Takifugu rubripes (torafugu): 101062804 Help Entry 101062804         CDS       T02386                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism tru  Takifugu rubripes (torafugu) Pathway tru04020   Calcium signaling pathway tru04260   Cardiac muscle contraction tru04261   Adrenergic signaling in cardiomyocytes tru04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tru00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101062804 (ryr2)    04020 Calcium signaling pathway     101062804 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     101062804 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     101062804 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tru04040]     101062804 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:tru04990]     101062804 (ryr2) Ion channels [BR:tru04040]  Voltage-gated cation channels   Ryanodine receptor    101062804 (ryr2) Domain-containing proteins not elsewhere classified [BR:tru04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101062804 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  101062804 NCBI-ProteinID:  XP_029697864 LinkDB All DBs Position 1:complement(5858863..5953804) Genome browser AA seq 4934 aa AA seqDB search MGEGVEGEDEIQFLRTDDEVVLQCSATIHNDQQKICLAAEGFGNRLCFLESISNSKNVPP DLSICAFVLEQSLSVRALQEILASREEKVEGTVAHRTLLYGHAVLLRHSYSGMYLCCLST SRSSTDKLAFDVGLQDNSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSISSERYLHLS YGIGSFHVDAAFQQTFWSVVPICTRSEVAQGFLIGGDVLRLLYGHMDECLTVPSGQYGEE HRRTIHYEGGAVSSHARSLWKLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSQTEDKSLL LVDKEKADIKSTVFCFRSSKEKLDPSVKKDVDGMGVPDIKYGDSVCYIQHVFSCQWLTYQ TVDAKCARMGGVQRKAIIHHEGHMDDGLTLSRSQHEESHAAGVIRSIVSVFNIFIKGLDA LWKNGKSLSPDLPIDTVRLSLQDLIGYFQPPGDQMEHEDKQNHLRALKNRQNLFQEEGII SLVLECIDHLHLYSNAAQFAEVLGRKAGDRWSSILNSLYQLLAALIRGNRKNCAQFSSSL DWLISRLERLEASSGILEVIHCVLVESPEALNIIKEEHITSIISLLDKHGRNHKVLEVLC SLCVCHGVAVRSNQHLICDNLLPGRGLLLQTRLINHISSMHPNIFLGVSDGSAQYKKWYY EVVVDHVQPFVTSDATHLRVGWGNTGCYAPYTTGGEGWGGNGVGDDLYSYGFDGLHLLSG CIAQPVNSTSQHLLKPEDVVSCCLDLSVPSISFRINGQPVQGMFENFNTDGLFFPVVSFS AGVRVRFLLGGRHGEFKFLPPLGYAPCFEAVLPRERLKLVSSQDITGPGNLIGPTVMMSQ AAFTPTPVDTSQIVLPPNLERIREKLAENIHELWVMNKIELGWTYGTERDDGKRQHPCLV EFSKLPDQEHNYNLQMSQETLKTLLALGCHVGLVDEHAVKTVKTLDLPKTYELSSGYRPA PLDLSHIKLTLTQEAMVDKLAENAHNAWAKDRIRQGWTYGIQQDVKNRRNPRLVPYILLD ERTKKSNKDSLKEAVRTLLGYGYNLEAPDHDHAHHSGLSKMSVERFRIFRAEKTYSVNVG KWYFELMVVTAGQMRVGWARPGCLPDQDLGSDDQAFVFDGFKVQRWHQGNEHYGRVWQAG DVVGCMIDLNDRTMMFTLNGEVLLDDLGSEVAFKDFEVNEGFIPVCSVGVCQVARLNLGK NVSTLKYFTICGLQEGYEPFAVNMNRDVTMWISKRLPQFVPIPTNHQHIQVTRVDGTTES CPCLRVTQCSFGSQNSDIGTTFYRLSMPIECSESFFRSRSNETLFSSKKDLDDFETVSDF EILSEFNNHKDYNQEKPPKSKQRLLLKRNRPENSCSPSSVSDEMLTKEREEYDCFAHYST