Thalassiosira pseudonana: THAPS_23587 Help Entry THAPS_23587       CDS       T01078                                  Name (RefSeq) predicted protein   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism tps  Thalassiosira pseudonana Brite KEGG Orthology (KO) [BR:tps00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:tps04121]     THAPS_23587 Enzymes [BR:tps01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      THAPS_23587 Ubiquitin system [BR:tps04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     THAPS_23587 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_ITPR Proteasom_PSMB Motif Other DBs NCBI-GeneID:  7450721 NCBI-ProteinID:  XP_002296305 JGI:  23587 UniProt:  B5YNP1 LinkDB All DBs Position 7:complement(1613200..>1629156) Genome browser AA seq 4773 aa AA seqDB search MPTLRSKRKRGNQNDDESASAAAAVSGNGTSGMDNDVAGEAEGVVVEAEARQSDKTEKKP KAKTSKGKKKSNDVTFVSNEQSTNPPEEESTTATTTTNNLTAIMTNNPSLLSNLLLEIQS LSNDKKRCTAALQALKDGKDIAMPLSTLGEDEDDDASTTALGDTKLSRGKKRGASGGDKK SSVHKDPFEEGDDNNNDSNSNTNDHSASNDAHLIMAVTQAINILISFVKTQKQASVATTN ASSSSQDATSNEEYKDASIILTALSHHLTTSLVNDKSMLESITKSSQYSYSTLNSLSSLG GGVNSPPSVFGSGLRSMEDVIDIDDPSSTSFSGRGAARGSSTRGGGATSPERGLQQQQAK KLILANAKAVAGRGLASAVMGVLYAMETLGEVCFMDGEDSVTGDAAVGKSDGSEKEEEAK GGDSKNMERTMLRKAVWTSLLTLEASFQLSVRPKLLMVSAVTVPTTGMSSMSASTSSSMM DFDGMLSGVGTAGQGSSSNVPWSHAHTMMGSDTIAMWNGFVQRIMADYKIGFHQMEGLGE GMSELKEENKQLVQLCSKVANSAFSSSEDVEFITLVLGSKGGEAAAAAASNPEPPAKKAK KGTRKTKQPDKRDEREEELAELSSLLARRPENLILFDCHVSVRRWAVLAFGWLCKGQRRL LETCTTLLARRAEWEKVMELAPLNGKLVASLGATEDPVVSSVASKKKKKKKDPKSKRSSA KGSPSDDLEGLPGSVALVTFVSCMVDVIYDAGATGGLTPPTSGWMDEYVNLIADTPCLPI SAASSAASALAAAPASPRKEEAPVRRTTRARATKATSKALGRSSPKGAKKPPTSPSNRVW VRPDVRDETALLTKYLIECHDRSLQDSFGRYLGRSGLTQAVDLFSLDWKLIINDDDSFHH PLLPKHISGTSSSLSFYPFMHRTLDTLGRTAASSSLFASSDGKSRIMAIGGAIALSRFHQ NYQSFTSVVMDAKLISSSVMQISDCLANESRNNDVGASAKESDTEETTTGIPECIVQSYL LNEPLVVARVDKKEEDEEGKGASFSSYGGVFSTSSESGDSDAGSKSSFRVQKGPELSQYA EILSCFIRANRAYALSASTASYVTGISSLLDSLFSVTLCCYNFQSSTQIFDAVSHSSKKR ASVSKKKKRKADGVSTTTASQESIARKTLSRCVLASDALNVIRGCLASSQELVPSSSTKE SESRCIRSFFRQVISTDNIIDFVHLGYALEDNLVYPRLVHSIGECAAPGTSLPENLKIYE LWERRLWSSHVKLGLTIGRGQAAYQPQKNNSLLGNGGRRLTIFQIIANIEQERQTNIVKG GKKSASRSNERWPLFLPAVQHALVSSTMSCDSNSAQRNTDDQADLFLCNAFLNSVEAFMN DLSCLPPIGSRHALLLDYQSTSPMVVNDNVMMSLQNARLFALAVGRVSQGHQKTIRSRLI DSLQTGFANANAQEPLNVNASRFLSRMLSVASFIVDIVSIPALLPPLSREVGSEHYCLPR VVRKQSADGERSESTQDVCFMGLFGDCHSPSVPASDISVTDYKVLPDGDFNKMLTAIKCG LTLGFTMANKDGGHLLFSSWNAAAKLTSWTSITWEGPETATIVKEKASIDRLIGLRDDLC EVNFLVNGADPSTEQTLLVKLTSNKRGQCRKNEALLSGITSCEKMLGNTTLEITKGAALV