KEGG   Thunnus thynnus (Atlantic bluefin tuna): 137171594
Entry
137171594         CDS       T11154                                 
Symbol
erbb2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2 isoform X1
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
tty  Thunnus thynnus (Atlantic bluefin tuna)
Pathway
tty04010  MAPK signaling pathway
tty04012  ErbB signaling pathway
tty04020  Calcium signaling pathway
tty04510  Focal adhesion
tty04520  Adherens junction
tty04530  Tight junction
Brite
KEGG Orthology (KO) [BR:tty00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    137171594 (erbb2)
   04012 ErbB signaling pathway
    137171594 (erbb2)
   04020 Calcium signaling pathway
    137171594 (erbb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    137171594 (erbb2)
   04520 Adherens junction
    137171594 (erbb2)
   04530 Tight junction
    137171594 (erbb2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tty01001]
    137171594 (erbb2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:tty04147]
    137171594 (erbb2)
   04090 CD molecules [BR:tty04090]
    137171594 (erbb2)
Enzymes [BR:tty01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     137171594 (erbb2)
Protein kinases [BR:tty01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   137171594 (erbb2)
Exosome [BR:tty04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   137171594 (erbb2)
CD molecules [BR:tty04090]
 Proteins
  137171594 (erbb2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Tcell_CD4_C Haspin_kinase
Other DBs
NCBI-GeneID: 137171594
NCBI-ProteinID: XP_067431712
LinkDB
Position
20:complement(15225432..15250318)
AA seq 1302 aa
MEAARSLLFVGAVLLGVTGALGREVCLGTDMKLALPSSLENHYETLKLLYTGCQVVHGNL
EITHLHGQPDLSFLQGIVEVQGYVLVAHVSVSLVPLDNLRIIRGSQLYNTSYALAVLDNT
LNGQGLSTLRLRSLTEILLGGVYIWGNPQLCFPDPQNITWRDTLDEQNIHAKQHRLQPRA
SKCPSCSPACETSCWGETAQDCQTLTRINCASGCQRCKGRLSNDCCHMQCAAGCTGPKDS
DCLACRHFNDSGVCKDNCPPPTIYDPVTFQTKPNPNKKFSFGATCVKTCPYNYLAMDVAC
TLVCPKANQEVIITNPDGNEMQKCEKCEGDCPKVCYGLGMDSHGVMDNHVVTMVTSSNVE
QFNSCKKIFGSLAFLPQSFERDPVTNTSGLTLMQLSAFKNLEEITGYLYIDAWPENWTDL
SVFENLKVIRGRMLYKGVFSLAIQNLHIQSLGLRSLRSISGGLVLLHNNSQLCYTSSLPW
GTLLHPTQGPHYIVSHNQDPELCEAEGRVCHSLCEGGCWGPGPSQCVSCKAFQRGTECVE
QCDIYQGPVREYTDGSLCVACHTECRPLNGSASCHGPGADQCTECQNFQDGESCVDHCPS
GVKEDQHTVWKYSNATRHCLPCNTNCTLSCTLMDERGCPIHTKTGPGTTIAAAVGGVVLF
FILLALLVFYLRRQRKLKRKETMRRILQEHELVEPLTPSGASPNQAQMRILKETELKKLR
VLGAGAFGTVYKGVWAPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCR
LLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQFLLNWCVQIAKGMSYLEEVRLVHR
DLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRKFTHQSD
VWSYGVTVWELMTFGAKPYDMIPAREIPDVLEGGERLPQPLICTIDVYMIMVKCWMIDPD
SRPRFKDLVNDFTAMARDPPRYVVIQNDEQMSMSSPVDSQFFRMLLEEEGNNMRELLDAE
EYLVPQPNLFPRAQGDGSQANGPSRHQSYRQSRDLGLDVEPSIAGGPRSMYSSLSTLGRS
QYPTLPLGGSTSNGMWTPQYPTLARSPSASGQSDSVFLDGPPDDSLPPASPGRYCKDPTY
PNGSQDDLETDGPNGFHHPHHFHHSLPRRSHGHNHNHALPEYVNQEVQDLRLGIPERPST
LPRKGSKVDRRLPNGLSSGHSVENPGYLVPMSSRGSTSPAFDNPYYLDLVAKAKAVAGAA
AVDGPGQVERDEGMPRQVNGFVTSTAENPEYLGLADTWSGYT
NT seq 3909 nt   +upstreamnt  +downstreamnt
atggaggcggcgagaagtttgctgtttgtcggggccgtgctgctcggagtgacgggcgcg
ttgggcagagaagtgtgcctgggtacagacatgaagctggccctgccctccagcctggaa
aaccactacgagaccctgaagctgctctacactggctgtcaggtcgtccacggcaacctg
gagattacacaccttcatggacagcctgacctctctttcctacagggtattgtggaggtg
cagggctatgtacttgtagcccatgtttcagtgagtttggtgcctttggacaaccttcgg
atcatccgaggcagccagctgtacaacaccagctatgccctggcagtgctggataatact
ttgaacggacaggggctcagtacactccggcttcgtagcctcacagagatcctgttgggt
ggggtgtatatttgggggaacccccagctgtgcttcccagatccccagaacatcacgtgg