YFYSVRVFPGQEPNNVWVGWVTPDFHQYNPDFDLNNVRTVTVTLGDEKGKVHKSIKCSNC YMVWAGESCSPNEGRNNNGLEIGCLIDTTNGLLTFTANGKELSTHYQVEPNTKLFPAVFA RATSPNVFQFELGHVKNAMPLSAGLFKSERKNTVAQCPPRLHVQCLTSAIWSRVPNCFPK VTVYRVSERHGWLVKCNEPLQFMSLHIPEENRSVDILELSEQSDLLKFYYHTLKLYSSLC ALGNNRVAHALCSHIDESQLLYAIENKHMPGLLRTGYYDLLIDIHLNSYTTARLMMNNEY IVPMTEETMSITMFPDETKKHGLPGIGLSTSLRPRMHFSSPSFICGQWLCGHSKDKPGLE ESFQYSPEFPLDILKTKTIEMLTEAVQEGNMHVRDPVGGSTELLFVPLIKLLHTMLIMGV FENRDLKNILILIEPSVFCENGDEEKGHNEADRMKDIKNEGRDNNSGRSVPKQGLLQMKL PEPVKLQICHILQHLCDCQVRHRIEALVAFSDGFVARLQDNQRLRYNEVMLALNMSAALT AKKTKEFRSPPQEQINMLLNFKDDICGCPCPDSLQEQLLDFHVDLMRHCGVELDEGRGTD CDSDFTIRGRLMSLVEKVAYVKNKIENRPKQKKDRKASTLQQLISDTVVRWAQESVIEDP ELVRAMFILLHHQYDGIREVMRALPKTYTINSVSIEDTINLLAALGQIRALLSVRMGKEE EKLMIRGLGNIMNNKVFYQHPNLMRALGMHETVMDVMVNVLGGGHSKEITFPKMVANCCR FLCYFCRISRQNQRAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALR EPDLEKVVQYLAGCGLQSCGMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAN VVVRLLIRRPECFGPALRGEGGDGLLAAMKEAIKISQDLSKDRPIPKSGIKKTLQNSLKE EEKKDDVIHIGNSIMTFYAALIDLLGRCAPEKHLIHAGKGEAIRIKAILRSLVPVEDLVG VISIPFFIPSLNKDGLVLEPDMSAGFCPDHKAAMVLFLERVYGIEDQNFLLYLLEVGFLP DMRAAASLETIALSATDMALALNRYLCTAVLPLLTECAPLFAGTEPFASLIDSLLHTVYR LSKGCCLTKAQRDVIEQCLLAICGKLRPSMMLNLIRRLVFDVSLLNEHIKMPLKLLTSHY EHCWKYYCLTEGWGNFGAASDEELHLTRKLFWGIFDALSHKQYDQELFKLALPCLSAVAG ALPPDYMESNSMDMAEKQSCVDSERNFTPRPADTTSVTVPENLDYFITRCAENIHENWCL EKFSKGWSFGEKICETSKSHILLKPYQFLSEKDKEAYCGPIRESLKTILSWGWIIERTGE SDFASLYNKSRMASQASQMSFDGDLGFSPRPTDISNITLSRDLQSLADLLAENYHNIWAK KKKGDLEAKGGGHHPLLVPYDTLTAKEKSNYKEKAQGILKFLHISGYTVSRGDKSKELET PVIEKRFAYTFLQRIISYVDQAHQYMMDFDEKTKWQDEKHPHEQQMKYFGKVVLALVDQY FKNHRLYFLSTSIHPICSGGHASNKEKEMVTSLFCKLGVLVRNRISLFGTSATSILNCLQ ILAQSLDIRTVMKTGSETVKAALWMYFNYAAEDLEKTQENLKLGRFTHSTEQSQGVIQII NYTTFALLPVLSSLFEHIGQNMFGQDLILDDVQVSCYRILNSLYFLGTNQSIYVERQRPA LGQCLAAFSAAFPVAFLEHHMNKFNSFSVYNSRSAKARKASGLPGQIEEVCPLIPNLEKS LEEIQQLAESGMRYTQMPHVIEVVLPMLCSYMSHWWEHGPENNLDTVDSCCTSVTSEHMN ILLGNILKIIYNNLGIEEGAWMKRLAVFSQPIISKSKPQLLKTHFLPLMEKLKNRAAVVL MDEENSKAEGRGEMTETELLIMDQFTILVRDLYAFYPLLIRFVDYNRTRWLKEANADAQE LFHMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLIMDSKCKISKGIISDQERKKMKK KTDKYSKQTSLIVATLKRLLPVGMNTCAPGEQHLVTLAKNRFSEKDSEEEVEEIIRNILH LQGKMEDPAIHWQIALYRNLPYHFDNSNPEKIVGRVLHIANVLFHLDQVEHPQRSKKAVW HKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEPYFEDKLIDDLAKP GKQESTEEEELVKHLDPLHQLIHLFSRTALTEKCKLDEDNLYMAYADIMAKSCHDEEDED GEEVKSFEEKEMEKQKLLYQQARLHNRGAAEMVLQTISASKGEMGRMVASTLKLGIAILN GGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGE KVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISD FYWYYSGKDVIDEQGQKNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGF LHAFAHMQMKLSQDSSQIELLKELMDLQKGMVVMLLSMLEGNVVNGTIGKQMVDMLVESS NNVAMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFYKAMESHKHYSQSETDFLL SCAETDENEVLDYKEFVDRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQSFLELADSVLN YFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKME LFVNFCEDTIFEMQLAAQMSDAGERLAAKEENEQDKPGKENTEMVFLSVTTVQTALLALQ CNIILLLKALSMKNLKKKINNKKNITVKDMMTTLVSFYWSVLLGILHVAFSVVRGFYRIF SVASTNDQVQGAKTIKVSELVATMPDPTQLVKGAVEDQDKIACSDCNTLEDDLPALRVHT SETELLSDIFGLDLRREGGQYKLTPHDPKASLTELLTSPITVPDASTVTSAELQHNKQSK DFPSDGKEATTEIKNEAKKIAGGGHIMKQQKNKKIKLKERRQHIFKCEEPDLQESAIFKK IVAYQQKLLNYFSRNFYNMRMLALFVAFSINFILLFYKVSTSSSANEEKKVVINNSQAES SKQWDSWAGNAVDMKEEVMKPVTVHFVLQESSGYMEPMLCILAILHTVISFFCIIGYYCL KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV MDKYGEFYGQERISELLGMDKAALDFSDAHKKRKPRRDSSLSAVLNSIDVKYQIWKLGVV FTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIED PAGDEYEIYRMIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI GNDYFDAVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP AGDCFRKQYEDQLN NT seq 14805 nt NT seq  +upstreamnt  +downstreamnt atgggtgaaggagtagaaggtgaagatgagattcaatttttgcggacggatgatgaggtg gtacttcagtgctcagcaacaatccataatgaccaacagaaaatctgtctggctgccgaa ggctttggaaacagactctgcttcctagaatccatctctaactccaagaatgtgccccca gatctgtccatctgtgccttcgtgttggaacagtcattgtctgtacgagctttacaggag atcctggccagtagagaggagaaagttgagggaacggtggctcataggactttactctac ggacatgctgtccttctccgacactcgtatagtggaatgtacttgtgctgtctgtctacc tcccgctcgtctacagacaaacttgcctttgatgtgggattgcaggacaacagcacggga gaggcatgttggtggaccatccatccagcatcaaagcagcgttcggaaggagagaaagtc agagtgggagatgatctcatcctggtcagcatctcctctgagagatatttgcatctgtcc tatggtattggcagtttccatgtagatgcagctttccagcagacattctggagcgtggtc cccatctgtactaggagtgaggtagcacaaggattccttattgggggagatgtcctgcgg cttctttatggtcatatggatgagtgtctgactgttccatctggccaatatggagaagag cacaggagaacgatacactatgaagggggagcagtgtccagtcacgctcggtccctgtgg aagctcgagacattacgtgttgtgtggagtggaagtcatatccgctggggtcagcctttc aggcttagacatgtgaccacaggaaagtatctcagtcaaacagaggacaaatcactcctc ctggttgacaaagagaaggctgatatcaaatccacagtcttctgctttaggtcctccaag gaaaaattagaccctagtgttaagaaagacgttgatggcatgggagttccagatattaaa tatggagactctgtgtgttatatccagcatgtctttagctgccagtggctcacctaccaa actgtcgatgctaaatgtgctcgtatgggtggagtgcagagaaaggcaatcatacaccat gagggtcacatggatgatggtcttacactgtccaggtcacaacatgaggaaagtcatgct gctggagtgatacgcagtatcgtgtctgttttcaacatattcataaagggtctggatgct ctgtggaaaaatggaaagagtttgtctccagatctgccaatagatacagtccgtctgagt ttacaggatctaattgggtacttccaaccacctggcgaccaaatggaacatgaagataag cagaaccatctgagggctctgaagaaccgacagaacctttttcaggaagaggggataatc agcctcgtattggagtgtattgatcacctccatttatacagcaatgcagctcaatttgct gaggtattaggaaggaaagccggggaccgctggagctcaatcctcaactccctctatcaa ctactggctgcactgatccgagggaaccgaaagaattgtgctcagttttccagttcactg