PSLPAFAYYEALPVYVSFLISMHTRPGTSNTSSILRFQPSQLQRTHHVSGYTDGDVIDEF PSDDSDMEHEESGGNAVRMNALARLRDACETLGAAPCFPDWLDTSCRMQEGIIPPIAVDS ADRCLAELTNFGAAAFKCYFTSLGRILELSVQDGMSFPSSLVLQILAAQQHAMNGTSGEA LFVHLSTLCRVESALLKHFSSNSHFLVGNIFAEHASQRVKGAVAAGGWEPTSGEYRANGQ WETLIGETLRGSSLEVITSYMFPGEQDVNKEMKSAVLAANHWQRVLCSVVNAMVPTAALL RFGVNDGKGRSPHPLCEDLVPGSALSSDGNREGFSRFSTKNEVGATLKKALSFLSCVSAY SAVDEDMILTAQAAASHLLDNAAHFDDLVSLWVIRICCDAIGGVVTALTTSNLSESQISS ATALIESTLKQFSSNSQNILDDEIPDPTDLDAAFDHGVNSDDYIDNDKAKKLLACFGLSG GVLTGRIIGNRTDIELTSILAKGEDIYPIKIESGGVFGQWGSSQKGVAKLWLECLGRVPL GRRARIFVAGSLLHDVFEAETTFLKNKVGSPLVRTLSAVALDSMTKDDVLLILEDICQTA DVSEESMEDDEREEERNELTQKFGVLHEVGSAIISLALREKDGNDVSPCIQSYFEFAAAL NGLANPSTRSSQLPPVSNGSAGQQKEKISEETVRALYEESSPVVDRTDVSTHQSDGFTNT LAESVFKRFPGEVKRSLQLLVEEAQTAEWNTSILTLFNNNYEKKPPASLDFSTIFSSTTP DSDASHGLLNLDSRRGSPLLLTPLVGTTILPLRAAKMNALKPRVNPLSAASHIRKVRTEG QLIASDDRGRLVCAESSSLLFFSGIACTNVRHIELSAAKHLTRSQLNVGGSERLKFEIYG IALCPENNRHLISWGASKACVNVLSKGFDSVERTIDLTLQLEPSECESEYLLELLWMTET IVIAICGTVIHVFDLKKTENDTCKATAHFVLAYEDVLIRSATFTSITLSDSGIQTKLAIL LDTGRLHFIQMSVDKNGHLEEQGETYIEIGSGASFSSAGICRYVGGEPIGAGSVSTTFGE GSTLKFLHQSNVMLYQCVSSCCIAMIIEKDGTIKGTFELLPNMISSDTLGAHFGVQGPYS QFNELGVVQKGGEAFYRLACVGKSTKSSQPRVLLVEFNSNSVYTKEVNWPGNCSGGLGYT ASHNFVGSCTFSVPYLVGGTAEEGHVGDDTKVYERAFLTMLSSNGSLLFFGEDCDIPSIH HTPAKLPTPDVYMFEKDDIFNVSEDSNLILGGDCVGKDPKSAKKKLSLNNNEFIISPSRD GCTLTARLQRNGALVRGGSSKTGGKTSSFAIVAVRVLVGSMPELVPREITIMGGRSIKTK RNAKRWYDFPLTDEEILLAIRNDSVTVHFSSSHDLTSSSSIDSVEVYVRAREDLQFLAAG TGSEQKTPATSLTIWPPADGDEEISTVSYVQSLTFLSKILGHNNMRSLSAGSKAMIKYII EQTALNSSEKGSLREETLSLLNEVVSDESQRSQFVDDSTIRGLMSVLIALGTYVKTDLST ISFNPSKHETMINGAIEVLTHIIINATSIAEARGENYRKAIIDLIAEKVSRASIAIEGKR VLDYLAHLSLLHGRTIQILSASESISRLILCEMACTESNDFGQFEALSEYLVHDDPSMVQ ACCKAVLEAAETTEGEQVFPSEVSDVQNHDHLSYVTYQCDSCKLFPITKQRYTIGGEVDV DLCRECFNLGCAYAAEHESGSPLVIRGSTLSVEDEEMTCDQIWQMKAITIPASSDDNSVD KSALEDALKLSQSKKGANANAATPHPSSKTFSTNTEAFRSQIFTRLLGLIARSLRTTDQE APPSYQLLQLALTLVLNSSTEKLRVARGNQLVHSFSSHIPTLVQSGQNEASCKKLVVCLR TLAALVTQKGYIESSPPVTSEKNKHLEDTQGHHHKDKTDPRFVCEVHGVPAVRRRCSHGV HKDRRFYVCGLEWADLPESVPNQSRKSHDDILATKHTDHIFVPIQTELLKVFSEGRGDGA SASLQEQFCILVGEQFEQTNDSSGAADDHAENDTPVDKTSFDSLKSEEEERQDVDDDGSA LVCESLNLFSLVAPANKWSSEWFSVSCAIISTSTSSGVRHLAKKFLQRLCGGKQDVYHRI RDHYVFGFQVRKLLEKSEGVLDNACMIREMARQCGSNWRDPEITYDTLSPTGLLGVEDLI SEDCYTLTYEENVKTILDELLSTANTRARGKNWRQFCALPEISVATKRAGATTASSEVVY SPLEQIFHRSPVVSLLWLSCCLRGTNQIKALSLIDIALVDAKEVVQTTVLSGTDEDDGNA GGISKDVTNASGSEQSLLKSLSVDDIHSFIAQFVLNGRTEELRTIACKVAYKLAAQLSQG DKNLLFIRLVEGPMRSVGKYGEASKNLFHLLRLIVQRFGSELDVSSASSHIATTVVFQMT TVYHYCAGLSHNTADGKTTTRFDLSDCVRCHKQCLRKKAMPDSSTVSKKSHACEGILSDQ QLSPFQRSRLESSTAATASSEFSTYTQLKFRVAMNEVSINISDPRGRLVKTVGVYFTPRQ VSDVSILKSDKYAGLWQKCGVLNLTRGATTSTLQLKVPVVAANLKFTYEDFYEKQGSGRA ADGSFILHCPRCTRQVNNAHGVCGNCGEVAFQCRKCRHINYDRLDAFLCVECGYCTSGGF NYDISIGTALNAVAILDEEGYQRSVAMLRIANKRQGDVRKSLQTKQLLLERHQRKGREDE DLDEMVLYGPSLNRAFLGELPKTDDGDSIKPTSKSNSAASRSVDAVSRANRARSLLSLAR QLRTEGSALGGESSDRLSRGDAMLRQALLNAGNSSGTGDVLDDSDESLFGALGGESATDQ LSRIVERSLARTAARAGGDGGGGNDDAAGSTPKDDKSKTSPEEECSRLYSQMREAERECY ELNRRIDAWNRLNRDALAIGGPHALSFAFIPSSCSSCSSEVLLHMLTLLHSVFTANIAQS EHTVSSELVKLLLDESHSFGHELKDLKRQVIISLASTSEVASKLILGELRARLTAMQDVT SAEILGKIVQLDFESVSDYIDLAIATLQRQGSK NT seq 14322 nt NT seq  +upstreamnt  +downstreamnt atgccaacactaagatccaaacgcaagcggggcaatcagaatgatgatgagtctgcctca gctgctgccgctgtctccgggaatggcaccagtggtatggataatgatgtagctggggag gctgaaggggtagtggtagaagctgaagcgagacaatcggataaaacagaaaagaagcct aaagccaagacatccaagggcaaaaagaagtcaaacgatgtcacgtttgtgtccaatgaa caatctaccaaccctcccgaagaagaatcaacaacagccaccacaacaaccaacaacctg acagcaataatgacgaacaatccttccctcctatccaacctactactcgaaatccaatct ctatccaacgataagaaacgatgcaccgctgccttacaggctttaaaggatgggaaggat attgccatgccactgtctactctgggagaagatgaggatgatgatgcctctactactgcg ctgggagataccaagttatctcgggggaagaaacgtggcgctagtggtggcgataagaag agcagtgtccacaaggatccgtttgaggaaggagacgacaacaacaacgacagcaacagc aacaccaatgatcactcggctagcaacgatgcccatcttatcatggcagttactcaagcc atcaacattttgatttcctttgtcaagacccaaaaacaagcttctgttgctactactaat gcctcctcctcttcacaagatgccaccagcaacgaagagtacaaagatgcatcaatcatc ttgacggcactctcacaccatctcactacctccctagtgaatgacaagtccatgttggaa agcattacaaagtcatctcagtattcttactccaccctaaactccctctcctcactcggg ggaggagtcaacagtcctccctccgtgtttggatccgggttacgctccatggaagatgtg atagatattgacgatccgtcatccacgagtttcagtgggcgtggtgccgcaaggggatca tccactaggggaggaggggctacttctcccgagaggggattacaacagcagcaggcgaag aagctgatattggcaaatgccaaggctgtggcggggaggggattggcgagtgctgtcatg ggagttttgtatgctatggagactttgggggaggtttgttttatggatggggaggatagt gtgacgggagatgcagctgtaggaaagagtgatggtagtgaaaaagaagaagaagcgaag gggggagattccaaaaacatggaacgcaccatgttgaggaaggcagtgtggacatctctt cttacattggaggcgtcgtttcaattgagtgttcgtccaaagttgcttatggtttcagca gtgacggtgccgacaactggaatgtcaagtatgtcagctagtacctcgagcagtatgatg gactttgacggcatgttgtctggtgtaggcacagcaggtcagggttcctcttccaatgta ccatggtcgcatgctcataccatgatgggatctgatacaattgcaatgtggaatggattt gtgcaacgcatcatggcagactacaagatcggttttcatcaaatggaaggtctgggagag ggaatgtcagaattgaaagaggagaataagcagctggttcagttgtgcagtaaagttgct aactctgcattctcttcgtcggaggatgttgagtttataaccttggtgctcgggagtaag gggggggaagcagcagcagcagcagcatcaaatcccgaaccaccagcaaagaaggccaag aagggaactcgcaagaccaagcaacccgataagagagacgagagggaagaagaactagcc