Triplophysa rosa: 130569510 Help Entry 130569510         CDS       T09216                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism tros  Triplophysa rosa Pathway tros04020   Calcium signaling pathway tros04260   Cardiac muscle contraction tros04261   Adrenergic signaling in cardiomyocytes tros04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tros00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130569510 (ryr2a)    04020 Calcium signaling pathway     130569510 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     130569510 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     130569510 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tros04040]     130569510 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:tros04990]     130569510 (ryr2a) Ion channels [BR:tros04040]  Voltage-gated cation channels   Ryanodine receptor    130569510 (ryr2a) Domain-containing proteins not elsewhere classified [BR:tros04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    130569510 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 EF-hand_5 Motif Other DBs NCBI-GeneID:  130569510 NCBI-ProteinID:  XP_057215190 LinkDB All DBs Position LG18:complement(322640..423052) Genome browser AA seq 4949 aa AA seqDB search MTDGGEAEDEIQFLRTDDEVVLQCSAMVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEERAEGHIDMERWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRAVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHV TTGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSV CYIQHVDSALWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESHTARVIR STVFLFNRFIRLDTHTKVHPEFHSFSHPYIPLKPQTQKGMINLVLECIDRLHVYSSAAHF ADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLVSRLERLEASSGILEV LHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQNLICD NLLPGRDLLLQTRLVNHVNSMRPNIFLGVSEGSAQYRKWYYELIVDHVEPFVTAEATHLR VGWASTQGYWPYPGGGEGWGGNGVGDDLYSYGFDGLHLWAGCVARSVSSPNQHLLRAEDV ISCCLDLSAPSISFRINGQPVQGMFENFNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFL PPSGYAPCFEAVLPREKLRVEHSQEYKHDHGNTRDLLGPTVTLTQAAFTPTPVDTSQIVL PPQIERIREKLAENIHELWVMNKIDLGWTYGAVRDDNKRQHPCLVEFSRLPEQERSYNLQ MSQETLKTLLALGCHVGVADERAAEKVNNLKLSAKYELSSGYKPAPMDLSHIKLASAQEA MVDKLAENAHNVWARDRTRQGWTYGIQQDIKNRRNPRLVPYILLDERTKKSNKDSLREAV RTLLGYGYNLEAPDQDHAARSDVNNLSVERFRIFRAEKTYSVNAGKWYFEFDVVTAGEMR VGWARPGCLPDQELGSDEQAFVFDGLKAQRWHQGNEHFGRMWQSGDVVGCMVDMNEGTMM FTLNGEVLLDDSGSELAFKDFEVCEGFIPVSSLGVSQVGRMNFGKDVSTLKYFTICGLQE GYEPFAVNMNRDTSMWISKRLPQFIPVPPNHEHIEVTRIDGTVESPPCLKVTQRSFGSQN SNTDIMFYRLSMPVECSETFGRSPGGMLSANGSFFSPKRDLDDFETVSDFEVLMKMPHSH VSSNGPERERDEFNNHKDHNQEKPSKIKQRFLLKRSKPDVNSSHSNTRLSEEVLADERDD TENLLQTSTYYYSVRIFPGQESSSVWVGWVTSDFHQYDPAFDLNMVRTVTVTLGDEKGKV HESIKRSNCFMVWGGECSNPSQGRNNNGLEIGCLVDTANGFLTFTSNGKELCTFYQVEPR TKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSERKNAVPQCPPRLHVQHLTPVSW SRVPNQFLRSEVSRVNERLGWMIQSSEPLQFMTLHIPEENRSLDILELTEQRDLLKFHYH TLRLYSAICALGNNRVAHALCSHVDEAQLLYAIQNKYMPGLLRTGYYDLLIDIHLSGYAT ARLMMNSEYIVPMTPETKSITLFPDEKKKHGLPGIGLSTSLQPRMRFSSPNFVGSVAGNH DNGVVAAAGDCFQYSPEFPLETLKSRTMEMLTEAVREGSLHVRDPVGGSTEFLFVPLIKL FYTLLIMGVFHNGDLKTILQLIEPSVFSQDSGLEGGADGPEVEESCGRGRLEGGGAEEHG LRGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAVVAFSDDFVANLQDNQRFR YNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDEKQDCPCPESIREQLLEFHEDL MTHCGIEIDDDKSGDGDGDFTIRGRLMSLVEKVTYLKKKMSEIPKKKKSKKPTTLQQLIS ETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINAVSVEDTINLLASL GQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGE SKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVA AASVMDNNELALALREPDLEKVVRYLAGCGLQSCVMLMSKGYPDIGWNPVEGERYLDFLR FAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAKKISGDPSRDGPS PTTEENRTPNDVIEEEEDETIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRA ILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPDMSAGFCPDHKAAMVLFLDRVYGIEDQ NFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPF ASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPVLNE HTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDEELHLSRKLFWGIFDALARKKYDVEL FKLALPCLSAVGGALPPDYMESNYVAMMEKQSSMDAEGNFNPQPADTSSVVVPEKLDHFI NKFAENSHEKWSMEKFAMGWVHGDLFCESSKVHPLLKPYKCLSEKDKEVYRWPIRESLKT MLSWGWCIERTKESDASTLHNRTRRISLSSQRSIEGAHGFCPQPVDMSNVTLSRDLHSMA ELLAENYHNIWARKKKLELESKGGGSHPLLVPYDTLTAKEKYKDREKAQDILKFFQINGY TVSRAMKEQDLDTPSIEKRFAYTFLQQLITYVDEAHEHMLEFDVGVRCKGDKIPHEQQVK FFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASNKEKEMVTSFFCKLGVLVRHRISL FGNDAASIVNCLHILGQTLDARTVMKTGQDSVKAALRAFFENAAEDLEKTMENLRQGQFT HTRAQPKGVTQIINYTTVALLPVLSSLFEHIGQNVFGEDVILDDVQVSCYRVLNSLYSLG TSKSIYVERHRPALGECLAAFSGAFPVAFLEPGLNRHNTYSIYNSKASRERAALGLPSQV EEACAQVPSLERALQDIMELAESGMRYTQMPHVMEVLLPMLCSYMSHWWESGPENNPEPS DSCCTSLTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIGKAKSQLLKSHFLP LMEKLKKKAATVLQDEDQMKAEGRGELSESELLILDEFTVLVRDLYAFYPLLIRFVDYNR AKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSK GAVSDPERKKMKKRGDRYSLQTSLIVAALKRLLPVGLNICVPGDQELIALAKNRFTQKDT EDEVREIVRNNLHLQGKLEDPAIRWQMALYKDVPNRSEDTSDPEKTVERVLNIAHVLFHL DQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEE HYFEDKLIEDLAKPGVDEPSEEDEMIKHIDPLHQLIQLFSRTALTEKCKLEEDQLYMAYA DIMAKSCHDGEEDEEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGP MVASTLKLGIAVLNGGNSTVQQKMLDYLKDKRDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSVLTHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTT VNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGP CTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLE GNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDLDGKGVISKRD FHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSE HMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAARMSDAGERSASKEDSEREKPEEE SPEMGFFSIATVRTALFALRYNVIMLMKVLSMKSIKKQVKKAKKMTVKDMVTALASFYWS VLLGLLHFTFSVARGFFRIVYNSFLGGCLVEGAKTMKVSELLANMPDPTQDEVRGETEEG EKKPADRTSPEEDLADLTVAADDTDLLSDIFGLDLKREGGQYKLMPHNPNASLTDLLNAP VPPPAAPSPEVRRRHQTKSSSSSAENNEITEDTKSVPEKAQGENGKKTQKKKKEEDEEVK RKVRLHYSRSDEPDLHESAFWKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFY KVSTSSAVSEGKDVMFSGTSDTSVPWDPLGSSSSPPVTVHFVLEESSGYMEPTLRILAIL HTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQ SFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKKKPKRDGSLAAVL NSIDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNFFFAAHLLDIAMGFKTLRTILS SVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCYMFHMY VGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQE QVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFFMYLINKDETEHTGQES YVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14850 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcggagaagccgaggatgagatccagttcttacggaccgatgacgaggtg gtcctgcagtgttcagcgatggtccataaggagcagcagaagctctgtctcgctgctgag ggcttcggaaacagactctgttttctggagtccacctccaactcaaagaacgttcctccg gatctctccatctgtacctttgtcctggagcagtctctgtctgtacgagcgctgcaggag atgctggccaacaccgaggaacgggccgaagggcacatagacatggagagatggaaattc atgatgaagacggctcagggtggaggtcaccggacgctgttgtacggtcatgcagtttta ctgcgacactcttacagcgggatgtatctgtgctgtctctccacggctcgctcatctaca gacaaactggcttttgatgttgggcttcaggaagacacgacaggtgaggcctgttggtgg accattcaccctgcgtccaaacagaggtcagaaggagagaaagtgagagtgggagatgat ctcattctggtcagcgtgtcgtctgaacgctatctgcacttgtcttatggtaatggaagt ttacatgtggacgcagcgttccagcaaaccctgtggagcgtagcacccatctgctcgggg agtgaagtggctcagggctttctgattggtggagatgttctacggctgcttcatggtcac atggatgaatgtttgacggtcccgtctggagaacacggagaagagcagcgcagggcggta cattatgaaggtggagccgtgtccattcacgcgagatcactgtggagactggagacgctc cgggtggcgtggagcggcagtcacactcgctggggtcagccatttcggctacgtcacgtg accaccggcaaatatctcagcatgatggacgatcaagggctcctgctgatggacaaagag aaagcagatgtcaagtccacggccttctgcttccgctcctcaaaagagaagctggacttt ggccttaggaaggaggtggatgggatgggtgttcctgacatcaaatatggcgactccgtc tgctacatccagcacgtggactccgccctctggctcacctaccaatcagtggacgccaag tgtgctcgcatgggcggagttcagagaaaggccatcatgcatcatgaaggtcacatggat gatggtttgacgctctcacggtcacaacacgaagagtctcatacagccagagtcatacgc agtactgtgttcctcttcaaccgcttcatcaggttggacacgcacacaaaagttcaccca gaattccactcattttctcatccttatatccctttaaaaccacaaacacaaaagggcatg ataaacctggtgctggagtgtatcgatcgtttacatgtctacagcagtgcggctcatttt gcagacgtggccggaagagaagcaggagaatcctggaaatccatcctgaactctctctac gagctcttggctgctcttatcagaggaaacaggaagaattgtgcacagttttccggctct