gactggctgatcagcagattggagagactggaagcctcctcaggtatactagaggtgatt cattgtgtgctggttgagagtcctgaggccttgaacataatcaaagaagaacacatcaca tctattatatctctattggacaagcatgggagaaaccacaaggttctagaagtgctgtgt tccctctgtgtttgccatggtgtggcagtacgttctaatcagcacttaatatgtgacaat cttttgccaggaagaggtcttctgttacaaactcgtctgattaaccatataagcagcatg catccaaacatcttcctgggtgtcagtgatggctcagctcaatacaaaaagtggtactat gaagtagtcgtggatcatgtgcagccatttgtgacatcagatgccactcatcttcgggtg ggctggggtaataccggttgctatgccccctacacaactggaggggagggctggggaggc aatggagtgggtgatgatctttattcatatggttttgatggacttcatcttttatcaggc tgtattgcccagccagttaactcaaccagtcaacaccttttgaaaccagaggatgtggta agctgctgcttagacctcagtgtgcccagtatctcctttaggattaatggccaacccgtt cagggcatgtttgaaaatttcaacacagatggccttttcttccctgtggtgagcttctct gctggagtcagggtacgtttcctccttgggggtcgtcatggagagtttaagttcctaccc cctctgggttatgcaccctgttttgaagcagtattgcccagggagaggctgaaactagtg tccagtcaggacataactggacctggaaacctaataggacccactgtaatgatgagccag gcagctttcacacccacacctgtggatactagccagattgtgctgccgcccaacttggag aggataagagaaaaacttgctgagaacattcatgaactttgggtgatgaataaaatagaa ctcggctggacctacggcacagaaagagacgatggcaagcgacaacatccctgtctcgtg gaattctcaaagcttcctgatcaagagcacaactataacttacagatgtcccaagagact ctcaaaactctcttggccttgggttgccatgttggcctagtagatgaacatgctgttaaa acagtgaaaaccttagatctaccaaaaacctacgagttgtctagtggctatagacctgct cctctggacctcagtcacatcaaactgaccttaactcaagaagccatggtggacaaactt gctgagaacgcacacaacgcctgggcgaaggaccgcatccgtcagggatggacctatggt attcaacaggatgtaaagaaccgcagaaatccccgtctggtcccctatattttgcttgac gagaggaccaaaaagtccaacaaagacagtctgaaagaagccgttaggactctcctagga tatggatacaatcttgaggctcctgaccatgaccacgcacatcactcaggcctcagcaag atgtctgttgagcggtttcgcattttcagagctgaaaagacctactctgttaatgtggga aagtggtactttgagctgatggtagtaacagcagggcagatgagggtaggctgggcccgc ccaggatgtctcccagaccaagatcttggatcagatgaccaggcctttgtttttgatggt ttcaaggttcaacgctggcatcagggtaatgaacattatggacgagtctggcaggctggt gatgtggttggatgcatgatagatctgaatgaccgcacgatgatgttcacactcaacgga gaagtgctgctggatgacttgggttctgaggtggccttcaaggactttgaagttaatgaa ggtttcattccagtctgcagtgtgggtgtttgccaggtggcaaggttaaaccttggaaaa aatgttagcacgctaaagtatttcaccatctgtggccttcaggagggctatgaaccattt gctgtcaacatgaaccgtgatgtgacaatgtggatcagcaaaaggctgcctcagtttgta cctattcctacaaatcatcagcacattcaggtgactagagtagatggaacaacagagagc tgtccatgcctcagagtcacccagtgttcttttggctcccagaacagtgatattggcacc accttctacagactaagcatgcctatagagtgttctgaatccttcttcagatctcgatct aatgagactctcttctcatcaaagaaggatttagatgactttgaaacagtgtctgacttt gagatcttgagcgaattcaacaaccacaaagactataaccaggagaagccccccaagtca aagcagaggttattactaaagagaaacaggccagaaaacagctgctcaccatcttctgtg tcggacgagatgttgactaaagaaagggaggaatatgactgctttgcacattactctaca tatttctattcagtgcgagtcttccctggacaggagccaaacaatgtttgggtgggctgg gtaacacctgactttcatcagtacaacccagattttgatttgaacaatgttcgaactgtc