Tupaia chinensis (Chinese tree shrew): 102492771 Help Entry 102492771         CDS       T02978                                  Symbol AKT1 Name (RefSeq) AKT serine/threonine kinase 1   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup01521   EGFR tyrosine kinase inhibitor resistance tup01522   Endocrine resistance tup01524   Platinum drug resistance tup04010   MAPK signaling pathway tup04012   ErbB signaling pathway tup04014   Ras signaling pathway tup04015   Rap1 signaling pathway tup04022   cGMP-PKG signaling pathway tup04024   cAMP signaling pathway tup04062   Chemokine signaling pathway tup04066   HIF-1 signaling pathway tup04068   FoxO signaling pathway tup04071   Sphingolipid signaling pathway tup04072   Phospholipase D signaling pathway tup04140   Autophagy - animal tup04150   mTOR signaling pathway tup04151   PI3K-Akt signaling pathway tup04152   AMPK signaling pathway tup04210   Apoptosis tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04218   Cellular senescence tup04261   Adrenergic signaling in cardiomyocytes tup04370   VEGF signaling pathway tup04371   Apelin signaling pathway tup04380   Osteoclast differentiation tup04510   Focal adhesion tup04550   Signaling pathways regulating pluripotency of stem cells tup04611   Platelet activation tup04613   Neutrophil extracellular trap formation tup04620   Toll-like receptor signaling pathway tup04625   C-type lectin receptor signaling pathway tup04630   JAK-STAT signaling pathway tup04660   T cell receptor signaling pathway tup04662   B cell receptor signaling pathway tup04664   Fc epsilon RI signaling pathway tup04666   Fc gamma R-mediated phagocytosis tup04668   TNF signaling pathway tup04722   Neurotrophin signaling pathway tup04725   Cholinergic synapse tup04728   Dopaminergic synapse tup04810   Regulation of actin cytoskeleton tup04910   Insulin signaling pathway tup04914   Progesterone-mediated oocyte maturation tup04915   Estrogen signaling pathway tup04917   Prolactin signaling pathway tup04919   Thyroid hormone signaling pathway tup04920   Adipocytokine signaling pathway tup04922   Glucagon signaling pathway tup04923   Regulation of lipolysis in adipocytes tup04926   Relaxin signaling pathway tup04929   GnRH secretion tup04931   Insulin resistance tup04932   Non-alcoholic fatty liver disease tup04933   AGE-RAGE signaling pathway in diabetic complications tup04935   Growth hormone synthesis, secretion and action tup04936   Alcoholic liver disease tup04973   Carbohydrate digestion and absorption tup05010   Alzheimer disease tup05017   Spinocerebellar ataxia tup05132   Salmonella infection tup05135   Yersinia infection tup05142   Chagas disease tup05145   Toxoplasmosis tup05152   Tuberculosis tup05160   Hepatitis C tup05161   Hepatitis B tup05162   Measles tup05163   Human cytomegalovirus infection tup05164   Influenza A tup05165   Human papillomavirus infection tup05166   Human T-cell leukemia virus 1 infection tup05167   Kaposi sarcoma-associated herpesvirus infection tup05168   Herpes simplex virus 1 infection tup05169   Epstein-Barr virus infection tup05170   Human immunodeficiency virus 1 infection tup05200   Pathways in cancer tup05205   Proteoglycans in cancer tup05207   Chemical carcinogenesis - receptor activation tup05208   Chemical carcinogenesis - reactive oxygen species tup05210   Colorectal cancer tup05211   Renal cell carcinoma tup05212   Pancreatic cancer tup05213   Endometrial cancer tup05214   Glioma tup05215   Prostate cancer tup05218   Melanoma tup05220   Chronic myeloid leukemia tup05221   Acute myeloid leukemia tup05222   Small cell lung cancer tup05223   Non-small cell lung cancer tup05224   Breast cancer tup05225   Hepatocellular