Triplophysa rosa: 130560740 Help Entry 130560740         CDS       T09216                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism tros  Triplophysa rosa Pathway tros04020   Calcium signaling pathway tros04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tros00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130560740    04020 Calcium signaling pathway     130560740  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tros04040]     130560740 Ion channels [BR:tros04040]  Voltage-gated cation channels   Ryanodine receptor    130560740 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Syntaxin-18_N Motif Other DBs NCBI-GeneID:  130560740 NCBI-ProteinID:  XP_057200726 LinkDB All DBs Position LG10:25668504..25759256 Genome browser AA seq 4822 aa AA seqDB search MAEGGDAEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLEPTSEAKYYPP DVCICSFVLEQSLSVRALQEMLAKTGQNNDQFIRKAAHSAGHRTLLYGHAILLRHSFSGM YLNCLKTSRSMTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGNIQVDASFMQTLWNVHPICSGSSVEEGYLLGGHVLRLFHGHDEVLTIPA SDQSEEEQRIVNYETGKAGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT EDRGVVLQDRERSDTSSTAFCFRASKEKLDCSVKRDVEGMGVAEIKYGDSLCFVMHVATG LWLSYQAPDVKSTRLGPLKRRVCLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSTF IRELESLSGKNRVFVVLPIEEVLQTLNDLIAYFRLPDAELEHEKKQIQLRSLKNRQNLFK QEGMLSLVSNCIDRLSVYNSAAHFGEHAGEEAAAAWKDILNLLYELLASLIRGNRNNCTQ FSQNLDWLVSKLERLESSSGILEVLHCILIESPEALNVIQRGHIKTIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLSRRDLLLQTRLVNDVQSMRPNIFVGVSEGSDQY RRWYFELVIDHVDHFMTGEPSHLRVGWASTKGYAPYPGGGEGWGANGVGDDLYSYGFDGL HLWSGRISRTVASVKQHVLTSDDVASCCMDLNAPSISFRINGQPVQGMFENFNTDGLFFP VVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDVGGVRDL LGNTHFTSQASFIPKPVDTSQTVMPPHLEKVRDRLAENIHELWGMNKIEMGWSYGKIRED NKRQHPCLVDFSKLPETERSYNIQMSTETLKTLLALGCHVVQVKVNAEEDLKKLKLPKNY MMSNGYKPAPLDLSDVKLTPGQELLVDKLTENAHNVWAKDRVKQGWTYGIQQDVKSKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYSVEPPDQDAGHVVERLSIDKIRFFRVER TYAVKTGKWYFEFEVVTGGDVRVGWARPGCKPDVELGTDDQAYVFDGHRGHRLHMGGRLF GRCWHAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFDLDDGFIPVCSLGLSQV GRMNLGKDASTFKYYTMCGLQEGFRPFAVNMNREVTMWFSKRLPTFFNVPRDHSDIAVTR IDGTVDSPPCLKVTHKTFGTQNSNSDMVFFRLSMPVDFHSAFRSSTSHMNGVYEEEPLKL RHRHPVKSMKHSEESRRIDYSSITTYYHSVRIFAGQDPSCVWVGWVTPDYHYYSNNFNLS KNRTVTVTLGDERGRVHESVKRNNCYMVWCGDVGSAGQTAGRSNADLEMGCLINVATGLL TFSVNGKELPTSHQVEPSTKLFPAVFVRPTSSSLFQFELGKIKNTMPLSSAIFKSEHKNP VPQCPPRLDVQTINSVLWSRMPNIFLKVETSRISERHGWMVQCQEPLQMLAVHIPEENRC VDIMELSEQEELRKFHYHTLKLYCALCAHGNTRVSHALCSHLDQSQLLYTIDNQYLSGML REGFYDVLISVHLETARAARLMMNNEFIIPVTAETRSILLFPDASKRHRPPGVGLSTSLK