ttggattggttggtcagtcgcctggagaggttggaagcctcgtccgggattctggaggtt cttcactgtgttctggtggagagtcctgaagctctgaacatcattaaagaaggacacatt aaatccatcatctctctgctggacaaacacggacgcaaccacaaggttctggatgtgttg tgttctctgtgtgtgtgtcacggcgtggcggttcgctctaatcagaatctgatctgtgat aatctgctgcccggcagagatctgctgctacagacacgactggtcaatcacgtcaacagc atgagacccaacatcttcctcggggtgagcgaaggctccgcccagtacaggaagtggtat tatgagctcatcgtggaccacgtggagccgttcgtgacggccgaagccacacacctgcgg gtgggctgggcatccacacagggttactggccgtacccgggcggtggagagggctggggc gggaacggagtcggagacgatctgtactcgtatgggtttgatgggctgcacctgtgggca ggttgcgtggcgcggtccgtgagctcacccaatcagcatctgctgcgggcggaggacgtg atcagctgctgtctggatctcagcgctcccagcatctcattccgaatcaacggtcagccg gtccagggaatgtttgagaactttaactcagacggactctttttccctgtggtgtctttc tcggcaggggtcaaagtgcgcttcctgttgggcggtcgtcatggagaattcaagttcctg cctccgtctggatacgctccgtgtttcgaggctgttttaccacgagagaagctgagagtg gagcacagtcaggagtataaacatgatcatgggaacaccagagacctcctgggacccaca gtcacactgacacaagctgccttcacaccaacacctgtggacaccagtcagattgtgctg ccgcctcaaatcgagcgaatccgtgagaaactggcagagaacattcatgagctgtgggtg atgaacaagatcgatctgggatggacctatggagcggtgcgagatgataataaacgtcaa catccctgtctggtggagttcagcagactgcctgaacaagagagaagctacaacctccag atgtctcaagagacgctcaagactcttctggctctaggttgtcatgtcggtgtggcagac gagcgtgcggcagagaaagtcaacaatcttaaactgtcagccaagtatgagctctccagc ggttataaacccgctcccatggacctgagccacatcaaactggcctcagcacaggaagct atggtggacaaactggcagagaatgcacacaacgtctgggccagagaccgcacacgacag ggatggacctacggtatacaacaggacattaagaaccgaagaaaccctcgtctggttcct tacattcttctcgatgaaagaaccaagaaatcaaacaaggacagtctgagagaagccgtc aggacgttactgggttacggctataacctggaggctccggaccaagatcacgcagcgaga tcggacgtcaataatctgtcggtggagcgcttccggatattccgagcagagaagacgtac agtgtgaatgcggggaagtggtattttgagtttgatgtggtgacggcgggggagatgcgg gtgggctgggctcgacccgggtgtttgccggatcaggagctgggctcagatgagcaggcc tttgtgtttgatggactcaaggcccagcgttggcatcagggtaacgagcactttggccgg atgtggcagtcgggtgatgtggtgggttgtatggtggatatgaatgaagggacgatgatg ttcactctgaacggtgaggttctgctcgatgactccggctctgaactcgcattcaaagac tttgaggtttgtgaaggcttcattcccgtctccagtctgggcgtctctcaggtcggccgg atgaatttcgggaaggacgtgagcacgctgaagtacttcaccatctgtggcctgcaggag ggctacgaacccttcgccgtcaacatgaacagagatacgagcatgtggatcagcaaacgt ctgcctcagttcatccccgtcccacccaaccatgagcacatagaggttaccagaatcgac gggacagtggagagcccaccgtgtctgaaggtcacgcagaggtcattcggctcacagaac agtaacacagacatcatgttctatcgtctgagcatgcccgtcgagtgctcggagacgttc ggaaggtcgcccggcgggatgctgtcggccaacggaagcttcttctctccaaagagagat ctggatgattttgagacggtgtccgattttgaggttctgatgaagatgccgcacagtcac gtcagctccaacgggccagagagagaacgagatgaattcaacaaccataaagatcacaat caagagaaaccctccaaaatcaaacagaggttcttgttgaagagatcgaagccggacgtc aacagcagtcattctaacactcgtttatcagaggaagttttagcagacgagagagacgac actgagaatctcctgcaaacatccacgtattattactcggtgaggatcttccccggtcag gagtcgtccagtgtttgggtcggttgggtgacgtcagattttcatcagtatgatccggcc