gaactatcctccctcctcgctcgacgaccagagaatctcattctattcgactgccacgtc tctgttcgtcgttgggcagtcttggcatttggttggctgtgcaagggtcagagacggcta ttggagacttgtaccacgctgctcgccaggagagcagagtgggagaaggtgatggagctg gctcctctgaatggcaagctggttgcatctttgggggcaaccgaggatcctgtcgttagc agtgtcgcatccaaaaagaagaaaaagaagaaggacccaaagagtaaacgctcgtctgcc aaaggttctccctcggatgatttggagggtcttcctggcagcgtcgccttggtaaccttt gtatcgtgcatggttgatgtgatttacgacgctggtgcaactggtggtctcactcctccg acatctgggtggatggatgagtatgtgaatctaatcgccgacacaccatgcttgccgata agtgctgcttcgtcggctgcttcggcacttgcagcggcacctgcctcccctcgaaaggag gaagctccagttcgtagaaccactcgtgcacgtgctacgaaagccacttcaaaggccttg ggacgcagcagcccaaagggagcaaagaaacccccaacgtcaccgagcaatcgcgtgtgg gtacgtcctgatgtaagagacgaaactgctttgttgacaaagtacttgattgagtgtcat gaccgttctctgcaggattcgtttggaaggtatttgggacgatccggattaactcaagct gtggatctgttcagccttgattggaagttgataatcaacgacgacgattcttttcatcac ccgcttcttcctaagcacatcagtggcacttccagttcactctcattttatcccttcatg caccgaacgttggatacacttggtcggactgcagcatcaagttccttgtttgcttcttcc gatggaaaatctcgcatcatggcaatcggaggagcaattgcattgagtagatttcaccag aactatcagagtttcaccagtgttgtgatggatgccaaactcatttcttcgtcagtgatg cagatatcggattgccttgcaaatgaatcccgaaacaacgacgtcggagcttcggcgaag gaaagtgatactgaagaaaccaccactggaattcctgagtgtattgtacaatcttatctt ctcaacgagccacttgttgtcgcacgagttgataaaaaagaagaggacgaagaaggcaag ggggcttcgtttagttcttacggtggggtgttttcaacatccagcgaatcgggggacagt gacgctggttccaagagtagctttcgtgtgcagaaaggccctgagctatcgcaatatgca gagattctttcctgctttatcagggctaaccgggcgtatgctttgtcggcatcaactgct tcttacgtcactggaatatcatctctgttggacagccttttttcagtcaccctttgctgc tacaactttcaatcgtcaactcagatatttgatgctgttagtcattcgtcaaagaagaga gcgtcggtttcaaagaagaagaaacgaaaagccgacggcgtatccaccacaacagcaagc caagaatcaatcgctcggaagactttgtcacgatgtgtacttgcatctgatgctctcaat gtgatcagaggttgtttggcttcgtcgcaagaactggtgccttcttcttctacgaaagaa tcagagtctcggtgcatacgttcctttttccgtcaagtaatctcaaccgacaacattatt gactttgttcacttgggatatgccctcgaagacaacttggtctatcctcgccttgtgcat agcattggcgaatgtgctgctcccggaacgagtctaccggagaacttgaagatatatgag ctttgggagcgtcgtttgtggtcatctcatgtgaagctggggctgactattggacgtgga caggctgcctaccagcctcaaaagaacaattcactccttggaaacggcggaaggagattg actatttttcagattattgcaaacattgagcaggaacggcaaactaacattgtgaaggga ggcaagaagtcagcctcgaggtcaaacgagagatggccgctgtttcttccagcagtgcag catgcgttggtatcatcgacaatgtcatgtgacagcaactcagcccaacgaaacaccgat gaccaagctgatctctttctgtgcaacgcctttctcaatagcgtggaggctttcatgaat gatttatcctgtcttccgccaatcggttcgcgtcatgcattgctactcgattatcaaagt acatccccaatggttgtaaacgacaacgtgatgatgtctctacaaaatgcgagactgttt gctttagctgtaggcagagtatctcaaggacatcaaaagacaattcgctctaggctcatt gattcattgcagacaggcttcgccaacgccaatgcgcaggagccgttaaatgtgaatgca