Trichomycterus rosablanca: 134321179 Help Entry 134321179         CDS       T09921                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism trn  Trichomycterus rosablanca Pathway trn04020   Calcium signaling pathway trn04260   Cardiac muscle contraction trn04261   Adrenergic signaling in cardiomyocytes trn04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:trn00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     134321179 (ryr2a)    04020 Calcium signaling pathway     134321179 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     134321179 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     134321179 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:trn04040]     134321179 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:trn04990]     134321179 (ryr2a) Ion channels [BR:trn04040]  Voltage-gated cation channels   Ryanodine receptor    134321179 (ryr2a) Domain-containing proteins not elsewhere classified [BR:trn04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    134321179 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RR_TM4-6 RYDR_ITPR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  134321179 NCBI-ProteinID:  XP_062858850 LinkDB All DBs Position 10:complement(4242599..4448834) Genome browser AA seq 4074 aa AA seqDB search MNKIELGWTYGAVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLAD ERAVDKVKHLKLPAKYELSSSYKPAPMDLSHVKLASTQEAMVDRLAENAHNVWARDRIRQ GWTYGVQQDVKNKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHARA DISNVSTERFRIFRAEKTYCVNAGKWYFELEVVTAGEMRVGWARPGCLPDQELGSDDQAF VFDGFKAQRWHQGNEHFGRSWSAGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDF EVWEGFIPVCSLGVSQVGRMNFGKDVSTLKFFTICGLQEGYEPFAVNMNRDVTMWLSKRL PQFIPVPAGHEHIEVTRIDGTVETPPCLKVTQRSFGSQNSNTDIMFYRLSMPIECAEGFT KPAGGTLPANGSFFSPKKDLEDFETVSDFEVLMKSAHGHMGSNGPDKDKDEFNNHKDYNQ EKPSKLKQRFMMKKSKPDFSTSNSSTRLSQEVLADERDDYELLMQTCTYYYSVRIFPGQE PSSVWVGWVTSDFHQYDPAFQLDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESNNPG QSRNNNGLEIGCMVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFEL GRIKNVMPLSAGLFKSERKNAVPQCPPRLHVQFLTPVLWSRVPNQFLRSEVNRVNERHGW MVHCTEPLQFMALHIPEENRTVDILELTEQRELLQFHYHTLRLYSAVCALGNHRVAAALC SHVDESQLLSAIQNKSMAGLLRTGYYELLIDIHLSSYATARLMMNNEYIVPMTEETKSIT LFPDEQKKRHGLPGIGLSTSLRPRMRFSSPNFVSAVYAGNGGGERFQFSPEFPLETLKIR TMEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKAILQLIEPSV FSQDSGEHSGSIGPDRDADPAEKRTEVGSGDEDESGKRKVPKEGLLQMKLPEPVKLQMCH LLQYLCDCQVRHRIEAVVAFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSP PQEQINMLLGFKNEKQECPCPEDIREQLLLFHEDLMTHCGIEIDDDKAGEGDDFTIRGRL MSLVEKVAYLKKKMTDMPKKKKAKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLH RQYDGIGGQVRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLSDI MNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQ NQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYL AGCGLQSCVMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPE CFGPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTSEDSKTLRDTLEDEEDDTIHMGNA IMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFSMPTLAK DGSVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAAL SATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRD AIEECLLSVCGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGW GSFGAASDEELHLTRKLFWGIFDALARKKYDAELFKLALPCLSAVAGALPPDYMESNYVA MMEKQSSMDAEGNFNPQPVDTSNVNVPERLDHFINKYAEHSHEKWSMEKFANGWVHGELL CDTSKVHPLLKPYKGLSEKDKEVYRWPIKETLKTMLSWGWSIERMRENDPASLHSRTRRI SLSSQLSIEGAHGFSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAKRKKLELEAKGGGS HPLLVPYDTLTAKEKSKDREKAQDILKFLQINGYTVSRAVKEQDLDTPSIEKRFAYTFLQ QLITYVDEAHEHMLEFDVSTRPKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAV RPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMK TGLESVKAALREFFDNAAEDLERTMENLRQGQFTHTRTQPKGVTQIINYTTVALLPILSS LFEHIGQNLFGEDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFP VAFLEPHLNKYNSYSIYNTKGSRERTTSSLPAQVEEACPLVPSLEKALQEIMELAESGMR YTHMPHVMEVVLPMLCSYMSHWWEHGPESNPERADTCCTSLTSEHMNTLLGNILKIIYNN LGIDEGAWMKRLAVFSQPIISKARPQLLKSHFLPLMEKLKKKAATVLLDEEHMKAEGRGE MSESELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWA KSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSMQTSLIV AALKRLLPVGLNICAPGDQELIALAKNRFTQKDTEEEVREIIRNNLHLQGKLEDPAIRWQ MALYKDMPNRSEDTSDPGKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAV VACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEGV KRIDPLHQLIQLFSRTALTEKCKLEEDSLYMAYADIMAKSCHDEEEEDEEEVKSFEEKEM EKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLD YLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDL FRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVID EQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLS QDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDM FLKLKDLTSSDAFKEHDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLD YEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIM GSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE MQLAAKMSDAGERSASKEESEREKPEEESPDMGFFSVSTVCTALLALRYNIMLLMKVLSM KSLKKQLKKAKKMTVRDMVTALAAFCFSVLAGLLHFAFSVARGFFRIIYSSFLGGGLVEG AKTMKVSELLANMPDPTQDEVRGESEELERKPAEKALPEEDLADLAVAAEDTDLLSDIFG LDLRREGGQYKLMPHNPNAGLTELLNTPVPSPPTPSPELRRRHTAKSSSSTDEKDGTEET KTVSEKAEGEDGEKHEKKKEEQKKRLRLHRFKSDEPDLQESAFWKKIIAYQRKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSAVKEEKQVVYSTSQLDNSLRWDSQSSSPADR PVTVHFVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGNDRISELLGMD KGALDFSDAHGKRKPKKDGSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 12225 nt NT seq  +upstreamnt  +downstreamnt atgaacaagatcgagctgggctggacctatggagcggttagagatgacaataagaggcag cacccgtgcctggtggagttctccaaacttccagaacaggagcgcagctacaacctgcag atgtctctggagactctaaagactctgctggcactgggttgccatgtcggcttggcagac gaacgagcggtggacaaagtgaagcacttgaagctgccggccaaatatgagctatccagc agttataaacctgctcctatggacctgagccacgtcaaactggcctctacacaggaggcc atggtggacagactggcagagaacgcacataacgtgtgggcaagggaccgcattcgccag ggatggacctatggggttcaacaggacgtgaagaacaagaggaatccacgcctggttcct tacgtcctgctggacgagagaaccaagaaatccaacaaagacagtctacgagaggccgtg agaacattgctgggctacggatacaacctggaggctcctgaccaagaccatgcccgagcc