carcinoma tup05226   Gastric cancer tup05230   Central carbon metabolism in cancer tup05231   Choline metabolism in cancer tup05235   PD-L1 expression and PD-1 checkpoint pathway in cancer tup05415   Diabetic cardiomyopathy tup05417   Lipid and atherosclerosis tup05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:tup00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102492771 (AKT1)    04012 ErbB signaling pathway     102492771 (AKT1)    04014 Ras signaling pathway     102492771 (AKT1)    04015 Rap1 signaling pathway     102492771 (AKT1)    04370 VEGF signaling pathway     102492771 (AKT1)    04371 Apelin signaling pathway     102492771 (AKT1)    04630 JAK-STAT signaling pathway     102492771 (AKT1)    04668 TNF signaling pathway     102492771 (AKT1)    04066 HIF-1 signaling pathway     102492771 (AKT1)    04068 FoxO signaling pathway     102492771 (AKT1)    04072 Phospholipase D signaling pathway     102492771 (AKT1)    04071 Sphingolipid signaling pathway     102492771 (AKT1)    04024 cAMP signaling pathway     102492771 (AKT1)    04022 cGMP-PKG signaling pathway     102492771 (AKT1)    04151 PI3K-Akt signaling pathway     102492771 (AKT1)    04152 AMPK signaling pathway     102492771 (AKT1)    04150 mTOR signaling pathway     102492771 (AKT1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102492771 (AKT1)   09143 Cell growth and death    04210 Apoptosis     102492771 (AKT1)    04218 Cellular senescence     102492771 (AKT1)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102492771 (AKT1)    04550 Signaling pathways regulating pluripotency of stem cells     102492771 (AKT1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102492771 (AKT1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102492771 (AKT1)    04613 Neutrophil extracellular trap formation     102492771 (AKT1)    04620 Toll-like receptor signaling pathway     102492771 (AKT1)    04625 C-type lectin receptor signaling pathway     102492771 (AKT1)    04660 T cell receptor signaling pathway     102492771 (AKT1)    04662 B cell receptor signaling pathway     102492771 (AKT1)    04664 Fc epsilon RI signaling pathway     102492771 (AKT1)    04666 Fc gamma R-mediated phagocytosis     102492771 (AKT1)    04062 Chemokine signaling pathway     102492771 (AKT1)   09152 Endocrine system    04910 Insulin signaling pathway     102492771 (AKT1)    04922 Glucagon signaling pathway     102492771 (AKT1)    04923 Regulation of lipolysis in adipocytes     102492771 (AKT1)    04920 Adipocytokine signaling pathway     102492771 (AKT1)    04929 GnRH secretion     102492771 (AKT1)    04915 Estrogen signaling pathway     102492771 (AKT1)    04914 Progesterone-mediated oocyte maturation     102492771 (AKT1)    04917 Prolactin signaling pathway     102492771 (AKT1)    04926 Relaxin signaling pathway     102492771 (AKT1)    04935 Growth hormone synthesis, secretion and action     102492771 (AKT1)    04919 Thyroid hormone signaling pathway     102492771 (AKT1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102492771 (AKT1)   09154 Digestive system    04973 Carbohydrate digestion and absorption     102492771 (AKT1)   09156 Nervous system    04725 Cholinergic synapse     102492771 (AKT1)    04728 Dopaminergic synapse     102492771 (AKT1)    04722 Neurotrophin signaling pathway     102492771 (AKT1)   09158 Development and regeneration    04380 Osteoclast differentiation     102492771 (AKT1)   09149 Aging    04211 Longevity regulating pathway     102492771 (AKT1)    04213 Longevity regulating pathway - multiple species     102492771 (AKT1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102492771 (AKT1)    05205 Proteoglycans in cancer     102492771 (AKT1)    05207 Chemical