Tupaia chinensis (Chinese tree shrew): 102468478 Help Entry 102468478         CDS       T02978                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00230   Purine metabolism tup01100   Metabolic pathways tup01522   Endocrine resistance tup04015   Rap1 signaling pathway tup04022   cGMP-PKG signaling pathway tup04024   cAMP signaling pathway tup04062   Chemokine signaling pathway tup04072   Phospholipase D signaling pathway tup04081   Hormone signaling tup04082   Neuroactive ligand signaling tup04114   Oocyte meiosis tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04261   Adrenergic signaling in cardiomyocytes tup04270   Vascular smooth muscle contraction tup04371   Apelin signaling pathway tup04540   Gap junction tup04611   Platelet activation tup04713   Circadian entrainment tup04714   Thermogenesis tup04723   Retrograde endocannabinoid signaling tup04724   Glutamatergic synapse tup04725   Cholinergic synapse tup04727   GABAergic synapse tup04742   Taste transduction tup04750   Inflammatory mediator regulation of TRP channels tup04911   Insulin secretion tup04912   GnRH signaling pathway tup04913   Ovarian steroidogenesis tup04914   Progesterone-mediated oocyte maturation tup04915   Estrogen signaling pathway tup04916   Melanogenesis tup04918   Thyroid hormone synthesis tup04921   Oxytocin signaling pathway tup04923   Regulation of lipolysis in adipocytes tup04924   Renin secretion tup04925   Aldosterone synthesis and secretion tup04926   Relaxin signaling pathway tup04927   Cortisol synthesis and secretion tup04928   Parathyroid hormone synthesis, secretion and action tup04934   Cushing syndrome tup04935   Growth hormone synthesis, secretion and action tup04961   Endocrine and other factor-regulated calcium reabsorption tup04962   Vasopressin-regulated water reabsorption tup04970   Salivary secretion tup04971   Gastric acid secretion tup04972   Pancreatic secretion tup04976   Bile secretion tup05032   Morphine addiction tup05163   Human cytomegalovirus infection tup05166   Human T-cell leukemia virus 1 infection tup05200   Pathways in cancer tup05207   Chemical carcinogenesis - receptor activation tup05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     102468478 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102468478 (ADCY6)    04371 Apelin signaling pathway     102468478 (ADCY6)    04072 Phospholipase D signaling pathway     102468478 (ADCY6)    04024 cAMP signaling pathway     102468478 (ADCY6)    04022 cGMP-PKG signaling pathway     102468478 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102468478 (ADCY6)    04081 Hormone signaling     102468478 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     102468478 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     102468478 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102468478 (ADCY6)    04062 Chemokine signaling pathway     102468478 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     102468478 (ADCY6)    04923 Regulation of lipolysis in adipocytes     102468478 (ADCY6)    04912 GnRH signaling pathway     102468478 (ADCY6)    04913 Ovarian steroidogenesis     102468478 (ADCY6)    04915 Estrogen signaling pathway     102468478 (ADCY6)    04914 Progesterone-mediated oocyte maturation     102468478 (ADCY6)    04921 Oxytocin signaling pathway     102468478 (ADCY6)    04926 Relaxin signaling pathway     102468478 (ADCY6)    04935 Growth hormone synthesis, secretion and action     102468478 (ADCY6)    04918 Thyroid hormone synthesis     102468478 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     102468478 (ADCY6)    04916 Melanogenesis     102468478 (ADCY6)    04924 Renin secretion     102468478 (ADCY6)    04925 Aldosterone synthesis and secretion     102468478 (ADCY6)    04927 Cortisol synthesis and secretion     102468478 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102468478 (ADCY6)    04270 Vascular smooth muscle contraction     102468478 (ADCY6)   09154 Digestive system    04970 Salivary secretion     102468478 (ADCY6)    04971 Gastric acid secretion     102468478 (ADCY6)    04972 Pancreatic secretion     102468478 (ADCY6)    04976 Bile secretion     102468478 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     102468478 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     102468478 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     102468478 (ADCY6)    04727 GABAergic synapse     102468478 (ADCY6)    04725 Cholinergic synapse     102468478 (ADCY6)    04723 Retrograde endocannabinoid signaling     102468478 (ADCY6)   09157 Sensory system    04742 Taste transduction     102468478 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     102468478 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     102468478 (ADCY6)    04213 Longevity regulating pathway - multiple species     102468478 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     102468478 (ADCY6)    04714 Thermogenesis     102468478 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102468478 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     102468478 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102468478 (ADCY6)    05163 Human cytomegalovirus infection     102468478 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     102468478 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     102468478 