gacatcagcaacgtatccacggagcgttttcggatcttccgggctgaaaagacctactgc gtgaatgccgggaagtggtatttcgagctggaggtggtgaccgcaggcgagatgcgggtg ggctgggctcgtccgggctgcctgcccgaccaggagctgggttccgatgaccaagccttc gtgttcgatggatttaaggcccagcggtggcaccaagggaacgagcactttgggcgttca tggtcggcgggtgatgtggtaggatgcatggtggacctgaacgagcacactatgatgttc acgctgaacggcgaggtgctgctggatgactcgggctccgaacttgcgttcaaggacttt gaggtctgggaagggttcatcccggtctgcagtctgggtgtgagtcaggtgggccggatg aattttgggaaggacgtgagcacgctgaagttcttcaccatctgcggcctgcaggagggt tacgagcccttcgccgtcaacatgaaccgagacgtcaccatgtggctgagcaagaggctt cctcagttcatccctgtacccgccggccatgagcacatcgaggtcacgagaattgacggc acagtggagaccccgccatgcctaaaagtcacgcagaggtcgttcggatcccaaaacagc aacacggacatcatgttttaccggttgagcatgcccatagagtgcgccgagggattcacc aaacccgccggcgggactctgccggccaacggaagcttcttctcgcccaagaaagatctg gaggattttgagaccgtgtccgacttcgaggttctgatgaagagcgctcacggtcacatg ggctccaacggcccggacaaagacaaggacgaatttaataaccataaggactacaaccaa gagaagccgtccaaactcaaacagaggtttatgatgaaaaagtccaaacccgacttcagt acgagcaactcctccacccgtctgtcacaagaagtgctggctgatgagagagacgattac gagttgctcatgcagacgtgcacatactactactctgtgaggatttttccgggccaggag ccgtccagtgtgtgggtgggctgggtgacatccgacttccaccagtacgacccagccttt cagctggacaaggttcgaaccgtcaccgtcactctcggagacgagaaaggcaaagttcac gagagtattaagcgcagtaactgctacatggtgtgggccggtgagagcaacaatcccggc cagagccggaacaataacggcctggagatcggctgtatggtggacacagccagcggcctg ctaaccttcaccgccaacggcaaggagctcagtacttattaccaggtggaacccagtact aaactcttccctgcagtgttcgcccaggccaccagccccaatgttttccagtttgagcta ggaagaataaagaacgtgatgccactctcagctgggctgtttaaaagcgagaggaagaac gccgtccctcagtgcccaccgcggctgcacgttcagttcctcacgccggtgctctggagc cgggtgcccaaccagttccttaggtcagaggtcaacagggtgaacgagaggcacggctgg atggtgcactgcacagaaccgctgcagtttatggccctgcacatacctgaagagaacagg acggtggatatcctggagctgacggagcagcgcgagctccttcagttccactaccacacg ctgcgcctctactcggccgtgtgcgccctggggaaccaccgggtggcggcggcgctctgc agtcacgtggacgagtcgcagctgctctcagccatccagaacaagagcatggcgggcctg ctgcgcaccggctactacgagctgctcatcgacatccacctgagcagctacgccaccgcc cgcctcatgatgaacaacgagtacatcgtgcccatgaccgaggagaccaagagcatcacg ctcttccccgacgagcagaagaagcgacacggtctgcccggcatcgggttgagcacctct ctgcgcccgaggatgcgcttctcgtccccgaacttcgtcagcgccgtgtacgcgggcaac ggcggcggggagcggttccagttcagcccagaattcccactagaaacgctaaagatccga acaatggaaatgctcacagaggcggttcaggagggcagcctgcacgtacgcgatccggta gggggcagcaccgagttcctcttcgtgccgctcattaaactcttctacaccctgctcatc atgggaatcttccacaacggagacctcaaggcgatcctgcagctcatcgagcccagcgtc ttctcgcaggactccggggaacacagcgggagcatcggcccggatagggacgcggatcct gcggaaaaacggaccgaagtgggatcaggagacgaggatgagagcgggaagagaaaagtg cctaaagagggtcttctgcagatgaagcttcctgaaccggtcaaactgcagatgtgccac ctgctccagtatctatgcgactgtcaggtccggcaccggatcgaggcggtagttgctttc tccgacgacttcgtagctaacctccaggacaaccagcgcttccgctataacgaggtcatg caggcgctgaacatgtcagccgcgctcaccgctcgcaaaaccaaagagttccgctcgccg cctcaggaacagattaacatgctgctgggctttaagaatgagaagcaggaatgcccgtgt ccagaggacatccgagagcagctactgctgttccatgaagatctaatgacccactgtggt atagagatcgacgatgataaggcgggggagggagacgattttactattagaggacgtctc atgtccctcgtggagaaggttgcctacctgaagaagaaaatgactgacatgccgaagaaa