PKLNFAPPCFISAKRNQHLYSPEIPLDVLKEKAISMLTEAVQGGGDHIRDPVGGSVEYQF VPILRLISTLLTMGVLTSRDVHKILLLIEPNVFGERKEEGSRETAVKEGLTGAEEKTVET GEEEPVKGRKVVKGLLEKKLPECVKRQMCDLLHYFCDCELRHRIESIVSFSDGFVSKLQF NQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFDMGEGCPCPEDIQEELYDF HTELRLHCGIPAEEPKEHEDTSIKGRLLALVYKIKGQPQKSDSQPREKEQTAPTNLKELI SQTMVSWAQETHIQDPELVRVMFSLLRRQYDSIGELLRAMRKTYTISAASVSDTIHLLAS LGQIRSLLSVRMGKEEEQLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGG KSQEIAFPKMVASCCRFLCYFCRISRENQKAMFDHLSYLLENSSVGLASPSMRGSTPLDV AASSVMDNNSLALALEEPDLDKVVTYLAGCGLQSCSMLVAKGYPDISWNPIEGERYLSFL RFAVFVKGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENPALDLP STGPGHTSDTSTEGEEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRA ILRSLVPIEDLVGIISIPLKMPVLNKDGSVTEPDVSASFCPDHKAPMVLFLDRVYGIEDQ SFLLHLLEVGFLPDLRAAALLDTESVRTTESALAMNRYIGSAMLPLLTRCAPHFTGTEHH AALIDSTLYTIYRLSTCCSLTKAQRDAIEECLLAVCRYLRPSMLQPLLRRLVFDVPSLSE YCKMPLKLLSNHYEQNWKYYCLPSGWGGHGLPSEEELLLTKKIFWGIFDSLSQKTYDQEL FKMAMPCLSAIAGALPPDYIDPSLSTALEKHESVDAQGNFDPRPINTANVCLPEKLEYIA NKYTEHCHEKWAAEKVMLGWKYGENVDEKFKTHPMMRSYKALTEKEKETYRWSVSESLKS MLAMGWTIDRTKEGEMTFQLREIEKMRRTSQVSQGNGYSPTPLDMSNVPLSRELQVRPRS QSMVEVLAENYHNIWAKKKKSDLGAKGGTHPLLVPYDTLTAKEKVKDRERAQDLFRFLQI NGHSVSRGLKDIEQDSSSMEKRFAYKFLKKLLKYVDSAQEFIAHLEVMASSGQNNRSPHE QEIKFFAKVLLPLIDQYFKNHSLYFLSSATKTLSSSGYASNKEKEMVTSLFCKLAALVRH RISLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVKAGLRMFFENAAEDLEKTLENLKL GKFTHSRSQMKGVSQNINYTTVALLPILTALFEHITEHQFGSDLLLDDVQVSCYRILSSL YSLGTGKNIYVERQLPALGECLATLAGVIPVAFLEPPLNKHNIYSVFNTKTSRERAVAGM PECVEDMCPELPRLDGLMKDINDMSESGARYAEMPHVIEVVLPMLCNYLSYWWEKGPENC PESRASVCSTTVTSEHLSIILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARANLLK AHFLPTLEKLKKKTVKVVAEEELLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRY VDNNRSRWLKEPDADSHELFKMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSK TKMSKSYLQKSGGQDQERKHKKRRGDFYSIQTSLIVAALKKMLPIGLNMCTPGDQELIML AKTRHGLKDTDEEVKEHIRQNLHLQEKSDDPAVRWQLNLYKDVIVKSEGPPDPETTVQRI HRISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTG YLRLWIEAETYAFEEKLVQDLSKTQPKTDEEEDEIRETQPDPLHQLILHFSHNALTERSS VEDDQLYVAYADMMAKSCAENEEDDDEEKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVL QMISSSKGRLGRMVTFTLKLGISILNGGNMLVQQKMLDYLKEKRDVGFFKSLSGLMQSCS VLDLNAFERQNKAEGLGMVTEEGCINMRERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQ NFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDTAGQRNFSKALAVAKQ IFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQ KDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEH DPDRKGVISKKEFQKSMESQKQYSQSEIDFLLSCAEADENDMFNYEEFVERFHEPAKDIG FNMAVLLTNLSEHMPHDARLATFLNLAESVLNYFEPFLGRIEIIGGAKRIERVYFEISES SRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASLISEPDAAERP EEDDDDDAQSVTENQEEEEDEAALESSSAFTLACVSMRKSLSNLRQMLSLKSMRRQYRKL RKMSVKELIRGFFCFFWTLFVGTFRFLINLVWGFFHILWSTLFGGGLVEGAKNMKVTDIL GNMPDPTQFGIHGDVLDMEKLEYCDASQVSELGCEAAGERVEMDLMSELMNVQPRREGGK HGMEPGLGDVSEVVGVDAPSLASAVHQKKAQEAAMTAAESETKWESEKADVEDREKTDQG RRDEPVAGPAADEERKPVKNRRGQKKEAPDACMASFLAGLDVYQTKMLNYLARNFYNLRF LALFVAFAINFILLFYKVTGEDSDDLDPWVRRGGDGDDADEGVVEYFVLQESSGYMAPTL RFLAVMHTLISSLCVLGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDR LVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEDAVMKDASL LSWLSSIDTKYHVWKMGVVFTDNSFLYLVWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSSDEEEPDMKCDDMMTCYL FHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNE NT seq 14469 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagacgcggaggatgagatccagttcttgcggaccgatgatgaggtg gtcctgcagtgtgtggcgtgtattcagaaagaaaaccggaagttctgtctgagcgctgag ggtttgggaaaccgtctctgttatctggagcccacatcagaggccaagtattatcctcca gatgtgtgtatctgtagtttcgtgctggagcagtctctgtccgtgcgtgcactgcaggag atgctcgccaaaactggacaaaacaatgaccaattcattagaaaggcggctcacagcgca ggacacagaacattactgtacggtcacgccatcctcctcagacactccttcagtggaatg tatctgaactgtttgaagacatccagatcaatgacagataaattatcctttgacgtcgga ctgcaagaggattcaacaggtgaagcctgctggtggaccattcacccggcgtccaagcag agatctgaaggagagaaagttcgtatcggtgatgatctcattctcgtcagtgtttcatcc gaacgctatcttcatctgtccatatccaacggcaacattcaggtggatgcatctttcatg cagacgctgtggaatgtgcatcccatctgttcaggaagcagcgtggaggaaggatatctt cttggcgggcacgtgttgcgtctgtttcatggtcatgatgaggttctgaccatcccggcc tctgatcagagtgaagaagaacagaggatagtgaactatgagacggggaaagcgggagct aaagcgagatctctgtggaggctggagccgttacgcatcagctggtgtggcagtcacatc cgctggggtcaacccttccgtctccgtcacctgaccaccggtcactatctggccctgacg gaggacagaggggtcgttctacaggaccgcgagagatcagacacctcgtctacagcgttc tgcttcagagcgtctaaggagaagctggactgcagtgtgaagcgtgatgttgaggggatg ggcgtggcagagatcaagtacggagattctctgtgttttgtgatgcacgtggcgacgggc ctgtggctgtcctatcaggcgcctgatgtcaaatcaacacgtctgggtcctctgaaacga cgagtgtgtcttcactcagagggacatatggatgatggtctgaccttacagcgatgtcaa catgaggaatcgagagccgcgcgaatcattcgcaacacaacacgactctttagtaccttc atcagagagctcgagagtttgagcggcaagaaccgtgtgtttgtggttctgcccattgaa gaagttcttcagacactcaatgatctgattgcgtacttcagactgcccgatgctgaactg gaacatgagaaaaaacagattcaactgcgttccctgaagaaccgacagaacctcttcaaa caggagggaatgctgtctctggtgtctaactgcatcgatcgcttgagtgtttataacagc gccgctcattttggtgaacacgctggtgaagaggcagctgcagcgtggaaagacattctc aacctgctctatgagctgctggcttctctcatacggggaaacagaaataactgcacacag ttttcacagaatctggactggttggtcagtaaactggagaggctagaatcatcttcaggg atcttggaggttcttcactgtattctgatcgagagtcctgaagctctgaacgtcatccag