KEGG   Talpa occidentalis (Iberian mole): 119247132
Entry
119247132         CDS       T07495                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01522  Endocrine resistance
tod04010  MAPK signaling pathway
tod04015  Rap1 signaling pathway
tod04068  FoxO signaling pathway
tod04071  Sphingolipid signaling pathway
tod04114  Oocyte meiosis
tod04148  Efferocytosis
tod04218  Cellular senescence
tod04261  Adrenergic signaling in cardiomyocytes
tod04370  VEGF signaling pathway
tod04380  Osteoclast differentiation
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04611  Platelet activation
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04621  NOD-like receptor signaling pathway
tod04622  RIG-I-like receptor signaling pathway
tod04625  C-type lectin receptor signaling pathway
tod04657  IL-17 signaling pathway
tod04658  Th1 and Th2 cell differentiation
tod04659  Th17 cell differentiation
tod04660  T cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04668  TNF signaling pathway
tod04670  Leukocyte transendothelial migration
tod04714  Thermogenesis
tod04722  Neurotrophin signaling pathway
tod04723  Retrograde endocannabinoid signaling
tod04728  Dopaminergic synapse
tod04750  Inflammatory mediator regulation of TRP channels
tod04912  GnRH signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04917  Prolactin signaling pathway
tod04926  Relaxin signaling pathway
tod04932  Non-alcoholic fatty liver disease
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04935  Growth hormone synthesis, secretion and action
tod04936  Alcoholic liver disease
tod05014  Amyotrophic lateral sclerosis
tod05020  Prion disease
tod05022  Pathways of neurodegeneration - multiple diseases
tod05132  Salmonella infection
tod05133  Pertussis
tod05135  Yersinia infection
tod05140  Leishmaniasis
tod05142  Chagas disease
tod05145  Toxoplasmosis
tod05152  Tuberculosis
tod05161  Hepatitis B
tod05163  Human cytomegalovirus infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05169  Epstein-Barr virus infection
tod05170  Human immunodeficiency virus 1 infection
tod05171  Coronavirus disease - COVID-19
tod05205  Proteoglycans in cancer
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
tod05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119247132 (MAPK12)
   04015 Rap1 signaling pathway
    119247132 (MAPK12)
   04370 VEGF signaling pathway
    119247132 (MAPK12)
   04668 TNF signaling pathway
    119247132 (MAPK12)
   04068 FoxO signaling pathway
    119247132 (MAPK12)
   04071 Sphingolipid signaling pathway
    119247132 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    119247132 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    119247132 (MAPK12)
   04218 Cellular senescence
    119247132 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    119247132 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119247132 (MAPK12)
   04613 Neutrophil extracellular trap formation
    119247132 (MAPK12)
   04620 Toll-like receptor signaling pathway
    119247132 (MAPK12)
   04621 NOD-like receptor signaling pathway
    119247132 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    119247132 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    119247132 (MAPK12)
   04660 T cell receptor signaling pathway
    119247132 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    119247132 (MAPK12)
   04659 Th17 cell differentiation
    119247132 (MAPK12)
   04657 IL-17 signaling pathway
    119247132 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    119247132 (MAPK12)
   04670 Leukocyte transendothelial migration
    119247132 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    119247132 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    119247132 (MAPK12)
   04917 Prolactin signaling pathway
    119247132 (MAPK12)
   04926 Relaxin signaling pathway
    119247132 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    119247132 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119247132 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    119247132 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    119247132 (MAPK12)
   04722 Neurotrophin signaling pathway
    119247132 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119247132 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119247132 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    119247132 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    119247132 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    119247132 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119247132 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    119247132 (MAPK12)
   05161 Hepatitis B
    119247132 (MAPK12)
   05171 Coronavirus disease - COVID-19
    119247132 (MAPK12)
   05163 Human cytomegalovirus infection
    119247132 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119247132 (MAPK12)
   05169 Epstein-Barr virus infection
    119247132 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119247132 (MAPK12)
   05135 Yersinia infection
    119247132 (MAPK12)
   05133 Pertussis
    119247132 (MAPK12)
   05152 Tuberculosis
    119247132 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119247132 (MAPK12)
   05140 Leishmaniasis
    119247132 (MAPK12)
   05142 Chagas disease
    119247132 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    119247132 (MAPK12)
   05020 Prion disease
    119247132 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    119247132 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119247132 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    119247132 (MAPK12)
   05415 Diabetic cardiomyopathy
    119247132 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    119247132 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    119247132 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119247132 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    119247132 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119247132 (MAPK12)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     119247132 (MAPK12)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   119247132 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Pribosyltran_N Kinase-like DUF4287
Other DBs
NCBI-GeneID: 119247132
NCBI-ProteinID: XP_037369247
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARRGFYRQEVTSTAWEVRAEYRDLQPVGSGAYGAVCSAVDSRSGAKVAIKKLYR
PFQSALFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLM
KHEQLSEDRVQFLVFQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMLTGKTLFKGNDHLDQLKEIMK
VTGTPPEEFVQRLQSEEAKTYMESLPELEKKDFASILTNASPLAVNLLEKMLVLDAQQRV
TAAEALAHPYFESLRDAEDDPKAQKYDESSDDMDRTLDEWKRITYKEVLSFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctcgccgccgcccgcgcgccggggcttctaccgccaggaggtgaccagcacggcc
tgggaggtgcgcgccgagtaccgcgacctgcagcccgtgggctcgggcgcctacggcgcc
gtgtgctcggccgtggacagccgctccggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtccgcgctgttcgccaagcgcgcctaccgcgagctgcgcctcctcaagcac
atgcggcacgagaacgtgatcgggctgctggacgtcttcactccagacgagagcctggat
gacttcacggacttctacctggtgatgcccttcatgggcaccgacctgggcaagctcatg
aagcacgagcagctgagtgaggaccgcgtgcagttccttgtcttccagatgctgaagggg
ctgaagtacatccacgctgccggcgtcatccacagggacctgaagccgggcaacctggcg
gtgaacgaggactgtgagctgaagatcctggacttcggcctggccaggcaggcagacagc
gagatgaccgggtacgtggtcacccggtggtaccgggcgccagaggtcatcttgaattgg
atgcactatacacagacggtggacatctggtcggtgggctgcatcatggcggagatgctc
acgggcaagacgctgttcaagggcaacgaccacctggaccagctgaaggagatcatgaag
gtgaccggcacgccccccgaggagtttgtgcagcggctgcagagtgaggaggctaagacc
tacatggagagcctccccgagctggagaagaaggattttgcctccatcctgaccaacgcg
agtcctctggccgtgaacctcctggagaaaatgctggtgctggatgcgcagcagcgggtg
acggcggccgaggcactggcccacccctactttgagtcgctgcgggacgcggaggacgac
cccaaggcccagaagtacgacgagtcctctgacgacatggaccgcacgctggatgagtgg
aagcgtatcacgtataaagaggtgctcagcttcaagcctccccggcagctgggggccaaa
gtgtccaaggagacggccctgtga

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