actgttacccttggagatgaaaaggggaaagttcacaagagtataaagtgtagcaactgt tacatggtgtgggctggagagagctgcagtcctaatgaggggaggaacaacaatggcttg gaaataggctgtctaattgatacaactaatggactgctgacctttacagccaatggcaaa gaacttagtactcactaccaggtggaacccaatactaagttgttccctgctgtttttgcc agggccacaagccccaatgttttccagtttgaattgggccatgttaagaatgcaatgcct ctgtcagctggtctgtttaagagtgagaggaagaacacagttgctcagtgtcccccacgg cttcatgtccagtgcctgacctctgctatatggagtcgtgtacctaactgctttcccaag gtgaccgtgtacagagtgagtgaaagacacggctggctggtgaagtgtaatgaaccgtta caattcatgtccttgcacatacctgaggaaaacaggtcggtggacatactggagctctca gagcagagtgatcttttaaagttttattaccacacactgaaactgtactcatcactctgt gctctgggaaataaccgggttgctcatgccctctgttcccacatagatgagtcacagctt ctctatgccatagagaacaagcatatgccaggtttgcttcggacaggctactacgacttg ctcattgacatacacctgaacagctataccacagctcgcctaatgatgaacaatgagtat attgtgcccatgacagaggaaaccatgagcataactatgtttccagatgaaacaaagaaa cacggcctgcctggcattggactcagcacgtcattgagacccagaatgcacttctcttcg cctagttttatctgtgggcaatggctttgtggtcacagcaaggacaagccagggttggaa gagagtttccaatatagccctgaattccccttagatattctgaaaaccaaaaccattgag atgttaactgaagctgtacaggaaggaaacatgcatgtacgggatcctgtaggcggcagc actgagttactctttgtccctcttatcaagctgttacacaccatgctgatcatgggagtt ttcgagaatagagatctgaagaacatccttatactgatagagccatctgtattctgtgaa aatggggatgaagaaaaaggccacaatgaagcagatcggatgaaggacatcaaaaatgaa ggaagagacaataattcagggagaagtgtgcccaaacaaggactgttacagatgaagcta ccagaacctgtaaaactccagatatgccatatactgcagcacctgtgtgactgtcaagtg cgccatcgcattgaagcattggttgccttctctgatggctttgtggctcgcctccaagat aaccagcgactgcgctacaatgaggtcatgctggccctcaacatgtcagcagccctcact gccaagaaaaccaaagagttccgctctcctccacaggaacagattaatatgcttctgaac ttcaaggatgacatttgtgggtgcccctgtcctgattccctccaagaacagctgctggat tttcatgtggacctgatgagacattgtggtgtagagttagatgaaggtagagggacagac tgtgacagtgatttcactatccgaggccgactcatgtcattggtagagaaagtggcttat gtgaagaataagattgaaaaccggccaaagcagaaaaaggacagaaaagccagtacatta cagcaactcatttcagatactgttgtccgctgggctcaagaatcagttattgaggatcca gagcttgttagagctatgtttatcctgctgcatcaccagtatgatggcatcagagaagtg atgcgggctcttcctaagacgtacactataaactcagtatcaattgaggacaccatcaat ttgctggctgctctaggtcagatcagggctctattgagtgtccgtatgggaaaagaagag gagaaactgatgatcagaggtcttggaaacattatgaacaacaaggtgttctaccaacat cctaacctaatgagggccctggggatgcatgaaactgtcatggacgtcatggttaatgtc cttggtggaggacattcaaaggaaatcacatttcccaaaatggtggccaactgttgtcgc ttcctctgttatttctgtcgaatcagccgtcagaaccagagggccatgtttgagcacctc agctatctgctagagaacagcagtgttggccttgcatcaccatccatgagaggctcgact cctctagatgtggctgcagcttctgttatggacaacaatgaactggccctcgctttaaga gaaccagacctggaaaaggtagtacagtatctcgctggctgtgggcttcaaagctgtggt atgcttgtgagtaaaggataccctgacattggatggaaccctgtggaaggggagcgctac cttgacttcctgcgctttgctgtgttctgtaatggagaaagcgtggaggagaatgccaat gttgtggtgaggcttctgatccgtcgtccagaatgttttggccctgctcttcgtggagaa ggcggtgatgggctgctggcagcaatgaaggaggcaataaagatatcacaggatctctcc