tctcgcttcctctctcgcatgttgtctgtggcgagttttattgtggatatcgtatctatt cctgcactcttaccacccttgtctcgtgaggtgggctctgaacattactgtcttcctcgc gttgtgaggaaacaatcagctgatggagaacgttcggaatctacccaagatgtgtgtttc atggggttatttggcgactgtcattcgccttcggtaccagcctctgacatttcagtcaca gactataaagttcttccggatggagattttaacaaaatgcttactgcgataaagtgtgga ctgacgttaggattcacaatggcaaacaaggatggtggtcacttgctgttttcatcatgg aatgctgcagcaaagctcacttcatggacttcaatcacttgggaaggaccagaaactgcg acaattgtgaaggagaaagcttccattgatcgtctcattggattgcgagacgacttgtgc gaggttaactttttggtgaacggggctgatccctctacggagcaaacgttgctcgtgaag ttgaccagcaataagagagggcaatgccgaaagaacgaggcattactctcgggcattacg agttgcgaaaagatgcttggaaatactacactggaaatcaccaagggagctgccctcgtc ccgtcactccctgcctttgcatattacgaggctttacctgtatatgtctcgtttctcatc agcatgcacactcgtcctggaacgagtaatacgtcatcaattcttcggtttcagccatct caactacaacgcacgcaccacgtttctggttacacagatggagatgtaattgatgagttc ccttctgacgattcggatatggaacacgaggagagtggtggaaatgctgttaggatgaat gcattggcacgactacgtgatgcatgtgagacgttgggggcagcaccctgtttcccagat tggttagatactagctgcagaatgcaggaaggtatcattccacccattgcagtagattcg gcggatcgatgcttagctgaattgacgaattttggagctgctgctttcaaatgctatttc acatctttggggcgtattttggagttgagtgttcaagatggaatgtcttttccttcttct cttgtactgcaaatcttagcagcacaacaacatgcaatgaatggtacttctggtgaagca ctctttgtgcacctatcaactctttgtcgtgtagagagtgctctgttgaagcatttctcg tcaaatagtcatttcttggtaggaaatatattcgcggaacacgcttctcagagagtcaag ggcgctgttgctgctggtggatgggaaccaaccagtggcgaatatcgtgccaatgggcag tgggagacacttatcggcgaaactctacgagggtcgtctctcgaagtcattacttcgtac atgtttcccggagaacaagatgtgaacaaagaaatgaaatctgcggttcttgctgccaat cattggcaacgggtgctatgtagcgtggtgaatgccatggtgccaacagcagcgttgctt cggtttggtgtcaatgacggaaaaggtcgtagtccacatcccttgtgtgaagaccttgtc ccgggaagtgccctttcatccgatggcaatcgcgaagggttctcacggttctctaccaaa aatgaggttggtgctacactaaagaaagccctgtcattcctctcctgtgtatctgcctac tctgctgtcgacgaggatatgattctcaccgcccaagcagccgcgagtcatttgttggat aatgctgcccactttgatgacttggtatctctctgggttattagaatatgctgtgatgca attggcggtgttgtgactgctcttacgaccagtaatttgtcagagtctcagatttcttcc gcaactgcactcattgaatcaactctgaagcaattctcgagcaacagccagaatatcttg gacgacgaaatcccagacccaacagacttggacgcagcatttgatcacggtgtcaattca gatgactacattgacaatgacaaagcgaaaaaactccttgcatgctttggtctatcaggg ggagtcctcactggaaggattattggcaataggactgatattgaactaacgagcatcctt gccaaaggcgaggatatctatcctatcaagattgaaagtggtggtgtttttggtcaatgg ggctcctcgcaaaagggggtggcaaagctatggcttgagtgccttgggagagtaccgctc ggccgaagagctcgcatctttgtggcaggatctttactccatgatgtatttgaagccgaa acgacatttctaaagaataaggttggcagtcctctcgtccgcactttatctgcagttgcg ttggattcaatgacgaaggatgatgtgctcttgattctggaggacatttgccaaacagcc gatgtttctgaggaatctatggaagacgatgaacgtgaagaagaaaggaacgaattgacg