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102468478 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     102468478 (ADCY6) Enzymes [BR:tup01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      102468478 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom HNOBA GBR2_CC TBK1_ULD Motif Other DBs NCBI-GeneID:  102468478 NCBI-ProteinID:  XP_006168285 UniProt:  L8Y3N4 LinkDB All DBs Position Un AA seq 1166 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRSRRGTRASGFCTPRYMSCLQDTEPPSPTPAAPS RCPWQDEAFIRKGGLGKGMELGRRAVALGFEDTEVTAAIGTAEVAPDISPRIGRSCWRRL AQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTVVLLAFHAAPSRPQPAYVA LLSCAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQIGGTLAAQPHSPSAGLWCP VFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRSDAFLWKQLGANVLLFLCTNVI GICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKK EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLR IKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC GVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYL KEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLVPRWVPDRAFSRTKDSKAFRQM GIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQRDDLEKKYS RKVDPRFGAYVACALLVFCFICFIQLLVFPHSTLMLGIYASIFLLLLVTVLICAVYSCGS LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNLTPA DITACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAMI FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVIL LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLA RERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEE RFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQ MKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTADLYQVLAAKGYQ LECRGVVKVKGKGEMTTYFLNGGPSS NT seq 3501 nt NT seq  +upstreamnt  +downstreamnt atgtcgtggtttagcggcctcctggtccccaaagtggatgaacggaagacagcctggggt gaacgcaatgggcagaagcggtcgcgccgtgggactcgggccagtggcttctgcacaccc cgctacatgagctgcctccaggacacggagccgcccagccccacccctgcggctccctct cggtgcccctggcaggatgaggcctttatccggaagggtggcctaggcaagggtatggag ctgggtcggcgggcagtagccctgggcttcgaggacactgaggtgacagcagctatcggg acagctgaggtggcacctgatatatcacccaggattgggcgatcctgctggcgtcgtctg gcacaggtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcgg tacttctttcagatgaaccagagcagcctgacgctgctgatggcggtgctggttctgctc acggtggtgctgctggccttccatgctgcgccctcccgccctcagcctgcctatgtggcc ctgctgtcctgcgctgccaccctctttgtggcactcatggtggtgtgcaaccgacatagc tttcgccaggactccatgtgggtggtgagctacgtggtgctggggatcctcgcggctgtg cagattgggggcactctggcagcccaaccacacagcccctctgccggcctctggtgccct gtgttctttgtctacatcacctacacgctcctaccaatccgtatgcgagctgccgtcctc agcggcctgggcctctccaccctacatctcatcttggcctggcagctcaaccgtagtgat gccttcctctggaagcagcttggtgccaatgtgctgctgttcctctgtaccaatgtcatt ggcatctgcacacactacccagccgaggtgtctcagcgccaggcctttcaggagactcgc ggttacatccaggcacggctgcatctgcagcatgagaatcggcagcaggagcggctgctg ctgtcggtgttgccccagcacgttgccatggagatgaaagaagacatcaacacaaaaaaa gaagacatgatgttccacaagatctatatccagaaacacgacaacgtcagcatcctgttt gcagacattgaaggcttcaccagcctggcatcccagtgcactgcacaggagctggtcatg accctgaacgaactctttgcccggtttgacaagttggcagcggaaaatcactgcctgagg atcaagatcttaggggactgttactactgtgtgtcaggcctgccggaggcccgggcagac cacgcccactgctgcgtggagatgggggtggacatgatcgaggccatttcgctggtgcgt gaggtgacaggtgtgaacgtgaacatgcgtgtaggcatccacagcgggcgtgtgcactgc ggcgtccttggcctgaggaaatggcagttcgacgtgtggtccaacgacgtgaccctggcc aaccatatggaggcagggggccgggctggtcgtatccacatcactcgggccacactgcag tacctgaatggggactacgaggtggagccaggccggggcggcgagcgcaatgcgtacctg aaggagcagcacattgagaccttcctcatcctgggcgccagccagaaacggaaagaggag aaggccatgctggccaagctgcagcggacgcgggccaactccatggaagggctggtgccg cgctgggtgccagatcgtgccttctcccggaccaaggactccaaggccttccgccagatg ggcattgatgactccagcaaagacaaccggggcgcccaagatgccctgaaccctgaggac gaggtagatgagttcctgggccgggccatcgatgcccgcagcatcgatcagctgcgcaag gaccacgtgcgccggttcctgctcaccttccagagagacgatcttgagaagaagtactca cggaaggtggatccccgcttcggagcctacgttgcctgtgccttgttggtcttctgtttc atctgcttcatccagctcctcgtcttcccgcactcaaccctgatgcttggtatctacgcc agtatcttcctgctgttgctggtcactgtgctgatctgcgcggtgtactcctgtggttct ctgtttcctaaggccctgcaacgactgtcccgcagcattgtccgctcacgggcacacagc actgcagtcggcatcttttcagtcctgcttgtattcacttctgccattgccaacatgttc acctgtaaccacacccccatacggacctgtgctgcccggatgctgaatttaacacctgct gacatcactgcctgccacctgcagcagctcaattactccctgggcttggatgctcccctg tgtgagggcaccgcacccacctgcagcttccctgagtacttcgtcgggaacatgctgctg agtctcttggccagctctgtcttcctacacatcagcagtattgggaagttggccatgatc tttgtcttggggctcatctatttggtgctgcttctgctgggtcccccagccaccatcttt gacaactatgacctgctgcttggcgtccatggcttggcttcttccaatgagacctttgat gggctggactgcccagctgcagggagggtggcactcaaatatatgacccccgtgattctg ctggtatttgcgctggcactgtatctgcatgcccagcaggtggagtcaactgcccgcctg gacttcctctggaaactccaggcaacaggggagaaggaggagatggaggagctccaggcg tacaaccggcggctgctacacaacattctgcccaaggacgtggccgcccacttcttggcc cgggagcgccggaatgatgagctctactatcagtcgtgtgagtgtgtggctgttatgttt gcctccattgccaacttctcagagttctatgtggagctggaggcaaacaatgagggcgtc gagtgcctgcgactgctcaatgagatcatcgctgactttgatgagatcatcagcgaggag cggttccgacagctggagaagatcaagacgattggcagcacctacatggctgcctccggg ctgaacgccagcacctacgatcaggtgggccgctcccacatcacggccctggccgactac gccatgcggctcatggagcaaatgaagcacatcaatgagcactccttcaataatttccag atgaagatcgggctgaacatgggcccagtcgtggcaggcgtcattggagctcggaagcca cagtatgacatctgggggaacacagtgaatgtttctagccggatggacagcacaggggtc cctgaccgaatccaggtgaccgcggacctgtaccaggttctagctgccaagggctaccag ctggagtgtcgaggggtggtcaaggtgaagggcaagggagagatgaccacctacttcctc aatgggggccccagcagttag

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