aaagacaggccaatacctaaatctgggatcaagaaaactcttcaaaactcactaaaggaa gaagaaaaaaaagatgatgtcatccatataggaaattcgatcatgaccttctacgctgca ctcattgacctgttgggccgttgtgctcctgagaaacacttgatccatgcaggtaaaggg gaagccatccggatcaaagctattttaaggtctcttgtacctgttgaagacttggtagga gtcatcagcattccattcttcataccaagtctgaacaaagatggattagtattggagcca gacatgtcagccggtttctgtcctgaccacaaagcagctatggttcttttcttggagaga gtatatggtatagaggaccaaaatttcctgttgtacctgctggaagttggtttcttacca gatatgagagctgctgcatcactggagacaattgctctcagtgcaacagatatggccctc gcactcaaccgatatctgtgtacggctgttttgcctcttctgactgaatgcgctcctctg tttgcggggacggaaccttttgcctctctcattgactctttgctgcacacggtttaccgc ttgtccaaaggctgctgcctcaccaaggcacagagggatgtcattgagcagtgtctgctg gccatttgtggcaagctgaggccatccatgatgctgaatctcatacgaaggctagtgttt gacgtttcgctccttaatgaacacatcaagatgcctttgaagctgttgaccagtcactat gagcattgctggaagtattactgtctaacagaaggttggggaaactttggagctgcatca gatgaagagcttcatctcaccaggaagctcttctggggaatctttgatgctctctcacac aagcaatatgaccaggagctttttaaactggcattaccatgtcttagtgccgtggcagga gctcttcctccagattacatggagtccaattctatggacatggctgagaaacaatcatgt gtggactcagagagaaattttactccaaggcctgcagacactaccagtgtgactgttccg gagaatctagactacttcatcacaagatgtgcagagaacatccatgagaactggtgtctc gagaagttttccaagggctggtcatttggggaaaagatatgtgagacatccaagagccac atcttgctgaaaccatatcaattcctctctgaaaaggacaaggaagcctactgtgggcca atcagagagtctctgaagaccatactgtcttggggatggatcattgaaaggactggagaa agtgactttgccagtctttacaataagtccaggatggcatcacaggcaagccaaatgtct tttgatggagatctaggctttagtcccagaccgactgatattagcaacattactttgtca agagatttgcagtctctggcagacttgcttgcagaaaattaccacaatatttgggccaag aaaaaaaagggggatctggaagctaaaggtgggggtcaccatcctctgctggttccctat gatacattgactgccaaagagaaatctaattacaaagaaaaagcacaaggcatcctcaag ttcctccatatcagtggctacactgtgtctcgaggtgacaagtcaaaggaactggaaaca ccagtgatagaaaaacgatttgcctacacctttctgcagcggatcatctcctatgttgac caggcccaccagtatatgatggattttgatgagaaaaccaaatggcaagatgaaaaacat ccacatgagcagcagatgaagtattttggaaaggttgtcttggcattggtggatcagtac tttaaaaaccacaggctgtacttcctgtccacatccatccatccaatttgcagtggtggt catgcttccaataaggaaaaagagatggtaaccagtcttttctgcaaactgggagttcta gtcagaaataggatatccttatttgggacaagtgccacatccatactcaactgtcttcag atactggcacaaagccttgatatcaggacagtgatgaagaccggttccgagacagtgaag gccgcactgtggatgtacttcaactatgctgcagaagatctggagaagactcaggagaat ctaaaactgggtcggtttacccacagcacagagcagtcacaaggagtcattcaaataatc aactacactacttttgctctcctgcctgttctgtcctctctgtttgagcacattgggcag aacatgtttgggcaagatctaatattggatgatgtccaagtgtcctgttacagaatcctt aacagtctgtactttctgggaaccaatcaaagcatctatgttgaaagacagcgtccagct ttaggtcagtgtttggctgccttctcagcagccttccctgttgctttccttgaacatcac atgaacaaattcaacagtttctccgtctacaacagcagaagtgcaaaagccagaaaagct tctggtcttccagggcaaattgaagaagtctgtcctctcattccaaacttagagaagtct ttagaggagatacagcaattagcagaatctggcatgagatacacgcagatgccccatgtt