Treponema pallidum subsp. pallidum Nichols: TP_0386
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Entry
TP_0386 CDS
T00016
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF)
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
tpa
Treponema pallidum subsp. pallidum Nichols
Pathway
tpa00300
Lysine biosynthesis
tpa00550
Peptidoglycan biosynthesis
tpa01100
Metabolic pathways
tpa01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
tpa00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
TP_0386
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
TP_0386
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
TP_0386
Enzymes [BR:
tpa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
TP_0386
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GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
SecD_1st
Motif
Other DBs
NCBI-ProteinID:
AAC65370
UniProt:
O83401
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Position
410125..411504
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AA seq
459 aa
AA seq
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MLLSFDEVCAAVQGARVCDARGARGFDGVSFDSRAVVPRDLFIPLRGAHVDGHTFVEEAL
QKGAVATLIDQRYPHAGEYVAWCTRFGAACIAVHDTLRALQDLASFYCKKFPALIRIGIT
GSSGKTTVKEMARAVFSERYRVVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGE
MRTLAQILVPHYAIITNVGCAHVGILGTQQAIAEEKKEIFSQFTEHSVGFVPDDAYRVFL
SNIPYGRVVVYDQGGRGLATEVIDEGLRGSRVLYQGRWIRVPLPGVHNAKNALAVIALAA
QVGLPAEEIQRGMERVKPPFGRSHVVCASLTFLLDCYNANPDSMAAALHLCAHISAVSKV
YVLGDMGELGVTAAEAHYRVCVLAAASDARAVYVFGPEFCRAVRKVSWGRKRVYAFALEE
LSALQETLDAQLRRGDFVLVKGSRSVALERLEPLLRKER
NT seq
1380 nt
NT seq
+upstream
nt +downstream
nt
atgcttctgagttttgatgaggtatgtgcggcagtgcaaggggctcgcgtgtgcgatgca
cgaggggcgcgcggttttgacggggtttcctttgacagtcgtgcggttgtgccgcgtgat
ttgtttattccgctccgtggtgcgcacgtagatggacatacgtttgttgaagaagcgctg
cagaagggcgcagttgcaacgcttatagatcaaaggtacccccatgctggggaatatgtt
gcttggtgcactcgctttggagctgcctgtattgcggtgcacgacacgctcagggcgctg
caagatcttgcctccttttactgcaaaaagtttcctgcgcttattaggattggcattacc
ggatcaagcggaaagacaaccgtaaaagaaatggctcgcgcggtgttcagtgaacggtat
cgggtggttgcgacgccaggaaatttaaattcagagataggtttaccgcagtcgctgttt
tttgtgcgtgcagaacatgaggtaggaatctttgagctggggatgaatcgtcggggggag
atgcgtacgctcgctcagatacttgttcctcattacgcgatcattaccaacgtaggttgt
gcgcacgtaggcattctgggcacgcagcaggcaattgcggaagagaaaaaagagattttt
tctcaatttactgaacacagcgtgggttttgtccccgacgatgcatatcgtgtattcctg
tctaatatcccgtacggtagggttgtagtttacgatcagggggggcgtggtctagcaact
gaggtgatagatgagggtttacgtggttctcgcgtgttatatcaaggacgatggattcgc
gtgccactacctggggtgcataacgcaaagaatgcgcttgcagtgattgcgcttgccgca
caggtaggacttcctgctgaggaaattcagcgggggatggagcgggtaaaaccgcccttt
ggccgctctcatgtggtgtgtgcgtcgctgacctttttgctcgattgttacaatgcgaat
cctgattcaatggctgcggcgcttcatttgtgtgcgcatatttctgcagtatcaaaagta
tatgtgctcggtgacatgggagagctaggagttaccgctgccgaagctcactatcgggtg
tgtgttttggcagccgcttctgacgcgcgtgcagtgtatgtgtttggtcccgaattttgt
cgtgcggtaagaaaagtttcctgggggaggaagcgcgtgtacgcctttgcactagaggaa
ctgtctgcgctgcaagaaacgttagacgcgcaattacggcggggtgattttgttctggtg
aaaggttcacgcagtgttgcgctcgagcggcttgaacctcttttgaggaaagagcgatga
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