agaggacacatcaagaccatcatctctcttctctacaaacacggacgaaaccacaagatt ctggacgttctctgctctctgtgtgtgtgtaacggcgtcgccgtgagagccaatcagaat ctcatctgtgatcacctgctgtccagacgagacctcctcctgcagacgcgattggtcaac gacgtccagagcatgcggcccaacatctttgtgggagtcagtgagggttcagatcagtac aggaggtggtatttcgagttggtgatcgatcacgtggatcatttcatgaccggcgagccc tcgcacctgcgggtgggttgggcctccacgaaaggttacgccccttacccaggaggagga gagggctggggggctaacggagtcggagatgatctgtactcgtatggcttcgatggactg cacctgtggtcggggcggatctctcgtaccgtagcgtccgtgaagcagcacgtgttgacg tctgatgatgtggcgagctgctgtatggatctgaacgctcccagcatctccttcaggatc aacggccagccggttcagggcatgtttgagaacttcaacaccgacgggctgtttttccct gtggtcagcttctctgctggggtcaaggtgcgtttcctgttaggtggtcgtcacggtgaa tttaagttcctgccgccggccggttacgcgccgtgttacgaggctctgctgcctaaagag aagatgagggtggagccagtgaaggaatacaaacgagatgtgggtggagtcagagattta ctgggaaacacccatttcacatcacaggcctcgtttatacctaaacccgtggacacgtct cagaccgtgatgcctcctcacctggagaaggttcgagatcgactcgccgagaacattcat gagctgtggggtatgaacaagatcgagatgggctggtcatacgggaagatccgagaggat aataaacgtcagcatccgtgtctggtggatttctccaaactgccagagacagagaggagc tacaacatacagatgtcaacagaaacgctgaagacacttctggctttgggttgtcatgta gttcaggtgaaggtcaatgccgaagaagacctgaagaaactcaaactgcctaagaactac atgatgtctaacggttataaaccagcgccgctggacctgtctgatgtcaaactgacccca ggtcaggagctgctggtggataaactgacagaaaatgcccacaacgtctgggccaaagat cgcgtcaaacagggctggacctacggcatacagcaggatgtgaagagcaagcgaaaccct cgcctggtgccgtacgctttactcgacgagcgaaccaagaagtcaaaccgcgacagcctc cgggaagccatccgcactctgattggatacggctacagcgtcgagccgcccgaccaagac gctggtcacgtggtggagcggttgagcatcgataagatccgcttcttccgtgttgagcgg acgtatgcggtgaagacggggaagtggtatttcgagttcgaggtggtgacgggtggagac gtgcgggtgggctgggctcggcccggctgtaagcccgacgtggagctcggaacagatgat caagcgtacgtctttgatggacaccggggtcatcgactccacatgggcggtcggctcttc ggtcgctgctggcacgcgggtgacgttgtgggttgtatgatcaacatggaggacaaatcc atgatcttcaccctcaacggagaaatcctgatcactaacaagggctcagaactctgtttc gctgactttgacctcgatgacggtttcattccggtctgcagtttaggactttctcaggtc ggccgtatgaatctggggaaagacgccagcacgtttaaatactacacaatgtgtggactg caggagggctttagacctttcgccgtcaacatgaatcgtgaggtgaccatgtggttcagt aaacgtctgcccaccttcttcaacgtgccgagagaccacagcgacatcgcggtgaccagg attgacggtactgtcgacagtccgccctgtctgaaggtcactcataagacgttcgggact cagaacagtaactcagacatggtgttcttcagactgagcatgcccgtagactttcactcc gccttcagaagctccaccagccacatgaacggagtctatgaggaggagccgctgaaactc agacacaggcatccggtgaagtcgatgaaacactcagaggagagcagaagaatcgactac agcagcatcaccacgtattatcattcagtccgaatattcgccggtcaggatccgtcctgc gtgtgggtcggttgggtcacccccgactatcattactacagcaacaactttaacctcagt aagaaccgcaccgtgacggtgaccctcggagacgagaggggtcgcgtgcatgagagcgtc aagaggaacaactgctacatggtttggtgtggagatgtcggcagcgcggggcagaccgcc ggcagaagtaatgcagatttagagatgggctgtcttatcaatgtggccaccggtctgttg