Thermomicrobium roseum: trd_0365
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Entry
trd_0365 CDS
T00845
Name
(GenBank) 2-isopropylmalate synthase/homocitrate synthase family protein
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
tro
Thermomicrobium roseum
Pathway
tro00290
Valine, leucine and isoleucine biosynthesis
tro00620
Pyruvate metabolism
tro01100
Metabolic pathways
tro01110
Biosynthesis of secondary metabolites
tro01210
2-Oxocarboxylic acid metabolism
tro01230
Biosynthesis of amino acids
Module
tro_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
tro00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
trd_0365
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
trd_0365
Enzymes [BR:
tro01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
trd_0365
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
Motif
Other DBs
NCBI-ProteinID:
ACM05033
UniProt:
B9KY22
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Position
366185..367873
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AA seq
562 aa
AA seq
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MTMRRPPRRGEAAERFREGRRERMSENGERRVVIYDTTLRDGTQGSGVSLTTEDKLKIAR
ALDELGVAYIEGGWPGSNPKDMAFFERARHQQWRHARITAFGSTRRAGGTVEEDVNLRLL
LEAETPAVTIVGKASPFQVRVILGTTLDENLRMVAESVAFLKAAGREVIFDAEHFFDGYA
EDPDYALAVLRAACDAGADAVVLCDTNGGTLTDPLVRAVRHALSSVSCTVGIHTHNDCEL
AVANTIAAVLAGAMHVQGTMNGLGERIGNANLCSIIPILEYKLGYRCLPPGNLRKLTETS
RYVAEVANLAHDPRLPFVGAFAFTHKAGLHVNAIAKHPSAYEHIPPEVVGNTRHVLVSEL
SGRSNIVVKARSFGIELGDKPEVVRRVLEQIKELEFHGYWFEDADASLELLIRRNLPDYR
PPFEVLDYTVLTEYRNGRGMLAEAMVKLRIGQHVFHTAAEGNGPVNALDRATRKALQEFY
PEIAAVDLEDYKVRVLDDHHGTGAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL
AYPLVTRPELAARIPELVSAVS
NT seq
1689 nt
NT seq
+upstream
nt +downstream
nt
atgacgatgaggcggcctccccgacgcggggaggccgccgagcgtttccgagaaggaagg
agggagcggatgagcgagaacggcgaacgacgagtggtcatctacgatacgacgttgcgg
gatgggacgcagggatccggtgtctccctaacgacagaagataaattgaagatcgcccgg
gcattggacgaactgggtgtggcctatatcgagggtggctggcccggctccaatccgaag
gacatggcgtttttcgagcgtgcccgacaccagcagtggcgacacgccaggatcactgcc
ttcggaagcacacgccgagccggcggaacggtcgaagaggacgtcaacttgcgtctcctg
ttggaagcggagacaccggcggtgacgatcgtcggcaaagcgtcaccgtttcaagtgcgc
gtaatcctcggcacgaccctcgatgagaatctccggatggttgcggaatcggtcgccttt
ctcaaggcggcaggacgcgaagtgatcttcgatgccgagcacttcttcgatgggtatgcg
gaggatccggactacgcgctcgccgttctacgggcggcctgcgatgctggcgcggacgcg
gtggtgctgtgcgacaccaacggtggaacactgacggacccactcgtgcgggcagtgcgg
catgcgctctcctcggtctcctgtactgtgggcattcacacacacaacgactgcgaactg
gctgtcgccaacacgatcgccgcagttctggctggtgccatgcatgttcaggggacgatg
aatgggctcggggaacggatcgggaacgccaatctctgttcgatcatcccgattctcgag
tacaagctgggctatcgctgcttgccgccgggtaatctgcgtaagctcaccgagacgtct
cgatacgttgcggaggtcgccaacctggcgcacgatcctcgcctcccattcgtgggagcc
ttcgcgttcacgcacaaggccggactgcacgtgaatgcgatcgccaagcacccctcggcc
tacgagcacattccgccggaagtagtgggcaatactcggcacgtcctcgtcagcgaactg
agcggtcggagcaacattgtcgtgaaggcgaggagcttcggcatcgagctcggcgacaag
ccggaggtcgtgcgacgtgtcctggagcagatcaaggaactcgagtttcacggttattgg
ttcgaggacgctgatgcatcattggaactcttgatccgccgcaacctgcccgactaccga
ccaccgttcgaggtgctcgactatacggtcctgaccgaatatcgcaatgggcgcggcatg
ctcgctgaggcgatggtgaagttgcgcatcggccagcacgtcttccacaccgcggccgag
ggtaacggaccagtgaacgccctggaccgggctactcgcaaggcgctgcaggagttctat
ccggagatcgctgcggtagacctcgaggactataaggtacgcgtcctcgatgatcatcac
ggaacgggcgcgaaggtgcgcgtctggatccgctccggtgacgcgcatggcagttggaac
acggtcggttcctcggagaacatcatcgaggcgtcctggttggcattggctgatagcctg
gcctatccgctggtgacccggccagaactcgccgctcgcattcctgagctcgtatcagct
gtttcgtga
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