caaaagtttggtgttctccatgaagttggaagtgccatcatatcgctggcactacgggag aaagacggaaatgacgtgtcaccttgtatccaaagctactttgagtttgcggctgcgttg aatggacttgccaatccatcaacacgatcgagtcaactgccaccagtctccaacggttct gctgggcagcaaaaggagaagatatcagaggaaaccgtgcgggctttgtacgaagaatca tctcctgtagtggatagaaccgacgtgtccactcaccagagtgatggtttcaccaatact ttggccgaatcggtattcaaaaggttccctggagaggtcaaacggtcattgcaacttttg gttgaagaagcacagacagcggaatggaatacgtcgattttgacgttattcaacaacaat tacgagaagaagccccctgctagcctcgacttctccaccatttttagcagcaccacgcca gattcagatgcaagtcatggactgttaaatcttgattctcggagaggaagtccgttgtta ctcacgccgcttgttgggactaccattttacctcttcgagctgctaagatgaacgctctt aaaccaagagtaaatccattgtcagcggctagtcacattcgaaaggtccgaaccgagggt caactgattgcttcagacgatagaggacgtctcgtatgtgcagaatcatcttcgcttttg ttcttcagtggtatcgcgtgtaccaatgttcgacacatcgagctatctgcagcaaagcac ctgacaaggtcgcagctgaacgttgggggaagtgagcgattgaagtttgagatttatggc attgcattatgccctgagaacaatcggcatttgatatcgtggggggcatcgaaggcctgc gtcaacgttctgtccaaggggtttgattctgttgaacgaacaatcgacttgactcttcag ctggagccgagtgaatgcgagagcgagtatttgttggaattattgtggatgacagagacg atagttatcgcaatctgcggcacggttattcatgtctttgatctgaagaagacagaaaat gacacttgtaaggcgacggcacattttgttctcgcctacgaagacgtgctcatccgatcg gcaactttcacgagcatcactttgagtgactctggcattcagacaaaactggcaattctc ttggataccggccgtctccacttcatccaaatgagtgtcgacaagaatggtcacctcgag gagcaaggggaaacttacatcgagattgggtctggcgcgtccttttcgtctgcgggcatt tgtcgttacgttggaggagagccgattggggctggatctgtatcaacaacatttggagaa ggttccacactgaagttcttgcatcaaagcaatgttatgctgtaccaatgtgtttcgtct tgctgcattgcaatgatcattgaaaaagatggtacaatcaagggtacctttgaactactg cccaatatgatatcatctgatacacttggtgcacatttcggcgtccaaggaccatactct caatttaacgagcttggagttgtccagaaaggaggcgaggctttctatcggttggcatgt gtaggtaaaagcacgaaatccagtcaaccccgagtgctgttggtcgaattcaactctaac tcggtgtataccaaagaagtcaattggccaggcaactgcagtggtggattaggttacacc gcgagtcacaactttgttggatcgtgcactttctctgtaccatacctagttggtggcact gccgaggagggacacgttggcgacgatacaaaagtttatgagagagcctttttgacaatg ttgtcctccaatggttcgcttcttttcttcggagaagactgtgatattccaagcatacat cacacaccagccaaacttccaactcctgatgtctacatgtttgagaaagatgacatattt aacgttagcgaggatagcaatctgatcttgggtggagattgcgtaggtaaggacccgaaa agcgcaaagaagaagttatctttgaacaacaacgagtttatcattagtccgtcgcgtgac ggttgtacactgactgcgagattacaaagaaacggtgctttggtcagaggtggcagttca aaaacaggagggaagacgagctctttcgcaatcgttgcggtgcgagtacttgtaggatct atgccagaattagtacctcgcgaaatcacaatcatgggagggcgatcaatcaaaacgaaa cggaacgcaaagcgttggtacgacttccctctcaccgatgaggaaatactccttgcaata aggaatgacagtgtaactgtgcatttttcatctagccacgacttgacatcgagttctagt atcgattccgttgaggtatatgttcgggcaagagaagatctccaatttctggcagcggga