accttcagcgtgaacggcaaagagcttccaacttcacaccaggtggagcccagcacaaaa ctctttcccgctgtgttcgtgcgtcccacaagctccagtctgttccagtttgaactgggc aaaatcaagaacaccatgcctttatcatcagccatctttaagagtgaacacaagaacccg gttcctcagtgtccaccgcgtctggacgtccagaccatcaactcggtgctgtggagccga atgccaaacatattcctgaaggtggagacgtcccggatcagtgagagacacggatggatg gtccagtgtcaggaacccctgcagatgctcgctgtacacatccctgaggagaaccgttgt gtggacatcatggagctgtcggagcaggaggaactgcgtaagttccactatcacacgctg aagctttactgcgctctgtgcgctcacggcaacacgcgtgtctctcacgccctgtgcagc cacctcgaccaatcccagctcctgtacaccatcgacaaccaatacctgtccggcatgctg cgcgagggcttctacgacgtcctcatcagcgtccacctggagacggcccgagctgctcgc ctcatgatgaacaacgagttcatcatccccgtcaccgccgagacgcgcagcatcctgctc tttccggacgcgtccaaacgccaccggccccccggcgtgggtctcagcacgtccctgaag cccaaactcaacttcgcacctccctgtttcatcagcgctaaacgaaaccagcacctgtac agccccgagatcccgctggacgtgctgaaggagaaagccatcagcatgctgacggaggcg gttcagggcggaggagatcacatcagagatcccgtgggaggaagtgtggagtatcagttc gtgcccatcctgcgcctcatcagtactctgctcaccatgggcgtcctgaccagccgagac gttcacaagatcttactgctcatcgagcccaacgtgttcggagaacgcaaggaggagggc tcgagagagacggcggtgaaggaaggtctgacaggagcagaggagaagaccgtcgagacc ggagaagaagaaccagtgaagggtagaaaggtcgtgaagggactgctggagaagaagtta cctgagtgtgtcaaacgacagatgtgtgatctgcttcattatttctgtgactgtgagttg aggcacaggatcgagtcgatcgtgtcgttctccgacggtttcgtttccaagctgcaattc aaccagaagtttcgctataatgagctgatgctcgcgctcaacatgtctgccgccgtcacc gccaaaaagaccaaagagtttcgctctcctccacaggaacagattaacatgctgttgaat tttgacatgggcgagggctgtccgtgtccagaggacatacaggaggaactctatgacttt cacactgaactgcggctacactgcggaatcccagcggaggaacccaaggagcatgaagac acgtctattaaaggtcgtctgctcgcgctggtctataagatcaaaggtcaaccgcagaaa tctgactcacagcccagagagaaagagcaaacagcaccaaccaatctgaaggagctgatc tctcagacgatggtgagctgggctcaagagacacacattcaggatcccgagctggtgcgc gtgatgttcagtctgttgaggagacagtacgacagcatcggcgagctgctgagagccatg aggaagacgtacaccatcagcgccgcctccgtgagcgacaccatccacctgctggcgtca ctgggacagatccgctcgctgctgagcgtccgcatgggtaaagaagaggaacagctcatg attgacggcttgagtgacatcatgaataacaaagtcttctaccagcatccgaacctgatg agagttctggggatgcacgagacagtgatggaggtgatggtgaatgtgctgggaggagga aaatcacaggaaatcgcttttcccaaaatggtagcgagctgctgtcgattcctgtgttac ttctgtcgaatcagtcgtgagaatcagaaagccatgttcgatcatttgagttatctgctg gagaacagcagtgttggactggcgtctccatccatgagaggatcgacacctttagacgta gcggcttcatccgtcatggataataacagtctggccctcgcgctggaggaacccgacctc gacaaggtggttacgtatctcgccggctgtgggctgcagagttgttccatgcttgtggct aaaggatatccagatatcagctggaaccctatcgagggtgaacgctacctttccttcctg cggtttgctgtgtttgtcaaaggtgagagcgtggaggagaactccagcgtggtggtcaag cttctgattcgccggccggagtgttttggcccagccttgcgaggagagggtggaaacggg ttgctggcggctatgaaggaggccataaagatctcagagaacccagcgctggatctgccc