tttgacctcaatatggtccgaacagtcactgttaccctgggagacgagaagggtaaagtt cacgagagtattaaacgcagtaactgcttcatggtttgggggggtgaatgcagtaacccc agtcagggtcgtaataataacggtctggagatcggatgtctggtggacacggccaacggc ttcctcaccttcacatccaatgggaaagaactctgcaccttttaccaggtggagccgaga actaaactctttcctgcagtgtttgcgcaggcgaccagtccaaacgtcttccagtttgaa ctgggacgcatcaagaatgtgatgcctctctctgcaggcctgtttaaaagtgaacggaag aacgcagtaccccagtgtccaccgcgcttacacgtgcagcacctcacacccgtctcatgg agtcgtgtgcccaaccagttcctgaggtcagaggtcagcagggtgaatgagagattgggc tggatgatccagagttcagaaccactgcagttcatgactctacatatacctgaagagaat aggtcgttggatattctggagttgacagagcagagagatctgctgaagtttcactatcac acactgcgtttatattcagccatctgcgctctggggaacaatcgagtagctcacgcgctc tgtagtcatgtggacgaggctcagctcctctacgccatccagaacaaatacatgccgggc ctcctgcgcaccggatactacgacctgctcatagacatccacctgagcggctacgccacc gcccgtctcatgatgaactccgagtacatcgttcccatgacgcccgagaccaagagcatc actctcttccccgatgagaagaagaaacacggcctgcccggcatcggactgagcacttcg ctgcagccgcgcatgcgcttctcctcgcccaacttcgtagggtccgtcgctggtaaccat gacaatggcgtggtggccgccgccggtgactgtttccagtacagcccagagtttccgttg gagacgctgaagagtcggacgatggagatgctgacggaggcggtgcgggagggcagttta cacgtgcgggatcctgtagggggcagcacggagttccttttcgttcctctcatcaaactc ttctacacgctcctcatcatgggcgtctttcacaacggagacctaaagaccatcctgcag ctgatcgaacccagcgtcttctcgcaggattctgggctggagggcggcgctgatggccca gaggtggaggagagctgtgggcggggccggcttgagggaggcggggccgaggagcacggt ttgagaggaaagatgcccaaagaaggacttttgcaaatgaaacttcctgaacctgtcaaa ctccagatgtgtcacctgctgcagtatctgtgcgactgtcaggttcggcatcgcatcgag gccgtggtcgcattctccgatgacttcgtagcaaatcttcaggataaccagcgcttccgt tataatgaagtcatgcaggcgctgaacatgtccgctgctctgaccgcacgaaaaaccaaa gagttccgctcacctccacaggaacagatcaacatgctgctgaattttaaagatgagaag caggattgtccgtgtccggagagcatcagagaacagctgctggagtttcacgaggacctc atgacacactgcggcattgagatagatgatgacaaatcgggagatggcgacggcgatttc acgatcagaggtcgtctgatgtctctggtggagaaggtcacctacctgaagaagaaaatg tccgaaataccaaagaagaagaaatcaaagaagcccaccactcttcagcagttgatctca gagacgatggtgcggtgggctcaggagtcagtcatcgaggatccagagctggtccgggcc atgtttgtgttactccaccggcagtatgacgggatcggcgggcaggtgcgagcgctgccc aaaacctacaccatcaacgccgtctctgtggaggacaccatcaaccttctggcgtctctg ggtcagatcagatctctgctcagcgtccgcatgggtcgtgaagaagagaagctcatgatt catggcctcagtgacatcatgaataataaagtgttttatcagcatccaaacctgatgaga gctttgggcatgcatgagactgtgatggaggtgatggtgaatgttctgggaggaggagaa tctaaggagatcacgtttcctaagatggtggcgaactgctgtcggtttctgtgttacttc tgtcgaatcagccgtcagaatcagaaggccatgtttgatcatctgagttatctgctggag aacagcagcgtgggactcgcgtctccgtccatgcgaggttccactcctctggatgttgct gcagcgtcagtgatggataacaatgaactggccctggcgctgagagaaccagacctggag aaagtagttcggtatctggccggctgcggtttgcagagttgtgtcatgttgatgtctaaa ggatatcctgacatcggctggaatccggttgagggtgaacgatatctggactttctcaga ttcgctgtcttctgtaatggtgagagcgtggaggaaaacgctaacgtggtggtgcggctc