actggctctgaacagaagacacccgcaacttctcttactatatggcctcctgctgacggc gacgaagagatttctactgtatcgtatgtacaatcgttgactttcttgtcaaagattctt ggacacaacaacatgagatccttgagtgctggcagcaaagccatgatcaaatacatcatt gaacagacagcgttgaactcctcggaaaagggatcactgcgagaagagacgctgtcactt ctgaatgaagtggttagcgatgagtcgcagcgttctcaatttgttgacgactctacaatc cgtggattgatgtcagtattgattgcgttgggaacctatgtcaagacggatctctccact attagcttcaacccgtcaaaacacgaaacgatgatcaatggcgccatcgaggtgttgact cacatcatcatcaatgctacgtctattgccgaggcccgaggagagaactataggaaagct attattgatttgattgcagaaaaggtttcaagggcgtcaattgctattgagggaaaacga gttcttgattatcttgctcatctgtcacttttacatggtcgtaccatacaaatcctttct gcatctgagagcatttcgaggctaatactatgcgagatggcatgtaccgaatcaaatgac tttgggcagtttgaagcactctcagaataccttgtacacgacgatccttcgatggtgcaa gcatgctgcaaagcagtattagaagccgcggaaacgacagaaggcgaacaggtatttcca tcggaagtgtcggacgttcaaaaccatgatcatctgtcgtatgtcacgtaccaatgcgac agctgcaagctatttcccatcacgaaacaacgatatacgattggcggagaggtggatgtg gatttatgtagagagtgtttcaatttggggtgtgcatatgctgcagaacacgagagcggc tcgccgttagtcatccgcggaagtactctcagtgttgaagacgaagagatgacatgtgat cagatctggcaaatgaaggcgataacaatccctgccagttcagatgataactcagtagac aaatcagccttggaagatgctcttaaactgagccaatcaaagaagggagccaatgctaat gctgctacgcctcatccctcgtcaaaaacattcagtacaaacacagaggcatttcggtct cagatctttactcgtcttcttggtttgatagcacgctcccttcgtacaacagatcaagaa gctccaccatcgtatcaattgcttcaacttgctttgactcttgttctcaactcaagtacg gagaagttgagggtagcacgtggtaatcaattggtgcactccttctctagtcacattcct actctggtacaatcagggcagaatgaagcaagctgcaagaagttggttgtgtgccttcgc actcttgcagctttggtaacgcagaaaggatacattgagtccagtcctcctgtcacttcg gagaaaaacaaacacttggaagatactcaagggcaccatcacaaagataaaacggatcca aggtttgtttgcgaagtccacggagttcctgccgttcgacgcagatgtagccatggcgtt cacaaagataggagattctatgtctgtggtctcgagtgggcagacctaccagaaagcgtt ccaaaccagtctcgtaaatctcacgacgacatcttagccacgaagcatactgatcacatc tttgtgcctattcaaactgagttgctgaaggtattcagtgagggaagaggggacggtgcc tcagcctcattgcaggaacagttttgcatattggttggtgaacagtttgaacaaacaaac gactcctctggtgcagccgatgatcatgccgaaaacgacaccccagtagataagacatcg tttgactcgctcaaaagcgaagaggaagagcgacaagacgttgatgatgacggatcggcc ttggtctgtgaatcactcaatttgttctcacttgtcgcccccgcaaacaaatggtcgtct gagtggttctctgtctcttgtgcaattatcagtacaagcacttcgtcaggcgtgcgtcac cttgcgaagaaatttctccagcggttatgcggtggcaaacaggacgtgtatcacaggata cgagaccactacgtgtttggttttcaagtcaggaagctacttgagaagagtgaaggcgtt ttagacaatgcatgtatgatacgtgagatggctcgtcagtgtggctccaattggagagat ccagagattacctacgatactctttctccaactggattacttggggtagaagatctcatt tcggaagactgctacacgttgacgtatgaagaaaacgtcaaaaccatcctggacgaattg ctgagcacggcgaacactcgtgcccgagggaagaattggagacagttttgtgctttgcca gagatatcagtagctaccaaacgtgccggcgctactacagcttcatctgaggttgtttat