agcacgggcccgggtcacacgtcagacacgtccactgaaggtgaggaagaggaggaggtg gttcacatggggaacgccatcatgtccttctactcggctctgatcgatctgctgggccgc tgcgctcctgagatgcacttgatcaataaaggtaaaggtgaagctctgaggattcgtgcc atcctgcgatctctcgtgcccattgaggacctggtcggcatcatcagcatccctctgaaa atgcccgtgctcaataaagatggcagcgtgaccgagcccgacgtgtctgccagtttctgt ccggaccacaaggctcccatggtgctgtttttggatcgtgtgtacggcatcgaggatcag agtttcttgctgcatctgttagaggtgggattcctgccggatctgagggccgctgcttta ctcgacacggaatctgtgcggacgaccgaaagcgctcttgcgatgaacaggtacatcggt tctgccatgttgcctctgctcacgcgctgcgctcctcacttcaccggtacagaacatcac gccgcgctcatcgactcgacgctttacaccatctacagactgtccacgtgctgttcgctc accaaagctcagagagacgccattgaggagtgtttactggccgtctgcaggtatctcagg ccgtccatgttacagcctctcttacgccgactggtgtttgacgtgccatcgttgtccgaa tactgtaagatgcctctgaagttgttatcgaatcattacgagcagaattggaagtattac tgcctcccgtcaggctggggcggtcacggtctgccgtctgaagaagagcttctgctcacc aagaagatcttctggggcatctttgattctctctctcagaagacgtacgatcaggagctg tttaaaatggccatgccgtgtctgagcgccatcgccggagctcttccacccgattacatc gacccgtcgctcagcaccgcgctggagaaacacgagtctgtggacgcgcagggcaacttt gaccccagacccattaacacggccaacgtttgtctgccggagaagctggaatacatcgcc aacaaatacactgaacattgtcatgagaaatgggctgcagagaaggtcatgttgggctgg aaatacggagagaatgtagatgagaaattcaaaacacacccaatgatgaggtcctacaaa gctctcacagagaaggagaaagagacgtaccgctggagcgtcagtgagtcactgaagagc atgttggcaatgggctggactatagaccgaaccaaagaaggagaaatgacctttcagctg agagagattgagaagatgcgcaggacgtctcaggtgtctcagggtaacggctacagcccg acaccgttggacatgagcaacgtgcctctctcacgagaactccaggtgagacccaggtct cagtcgatggtggaagttctggccgaaaactatcacaacatctgggccaagaagaagaag agcgacctaggagccaaaggtggcactcatcctcttctcgtgccgtacgacacgctcaca gctaaagagaaagtcaaagatcgtgagagagcccaggatctgttccgcttcctgcagatt aacggacattcggtcagcaggggtttgaaggacatagaacaggactcctcctccatggag aaacgctttgcttataaatttctcaagaagttgctgaagtatgtggattctgcgcaggaa ttcatcgctcatctcgaggtgatggccagcagtggacaaaacaacagatctccacatgaa caggagatcaaattctttgctaaggttctcttgcctctcatagatcagtacttcaagaat cactcgctctactttctgtcctcggccaccaagacactgagcagcagtggatacgcctct aataaagaaaaagagatggtgaccagtctcttctgtaagctggccgctctggttagacac aggatctctctctttggaagtgactccaccactatggtcagctgtcttcacatcctcgca cacacattagacaccaggacggtgatgaagtcgggatctgaactggttaaagcgggtttg aggatgttctttgagaacgcagcagaagatctggagaagacgttggagaatctgaagttg gggaagttcactcactctcgcagtcagatgaagggagtttctcagaacatcaactacacc accgttgctcttctgcccatcctcacggctctgtttgaacacatcacggaacatcagttc ggctcggatctgctgctggatgatgtgcaggtgtcgtgttatagaattctgtccagttta tattcactgggaactggaaagaacatctatgtggagcggcagttgccggcgttgggcgag tgtttggcgactctcgcgggtgtgattcccgtggcgttcttagagcctccgctgaacaaa cacaacatctactccgtgtttaacacgaagacgtctcgtgagcgtgcagtcgcaggaatg ccggagtgtgtggaggacatgtgtcctgagctccctcgtctggacggtctgatgaaggac