agggacactttggatgagcagaacatccacgccaagcagcaccgactgcagcctcgggcc
tctaaatgtccaagttgttcccctgcatgtgagacaagctgctggggagaaactgcacag
gactgccaaaccttgacccgaatcaactgtgcgtctggctgtcagcggtgtaaaggacgt
ctgtccaatgactgctgtcacatgcagtgtgctgctggatgcacaggacccaaagactca
gactgtctggcgtgtcgtcatttcaacgacagtggtgtgtgtaaggacaactgtcctcca
cccactatctacgaccccgtcacctttcagaccaaaccaaacccaaacaagaagttcagc
tttggagccacctgtgtcaagacgtgtccctataactacctggctatggatgtggcttgc
actttggtttgtcccaaagccaaccaagaagttatcatcaccaatcctgatggaaacgag
atgcagaaatgtgaaaagtgtgaaggagactgtcctaaagtgtgttatggtctgggtatg
gacagccatggcgtcatggacaaccatgttgtcaccatggtaacctcttctaatgtggag
cagtttaactcttgtaagaagatttttggcagtctggccttcctccctcagagctttgag
agggaccctgtgaccaacacatcaggcctgactctcatgcagctgagcgccttcaagaac
ctggaggagattacaggttatttgtacattgatgcctggccagagaactggactgactta
agtgtgtttgagaacctgaaggtgatcagaggcaggatgctctacaagggtgtgttttca
ctggccatccagaacttacacatccagtcacttgggttgcgttcactacgcagcatcagt
ggaggtttagtcctgttgcacaacaattcccagctgtgctacaccagttccctgccctgg
gggactctcctccatcccacccagggaccgcactacatcgtcagccacaaccaagatccc
gaactctgtgaggcagagggccgtgtttgtcactcgctgtgtgaggggggctgttggggc
ccagggcccagccagtgtgtgtcctgtaaggctttccaacgaggaactgagtgtgtagag
cagtgtgacatctatcaggggcctgtgcgtgaatacacagatggatccttgtgtgtcgcc
tgtcacacagagtgtcggcctctcaacggctctgcgtcctgtcatggcccgggtgcagac
cagtgcacagagtgtcagaacttccaggacggtgagtcttgtgtggatcattgtccaagc
ggtgtgaaggaggatcagcatactgtgtggaagtacagcaatgccacaagacactgtctg
ccctgcaacaccaactgtacactgtcctgcactctgatggatgagagaggctgccccatt
cataccaagacaggaccgggtacgaccatagcggctgcagtgggtggtgtggtgctcttc
ttcatcctgctggctctgcttgtcttctacctgaggagacagagaaagcttaagaggaag
gagaccatgaggaggatcctgcaggagcacgagctggtggagcctctaacacccagcggt
gcctcacccaatcaggctcaaatgcgtatcctgaaagagactgagctgaaaaagctcagg
gttctgggtgcaggggcttttggtactgtttacaagggagtgtgggctcctgatggggaa
aacgtgaagataccagtggccattaaggttttacgagagaacacctcaccaaaagccaat
aaagaaatccttgatgaggcctatgtgatggcaggggtggccagcccctacgtgtgtcgt
ctgctggggatttgtctgacctccacagtgcagctggtcactcagctgatgccgtacggc
tgcctcctcgactacgtcagggagaacaaggaccgcattggctcccagttcctcctcaac
tggtgcgtccagattgccaaggggatgagctatctagaggaggtccggttggtccacaga
gatttggccgctcgcaatgttttagtgaagaacccaaatcacgtgaagatcactgacttt
ggcctggcccgcttgctcgatatagatgagactgaatatcacgcggacggagggaaggtg
ccgattaaatggatggctctggagtcaattctgcacagaaagttcactcatcagagtgat
gtttggagctacggggtgacggtatgggagctgatgacgtttggtgctaaaccctacgac
atgatcccagcaagggaaatcccagatgttttggagggaggagagcggcttccgcagccc
ctcatctgcaccattgacgtctacatgatcatggtcaaatgttggatgattgacccagac
agcagaccaaggttcaaagatctggtgaatgattttactgccatggccagagatccacct
cgttatgtagttattcagaatgatgagcaaatgagcatgtccagcccagtggacagccag
ttcttccggatgcttctggaagaggaggggaacaatatgagggaactgctggatgctgag
gagtatctggtgccacaaccaaacctctttcccagggctcagggagacgggtctcaagcc
aacgggccatctagacaccaatcatacaggcagagtagagatctgggcttagatgttgag
ccctccattgctggtggccctcgcagcatgtactcctccctaagcactcttggccgcagt
cagtaccccaccttaccattaggaggtagcacctccaatggcatgtggactccccaatac
ccaactctggctcgaagcccctcagccagcgggcagtctgactcggtcttcctggatggg
cctccagatgactcgctgcccccggccagccccggccgttactgcaaagaccccacctac
cccaacggcagccaggatgacctggagacagatgggccaaatggctttcatcatcctcat
cactttcatcactcactgcccagacgaagtcatgggcataatcataatcatgccttgcca
gagtatgtcaaccaagaagtccaggatctcaggctggggatccctgagcggcccagcacg
ctgcctcgtaaaggctccaaagtggaccgacgcctccccaatggcctgagctctggtcac
agtgtggagaacccgggatacttggtccccatgagctctaggggttccacctccccagcc
tttgacaacccgtactacctggaccttgtggccaaagccaaagctgtagcaggggctgca
gcagtggacggccccgggcaagtggagcgagacgaaggaatgcccaggcaggtgaacggg
tttgtgacctccacggcggagaatccagagtatctgggactagcggacacctggagtgga
tatacttga

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