Tupaia chinensis (Chinese tree shrew): 102490273 Help Entry 102490273         CDS       T02978                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00230   Purine metabolism tup01100   Metabolic pathways tup01522   Endocrine resistance tup04015   Rap1 signaling pathway tup04020   Calcium signaling pathway tup04022   cGMP-PKG signaling pathway tup04024   cAMP signaling pathway tup04062   Chemokine signaling pathway tup04072   Phospholipase D signaling pathway tup04081   Hormone signaling tup04082   Neuroactive ligand signaling tup04114   Oocyte meiosis tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04261   Adrenergic signaling in cardiomyocytes tup04270   Vascular smooth muscle contraction tup04371   Apelin signaling pathway tup04540   Gap junction tup04611   Platelet activation tup04713   Circadian entrainment tup04714   Thermogenesis tup04723   Retrograde endocannabinoid signaling tup04724   Glutamatergic synapse tup04725   Cholinergic synapse tup04727   GABAergic synapse tup04742   Taste transduction tup04750   Inflammatory mediator regulation of TRP channels tup04911   Insulin secretion tup04912   GnRH signaling pathway tup04913   Ovarian steroidogenesis tup04914   Progesterone-mediated oocyte maturation tup04915   Estrogen signaling pathway tup04916   Melanogenesis tup04918   Thyroid hormone synthesis tup04921   Oxytocin signaling pathway tup04923   Regulation of lipolysis in adipocytes tup04925   Aldosterone synthesis and secretion tup04926   Relaxin signaling pathway tup04927   Cortisol synthesis and secretion tup04928   Parathyroid hormone synthesis, secretion and action tup04934   Cushing syndrome tup04935   Growth hormone synthesis, secretion and action tup04970   Salivary secretion tup04971   Gastric acid secretion tup04972   Pancreatic secretion tup04976   Bile secretion tup05032   Morphine addiction tup05163   Human cytomegalovirus infection tup05166   Human T-cell leukemia virus 1 infection tup05200   Pathways in cancer tup05207   Chemical carcinogenesis - receptor activation tup05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     102490273 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102490273 (ADCY4)    04371 Apelin signaling pathway     102490273 (ADCY4)    04020 Calcium signaling pathway     102490273 (ADCY4)    04072 Phospholipase D signaling pathway     102490273 (ADCY4)    04024 cAMP signaling pathway     102490273 (ADCY4)    04022 cGMP-PKG signaling pathway     102490273 (ADCY4)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102490273 (ADCY4)    04081 Hormone signaling     102490273 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     102490273 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     102490273 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102490273 (ADCY4)    04062 Chemokine signaling pathway     102490273 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     102490273 (ADCY4)    04923 Regulation of lipolysis in adipocytes     102490273 (ADCY4)    04912 GnRH signaling pathway     102490273 (ADCY4)    04913 Ovarian steroidogenesis     102490273 (ADCY4)    04915 Estrogen signaling pathway     102490273 (ADCY4)    04914 Progesterone-mediated oocyte maturation     102490273 (ADCY4)    04921 Oxytocin signaling pathway     102490273 (ADCY4)    04926 Relaxin signaling pathway     102490273 (ADCY4)    04935 Growth hormone synthesis, secretion and action     