attaatgacatgtctgagtccggcgctcgatacgcagagatgcctcacgtcattgaggtg gttctgcccatgctctgtaactatctgtcatactggtgggagaaaggaccagagaactgt cctgagagcagagcgtccgtctgcagcaccactgtcacatcggaacatctcagcatcatc ctgggcaacatcctcaagatcctcaacagtaacctgggcattgacgaagcctcctggatg aaacgcatcgcagtttacgctcagcccatcatcagcaaagcccgcgccaacctgctgaaa gctcactttctgcccacgctggagaagctgaagaagaaaacggtgaaggtggtggcggag gaggagcttctgaaggctgacggcaagggcgacacccaggaggcggagcttctgattctg gatgagtttgcggtgctctgcagagatctgtacgctttctacccgatgctcatccgctac gtggacaacaacaggtctcgttggctgaaggaacccgacgccgattcacacgaactcttc aagatggtggcagaaattttcatcctttggtgtaaatcacacaatttcaagagagaagag cagaactttgtggttcagaatgagattaacaacctctcgtttctcactggcgacagtaaa accaagatgtcgaagtcgtatctgcagaagtcaggaggtcaggaccaggagcggaagcac aagaagcgtcgtggtgatttttactccatccaaacctctctgatcgtggcggcgctgaag aagatgctgcccatcggtctgaacatgtgcacgccgggcgatcaggagctcatcatgctg gccaagactcgacacggcctgaaggacacagatgaggaggtgaaggaacacatcaggcag aatctgcatctccaggagaagtcagatgatcctgctgtacgctggcagctcaatctttat aaagacgtgattgtgaagagcgagggacctccagacccggagacaacggtccagcggatc cacaggatctcagcggctgtgtttcacctcgagcaggttgaacagccgttaagatctaag aagtgtgtttggcagaagctgttgtctaaacagaggaagcgagctgtggttgcgtgtttc aggatggcaccgctgtacaacctgccccggcaccgctccattaatctgttcctcacgggc tatctgcgcctctggatagaggccgagacttacgcgtttgaggagaaactagtgcaggat ctgtctaagacacaaccgaagacagatgaggaggaagatgagatcagagagacacaacca gatcctcttcatcaactcatactgcacttcagtcataatgcactgacagaacgcagttct gtggaggatgatcagctgtacgtggcttacgcagacatgatggcgaagagctgtgctgag aatgaggaagatgatgatgaagagaaagagaaaacatttgaggagaaggagatggagaag cagaagactctctatcaacaggctcgacttcatgacagaggagcagcagaaatggtgcta cagatgatcagttctagtaaagggcgtttgggtcggatggtcacgttcacactgaaactg ggcatctctattctgaacggaggaaacatgttagttcagcagaaaatgctggactatctg aaggagaaacgagatgtgggatttttcaagagtttgtctggactcatgcagtcgtgcagt gttctggatctgaacgcattcgagcgtcagaacaaagctgaaggtttggggatggtcact gaagaaggttgcatcaacatgagagaacggggttccaaagttcttcagaatgatgagttt accaaagatcttttcaggtttctgcagctgttatgtgaaggacataataacgattttcag aacttcctcagaacacaaacaggaaacacgaccacagttaatatcatcataagcactgtg gactatctgctcagactgcaggaatccatcagtgatttttactggtattactctggtaaa gacgtcatggatacagcggggcagcgtaatttctccaaagctcttgccgtagcgaaacag atcttcaattcactcactgaatacatccagggtccgtgtattgggaatcagcagagtttg gctcacagcagactctgggatgctgttgttggatttcttcatgtttttgctaacatgcaa atgaagctgtcacaggactccagtcagatcgagctgttgaaggagctgttggatcttcag aaggatatgattgtcatgatgttgtcactgctggaaggtaatgttgtgaacgggactatc ggtaaacagatggtggacactctcgtggaatcctccagcaatgtggagatgatcctgaag ttcttcgacatgttcctcaagctgaaagatttgaccacctccgacagcttcaaagagcac gaccccgaccgtaaaggtgtcatctccaagaaagagtttcagaagtccatggagagccag