcacttccaagaccccgcactgcagctggacgac
ctgtactttgtggaccccaagtggctctgcaaggcggtggcccagatcctgacggtgagg
acggaggggtacccgaagcacccccagggcatcgtgtcccgaagagacgtggagaagttc
ctcaccaagagaaggcgctttcccaagaagcacctgccgcagtacttcagcctcctggag
aagttccagctcgcactgcccctcggggaggacctcctgctggtgccaagcagcctgccc
ggccacacgccggtgatcgagctgccccactgcgagaactcggaggtcactgtgcggctg
tacgagacgccctgcttccccatgggcttctggccgcggctcatcaaccgtgtcctggag
atctcgccctacatgttgtccgggagagagcgcgcactgcgccccaacaggatgtactgg
cggcagggcgtctacctgagctggtcctccgaggcctactgcctggtgggcgccgaggcc
ccggacggccgccccgagagctgcctgcggatcaccgtcccctcctgcaggaaaggccgc
atcctgctgggccaggcggtggaccacatcgattcgctcctggaggagtggttcccgggg
ctgctggagacagacgtctgcggggacggggagacgctgctcaagaagtgggcgctgtac
agcttccgcgatggcgaggagccccagaggatcctgctggacgacctggcccgggaggca
gagcagggagacctcctggtcagcccagacgagccccggctcacggtgcccatcgcccag
atcgcgcccgacctgatgctggctgacctgcccaggagcatcgtgttgcgtcgtgaggcc
ctggagctccagcaggcgcccgagctgctcctgggcgacggcagcttcggctccgtgtac
cgcgcacgctacgacggggaggaggtggccgtgaagatcttcaacaagcacacgtcgctg
cggctgctgcggcaggagctggccgtgttgtgccgcctgcaccaccccagcctggtctcc
ctgctggcggccggcatccgcccgcgcatgctggtcatggagctggctggcaggggctcg
ctggaccggctgctggagcagggccccgccggcctcccccgcaccctgcagcaccggatc
gccctgcacgtggccgatggcctcaggtacctgcactcggccatgatcatctaccgggac
ctgaagccgcacaacgtgctgctcttcacgctgcaccccagcgcggccgtcattgccaag
atcgccgactacggcatcgcccagtactgctgccgcatgggcatcaagacctcagagggc
accccagggttccgcgcgcccgaggtggccaagggcaacgtggtctacaaccagcgggcg
gacgtgtactccctggggctgctgctctacgacgtcctgacggccggacgcaggatcgca
gaggggctgaagtttccaaacgagtttgatgagttggccgtacaaggaaagctgccggac
ccagtcagagagtacggctgcgccccgtggccgctggtcgagcagttgatcaagaagtgc
ctgaaggagaaccctcaggacaggcccacctctgcccaggtcttcgacagcctgacggcg
gccgagctggtctgcctcgcgagacacgtcccgctgcccggagacccgcaggccgagtgc
gcggcagcctggagccttggcggtgggcgcgtgggcgtctggctgggctgcgggcgggcc
agcagcgggcatctggccagcctggacctgcacacggaggcgctcacctcccaggaggtg
gcagatagccaggtcctctgcctggccctggtgcccctgccggccgaccaggacgtctgg
gttgtgtgcgggacccagtccggggcgctcctggctgtcaacgcccaggacggggagagg
aggcacgccctggggcgcatgacggatgccgtgacctgcatgtgctgcaaggccttctgc
gggcagagacaaagcagttttcttttggtgggaacggccgatggcaccttagtggttttt
gaagaccgagccgtcaagagcccgggagccgcccctctgcagacagtgactctgggggac
gccagcacccccctgctgtgcttgagcgaatccgcgaactcagctgaacggaacctggtg
tggggaggctgcgggaccagggtcttctcccttggccaggacctctccgtgcagacgctc
atcgagacccgcaccaggcagctgttctcctacggggcattcggcgaggccaacgtcaca
gctgtggtgggggacatggtgctctacgtggccaagcagagcagccccttcgtggaggtc
tgggaccagaagacccggaagctatgccagctcgtggactgtgcccactggttaagggag
gaggcggcaccaggaagcaaggactgcaggccctcagccacctacgtggggagggtgaag
gcgctgtgtctgcagaagaacacagccctgtgggtgggcaccggcggaggctgcatccta
ctgctggacctgtccacgcatcggctcatccggctcatccgcggtttctacgactccgtg
cgggtcatggtgaccgcacagctgggcaagtccccaggcttcttgcctggtccctctctc
tttttaaagattacatgtttacttgtttttgtcttcttgcacagtcgttcatttttgtac
agtgactggtttctcccccaggtgcggcccccacggtttttctaccaccacagcccccca
actgtcaccctgtcccttgagctcatccctcctgtcttctga
DBGET
integrated database retrieval system
