Tupaia chinensis (Chinese tree shrew): 102483786 Help Entry 102483786         CDS       T02978                                  Symbol PLCG2 Name (RefSeq) phospholipase C gamma 2   KO K05859   phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00562   Inositol phosphate metabolism tup01100   Metabolic pathways tup01521   EGFR tyrosine kinase inhibitor resistance tup04012   ErbB signaling pathway tup04014   Ras signaling pathway tup04020   Calcium signaling pathway tup04062   Chemokine signaling pathway tup04064   NF-kappa B signaling pathway tup04066   HIF-1 signaling pathway tup04070   Phosphatidylinositol signaling system tup04072   Phospholipase D signaling pathway tup04360   Axon guidance tup04370   VEGF signaling pathway tup04380   Osteoclast differentiation tup04517   IgSF CAM signaling tup04611   Platelet activation tup04613   Neutrophil extracellular trap formation tup04625   C-type lectin receptor signaling pathway tup04650   Natural killer cell mediated cytotoxicity tup04662   B cell receptor signaling pathway tup04664   Fc epsilon RI signaling pathway tup04666   Fc gamma R-mediated phagocytosis tup04670   Leukocyte transendothelial migration tup04722   Neurotrophin signaling pathway tup04750   Inflammatory mediator regulation of TRP channels tup04919   Thyroid hormone signaling pathway tup04933   AGE-RAGE signaling pathway in diabetic complications tup04935   Growth hormone synthesis, secretion and action tup05167   Kaposi sarcoma-associated herpesvirus infection tup05169   Epstein-Barr virus infection tup05170   Human immunodeficiency virus 1 infection tup05171   Coronavirus disease - COVID-19 tup05200   Pathways in cancer tup05205   Proteoglycans in cancer tup05206   MicroRNAs in cancer tup05214   Glioma tup05223   Non-small cell lung cancer tup05225   Hepatocellular carcinoma Module tup_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102483786 (PLCG2)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102483786 (PLCG2)    04014 Ras signaling pathway     102483786 (PLCG2)    04370 VEGF signaling pathway     102483786 (PLCG2)    04064 NF-kappa B signaling pathway     102483786 (PLCG2)    04066 HIF-1 signaling pathway     102483786 (PLCG2)    04020 Calcium signaling pathway     102483786 (PLCG2)    04070 Phosphatidylinositol signaling system     102483786 (PLCG2)    04072 Phospholipase D signaling pathway     102483786 (PLCG2)   09133 Signaling molecules and interaction    04517 IgSF CAM signaling     102483786 (PLCG2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102483786 (PLCG2)    04613 Neutrophil extracellular trap formation     102483786 (PLCG2)    04625 C-type lectin receptor signaling pathway     102483786 (PLCG2)    04650 Natural killer cell mediated cytotoxicity     102483786 (PLCG2)    04662 B cell receptor signaling pathway     102483786 (PLCG2)    04664 Fc epsilon RI signaling pathway     102483786 (PLCG2)    04666 Fc gamma R-mediated phagocytosis     102483786 (PLCG2)    04670 Leukocyte transendothelial migration     102483786 (PLCG2)    04062 Chemokine signaling pathway     102483786 (PLCG2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102483786 (PLCG2)    04919 Thyroid hormone signaling pathway     102483786 (PLCG2)   09156 Nervous system    04722 Neurotrophin signaling