aagcagtactcgcagtctgagatcgatttcctgctgtcctgcgccgaggccgacgagaac gacatgttcaactacgaggagttcgtcgagcgcttccacgaaccggccaaggacatcggc ttcaacatggcggttctgctcaccaacctatcggagcacatgccccacgacgcccgtctc gccaccttcctgaacctggccgaaagcgtcctgaactacttcgagcccttcctgggccgc atcgagatcataggtggagctaagagaatcgagagggtttacttcgagatcagcgagtcc agcagaactcagtgggaaaaaccgcaggtcaaggagtccaagcggcagttcatcttcgat gtcgtcaacgagggcggagaatccgagaagatggagctgttcgtcaacttctgcgaggac accatcttcgagatgcagctggcatctctgatctccgagccggacgctgcggagaggccg gaggaggacgatgatgacgacgcacagagtgtgactgagaatcaagaggaggaggaagac gaagcggcgttggagtcgtcctctgcgttcactctggcctgcgtctccatgaggaagagt ctgtcaaacctcagacagatgctgtcactgaaaagcatgagacgacagtaccgaaagctg aggaagatgagcgtgaaggagctgatacgaggcttcttctgcttcttctggaccctcttc gtcggcacgttccgcttcctcatcaatctggtgtggggtttctttcacatcctctggtcc accctgttcggcggaggtctggtggaaggagccaagaacatgaaggtgacggatatcctg gggaacatgcccgatcccacgcagtttgggatccacggtgacgttctggatatggagaag ctggaatactgcgacgcgtctcaggtgtccgagctcgggtgcgaggcggccggtgagcgg gtggaaatggacctgatgtcagaactgatgaacgttcagcccaggagagagggaggcaaa cacgggatggagccgggactgggagacgtgtctgaggtggtcggggtggacgctccttca ttggccagcgctgttcaccagaagaaagctcaggaagctgcgatgaccgccgcagagtct gaaaccaaatgggagtccgagaaggccgatgttgaagacagagagaagacagatcagggc aggagagatgaacccgtggcagggccagcagcagatgaagagaggaagcctgtgaagaac agacgtgggcagaagaaagaagcgcctgacgcctgcatggcttcatttttagccggtctg gacgtctatcagactaaaatgctgaattatctggctagaaacttttacaacctgcgtttt ctggctctgtttgtggcttttgccatcaacttcattctgctcttctacaaggtgacaggc gaggactctgatgatttggatccgtgggttcggcgcggtggtgatggtgatgatgctgat gaaggtgttgtggagtattttgttcttcaggagagcagtggttatatggctccgactctc cgcttcctcgctgtcatgcacacgctcatctcctctctctgtgtgctgggatattattat ctgaaggttccgttggtggtcttcaagcgtgagaaggagatcgcacgtaagctggagttt gatgggctgtacatcactgagcagccgtcagacgatgatataaaaggacagtgggacaga ctcgtcattaacacaccatctttccccaacaactactgggacaaattcgtgaaacgcaag gtgataaacaagtacggagatctgtacggtgccgagcggatcgcagaactgctgggtttg gataaaagcgctctggattttaatcccaccgaagacgcggttatgaaagacgcctcgctg ctgtcctggttaagctccattgacaccaagtatcacgtgtggaagatgggcgtggtcttc acagataactctttcctgtatctggtctggtacaccactatgtctgtactgggacattat aataacttcttcttcgccgcgcatctgttggacatcgccatgggctttaaaaccctgcgg accatcctgtcatcggtcacacacaacggcaaacagttggtgttgacggtcggtctgctg gctgtggtcgtctatctctacaccgttgtggctttcaactttttccgcaagttctacaac aagagttcagacgaggaagagcccgacatgaagtgtgatgatatgatgacttgttacctg tttcacatgtacgttggcgtccgtgctggtggaggtattggagatgaaatcgaggacccc gcgggcgacccgtatgaactctaccgcattctgtttgacatcacgtttttcttctttgtg attgttatactgctggctatcatacaaggtttgatcatcgacgcgttcggagagttgaga gatcagcaggaacaggtcaaagaagacatggagactaaatgtttcatctgtgggatcggt aacgagtaa

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