Tsukamurella paurometabola: Tpau_2650
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Entry
Tpau_2650 CDS
T01228
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanylligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
tpr
Tsukamurella paurometabola
Pathway
tpr00300
Lysine biosynthesis
tpr00550
Peptidoglycan biosynthesis
tpr01100
Metabolic pathways
tpr01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
tpr00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
Tpau_2650
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
Tpau_2650
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
Tpau_2650
Enzymes [BR:
tpr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
Tpau_2650
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
ADG79250
UniProt:
D5USH9
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Position
complement(2753466..2754998)
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AA seq
510 aa
AA seq
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MIELTLAQIADIVGGTLHDVPDPQATVTGTVEFDSREIGSGDLFLALPGARVDGHDFAAT
AIEKGAVAVLGARPVGVPAIVVPVSGETDNRVMALESDTDGAGAAVLTALGDLAAYCTKS
LAADGLTVVGVTGSAGKTSTKDLIAAVLRPLGETVAPPGSFNNEIGHPWTALRATASTKF
LVLEMSARGEGHIAALAKLAPPRIGVELNVGTAHLGEFGSREAIARAKGELVEALPVDGV
AVLNADDAAVAAMASRTAARVVFYGTAEAQVRATDVVLDAHARAAFTLHTAGGTAPVALK
VHGEHQVHNALASAAVGLECGATTAQVAEALSGAGAASPRRMDVFTTDGGVTVVNDTYNA
NPDAMRAALRSLVLMSEHDEAGERLPGRDRRRTFAVLGEMGELGEESILEHDRLGRFLVR
LDITSTICVGSSRAVHALWQGAVMEGSWGSEAIRVDTRAEAVERLRAELRPGDLVLVKAS
KSEKMWEVAESLGSAGNAENEENMQGESPK
NT seq
1533 nt
NT seq
+upstream
nt +downstream
nt
atgatcgagctgaccctggcgcagatcgccgatatcgtcggcggcaccctgcacgatgtg
cccgacccgcaggcgacggtgaccggcaccgtcgaattcgactcgcgcgagatcggttcc
ggcgatctgttcctcgctctgcccggcgcccgcgtcgacgggcacgacttcgccgcaacg
gcgatcgagaagggcgcggtcgccgtgctcggtgcccggcccgtgggcgtcccggcgatc
gtggtgcccgtctcgggcgagacggacaaccgggtcatggccctggagagcgataccgac
ggcgccggcgccgcggtgctcacggccctgggtgatctggccgcgtactgcacgaagtcg
ctcgcggcggacggcctgaccgtggtcggcgtgaccggttccgcgggcaagacctccacc
aaggacctgatcgccgctgtgctccgcccgctcggcgagaccgtcgcgccgcccggctcg
ttcaacaacgagatcggccacccgtggaccgccctgcgtgccaccgcgtcgacgaagttc
ctggtcctggagatgtcggcccgcggcgaaggacacatcgccgcgctggcgaagctcgcg
ccgccccgcatcggcgtcgagctcaacgtgggtaccgcgcacctcggggagttcggttcc
cgcgaagccatcgcccgtgccaagggcgaactggtcgaagcactcccggtggacggtgtg
gcggtgctcaacgccgacgacgctgcggtcgccgccatggcgtcccgaacggcagcgcgg
gtggtcttctacgggaccgccgaggcgcaggtgcgtgcgaccgacgtcgtgctcgacgct
cacgcccgtgcggccttcacgctgcacaccgcgggcggcaccgcgccggtggcgctcaag
gtgcacggcgaacaccaggtgcacaatgcgctcgcgtccgcggcggtcggcctggaatgc
ggcgccacgacggcgcaggtcgccgaggcgctgtccggcgccggcgccgcatcgccgcgc
cggatggacgtcttcaccaccgacggcggcgtcaccgtggtcaacgacacctacaacgcc
aatcccgatgcgatgcgggccgcgctccgcagcctcgtgctcatgtccgagcacgacgag
gcgggggagcggctgcccggccgggatcgccgccgcaccttcgcggtgctcggcgagatg
ggtgaactgggagaggagtcgatcctcgaacacgaccggctcgggcggttcctggtgcgc
ctggacatcacctcgaccatctgcgtcggttcttcccgtgcggtgcacgccctctggcag
ggcgctgtgatggaggggtcctggggcagcgaggcgatccgggtggacacccgcgcggag
gccgtcgaacggctccgtgcggagctgcggcccggcgacctggttttggtgaaggcctcc
aagtccgagaagatgtgggaggtcgccgagagcctcgggtcggccgggaatgcggagaac
gaagagaacatgcaaggggagtcaccgaagtga
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