atagaggtggtgctacccatgttgtgcagctacatgtctcattggtgggaacatgggcca gaaaacaatctagacactgtcgacagctgctgcacttctgtgacttctgaacacatgaac attcttctgggaaatattctcaagattatctacaacaaccttggaattgaagaaggagca tggatgaaaagactagctgtcttctctcagccaatcatcagcaagtctaaaccccagcta ctcaaaacccattttttgcctctgatggagaaactgaaaaacagagcagctgttgttctg atggatgaggaaaacagcaaagcagagggacgaggggaaatgacagagacagagcttctc atcatggaccagttcactatattggtacgagacctgtatgccttctacccactcctcata agatttgtggactacaacaggaccagatggctcaaagaagcgaatgcagatgcccaggag ctgttccacatggtggctgaagtattcatcttctgggcaaaatctcataacttcaagaga gaagagcagaactttgtggtccagaatgagatcaacaacatgtcttttctgatcatggac agcaagtgtaagatatcaaagggaatcatttcagaccaggaaaggaaaaaaatgaaaaag aagacagacaaatattcaaaacaaacgagtcttattgttgctactctgaaacgcctgctg cctgtcggaatgaacacatgtgctcctggagaacaacatcttgtcacgctcgctaagaac cgtttctctgagaaagattcagaggaggaagttgaggagattatcagaaacatccttcac ctgcaaggaaagatggaggacccagctattcattggcaaatagctttgtacagaaatctc ccataccattttgacaactcaaatccagagaagattgtggggagagtcctccacattgct aatgtgctctttcacttggatcaggttgaacatcctcagcgcagtaagaaggctgtctgg cacaaactgctgtccaaacaacggaagagagctgtggttgcctgttttaggatggcacca ctctacaatctgcctaggcaccgtgctgtcaacttgttcctgcaaggctatgagaagtca tggattgaggcagaggaaccctactttgaagataagctcatagatgatcttgctaaacca ggtaaacaggagtcaactgaagaagaagagttggtgaaacaccttgatccactgcatcag ttaattcatctgtttagcagaacagccctcacggagaaatgtaaactggatgaggataat ctctatatggcctacgctgacatcatggccaagagttgccatgatgaagaggatgaggat ggagaagaagtaaagagctttgaagagaaggaaatggagaagcagaaactgttgtatcag caagctcgtcttcataaccgtggagctgcagagatggttcttcaaaccatcagtgcgagc aaaggtgaaatgggtcggatggtagcctccacattaaagctgggaatcgcaattctcaat ggaggaaactcaactgtccaacagaaaatgttggattatcttaaagacaagaaggatgtc ggcttctttcagagtctggcaggactgatgcagtcatgcagtgttttggatctcaatgca tttgagaggcagaacaaagctgagggacttggaatggtgactgaggaaggatcaggtgag aaggttatgcaggatgatgagttcacctgtgaccttttccgcttcctgcagctgctctgt gaaggacacaactccgactttcagaactatttgaggacacaaacaggaaacaacactaca gtcaacatcataatctcaactgttgattacctcctcagagtacaggagtcaatcagtgat ttctactggtattattctggaaaagatgtcattgatgagcagggccagaagaacttttca aaggcaataaacgtggcaaagcaggttttcaatacgctcacagagtacatccagggtccc tgtactggtaaccagcagagtttggcccacagtcgactttgggatgctgtggtggggttt ttacatgcctttgctcacatgcagatgaaactgtcccaggactccagccagatcgagctc ttgaaggagctaatggacctgcagaaaggaatggtggtcatgctgctctccatgctagag ggtaatgttgttaatggaacaatcgggaaacaaatggtggacatgctagtggaatcctcc aacaatgtggcaatgatcctcaaattttttgacatgttcctcaaactcaaagacctgacc tcttcagacactttcaaggaatacgaccctgatggaaaaggtgtcatctccaagagggac ttttataaggcaatggagagccacaaacattacagccagtctgagacagactttttgctc tcctgtgctgagaccgatgagaatgaggttttggactacaaagaatttgttgatcgcttt catgagccagcaaaggacatcggctttaatgtggcagttctgttgaccaacttgtcggag cacatgcctcatgacacccggctccaatccttccttgagcttgcagacagcgtcctcaac