pathway     102483786 (PLCG2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102483786 (PLCG2)   09158 Development and regeneration    04360 Axon guidance     102483786 (PLCG2)    04380 Osteoclast differentiation     102483786 (PLCG2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102483786 (PLCG2)    05206 MicroRNAs in cancer     102483786 (PLCG2)    05205 Proteoglycans in cancer     102483786 (PLCG2)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102483786 (PLCG2)    05214 Glioma     102483786 (PLCG2)    05223 Non-small cell lung cancer     102483786 (PLCG2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102483786 (PLCG2)    05171 Coronavirus disease - COVID-19     102483786 (PLCG2)    05167 Kaposi sarcoma-associated herpesvirus infection     102483786 (PLCG2)    05169 Epstein-Barr virus infection     102483786 (PLCG2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102483786 (PLCG2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102483786 (PLCG2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tup04131]     102483786 (PLCG2) Enzymes [BR:tup01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102483786 (PLCG2) Membrane trafficking [BR:tup04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102483786 (PLCG2)  Endocytosis   Macropinocytosis    Phospholipase C     102483786 (PLCG2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH EF-hand_PLCG1 PH_12 SH3_2 SH2_1 PH_14 Motif Other DBs NCBI-GeneID:  102483786 NCBI-ProteinID:  XP_006152647 LinkDB All DBs Position Un AA seq 1265 aa AA seqDB search MPTMVNVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK IEGFLDIMEIKEIRPGKSSRDFERAKVVRQKEDCCFVILYGTQFVLSTLSLAADSKEDAM KWLSGLKILHQEAMAASTPTVIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGA KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA VHLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENT IWDEKHDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYVRCLRLGCRCIELDC WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFISSSFPVILSIEEHCSVEQQRHMAKV FKEVLGDLLLTRPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE LYMWDPIDQKWTRHYCAIADAKLSFSDDIEQTVEEEPPQDTPPTELHFGEKWFHKKVEKR TSAEKLLQEYCAETGGKDGTFLVRESETYPDDYTLSFWRSGRVQHCRIRSTMEGGTMKYY LTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML MRIPRDGAFLIRRREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY KAKRNDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE TKADSIVRQKPVDLLKYNQKALTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC RQLRRRQEELNHQLFLYDTHQNLRNASRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN SKFYS NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt atgcccaccatggtcaacgtggatgccctcccggagtatgagaagagccagatcaagagg gccctggagctggggacggtgatgacggtgttcagcttccgcaagtccacccctgagcgg aggactgtccaggtgatcatggagaccaggcaggtggcctggagcaagaccgccgacaag atcgagggcttcctggatatcatggaaataaaggagatccgcccagggaagagctccagg gactttgagcgcgcgaaagtagtccgccagaaggaagactgctgcttcgtcatcctctac ggcacgcagttcgtcctcagcacgctcagcttggcagctgactccaaggaggatgcaatg aagtggctctctggcttgaagatcttacaccaggaagcaatggctgcgtccacacccacc gtcatcgaaagttggctgagaaagcagatttattctgtggatcaaaccagaaggaacagc atcagcctccgagagctgaagaccatcttgcccctggtcaacttcaaagtgagcggtgcc aagttcctcaaagataagtttgtggaaataggcgctcacaaggacgagctcagctttgaa cagttccatctcttctataagaaacttatgtttgagcaacaaaagtcgattcttgatgaa