agtcctctggagcaaatatttcatagatcaccagttgtatcattgctctggctcagttgc tgtttgagagggacgaaccaaatcaaagcattgtcgttgatagatatagctcttgtagat gctaaggaggttgttcaaacaactgttttgagtggcacagatgaggacgacggcaacgct ggaggaatctccaaggatgttacaaacgcatccggctctgaacagtctctcttgaaaagc ttgagcgtggacgacattcactcgtttattgctcagtttgttttgaatggacggaccgaa gaacttcgaacgattgcatgcaaagttgcttacaaacttgcagcgcaactaagccagggt gacaaaaatcttctcttcatcaggctggttgaaggtccaatgcgatcagttggaaagtat ggggaagcatccaagaacttgtttcatttacttcgtctgatagtgcagagatttggatcg gagcttgacgtgtccagtgcttcctcacacattgcaactaccgttgtgtttcaaatgacg acagtgtatcattactgcgctggcctgagccacaacactgccgatggcaaaacaacaact agatttgatctatcagattgtgtccgatgccataagcaatgcttgcgaaagaaagctatg cccgattcgtcgacggtgagcaagaaatcccatgcctgtgagggcattttgagtgaccag caactaagtccatttcaacgatcacgtctcgaatcatctaccgccgccaccgcctcaagt gaattctcaacatacacacagttgaagtttcgtgtcgccatgaatgaagtctccatcaat atttccgacccacgaggcagattggtcaagacagtaggagtctacttcaccccgaggcaa gttagcgacgttagtattctcaagagcgacaagtatgcaggattatggcaaaaatgcgga gtgttgaacttaaccagaggtgctacaacatccacattacaactgaaggttcccgttgtt gcagctaatctgaaatttacatacgaagacttttatgagaaacaaggtagtgggagagcg gcagatggttcgttcattttgcattgtcctcgttgcacgcgacaagtcaacaatgctcac ggagtctgtggtaattgcggagaggttgccttccaatgcagaaagtgtcgacatataaat tatgatcgccttgatgcgttcttatgcgtggagtgtggttattgtactagtggaggattc aactacgacatttcaattggcaccgctctgaacgctgttgcgattttggacgaggaaggg taccaaaggagtgtggcaatgctccgaattgcgaacaagcgccaaggggacgtgcggaaa agtttgcaaacgaagcagctcttgttggaacgacatcagcggaagggtagagaagacgaa gaccttgatgagatggtgctctatggtccgtctttgaaccgcgccttcctgggggagttg cccaaaactgacgacggcgactctatcaaaccaacttcaaagtctaatagtgcagcgtct cgctctgtagatgcagtcagtagagcgaatcgtgcgaggtcgctgctttcattggcaaga caactgcgaacagagggtagtgctttgggaggagaaagttcagataggcttagtagaggc gatgctatgttacgacaagcattgctcaacgcgggaaattcaagtgggactggagacgtt ctggatgacagcgacgagagcttgtttggagccttgggtggtgagtctgctactgaccaa cttagccgtattgtcgagcgtagtctagcgcgaactgctgccagggcagggggtgatggc ggtggtggaaatgacgatgctgctggctctacccccaaagacgacaaatctaagacctct cccgaggaagagtgctctcgtctttactcacaaatgagagaagccgagcgagagtgctac gaactcaatcgtcgcattgacgcatggaaccgtctcaacagagatgccttagcaatcggt ggaccacatgctctctcatttgcattcattccatcgtcatgttcttcgtgcagtagtgaa gttttacttcatatgttgacgctcctgcactctgtgtttacggcaaacattgctcagtcc gagcatacggtgtcaagtgaacttgtgaaattacttcttgacgagtcccacagtttcggt cacgaattgaaagatctgaagcgtcaagtcatcattagcctcgcaagtacatcagaggtg gcatccaaattgattctaggtgagctcagagcacgcctcactgcaatgcaagatgttacc agtgccgagattcttggcaagatagttcagctcgactttgagtctgtcagcgactacatt gatctagcgattgccacgttacagcgtcaggggagtaaatga

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