Tupaia chinensis (Chinese tree shrew): 102476196 Help Entry 102476196         CDS       T02978                                  Symbol PLCB4 Name (RefSeq) phospholipase C beta 4   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00562   Inositol phosphate metabolism tup01100   Metabolic pathways tup04015   Rap1 signaling pathway tup04020   Calcium signaling pathway tup04022   cGMP-PKG signaling pathway tup04062   Chemokine signaling pathway tup04070   Phosphatidylinositol signaling system tup04071   Sphingolipid signaling pathway tup04072   Phospholipase D signaling pathway tup04081   Hormone signaling tup04082   Neuroactive ligand signaling tup04261   Adrenergic signaling in cardiomyocytes tup04270   Vascular smooth muscle contraction tup04310   Wnt signaling pathway tup04371   Apelin signaling pathway tup04540   Gap junction tup04611   Platelet activation tup04613   Neutrophil extracellular trap formation tup04621   NOD-like receptor signaling pathway tup04713   Circadian entrainment tup04720   Long-term potentiation tup04723   Retrograde endocannabinoid signaling tup04724   Glutamatergic synapse tup04725   Cholinergic synapse tup04726   Serotonergic synapse tup04728   Dopaminergic synapse tup04730   Long-term depression tup04742   Taste transduction tup04750   Inflammatory mediator regulation of TRP channels tup04911   Insulin secretion tup04912   GnRH signaling pathway tup04915   Estrogen signaling pathway tup04916   Melanogenesis tup04918   Thyroid hormone synthesis tup04919   Thyroid hormone signaling pathway tup04921   Oxytocin signaling pathway tup04922   Glucagon signaling pathway tup04924   Renin secretion tup04925   Aldosterone synthesis and secretion tup04926   Relaxin signaling pathway tup04927   Cortisol synthesis and secretion tup04928   Parathyroid hormone synthesis, secretion and action tup04929   GnRH secretion tup04933   AGE-RAGE signaling pathway in diabetic complications tup04934   Cushing syndrome tup04935   Growth hormone synthesis, secretion and action tup04961   Endocrine and other factor-regulated calcium reabsorption tup04970   Salivary secretion tup04971   Gastric acid secretion tup04972   Pancreatic secretion tup04973   Carbohydrate digestion and absorption tup05010   Alzheimer disease tup05016   Huntington disease tup05017   Spinocerebellar ataxia tup05022   Pathways of neurodegeneration - multiple diseases tup05142   Chagas disease tup05143   African trypanosomiasis tup05146   Amoebiasis tup05163   Human cytomegalovirus infection tup05200   Pathways in cancer tup05415   Diabetic cardiomyopathy tup05417   Lipid and atherosclerosis Module tup_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102476196 (PLCB4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102476196 (PLCB4)    04310 Wnt signaling pathway     102476196 (PLCB4)    04371 Apelin signaling pathway     102476196 (PLCB4)    04020 Calcium signaling pathway     102476196 (PLCB4)    04070 Phosphatidylinositol signaling system     102476196 (PLCB4)    04072 Phospholipase D signaling pathway     102476196 (PLCB4)    04071 Sphingolipid signaling pathway     102476196 (PLCB4)    04022 cGMP-PKG signaling pathway     102476196 (PLCB4)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102476196 (PLCB4)    04081 Hormone signaling     102476196 (PLCB4)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     102476196 (PLCB4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102476196 (PLCB4)    04613 Neutrophil extracellular trap formation     102476196 (PLCB4)    04621 NOD-like receptor signaling pathway     102476196 (PLCB4)    04062 Chemokine signaling pathway     102476196 (PLCB4)   09152 Endocrine system    04911 Insulin secretion     102476196 (PLCB4)    04922 Glucagon signaling pathway     102476196 (PLCB4)    04929 GnRH secretion     102476196 (PLCB4)    04912 GnRH signaling pathway     102476196 (PLCB4)    04915 Estrogen signaling pathway     102476196 (PLCB4)    04921 Oxytocin signaling pathway     102476196 (PLCB4)    04926 Relaxin signaling pathway     102476196 (PLCB4)    04935 Growth hormone synthesis, secretion and action     102476196 (PLCB4)    04918 Thyroid hormone synthesis     102476196 (PLCB4)    04919 Thyroid hormone signaling pathway     102476196 (PLCB4)    04928 Parathyroid hormone synthesis, secretion and action     102476196 (PLCB4)    04916 Melanogenesis     102476196 (PLCB4)    04924 Renin secretion     102476196 (PLCB4)    04925 Aldosterone synthesis and secretion     102476196 (PLCB4)    04927 Cortisol synthesis and secretion     102476196 (PLCB4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102476196 (PLCB4)    04270 Vascular smooth muscle contraction     102476196 (PLCB4)   09154 Digestive system    04970 Salivary secretion     102476196 (PLCB4)    04971 Gastric acid secretion     102476196 (PLCB4)    04972 Pancreatic secretion     102476196 (PLCB4)    04973 Carbohydrate digestion and absorption     102476196 (PLCB4)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     102476196 (PLCB4)   09156 Nervous system    04724 Glutamatergic synapse     102476196 (PLCB4)    04725 Cholinergic synapse     102476196 (PLCB4)    04728 Dopaminergic synapse     102476196 (PLCB4)    04726 Serotonergic synapse     102476196 (PLCB4)    04720 Long-term potentiation     102476196 (PLCB4)    04730 Long-term depression     102476196 (PLCB4)    04723 Retrograde endocannabinoid signaling     102476196 (PLCB4)   09157 Sensory system    04742 Taste transduction     102476196 (PLCB4)    04750 Inflammatory mediator regulation of TRP channels     102476196 (PLCB4)   09159 Environmental adaptation    04713 Circadian entrainment     102476196 (PLCB4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102476196 (PLCB4)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     102476196 (PLCB4)   09174 Infectious disease: parasitic    05146 Amoebiasis     102476196 (PLCB4)    05142 Chagas disease     102476196 (PLCB4)    05143 African trypanosomiasis     102476196 (PLCB4)   09164 Neurodegenerative disease    05010 Alzheimer disease     102476196 (PLCB4)    05016 Huntington disease     102476196 (PLCB4)    05017 Spinocerebellar ataxia     102476196 (PLCB4)    05022 Pathways of neurodegeneration - multiple diseases     102476196 (PLCB4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102476196 (PLCB4)    05415 Diabetic cardiomyopathy     102476196 (PLCB4)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102476196 (PLCB4)    04934 Cushing syndrome     102476196 (PLCB4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tup04131]     102476196 (PLCB4) Enzymes [BR:tup01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102476196 (PLCB4) Membrane trafficking [BR:tup04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102476196 (PLCB4)  Endocytosis   Macropinocytosis    Phospholipase C     102476196 (PLCB4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PLC-beta_C C2 EF-hand_7 EF-hand_6 Motif Other DBs NCBI-GeneID:  102476196 NCBI-ProteinID:  XP_006150982 LinkDB All DBs Position Un AA seq 1194 aa AA seqDB search MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL ECSLINSIRLGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGIDLVNINFTYMVAENPE VTKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM MEAGESAAPANILEDDNEEEIENADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKGLV TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA MGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ VDKIVAQYDKEKSTHEKTLEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH TKEWSEMINTHSAEEQEIRDLHLSQQCDLLKKLLINAHEQQTQQLKLSHDREKKEMRAHQ AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ LEHLEFLEKQNEQLLKTCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt atggccaaaccttatgaatttaactggcagaaagaagttccttcctttttgcaagaagga gcagtttttgacagatacgaggaggaatccttcgtatttgaacccaactgcctcttcaaa gtggatgaatttggcttctttctgacctggaaaagtgaaggcaaggaagggcaagtgcta gaatgttccctcatcaacagtatccggttgggagccataccaaaggatcccaaaattctg gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc tgcagtggtatagatttggtgaacataaacttcacttacatggtggccgaaaatccagaa gtaactaagcaatgggtagaaggcctgagagcaatcatacacaacttcagggccaacaac gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca aatggtaaaattccagttagaagtattactagaacttttgcatcgggaaaaacagaaaag gtgatctttcaagcactcaaggaattaggtcttcccagtggaaagaatgatgaaattgag cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca gacatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattt ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagat ttaaagaaaaaaggcctcatatccagtgacgggttttgcagatatctgatgtccgatgaa aatgccccggtcttcctagatcgcttagaactttaccaagaaatggaccatcctctggct cactacttcatcagttcttcccataacacctacctcacgggccggcagtttggtggcaag tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgagcttgat tgttgggatggaaaaggtgaagatcaggaaccgataataactcatggaaaagcaatgtgt acagatatccttttcaaggatgtgattcaagccatcaaggaaactgcatttgtcacatca gaatatcctgtaatcctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgagtcacat ccactcgaaccaggcaggcccttgccatccccgaatgacctcaaaagaaagatactcatc aaaaacaaacgactgaaacctgaagttgagaaaaaacagcttgaagctttgaaaagcatg atggaagctggagaatctgctgccccagctaacatcttggaggacgataatgaagaggag atagaaaatgctgaccaagaggaagaagcacaccctgaatacaaatttggaaatgaactt tctgctgatgacttgggtcataaggaggctgttgcaaatagcgtcaagaagggcctggtt actgtagaagatgaacaagcgtggatggcctcttataaatatgtaggtgctaccactaat atccatccctatttgtctacaatgatcaactacgcacagcctgtaaagtttcaaggtttc catgtggctgaagaacgcaatattcattataacatgtcatcttttaatgagtcagttggt cttggctacctgaagacacacgccattgaatttgtaaattataataaacggcaaatgagt cgcatttaccccaagggaggtcgagtcgattccagtaattacatgcctcagattttctgg aacgctggctgccagatggtttctctgaactatcaaaccccagatttagcgatgcaattg aatcagggaaaatttgagtataatggatcatgcgggtaccttcttaaaccagatttcatg agacgaccagatagaacctttgatcccttttctgaaactcctgttgacggagttattgca gccacttgttcagtacaggtcatatcaggacagttcttatcagataagaaaatcggcact tacgtagaagtggatatgtacgggttacccaccgacactatacgtaaagaattccgaact cgcatggtcatgaacaatggactcaacccggtgtacaatgaagaatcatttgtatttcgg aaggtgatcctgcctgacctggctgtcttgagaatagcagtgtacgatgacaacaacaag ctgattggccagaggatcctgccactggatggcctccaagcaggctatcggcacatttcc cttcgaaatgagggaaacaaaccattatcactgccaacaattttctgcaatatcgttctt aaaacatacgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaaa tttctttcaattacggaaaagagagcagaccaaatgagagctatgggcattgaaactagt gacatagccgatgtgcccagtgacacttccaagaatgacaagaaaggaaaggccaatact gccaaagccaatgtgacccctcagagtagctctgagctcagaccaaccactacagctgct atgggttctggtgtggaagccaaaaaaggtattgaacttatccctcaagtgaggatagaa gatttaaagcagatgaaggcttacttgaagcatttaaagaaacagcagaaggagctaaat tctttaaagaagaaacacgcaaaggagcacagtaccatgcagaagttacactgcacacaa gtggacaaaatcgtggcacagtatgataaagagaagtcaactcatgagaaaaccctagag aaggcgatgaagaagaaggggggaagtaattgtctcgaaatgaaaaaagaaacagaaatt aaaattcagacactgacatcagatcacaaatctaaggtcaaagagattgtggcccagcat acaaaagagtggtcagaaatgatcaacacccacagtgctgaggaacaagaaatccgggac cttcacctgagtcagcaatgtgacctgctgaaaaagctgctcatcaacgcccacgagcag caaacccagcaactgaaactgtcgcatgacagggaaaaaaaggaaatgcgggcacaccag gctaagatttcgatggaaaatagcaaagccatcagccaagataaatctatcaagaataaa gctgaacgggaaaggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaa gaaagaaagagacttgcaatgaaacagtccaaagaaatggatcagttgaaaaaagtccag cttgaacatctagaattcctggagaaacagaatgagcagcttttgaaaacctgtcatgca gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga ccgcagaccagcaacagtagtatgaaactccaaaatgcaaactaa

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