ctgattcgtcggccagagtgttttggccccgccctgcgtggagaaggcgggaacgggctg ctggcagcgatggaggaagccaaaaagatttcaggagatcctagcagagacggaccatca cccaccacagaagagaacagaacacctaatgatgtcatagaggaagaggaagatgagacc attcacatgggaaatgccatcatgaccttctatgccgctctcattgatctgttgggccgc tgtgctccagagatgcacctgattcacgcggggaagggtgaggccatccgcatccgagcc atcctgagatctctcattcccatcgaggacctggtgggcgtgatcagcatcccgttcctg atgcccacgctggctaaagacggttctgtgatcgagccggacatgtcggcaggcttctgt cccgatcacaaagcggccatggttctgtttctggaccgtgtttatggcatcgaggatcag aactttctcctgcacctgctggaggtgggattcctgcctgacctccgagccgccgcctca ttggacaccgttgctctgagcgccacagacatggcgttagctctgaaccggtacctgtgc acggccgttctgccgctcctcaccaaatgtgctcctctgtttgccggcaccgagccgttc gcctccctcattgactctctgctgcacaccgtctacagactctccaaaggctgctgtctc actaaagctcagagagacgccatcgaggagtgcctgctggccgtctgcggtaaactgcgg ccctctatgatgcagcatctgttgagacgtctggtgtttgatgttcctgtcctcaatgaa cacaccaagatgcccttgaagctcttgaccaatcactacgagcgctgttggaagtattac tgtctgtcaggaggatggggaagtttcggggcggcgtcagacgaggagctgcatctgtcc agaaagctcttctggggaatctttgatgctctggccagaaagaaatatgacgtggagttg tttaaattagcgctgccgtgtctgagtgcggtgggcggagctttacctccagattacatg gagtcaaactacgtggccatgatggagaaacagtcgtctatggacgctgaaggaaacttt aacccacagccggctgacaccagcagcgttgttgttccggagaagctcgatcatttcatc aacaaatttgccgaaaattctcatgagaaatggtcgatggagaagtttgcgatggggtgg gttcatggagacttgttctgtgaatcatctaaagttcatcctctgctgaagccttacaag tgtctctctgagaaggataaagaggtttaccgctggccaatcagagagagcctgaagacg atgctgtcgtgggggtggtgcatcgagcggacgaaagagagcgacgcgtccacgttacac aaccgcacacgcagaatatctctgtccagtcagcggtctatagagggcgctcatggtttc tgtcctcagccggtggacatgagtaacgtcaccctgtccagagatctacattcgatggca gaactgctggcagagaattatcacaacatctgggctcggaagaaaaaactggagctggaa tccaaaggtggaggcagtcatccgttgctggttccttacgacactttaactgccaaagaa aaatacaaagaccgagaaaaagcacaagacatcctgaagttctttcagatcaacggatac acagtgtcaagggctatgaaagaacaggatctggacacaccgtctatagagaagcgcttc gcgtacacatttctccagcagttgatcacgtatgtggacgaagctcatgaacacatgctg gagtttgatgttggcgtgagatgtaaaggcgataagattcctcatgagcagcaggtgaag tttttcggaaaggttgttttgccgctggtggatcagtacttcaaaaaccatcgactttac ttcctgtccactgccgtccgtccaatcagcagcggcggtcacgcctccaataaagagaag gagatggtgaccagctttttctgcaaactgggagttctggtcagacacaggatttctctg tttggaaatgacgcggcttcaatagtgaactgcctgcacatactgggacaaactctggac gccaggacggtgatgaaaaccggtcaggattcggtgaaagcggctctgcgagcgttcttc gagaacgcagcagaagatctggagaagacgatggagaatctgcgacagggtcagttcaca cacacccgcgcacaacccaaaggtgtgacgcagatcatcaactacaccaccgtggcgttg ctgcccgtcctctcatcgctgttcgaacacatcgggcagaacgtgtttggagaggatgtg atactggatgatgtccaggtgtcctgctatcgcgttttaaacagtttgtactcgctcgga accagtaaaagcatctatgttgagagacaccggccggctctgggggaatgtctggctgcg ttctcgggtgcgtttcccgtggccttcctggaacccggtctgaaccgacacaacacgtac tccatctacaacagcaaagcatcccgagaacgagcagctctcggtcttccgtcgcaggtg gaggaggcgtgtgcgcaggtgccgtctctggagcgagcgctgcaggacatcatggagctg