aaaaaggccaagaagcctagcactctgcagcagctgatctccgagacgatggtgcgctgg gctcaggagtccgtgatcgaggacccagagctggtcagggccatgttcgtgctgctgcac agacagtacgacggcatcggagggcaggtgcgcgccctgcccaaaacctacaccatcaac gccgtctccgtggaggacaccatcaacctgctggcgtcgctggggcagatccgctcgctg ctcagtgtccgcatgggccgcgaagaggagaagctcatgatccgcggcctcagtgacatc atgaacaataaggtgttctatcagcacccgaacctgatgagagctctgggcatgcacgag actgttatggaggtcatggttaacgtactgggtggaggagagtccaaggaaatcacgttc cctaagatggtggccaactgctgtcgtttcctctgctacttctgtcggatcagccggcaa aaccagaaggccatgtttgatcacctgagctacctgctggagaacagcagcgtgggtctc gcgtctccgtccatgcggggctccactccactagatgtggccgctgcctcagtgatggac aataacgagctagctctggccctcagagagcccgacctagagaaggtggtgcagtatctg gctggctgtggcctccagagctgtgtaatgttggtatctaagggttatcctgatatcgga tggaatcccgtagagggagaacgatacctcgacttcctccgcttcgccgtcttctgtaac ggcgagagcgtggaggagaacgcgaacgtagtggtgcggctcctgatccgccggccggag tgcttcgggcccgccctgcgcggcgagggtggaaacggcttgctggcagcgatggaggaa gccattaagatatcggaggacccgagcagagacggaccgtcgcccacatcggaggacagc aagaccctcagggatacactggaggatgaggaggacgacacgatacacatgggcaatgcc atcatgactttctatgctgctttgattgatctgctgggtcgctgtgctccggaaatgcac ctgatacacgctggcaaaggcgaggccatccgtatccgggccatcctgcgctctctcatc cccatcgaggacctggaaggggtgatcagcatccccttctccatgcccacactcgccaaa gatggctctgtggtggagccggacatgtcagctggcttttgtccggaccacaaggcagca atggttctgtttctggaccgtgtttatggaatcgaggaccagaacttcctgctgcacctg cttgaggtcggcttcttgcctgaccttagagctgctgcctccttggacacggccgctctg agtgccacagacatggctctggctctgaaccgctacctgtgcacggcggtgctccccctg ctgaccaagtgcgcccctctgttcgcgggcacagagccgttcgcttcactcatcgactcg ctcctccacaccgtctaccgcctctctaagggctgctgcctcaccaaggcacaaagagac gccatcgaagagtgcctgctttctgtgtgtggcaaactcagaccttctatgatgcagcat cttctgaggcgcctggtattcgacgttccgttactgaacgaacacaccaagatgccactc aagctgttaaccaatcattacgagcgatgctggaagtactactgcctgtccggtggatgg ggaagcttcggcgctgcatccgacgaggagctccacctcaccaggaaactcttctgggga attttcgatgctctggccagaaagaaatatgatgctgagctgttcaagctggctctaccg tgcctcagtgccgtggcaggagctctaccaccagactacatggagtccaactacgtggcc atgatggagaaacagtcatctatggacgcagagggcaattttaaccctcagcctgtcgac accagcaatgtaaacgttcctgaaaggctggatcacttcatcaataagtatgctgagcac tcacatgagaaatggtccatggagaagtttgctaatggatgggtgcatggagagctgttg tgtgacacatccaaagtacatccactgctaaaaccctataaaggattgtctgagaaggat aaggaggtgtaccgctggccgatcaaagagactctgaagaccatgctgtcatggggctgg agcatcgagaggatgagggagaacgacccagccagcttacacagccgcacccgccggatc tccctgtccagccagttgtctatagagggcgctcatgggttcagtccccggccagtggat atgagcaatgtgaccctgtcccgggacctgcattctatggcggagctgctggcagaaaat taccataacatttgggccaagaggaagaagcttgaactggaggccaaaggagggggaagc cacccactgctggtcccctacgacacattaactgccaaagagaaatccaaagacagagaa aaagcacaagacatcctcaagttccttcaaatcaatggctacactgtatcaagggctgtg aaggagcaggatctggacaccccgtccatagagaagcgcttcgcctacacctttctgcag cagctcatcacctatgtggacgaagcccatgaacacatgctggaattcgatgtttctaca cgtccaaagggagaaaaaattcctcacgaacagcagatgaagttcttcggaaaggtcgtt ctgcctctggtcgaccagtacttcaagaaccatcggctgtacttcctctcaacagctgtc cgaccaatcagcagtggaggtcacgcgtccaataaggagaaagaaatggtcaccagtctt ttctgcaaactgggagttcttgtcagacataggatatcactgtttggaaatgatgctaca