tatttccaaccatacctgggccggatagaaataatgggcagtgcaaagcgcattgagagg gtgtactttgagatcagcgagtccagtcgtacacagtgggagaaacctcaggtcaaagag tccaagcgtcagttcatctttgatgttgttaatgagggtggtgagaaggagaagatggag ctttttgtgaacttctgcgaggacaccatttttgagatgcagctggcagctcagatgtcg gatgctggggagcgtttggcagccaaagaggagaatgagcaggacaagcctggcaaggag aacaccgaaatggtctttctgtctgtcaccacagtacaaacggccctgttagcacttcag tgcaacatcatactgcttctcaaggcactttcaatgaagaatctgaaaaagaagataaat aataaaaagaacatcacagtgaaagacatgatgaccaccctggtgtccttctactggtcg gtgctgctgggaatactccatgtggccttcagtgttgttcgaggattttacaggattttc tccgtcgcctccacaaatgaccaagtacagggggccaagaccatcaaggtgtcggaactt gtggccactatgcccgatcccactcagctggtgaaaggtgcagtggaagaccaggacaaa atagcctgttctgactgtaacacactggaggatgatttgcctgctctaagagtccacacc agcgagaccgagctcctgtcagacatttttggccttgacttgagacgagagggggggcag tacaagctcaccccacatgaccccaaagccagcctgactgaactcctcacctctcctatt acggtcccagatgcatccacagtaacttctgctgaactccaacataacaagcagtctaag gactttccctcagacggaaaggaagcgactacagagattaaaaatgaagcaaagaaaata gcaggtggtggacacataatgaaacaacagaaaaacaagaaaataaaacttaaagagaga agacagcacatctttaaatgtgaggaacctgacctgcaggagtctgccatcttcaagaag atcgtggcctaccaacaaaaactgcttaactatttctccagaaacttttacaacatgaga atgttggcactgtttgtagcattttcaatcaatttcatcctcctcttctataaggtttca acatcatcatctgcgaatgaggaaaagaaagtagtgatcaacaacagccaggcagagagc agcaagcagtgggattcatgggcaggaaacgctgtagacatgaaggaagaggtgatgaag cctgtcactgtccactttgttctgcaggagagtagtggatacatggagcccatgttgtgc atcctggccatcctgcacacggtcatctccttcttctgcattattggatactactgcctt aaggttccactggtgatctttaaacgggagaaagaagttgcccggaaactggagtttgat gggctttacattacagaacaaccatctgaggatgacattaaaggccaatgggaccgacta gtcatcaacacgcagtctttccccaacaattactgggataaatttgtaaagagaaaggtg atggataaatatggagaattctatggtcaggaacgtatcagtgagttactgggaatggac aaggctgctctggacttcagtgatgctcataaaaagaggaagccaagaagagacagctct ctgtctgctgtgctaaattcaattgatgtcaagtaccagatctggaagctgggtgttgtt ttcacagataattctttcttatatctggcatggtatatgacaatgtccatcctgggtcac tacaacaacttcttcttcgctgcccatttgcttgacattgctatgggcttcaagacactg cgcactatattgtcctcagtcacacacaatggaaaacagctggtgttaaccgtcggcctc ttagcagtggtggtttacctctacactgttgtggccttcaacttcttcaggaagttttac aacaagagtgaagatggagaactgcctgatatgaagtgtgatgacatgctgacatgctac atgttccacatgtacgtgggagtcagagcaggtggtggaatcggagaccagattgaggac ccagctggtgatgaatatgaaatctatcgaatgatctttgacatcaccttcttcttcttt gtcatcgtgatcctcctggcaatcatccaggggttgatcattgatgcttttggagagttg agagatcaacaggaacaagtgaaagaagacatggagaccaagtgttttatttgtggaatt ggcaatgactactttgacgcagtcccacatggtttcgaaacacacacgttacaagagcac aacttagccaactacctattctttttgatgtaccttatcaacaaagatgaaacggagcac accggccaggaatcttatgtgtggaaaatgtaccaggagcgctgctgggagttctttcca gcgggtgactgctttcgaaagcagtatgaggaccagctcaactga

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