Treponema pallidum subsp. pallidum Nichols: TP_0670
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Entry
TP_0670 CDS
T00016
Name
(GenBank) D-alanine--D-alanine ligase (ddlA)
KO
K01921
D-alanine-D-alanine ligase [EC:
6.3.2.4
]
Organism
tpa
Treponema pallidum subsp. pallidum Nichols
Pathway
tpa00470
D-Amino acid metabolism
tpa00550
Peptidoglycan biosynthesis
tpa01100
Metabolic pathways
tpa01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
tpa00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00470 D-Amino acid metabolism
TP_0670
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
TP_0670
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
TP_0670
09180 Brite Hierarchies
09181 Protein families: metabolism
01011 Peptidoglycan biosynthesis and degradation proteins [BR:
tpa01011
]
TP_0670
Enzymes [BR:
tpa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.4 D-alanine---D-alanine ligase
TP_0670
Peptidoglycan biosynthesis and degradation proteins [BR:
tpa01011
]
Precursor biosynthesis
Amino acid ligase
TP_0670
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Gene cluster
GFIT
Motif
Pfam:
Dala_Dala_lig_C
Dala_Dala_lig_N
ATP-grasp
CPSase_L_D2
ATPgrasp_ST
Motif
Other DBs
NCBI-ProteinID:
AAC26568
UniProt:
O83676
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Position
complement(734274..735464)
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AA seq
396 aa
AA seq
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MVHVTLLYGGRSAEHDVSVRSARFVARTLCLQHTVMLIGITRRGVWYAQPACALEQLCTG
TVALSIQEDEKRRVCLVPGGGTAGAFVIAGMPCVTDVVFPVLHGSYGEDGTVQGLLEMLQ
VPYVGCGVCASALAMDKVKAKMLWQAAGLPVLPFVFFRKDAWRMHMQEFVAQLETRLGYP
LFVKPAQAGSSVGASAVQTRAPLIPAIEAAFQWDEVVLVERYVRAREIECALSGNGPYTV
HGAGEVIAQGAFYDYEEKYADASVARVLVTAPLETAQYEQITTLALRAYEALGLTGLARV
DFFLLETGEVYVNEVNTMPGFTSISLFPQICQAAGVAPQDLMAQLLSCARERFAARAALS
TDLHAHVCAPSVTAAHDPDAQGDDWDQRDSNPLPTA
NT seq
1191 nt
NT seq
+upstream
nt +downstream
nt
gtggtgcatgtgacgcttttgtacggaggccgttctgcagagcacgatgtttctgtacgt
tctgcacgttttgtggcgcgcacgttgtgcttacaacacaccgtaatgctcatcggtatt
acccgtcgtggcgtgtggtatgcgcagcctgcgtgtgcattagagcagttgtgtaccggc
actgtcgcgctcagtattcaggaagatgaaaagaggcgcgtgtgtcttgtcccgggaggt
ggtactgcaggcgcttttgtcatagcggggatgccgtgtgtcacggatgtggtattcccc
gtattgcatggcagttatggggaagatggtacggtgcagggtttgcttgagatgctgcag
gtgccgtacgtggggtgtggagtgtgtgcaagtgctcttgcgatggataaggtaaaggca
aagatgctatggcaggcggcgggacttcccgttttaccgtttgtctttttccgtaaagat
gcatggcgtatgcatatgcaagaatttgttgcgcagcttgaaacacgccttggctatcct
ctttttgtaaagccagctcaagcaggcagttccgtaggagccagtgcagtgcagacgcgt
gcaccgcttatccctgcgattgaagcggcttttcagtgggatgaagtggtgttggtggag
cgatatgtgcgcgcgcgagaaattgaatgtgcgctcagtgggaacggaccctatactgta
catggggcaggagaggtgattgcgcagggagccttttatgactacgaggaaaaatatgct
gatgcaagtgtcgcgcgtgtactcgttacggctcctcttgagactgcccagtacgaacag
attaccacacttgccctgcgcgcatacgaagcattaggactcacgggtctggcgcgggtt
gatttttttctgttagaaacgggagaagtatatgtgaacgaagtaaacacgatgccgggt
tttacgtcgatatcactctttccccaaatatgtcaggctgcaggtgttgcaccgcaggac
ttaatggcacaactcctttcttgcgcacgagagcgctttgcagcgcgcgccgcactgagc
accgacttgcacgcccacgtgtgtgcgccctcggtgactgctgcacatgaccccgatgcg
caaggggacgactgggaccagagggactcgaaccccctccctactgcttag
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