gcggagtcgggcatgcgctacacgcagatgccgcacgtgatggaggttcttctgcccatg ctctgcagctacatgtctcactggtgggagagcggacctgagaacaatccagagccgtct gacagctgctgcacgtctctcacctctgaacacatgaacacgctgctgggaaacatcctg aagatcatctacaacaacctgggcatcgacgagggagcctggatgaagagactcgccgtg ttttctcagcccatcattggtaaagctaaatctcagctgttgaagtctcactttctgccg ctgatggagaagctgaagaagaaggcggcgacggttcttcaggatgaagatcagatgaaa gctgagggtcgaggcgagttgtctgaatccgagctgctcatcctcgacgagttcaccgtc ctcgtgcgagatctgtacgccttctacccgctgctcatacgattcgtcgactacaacaga gccaagtggctgaaagaaccgaatccagaggcagaagaattgttccggatggtggcagaa gtctttatcttctgggccaaatcacacaactttaagagagaggagcagaactttgtggtt caaaatgaaatcaacaacatgtccttcctcatcacagacaccaaatccaaaatgtcaaag ggtgcggtgtcagacccggagaggaagaagatgaagaagcgcggcgaccgctactcactg cagacgtctctgatcgtggcggctctgaagagattactgcccgtgggtctgaacatctgt gtgccgggagatcaggagctcatcgcgctcgccaagaaccgcttcacacagaaagacacc gaagatgaagtgagagagatcgtccggaacaacctccatctgcaggggaagttggaggat cctgcgatccgctggcagatggctctgtataaagacgtgccgaaccgcagcgaggacaca tctgaccccgagaagacggtggagagagttctgaacatcgctcacgtgctctttcacctg gatcaggttgaacatccacagagaagcaagaaggccgtttggcacaagctgttgtcgaaa cagagaaagagagccgtggtggcgtgtttcaggatggcgccgctctataatctgcccaga cacagagccgtcaatctgttccttcagggttatgagaagtcctggatcgagaccgaggaa cattatttcgaagacaagttgatcgaggatttggctaaacccggtgttgacgaaccgtca gaagaagatgagatgatcaaacacattgatccgttacatcagctcattcagctcttcagc agaactgcactgactgagaaatgtaaactggaggaggatcagctctacatggcgtatgct gatataatggcgaagagctgtcatgatggagaggaggatgaagaggaggaggtgaagagt tttgaggagaaggagatggagaaacagaagctgttatatcagcaggccagacttcatgat cgaggagctgcagagatggtcctgcaaaccatcagcgccagcaaaggagagatggggccg atggttgcttctacactcaaactgggtatcgccgtgctcaacggaggaaactcaaccgta caacagaaaatgttggattacctgaaagacaagcgggatgtgggcttcttccagagtttg gccggactgatgcagtcgtgcagtgttttggacctgaacgcgtttgagcggcagaataaa gctgaaggtctcgggatggtgacagaagaaggttcagtcctcactcatgagcgtggtgaa aaggtcatgcaggatgatgaattcacctgtgacctcttccgcttcctgcagctgctctgt gagggacacaactcagattttcagaactacctgcgaacacagacaggtaacaacacaaca gtcaacatcatcatctctacagtagattatctgctgagagtacaggagtccatcagtgat ttctactggtattattctgggaaagacgtcatcgatgaacaaggccagaggaatttctct aaagccatcaatgtggccaaacaggtgttcaacacactgacggagtatattcagggtccc tgcacggggaatcaacagagtctggctcacagtcgtctgtgggatgctgtcgttggattt ctacacgttttcgcacacatgcagatgaagctgtcacaggattcaagtcaaatcgagctg ttaaaggagctgatggatcttcagaaggatatggttgtcatgctcttgtccatgttagaa ggaaatgttgtgaacgggaccattggaaagcagatggtggatatgttagtggagtcgtcc aacaacgttgagatgatcctgaagttctttgacatgttcctcaaactgaaagatttgaca tcatcagatgccttcaaagagtacgacctcgacggcaaaggcgtcatctccaagagagat tttcataaagccatggagagccacaaacattacacccaatctgagaccgagttcctcctg tcgtgtgcagaaacggacgaaaacgaactcttagattatgaagagtttgtcgagcgcttc cacgaaccggccaaagacatcggcttcaacgtggccgtccttctcaccaacctctccgaa