102490273 (ADCY4)    04918 Thyroid hormone synthesis     102490273 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     102490273 (ADCY4)    04916 Melanogenesis     102490273 (ADCY4)    04925 Aldosterone synthesis and secretion     102490273 (ADCY4)    04927 Cortisol synthesis and secretion     102490273 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102490273 (ADCY4)    04270 Vascular smooth muscle contraction     102490273 (ADCY4)   09154 Digestive system    04970 Salivary secretion     102490273 (ADCY4)    04971 Gastric acid secretion     102490273 (ADCY4)    04972 Pancreatic secretion     102490273 (ADCY4)    04976 Bile secretion     102490273 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     102490273 (ADCY4)    04727 GABAergic synapse     102490273 (ADCY4)    04725 Cholinergic synapse     102490273 (ADCY4)    04723 Retrograde endocannabinoid signaling     102490273 (ADCY4)   09157 Sensory system    04742 Taste transduction     102490273 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     102490273 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     102490273 (ADCY4)    04213 Longevity regulating pathway - multiple species     102490273 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     102490273 (ADCY4)    04714 Thermogenesis     102490273 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102490273 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     102490273 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102490273 (ADCY4)    05163 Human cytomegalovirus infection     102490273 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     102490273 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     102490273 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102490273 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     102490273 (ADCY4) Enzymes [BR:tup01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      102490273 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA CD52 Motif Other DBs NCBI-GeneID:  102490273 NCBI-ProteinID:  XP_006144671 LinkDB All DBs Position Un AA seq 1118 aa AA seqDB search MAPQSSTRTCSHPRAAVRTGLDPWDAAAAAVGKRERLRSETFAGQLPSLGLRERSQGLRP LAAIWEWAERPQGVLEGDRIAARRGAPGRKGEQQELTSDSGFLATVVCALGGFSLLLVLA SREQRLQRWTRPLSGLVWAALLALGHGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPLGMR EATAAGLASSLSHLLALGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGAYHKALMERAL RATFREALSSLHSRRRLDTEKRHQEHLLLSILPAYLAQEMKAEIMARLQAGQGSRPESTN NFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKI LGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVI GLQKWQYDVWSHDVTLANHMEAGGVPGRVHITRATLALLAGAYAVEDTAMEHRDPYLREL GEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMTRYLESWGAAKPFAHLSHVDS PVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKD FNPVTLYFRKKEMEKEYRLSALPAFKYYAACTFLVFLSNFIVQMLVTNRPPALAITYCVT FLLFLLLLFVCFSEHLTRCVLKGPKILHWLPTLSSLVATRPGLRVALGTATILLVFAMAI TSLFFLPASSDCPFWAPNVSSMAFNLSWELPGSLPLISVPYSMHCCVLAFLSCSLFLHMS FELKLLLLLLWLVTSCSLFLHSHAWLSDCLVARLYLGPLDSRPGVLKEPKLMGAVSFFIF FFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNR RNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFS GVEKIKTIGSTYMAATGLNATSGQEAQQDTERSCSHLGTMVEFAVALGSKLDVINKHSFN NFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSL GYTCYSRGVIKVKGKGQLCTYFLNTDLTRAGPPSAALG NT seq 3357 nt NT seq  +upstreamnt  +downstreamnt atggccccacagagctccacgcggacatgctcccacccacgagctgccgtccgcacgggc