ttcaagaaggattcctcggtgttcatcttggggaacactgaccggccggacgcctctgct gttcacctgcacgacttccagaggttcctcttacacgaacagcaggagctctgggctcag gacctcaacaaagtccgcgagcggatgacgaagttcatcgacgacacgatgcgggagacc gcggagccgttcctgtttgtcgacgagttcctcacctacctgttttcgcgggaaaacacc atctgggatgagaagcatgacgtggtggacatgcaggacatgaacaaccccttgtcgcac tactggatctcctcgtcacacaacacgtacctcacgggggaccagctgcgcagcgagtca tccccggaggcgtacgtccgctgtctgcgcctgggctgccgctgcattgagttggactgc tgggatgggcctgatgggaagcctatcatctaccacggctggacgcggaccaccaagatc aagttcgatgacgtcgtccaggccatcagagatcacgccttcatttcctcaagcttcccg gtgatcctgtccatcgaggagcactgcagcgtggagcagcaacgccacatggccaaggtg ttcaaggaagtgcttggcgacctgctgctgacaaggcccacggaggctagcgcggaccag ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagcttggcccc cgaggagacgtggatgtcaacgtggaggacaagaaggatgagcacaagcagcagggggag ctgtacatgtgggaccccattgaccagaaatggactcggcactactgcgccattgccgat gccaagctgtccttcagtgatgacatcgaacagaccgtggaggaggagccgccccaggac acgcccccgacagagctgcactttggggagaaatggttccacaagaaggtcgagaagagg acgagcgccgagaagctgctgcaggagtactgcgccgagaccgggggcaaggacggcacc ttcttggtgcgagagagcgagacctaccctgatgactacacactgtccttctggcggtcg ggccgagtccagcactgccggatccgctccaccatggagggcgggaccatgaagtactac ctgactgacaacctcatgttcaccagcatctacgccctcatccagcactaccgcgagacg cacctgcgctgtgccgagttcgagctgcggctcaccgaccctgtgcccaaccccaacccg cacgagtcaaagccgtggtactatgacagcctgagccggggggaagccgaggacatgctg atgaggatcccccgggacggagccttcctgatccggaggcgagaagggaccgactcctac gccatcaccttcagggccaggggcaaagtaaagcactgccgcatcaaccgggatggccgg cactttgtgctggggacctctgcctactttgagagcctcgtggagcttgtcagttactat gagaagcacgcactttaccgcaagatgagactgcgctaccctgtgactcccgagctcctg gagcgctacaatatggaaagagatataaactctctctatgatgtcagcagaatgtatgtg gatccgagcgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac aaagccaagcgaaatgatgagctgagcttctgccgcggtgccctcatccacaacgtctcc aaggagccagggggctggtggaagggcgactatgggaccaggatccagcagtacttccca tccaactacgtggaggacatttcgacggccgatgtggaagagctggaaaagcagattatt gaagacaatcccttagggtccctttgcagaggcattttggacctcaatacctacaacgtt gtgaaagccccccaggggaaaaaccagaagcccttcgtcttcatcctggagcccaagaag cagggcgatcccccggtggagtttgccacagacagggtggaggagctcttcgagtggttt cagagcatccgggagatcacctggaagattgacaccaaggagaacaacatgaagtactgg gagaagaaccagtcgatcgccattgagctctcggacttggttgtctactgcaaaccgacc agcaagaccaaggataatttagaaaaccctgacttccgagaaatccgctcctttgtggag acgaaggctgacagcatcgtcagacagaagcccgtcgatctcctgaagtacaatcagaag gccttgacccgcgtctacccgaagggacagagggtcgactcttccaactacgatcctttc cgcctctggctgtgcggctcccagatggtggcgctcaacttccagactgcagacaagtac atgcagatgaatcacgcactgttttctctcaacggccggacgggctacgtcctccagcct gagagcatgcggacagagaagtacgacccgatgccgcccgagtcccagaggaagatcctg atgactctgaccgtcaaggttctcggggctcgtcatctccccaaacttggacgaagtatt gcttgtccctttgtagaggtggaaatatgtggagccgagtacgacaacaacaagtttaag acaacagttgtgaatgataacggcctaagcccggtctgggctcccacacaggagaaggtg acgtttgaaatttatgaccccaaccttgcgtttctgcgtttcgtggtttacgaggaggac atgttcagcgaccccaattttctcgctcatgccacataccccattaaaggaatcaaatca ggttttaggtctgttcctctgaagaatgggtacagtgaagacatcgaactggcttctctc ctggttttctgtgagatgcggccagtcctggagagcgaagaggagctctattcctcctgt cgccagctgcggaggcggcaggaggagctgaaccaccagctcttcctgtatgacacgcac cagaacttgcgcaatgccagccgggatgccctcgttaaagagttcaacgtcaacgagaac cagctccagctgtaccaggagaagtgcaaccggaggctgagggagaagagagtcagcaac agcaagttctactcgtag

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