cacatgccgcacgactctcgactccagacgttcctggagctggccgagagcgtgctgaat tatttccagccgtatctgggccggatcgagatcatgggcagcgccaagcgcatcgaacgt gtgtatttcgagatcagcgagtccagccgcacgcagtgggagaagccgcaggtcaaagag tccaaacgtcagttcatcttcgatgtggtcaacgagggaggcgagaaagagaaaatggag ctcttcgtgaacttctgcgaggacaccatctttgagatgcagctggccgctcggatgtcg gacgccggcgaacgctcggccagcaaagaggacagcgagagagagaaaccggaggaggag agtcccgagatgggtttcttctccatcgccaccgtgaggacggctctgttcgctctgcga tacaacgtcatcatgctgatgaaggttctgtccatgaagagcatcaagaaacaggtgaag aaagccaagaagatgacggtgaaggacatggtgacggcgctggcgtctttctactggagc gtcctgctgggtctcctgcacttcaccttcagcgtcgctcgaggattcttccgcatcgtg tacaacagttttctgggagggtgtctggtggagggcgccaagaccatgaaggtgtccgag ctcctggccaacatgcccgatcccacgcaagacgaagtgagaggagagacggaggagggc gagaagaaacctgcggatagaacctcgcctgaagaagacctggctgatctgacggtggcg gcggacgacacggatcttctgtcggatatatttggtttggatctgaagagagaaggcgga cagtataaactcatgcctcacaatcccaacgccagcctcaccgatctgctcaacgcaccc gttccacctccggccgcaccgtcacctgaagtccgccggagacaccagaccaagagctcc tcatcttcagcagagaacaatgagattacggaagacaccaaatctgtgcccgagaaagcc caaggtgaaaatggaaagaagacccagaagaagaagaaggaggaggatgaggaggtgaag cgtaaagtacgacttcattacagcagatcagatgagccggatcttcatgagtctgcattc tggaagaagatcatcgcttatcaacgcaaacttctgaattatttcgcgcggaatttctac aacatgagaatgttggctctgttcgtggcgtttgccatcaacttcattctgctgttttac aaggtgtcgacgtcttcagcggtctctgaggggaaggacgtgatgttcagcggtacatca gacaccagcgttccgtgggatcctctgggatcctccagcagtccacccgtcactgttcac ttcgttctggaggagagcagcgggtacatggagcccaccctcaggattctggccattcta cacaccgtcatctctttcttctgtatcatcggctactattgtttaaaggttcctctggtg atatttaagcgtgagaaggaggtggccagaaagctggagtttgatggtctgtacatcacc gaacagccgtcagaagatgatattaaaggtcaatgggacagactggtcattaacactcag tccttcccaaacaattactgggataaatttgtgaagaggaaggtgatggataagtacgga gagttttatggtcatgatcggatcagtgagctgctcgggatggataaagccgctctggac ttcagcgacgctcacaagaagaagaaaccaaagagagacggatcactggcagcagtactg aactccatcgatgtgaagtatcagatttggaagttaggagtggtcttcacagataattct tttctgtatctggcctggtacatgagcatgtctattctgggacactacaataatttcttc ttcgctgctcatctgttggacatcgccatgggctttaagaccctgaggaccatcctgtcg tctgtcacacacaacggcaaacagttggtcctgaccgtaggtctgctggcggttgtggtt tatctctacactgtggtggctttcaacttcttccgtaagttctacaacaagagtgaagat ggagaatctccagacatgaagtgtgacgacatgctgacgtgttatatgttccacatgtat gttggcgttcgggctggcggtgggatcggtgatcagatcgaagatccagccggggatgag tacgagatctatcgcatcatctttgacatcaccttcttcttcttcgtcatagtcatcctc ctggccatcatacaaggtcttattattgatgcatttggtgagttaagagaccaacaagag caggtgaaagaagacatggagactaaatgtttcatctgtggaattggaaatgattatttt gacacagttccacacggctttgaaacccacacgctacaggaacacaacctggccaactat ctatttttctttatgtatctcatcaacaaagatgaaacagagcacacaggccaggagtca tacgtttggaaaatgtaccaggaacgctgctgggaattctttccagctggcgactgtttc cggaaacaatacgaggaccagctgaattaa

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