Treponema pallidum subsp. pallidum SS14: TPASS_0386
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Entry
TPASS_0386 CDS
T00716
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
tpp
Treponema pallidum subsp. pallidum SS14
Pathway
tpp00300
Lysine biosynthesis
tpp00550
Peptidoglycan biosynthesis
tpp01100
Metabolic pathways
tpp01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
tpp00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
TPASS_0386 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
TPASS_0386 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
TPASS_0386 (murF)
Enzymes [BR:
tpp01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
TPASS_0386 (murF)
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GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
SecD_1st
Motif
Other DBs
NCBI-ProteinID:
ACD70812
UniProt:
A0A0H3BJ28
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Position
411305..412684
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AA seq
459 aa
AA seq
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MLLSFDEVCAAVQGARVCDARGARGFDGVSFDSRAVVPRDLFIPLRGAHVDGHTFVEEAL
QKGAVATLIDQRYPHAGEYVAWCTRFGAACIAVHDTLRALQDLASFYCKKFPALIRIGIT
GSSGKTTVKEMARAVFSERYRVVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGE
MRTLAQILVPHYAIITNVGCAHVGILGTQQAIAEEKKEIFSQFTEHSVGFVPDDAYRVFL
SNIPYGRVVVYDQGGRGLATEVIDEGLRGSRVLYQGRWIRVPLPGVHNAKNALAVIALAA
QVGLPAEEIQRGMERVKPPFGRSHVVCASLTFLLDCYNANPDSMAAALHLCAHISAVSKV
YVLGDMGELGVTAAEAHYRVCVLAAASDARAVYVFGPEFCRAVRKVSWGRKRVYAFALEE
LSALQETLDAQLRRGDFVLVKGSRSVALERLEPLLRKER
NT seq
1380 nt
NT seq
+upstream
nt +downstream
nt
atgcttctgagttttgatgaggtatgtgcggcagtgcaaggggctcgcgtgtgcgatgca
cgaggggcgcgcggttttgacggggtttcctttgacagtcgtgcggttgtgccgcgtgat
ttgtttattccgctccgtggtgcgcacgtagatggacatacgtttgttgaagaagcgctg
cagaagggcgcagttgcaacgcttatagatcaaaggtacccccatgctggggaatatgtt
gcttggtgcactcgctttggagctgcctgtattgcggtgcacgacacgctcagggcgctg
caagatcttgcctccttttactgcaaaaagtttcctgcgcttattaggattggcattacc
ggatcaagcggaaagacaaccgtaaaagaaatggctcgcgcggtgttcagtgaacggtat
cgggtggttgcgacgccaggaaatttaaattcagagataggtttaccgcagtcgctgttt
tttgtgcgtgcagaacatgaggtaggaatctttgagctggggatgaatcgtcggggggag
atgcgtacgctcgctcagatacttgttcctcattacgcgatcattaccaacgtaggttgt
gcgcacgtaggcattctgggcacgcagcaggcaattgcggaagagaaaaaagagattttt
tctcaatttactgaacacagcgtgggttttgtccccgacgatgcatatcgtgtattcctg
tctaatatcccgtacggtagggttgtagtttacgatcagggggggcgtggtctagcaact
gaggtgatagatgagggtttacgtggttctcgcgtgttatatcaaggacgatggattcgc
gtgccactacctggggtgcataacgcaaagaatgcgcttgcagtgattgcgcttgccgca
caggtaggacttcctgctgaggaaattcagcgggggatggagcgggtaaaaccgcccttt
ggccgctctcatgtggtgtgtgcgtcgctgacctttttgctcgattgttacaatgcgaat
cctgattcaatggctgcggcgcttcatttgtgtgcgcatatttctgcagtatcaaaagta
tatgtgctcggtgacatgggagagctaggagttaccgctgccgaagctcactatcgggtg
tgtgttttggcagccgcttctgacgcgcgtgcagtgtatgtgtttggtcccgaattttgt
cgtgcggtaagaaaagtttcctgggggaggaagcgcgtgtacgcctttgcactagaggaa
ctgtctgcgctgcaagaaacgttagacgcgcaattacggcggggtgattttgttctggtg
aaaggttcacgcagtgttgcgctcgagcggcttgaacctcttttgaggaaagagcgatga
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