ttggacccttgggacgctgccgcagcggctgtcggcaagagggagaggctgcgaagtgag acctttgctgggcagctccccagtctaggtttgagggagaggagccaaggactgaggccc ctggccgccatctgggagtgggctgagaggccgcagggagtccttgaaggagaccggatt gcagcgcgtcggggggcgccgggcaggaagggcgagcagcaggagctgacctcagactcg ggcttcctggccaccgtcgtgtgtgcactgggcggcttctcactgctattggtcctcgct tcccgcgagcagcgactgcagcgctggacacggccactctcgggactcgtgtgggccgcg ctgctcgcattaggccatggctttctgttcaccgggggtgttgtcagcgcctgggaccag gtgtcttttttcctcttcatcatcttcactgtgtatgccatgttgcccttgggcatgcgg gaagccaccgctgcaggcctcgcctcctccctgtcgcacctgctggccctcgggctgtac cttgggccgcagccagactcaaggccagcgctgctgccacagctcgcagcaaacgcggtg ttgttcctgtgcgggaacgtggcgggagcataccacaaggcgttaatggagcgagcgctg cgggccacgttcagggaggcactcagctctctgcactcgcgaaggcggctggacactgag aagaggcaccaggaacaccttctcttgtccatccttcctgcctacctggcccaagagatg aaggcagagatcatggctcggctgcaggctggacaagggtcccggccagagagcaccaac aacttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtatgctgacatc gtgggcttcacccggctggccagcgagtgctcccctaaggagctggtgctcatgctcaat gagctttttggcaagttcgaccagatcgccaaggagcacgaatgcatgcggatcaagatc ctgggggactgttactactgtgtctctgggctgcccctgtcactaccagaccacgccatt aactgtgtacgcatggggctggacatgtgccgagccatcaggaaactgcgggcagccact ggtgtggacatcaacatgcgtgtgggggtgcactcaggcagcgtgctctgcggagtcatc gggctgcagaagtggcagtacgatgtgtggtcccacgacgtcacactggccaaccacatg gaggcgggtggcgtgccagggcgagtgcacatcacaagggctaccctggccctcctagca ggggcgtatgctgtggaggataccgccatggaacaccgggacccctaccttcgggagcta ggggaacctacctatctggtcatcgatccccgggctgaggaggaggatgagaagggcacc gcagggggattgctgtcctctcttgagggccccaagatgcgtccatcactgctgatgacc cgctacctggagtcctggggtgcagccaagccttttgcccacctgagccacgtagacagc cctgtgtccacctctacccctcttccggagaaggccctggcttccttcagtccccagtgg agcctggaccggagccgaactcccaggggactggatgatgagctggacactggggatgcc aagttcttccaggtcatcgaacagctcaactctcagaaacagtggaagcagtccaaggat ttcaacccagtgacactgtacttccgaaagaaggagatggagaaagagtatcgactttcg gcacttcctgccttcaaatactatgcagcctgcactttcctggtttttctctccaacttc attgtccagatgctggtgacaaacaggcccccagctctggccatcacctattgcgtcacc ttcctcttgttcctcctcctgctcttcgtgtgcttctcagagcacctgacgaggtgtgtc ctgaaaggccccaagatactacactggcttcccacactgtccagcctggtggccacaagg cccggactgcgagtggccctgggtactgctaccatcctcctcgtctttgccatggccatt accagcttgttcttcttaccagcatcatcggactgccctttctgggctcccaatgtgtcc tccatggctttcaacctgtcctgggagctccctgggtccctgcctctcatcagtgtccca tactccatgcactgctgcgtgctggccttcctctcctgctccctctttctgcacatgagc ttcgaactgaagctgctgctgctcctgctatggctggtgacgtcctgttccctcttcctg cactcccatgcctggctgtctgactgcctcgtcgcccgcctctatctggggcccctagac tccaggccaggagtactgaaggagccaaaactgatgggagctgtctccttcttcatcttc ttcttcaccctccttgtcctagctcggcagaatgagtattattgccgcttggacttcctg tggaaaaagaagctgaggcaagagcgggaggagacagagacgatggagaacctgacccgg ctactcttggagaatgtgctccctgcccacgtggccccccagttcattggccagaaccgg cgcaatgaggacctctaccatcagtcctacgagtgtgtttgtgtcctgtttgcctcagtc ccggacttcaaagagttttactctgaatccaacatcaaccatgaggggctagagtgtctg cggctgcttaatgagatcattgctgactttgatgagctgctctccaagcccaagttcagt ggagtggagaagatcaaaaccattggcagcacctacatggcagccacaggcttaaatgcc acctctggacaggaggcacaacaggatactgagcgaagctgcagccaccttggcaccatg gtggaatttgcggtggccctggggtctaagctggatgtcatcaacaagcactcgttcaac aacttccgtctgcgtgtggggttgaatcacggaccagttgtggccggagtgattggggct caaaagccacaatacgacatttggggcaacacggtgaatgtggccagccgcatggagagt acaggagtccttggcaagatccaagtgacggaagagacagctcgggccctgcagtccttg ggctacacctgctacagccggggtgtcatcaaggtcaaaggcaaaggccagctctgcacc tactttctaaacacagacttgacacgagctggacctccttcagctgccctcggctga

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