tctatcgtgaactgtcttcacatcctgggacagacgctggatgcaaggacagtgatgaag accggtttggagtctgtgaaagcagcactgcgggaatttttcgacaacgccgccgaggat ctggagcggacgatggagaacctgcgacagggtcagttcacgcacacccgaacccagccg aaaggagtcacccagatcatcaactacaccaccgtggcactgctgcccatcctctcctcg ctattcgagcacatcggtcagaacctgttcggagaggatcttatactggatgatgtccag gtctcctgttatagaatcctaaacagtctctactccctcggcaccagcaaaagcatttat gtggaaaggcagcgtcctgctcttggcgagtgcctggcggcgttctccggagccttcccc gtggccttcctggagcctcatctcaacaagtacaacagctactccatctacaacacaaag ggctccagagagagaacgacgagcagtcttccagcgcaggtagaggaagcctgccctctg gtgccgtcgctagagaaggctctgcaggaaatcatggagctggccgagtcgggcatgcgc tacacccacatgcctcacgtgatggaggtggtgttgcccatgctgtgcagctacatgtct cactggtgggagcacggacccgagagcaacccggagcgcgccgacacctgctgcacctcg ctcacctccgagcacatgaacaccctgctgggtaacatcctcaagatcatctacaacaac ctgggcatcgacgagggcgcctggatgaagaggctcgcggtcttctctcagccaatcatc agcaaggctcggccacagctgctgaagagtcacttcctgcctctgatggagaagctgaag aagaaggcggccaccgttctcctggacgaggagcacatgaaggctgaaggtcgcggtgag atgtcggagtcggagctgctcatcctggacgagttcaccatcctggtgcgggacctgtac gccttctacccgctcctcatccgcttcgtggattacaacagagcaaagtggctgaaggag ccgaaccccgaggccgaggaactgttccgcatggtggcagaggtcttcattttctgggcc aaatctcataatttcaaacgggaggagcagaactttgtggttcagaacgagatcaacaac atgtccttcctcattaccgacaccaagtccaagatgtccaagggggcagtatcagaccag gagaggaagaagatgaaaaagaggggtgatcgatattccatgcagacctctctgattgta gctgctctgaagaggttgcttcctgtcggcctgaatatttgtgctcccggagaccaggag ctcatcgccctcgccaagaaccgctttacccagaaagacacagaggaggaggttcgggag atcatccgtaacaacctccacctgcagggaaagctggaggaccctgctatccgttggcag atggctttatataaggacatgcccaaccgcagtgaggacacctcagacccagggaagacc gtcgagcgagtgctggacatcgcccacgtgctcttccatctagaccaggttgagcaccct cagaggagtaagaaagctgtgtggcacaagctgctgtccaagcagaggaaacgagccgtg gtggcctgcttcaggatggcgccgctgtacaacctgcccagacatcgagcggtgaacctc ttcctgcagggctacgagaagtcctggattgagacagaggagcattatttcgaagacaaa ctcattgaggatttagctaagccgggcggagaggagccctcggaggaggacgaaggggtt aaacgcatcgaccctctgcaccagctcattcagctcttcagcaggacggcgctcaccgag aaatgtaaactggaggaggacagcctgtacatggcttatgccgacatcatggccaagagc tgccacgatgaggaggaagaagatgaagaagaagtgaaaagttttgaagagaaggagatg gagaagcagaagttgttgtaccagcaggctcggctacacgatcgcggagctgccgagatg gtgctacagaccatcagtgccagcaaaggcgagatgggaccgatggtggcgtccactctg aagctaggcatcgctattctgaacggcggaaattccacagtccaacagaaaatgctagac tacctaaaggacaagaaggatgtgggattcttccaaagcctggcaggactaatgcagtcc tgcagcgttttggatctgaatgctttcgagagacagaataaagccgagggtctgggcatg gtgacggaggaaggctcaggcgaaaaggtgatgcaggatgacgagttcacctgcgacctc tttcggttcctgcagctgctttgtgaaggacacaactcagatttccagaactacctgaga acacaaactggaaacaacacaaccgtcaacattatcatctccaccgtggattatctgctt cgagtacaggagtcaatcagcgatttctactggtattattccggaaaggacgtgattgac gagcaaggtcagcgcaatttctccaaggccatcaacgtggcaaaacaggtcttcaataca ctcacagagtatattcagggtccctgcaccgggaaccagcagagcctggcgcacagtcgc ctgtgggacgccgtggttggtttccttcatgtttttgcacatatgcagatgaagctctca caggattcgagccagattgagctgttgaaggagcttatggacctgcagaaggacatggtt gtaatgctgctctccatgttagagggaaacgtggtaaacggcaccattgggaagcagatg gtggacatgttggtggaatcctccaataacgtggagatgatcttgaagttcttcgatatg