KEGG   Talpa occidentalis (Iberian mole): 119250024
Entry
119250024         CDS       T07495                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod00562  Inositol phosphate metabolism
tod01100  Metabolic pathways
tod04015  Rap1 signaling pathway
tod04020  Calcium signaling pathway
tod04022  cGMP-PKG signaling pathway
tod04062  Chemokine signaling pathway
tod04070  Phosphatidylinositol signaling system
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04081  Hormone signaling
tod04082  Neuroactive ligand signaling
tod04261  Adrenergic signaling in cardiomyocytes
tod04270  Vascular smooth muscle contraction
tod04310  Wnt signaling pathway
tod04371  Apelin signaling pathway
tod04540  Gap junction
tod04611  Platelet activation
tod04613  Neutrophil extracellular trap formation
tod04621  NOD-like receptor signaling pathway
tod04713  Circadian entrainment
tod04720  Long-term potentiation
tod04723  Retrograde endocannabinoid signaling
tod04724  Glutamatergic synapse
tod04725  Cholinergic synapse
tod04726  Serotonergic synapse
tod04728  Dopaminergic synapse
tod04730  Long-term depression
tod04742  Taste transduction
tod04750  Inflammatory mediator regulation of TRP channels
tod04911  Insulin secretion
tod04912  GnRH signaling pathway
tod04915  Estrogen signaling pathway
tod04916  Melanogenesis
tod04918  Thyroid hormone synthesis
tod04919  Thyroid hormone signaling pathway
tod04921  Oxytocin signaling pathway
tod04922  Glucagon signaling pathway
tod04924  Renin secretion
tod04925  Aldosterone synthesis and secretion
tod04926  Relaxin signaling pathway
tod04927  Cortisol synthesis and secretion
tod04928  Parathyroid hormone synthesis, secretion and action
tod04929  GnRH secretion
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04934  Cushing syndrome
tod04935  Growth hormone synthesis, secretion and action
tod04961  Endocrine and other factor-regulated calcium reabsorption
tod04970  Salivary secretion
tod04971  Gastric acid secretion
tod04972  Pancreatic secretion
tod04973  Carbohydrate digestion and absorption
tod05010  Alzheimer disease
tod05016  Huntington disease
tod05017  Spinocerebellar ataxia
tod05022  Pathways of neurodegeneration - multiple diseases
tod05142  Chagas disease
tod05143  African trypanosomiasis
tod05146  Amoebiasis
tod05163  Human cytomegalovirus infection
tod05200  Pathways in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
Module
tod_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tod00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    119250024 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    119250024 (PLCB3)
   04310 Wnt signaling pathway
    119250024 (PLCB3)
   04371 Apelin signaling pathway
    119250024 (PLCB3)
   04020 Calcium signaling pathway
    119250024 (PLCB3)
   04070 Phosphatidylinositol signaling system
    119250024 (PLCB3)
   04072 Phospholipase D signaling pathway
    119250024 (PLCB3)
   04071 Sphingolipid signaling pathway
    119250024 (PLCB3)
   04022 cGMP-PKG signaling pathway
    119250024 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    119250024 (PLCB3)
   04081 Hormone signaling
    119250024 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    119250024 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119250024 (PLCB3)
   04613 Neutrophil extracellular trap formation
    119250024 (PLCB3)
   04621 NOD-like receptor signaling pathway
    119250024 (PLCB3)
   04062 Chemokine signaling pathway
    119250024 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    119250024 (PLCB3)
   04922 Glucagon signaling pathway
    119250024 (PLCB3)
   04929 GnRH secretion
    119250024 (PLCB3)
   04912 GnRH signaling pathway
    119250024 (PLCB3)
   04915 Estrogen signaling pathway
    119250024 (PLCB3)
   04921 Oxytocin signaling pathway