ttcctcaagctgaaagacctcacctcctcggacgccttcaaagaacacgacccggacggg aaaggcgtcatctccaaaagagacttccacaaggccatggagagccacaagcactacacg cagtccgagaccgagttcctgctgtcgtgcgccgagacggacgagaacgagctcctggac tacgaggagttcgtggagcgcttccacgagccggccaaagacatcggcttcaacgtggcc gtgctcctcaccaacctctcggagcacatgcctcacgactcgcgcctgcagaccttcctg gagctggcggagagcgtgctcaactacttccagccgtacctgggccgtatcgagatcatg ggcagcgccaagcgcatcgagcgcgtgtacttcgagatcagcgagtccagccgcacgcag tgggagaagccgcaggtcaaggagtccaagcggcagttcatcttcgacgtggtcaacgaa gggggcgagaaggagaagatggagctgttcgtgaacttctgcgaggacaccatcttcgag atgcagctggccgcgaagatgtccgacgcgggggagcggtctgcaagtaaagaggagagc gagagggagaaaccagaggaggagagtccagacatgggattcttctccgtcagcaccgtg tgcaccgccctgctcgccctccgctacaacatcatgcttctgatgaaggttctctccatg aagagcctgaagaagcagctgaagaaggccaagaagatgactgtgagggacatggtgacg gcactggcggcgttctgcttcagcgtcctcgccggcctgctgcacttcgccttcagcgtg gcccgaggtttcttccgcatcatctacagcagcttcctgggagggggcctggtggaggga gccaagaccatgaaggtgtccgagctgctggccaacatgcccgaccccacacaggacgag gtcagaggggagagcgaggagctggagaggaaacctgcagagaaagctttacctgaggaa gacctggcggacctggccgtggctgcagaggacactgacctgctgtctgatatattcggg ctcgatttgagaagagagggagggcagtacaaactcatgcctcataaccccaacgccggc ctgaccgagctgcttaatacgcccgtgccatcaccgccgacaccctcacccgaactccgc cggagacacacggcaaaaagttcatcatcaacagatgagaaagacggcacagaggagacc aagaccgtgtccgagaaagcagaaggtgaagacggcgagaaacatgagaagaaaaaagag gagcagaagaaaaggctcagactccaccgttttaaatcagacgagccggatcttcaagag tcggcattctggaagaagatcatcgcctaccagcgcaaactcctcaactatttcgcacgc aatttctacaacatgagaatgctggctttgtttgtggccttcgcaatcaacttcatcctg ctcttctataaggtgtccacgtcgtctgcagtgaaggaggagaagcaggtggtgtacagc acatcacagctggataatagcctgaggtgggactcgcagagcagctctcccgccgatcgt ccggtcacggtgcacttcgtgctggaggagagcagtggctacatggagcccacgctgcgc atcctggccatcctccacaccatcatctccttcttctgcatcatcggatactactgtctc aaggttcctctggtgatctttaagagggagaaggaggtagccaggaagctggagtttgat gggttgtatataacggagcagccgtcagaggatgacatcaaaggccagtgggacagactg gtcatcaacacacagtcctttccaaacaactactgggacaaattcgtcaaaaggaaggtg atggataagtacggcgagttttacggtaacgatcgcatcagcgagctgctgggcatggat aaaggcgctctggatttcagtgatgcccacgggaagaggaagcccaagaaagacggctcg ttagctgctgtgttaaactcggttgatgtgaagtaccagatctggaagctgggtgtggtc ttcacagataattcattcctgtatctagcctggtacatgaccatgtccatactgggccac tacaacaactttttcttcgctgctcacctgctggacatagctatgggcttcaagacacta aggaccatcctgtcttctgtcactcacaatggcaaacagctggtcctgacagtgggcttg ctggcagtggtagtctacctctacacagtggtggccttcaacttcttccgcaagttctat aacaagagcgaggacggagagtcaccagacatgaagtgcgacgacatgctaacgtgttac atgttccacatgtacgtgggcgtgcgtgccggcggtggcatcggcgatcagatcgaggac cctgcgggtgacgagtacgagatctaccgcatcatcttcgatatcacgttcttcttcttc gtcatcgtcatcctgctcgccatcatccagggtctgatcatcgatgcgtttggtgagctg agagaccagcaggaacaagtgaaggaagatatggagaccaagtgttttatctgtgggatt ggaaacgactattttgacacagtccctcatggctttgagacacacactttacaggagcac aacttggcaaactatctattttttgtgatgtatctcattaataaggatgaaacagagcac acgggccaggagtcgtacgtttggaaaatgtaccaggagcgctgctgggaattcttcccg gccggagactgcttccgaaaacaatacgaggaccagcttaactaa

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