    119250024 (PLCB3)
   04926 Relaxin signaling pathway
    119250024 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    119250024 (PLCB3)
   04918 Thyroid hormone synthesis
    119250024 (PLCB3)
   04919 Thyroid hormone signaling pathway
    119250024 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    119250024 (PLCB3)
   04916 Melanogenesis
    119250024 (PLCB3)
   04924 Renin secretion
    119250024 (PLCB3)
   04925 Aldosterone synthesis and secretion
    119250024 (PLCB3)
   04927 Cortisol synthesis and secretion
    119250024 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119250024 (PLCB3)
   04270 Vascular smooth muscle contraction
    119250024 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    119250024 (PLCB3)
   04971 Gastric acid secretion
    119250024 (PLCB3)
   04972 Pancreatic secretion
    119250024 (PLCB3)
   04973 Carbohydrate digestion and absorption
    119250024 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    119250024 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    119250024 (PLCB3)
   04725 Cholinergic synapse
    119250024 (PLCB3)
   04728 Dopaminergic synapse
    119250024 (PLCB3)
   04726 Serotonergic synapse
    119250024 (PLCB3)
   04720 Long-term potentiation
    119250024 (PLCB3)
   04730 Long-term depression
    119250024 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    119250024 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    119250024 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    119250024 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    119250024 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119250024 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    119250024 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119250024 (PLCB3)
   05142 Chagas disease
    119250024 (PLCB3)
   05143 African trypanosomiasis
    119250024 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119250024 (PLCB3)
   05016 Huntington disease
    119250024 (PLCB3)
   05017 Spinocerebellar ataxia
    119250024 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    119250024 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119250024 (PLCB3)
   05415 Diabetic cardiomyopathy
    119250024 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    119250024 (PLCB3)
   04934 Cushing syndrome
    119250024 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tod04131]
    119250024 (PLCB3)
Enzymes [BR:tod01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     119250024 (PLCB3)
Membrane trafficking [BR:tod04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    119250024 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    119250024 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 119250024
NCBI-ProteinID: XP_037373555
LinkDB
Position
Unknown
AA seq 1220 aa
MAGARPGVHALQLEPPAVGETLRRGSKFIKWDEETSSRNLVTLRVDANGFFLFWTGPNME
VDMLDISSIRDTRIGRYARMPKDPKLREVLGFGGPEARLEERLMTVVAGPDPVNTAFLNF
IAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDGFTLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARQLIEKYEPNKQFLERDQMSMEGFSRYL
GGEENGILPLETLDLSADMTQPLSSYFINSSHNTYLTAGQLTGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRTIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSSSVPDS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCTGLSNGEEVGLEKPSLELQKSLGE
EGLLQGPDVLGPADREDEEEDEEEEEQSDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRRYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRANQLAALIGENEDQAGPETCQATESQQL
GSQLCPNPAPSTPDASPRRPPCTVTSPSSPSLSSPGQRDDLIASILSEVGPASLEEHRGH
KSLLKLQSRQERDLRELLKKHQRKAAALTRRLLDILAQARARSVQGKENEEDVGKRFLEF
QKKQVQTLLELREAQAVTEAERRLEHLKQAQQRIREIVHDAHATQLKKLKETSEREKKEL
QKILDRKRHNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLLAGQ
QQVLQQLAEEEPKLRAQLVRECEEQRARLPQEIRRSLLGETPEGLGDGPLVACASNGHAP
GSSGHLSGADSESQEENTKL
NT seq 3663 nt   +upstreamnt  +downstreamnt
atggcaggcgccaggcccggcgtccacgctctgcagctggagccgcccgcggtgggggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgcgtggacgccaatggcttcttcctgttctggacgggacccaacatggag
gtggacatgctggacatcagctccatcagggacacaaggattggccgttacgcccgcatg
cccaaggatcccaagctccgggaggtgctgggctttggtggccctgaggcccgactggag
gagaggctgatgacggtggtggctgggccagacccagttaacacagcattcttgaacttc
atagccgtgcaggacgacacagctaaggtctggtccgaggagctgttcaaactggcaatg
aacatcctggcccagaatgcctcccggaacacctttctgcgcaaagcatacacgaagctg
aagctgcaggtgaaccaggatggacgcatccctgtcaagaacatcctgaagatgttttca
gcagacaagaagcgagtagagacagcactggaatcctgcggcctcaatttcaaccggagt
gagtccattcggcctgatggatttaccttggaaatctttgaacggtttttgaacaagttg
tgtctccggccggacattgacaagatcctgctagagataggggccaagggcaagccgtac
ctgacgctggagcagctcatggacttcatcaaccagaaacaaagggacccgaggctcaac
gaagtgctctacccgcccctgcggccctcccaggcccggcagctcatcgagaagtacgaa
cccaacaagcagttcctggagcgggatcagatgtccatggagggcttcagccgctacctg
gggggcgaggagaatggcatcctgcccctggagaccctggacctgagtgcggacatgacc
cagccgctgagctcctacttcatcaactcctcccacaacacctatctcacggccgggcag
ctgacggggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgc
gtggagctggacgtgtggaaagggcgtccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccaccgaggtgccgctgcgtgacgtgctggaggccatcgcggagactgcc
ttcaaaacgtcgccctaccctgtcatcctctcctttgagaaccacgtggactcggccaag
cagcaggccaagatggcggagtactgccgcaccatctttggggacgcgttgctcattgac
cccctggacaagtacccgctggccccgggcgtccccctgcccagcccccaggacctgatg
ggccgaatcctggtgaagaacaagaagcggcaccggcccagctccagcgtccctgacagc
tccgtgcgcaagaggcctctagagcagagcaactccgccctgagcgagagctccgcggcc
accgagccctcctccccccagctggggtctcccagctctgacagctgcacaggcctgagc
aacggggaggaggtgggccttgagaagcccagcctggagcttcagaagtctctgggggaa
gaagggctgctgcagggccctgatgttcttggacctgctgaccgtgaggatgaggaagaa
gatgaggaagaggaggaacagtcagaccctaaaaagccaaccacggatgagggcactgcc
agcagcgaggtcaatgccacagaggaaatgtcgacactcgtcaactacattgagccagtc
aagttcaagtcctttgaggctgctcgaaagaggaacaagtgcttcgagatgtcatccttc
gtggagaccaaggccatggagcaactgactaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcatccaactacatg
ccccagctcttctggaacgtgggctgtcagctcgttgcgctcaacttccagaccttggac
gtgcccatgcagctcaacgcgggcgtgtttgagtacaatggacgcagcggctacctgctc
aagccggagttcatgcggcggcccgacaagtccttcgaccccttcaccgaggtcatcgtg
gacggcatcgtggccaacgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgttcggcctcccggtcgacacccggcgc
cggtaccgcactcggacctcccagggcaactccttcaaccctgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcccacactggcctcactgcgcatcgcagcctttgag
gaggggggcaagttcgtggggcaccgaatcctgcccgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgctcatc
tataccgaggcatccgactacatccccgatgaccaccaggactacgctgaggccctgatc
aaccccatcaagcacgtcagcctgatggaccagagggccaatcagctggccgcccttatt
ggggagaatgaggatcaggctggcccggagacctgccaggcgaccgagtctcaacagctg
gggtcccagctatgccccaatcctgcgcccagcacgccggatgcctctccccgccggccc
ccgtgcactgtcacctcccccagcagtccctccctgagcagcccagggcagcgggacgac
ctcattgccagcatcctctcagaggtgggccccgcctcactcgaggagcatcgcggccac
aagtctctgttgaagctccagagccggcaggagcgagacctacgggaactgctcaagaag
caccagcgcaaggctgcggccctcactcgccggctgctcgacatcctggcccaggcgcgg
gcccggagtgtccaaggtaaagagaacgaggaggacgtggggaagcggtttctagagttc
cagaagaaacaggtacagactctgctggagctgagggaggcccaggcagtcacagaggct
gagcggaggctagagcacctgaaacaggctcagcagcggatcagggagattgtccacgat
gcacatgccactcaattaaagaagctgaaggaaacgagcgagagggagaagaaggagcta
cagaagatcctggacaggaagcgccacaacagtatctcggaggctaagacgagggagaaa
cataagaaggaggtggaactgaccgagattaatcgccggcacatcacggagtcagtcaac
tccatccgtcggctggaggaggcccagaagcagcggcacgaacgcctcctggccgggcag
cagcaggtccttcagcagctggcggaagaggagcccaagctgcgggcccagctggtccgg
gagtgtgaggagcagcgggcgaggctgccccaggagatccgccggagcctgctaggcgag
acgccagaggggctgggggacgggcctctagtggcctgtgccagcaacggtcacgcaccc
gggagcagcgggcacctgtccggcgccgactcggagagccaggaggagaacacgaagctc
tga

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