carcinogenesis - receptor activation     102492771 (AKT1)    05208 Chemical carcinogenesis - reactive oxygen species     102492771 (AKT1)    05230 Central carbon metabolism in cancer     102492771 (AKT1)    05231 Choline metabolism in cancer     102492771 (AKT1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102492771 (AKT1)   09162 Cancer: specific types    05210 Colorectal cancer     102492771 (AKT1)    05212 Pancreatic cancer     102492771 (AKT1)    05225 Hepatocellular carcinoma     102492771 (AKT1)    05226 Gastric cancer     102492771 (AKT1)    05214 Glioma     102492771 (AKT1)    05221 Acute myeloid leukemia     102492771 (AKT1)    05220 Chronic myeloid leukemia     102492771 (AKT1)    05218 Melanoma     102492771 (AKT1)    05211 Renal cell carcinoma     102492771 (AKT1)    05215 Prostate cancer     102492771 (AKT1)    05213 Endometrial cancer     102492771 (AKT1)    05224 Breast cancer     102492771 (AKT1)    05222 Small cell lung cancer     102492771 (AKT1)    05223 Non-small cell lung cancer     102492771 (AKT1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102492771 (AKT1)    05170 Human immunodeficiency virus 1 infection     102492771 (AKT1)    05161 Hepatitis B     102492771 (AKT1)    05160 Hepatitis C     102492771 (AKT1)    05164 Influenza A     102492771 (AKT1)    05162 Measles     102492771 (AKT1)    05168 Herpes simplex virus 1 infection     102492771 (AKT1)    05163 Human cytomegalovirus infection     102492771 (AKT1)    05167 Kaposi sarcoma-associated herpesvirus infection     102492771 (AKT1)    05169 Epstein-Barr virus infection     102492771 (AKT1)    05165 Human papillomavirus infection     102492771 (AKT1)   09171 Infectious disease: bacterial    05132 Salmonella infection     102492771 (AKT1)    05135 Yersinia infection     102492771 (AKT1)    05152 Tuberculosis     102492771 (AKT1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102492771 (AKT1)    05142 Chagas disease     102492771 (AKT1)   09164 Neurodegenerative disease    05010 Alzheimer disease     102492771 (AKT1)    05017 Spinocerebellar ataxia     102492771 (AKT1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102492771 (AKT1)    05418 Fluid shear stress and atherosclerosis     102492771 (AKT1)    05415 Diabetic cardiomyopathy     102492771 (AKT1)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     102492771 (AKT1)    04932 Non-alcoholic fatty liver disease     102492771 (AKT1)    04931 Insulin resistance     102492771 (AKT1)    04933 AGE-RAGE signaling pathway in diabetic complications     102492771 (AKT1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102492771 (AKT1)    01524 Platinum drug resistance     102492771 (AKT1)    01522 Endocrine resistance     102492771 (AKT1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tup01001]     102492771 (AKT1) Enzymes [BR:tup01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      102492771 (AKT1) Protein kinases [BR:tup01001]  Serine/threonine kinases: AGC group   AKT/PKB family    102492771 (AKT1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7 Pkinase_fungal Motif Other DBs NCBI-GeneID:  102492771 NCBI-ProteinID:  XP_014447718 LinkDB All DBs Position Un AA seq 480 aa AA seqDB search MDDVAVVKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPQDVDQREAPLNNFSVAQC QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEGMDF RPGSPSDSSGAEDMEVSLARPKHRVTMSEFEYLKLLGKGTFGKVILVKERATGRYYAMKI LKKEVIVAKDEVAHTLTENRVLQNSKHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHVKITDFGLCKEGI KDGATMRTFCGTPEYLAPEVLEDNDYGRAVGWWGLGVVMYEMLCGRLPFYNQDHEKLFEL ILMEDIRFPRTLGPEARALLAGLLKKDPRQRLGGGPEDAKEIMRHRFFANIVWQDVYEKK LSPPFRPQVTSETDTRYFDEEFTAQIITITPPDQDDSMECVDSERRPHFPQFSYSASGTA NT seq 1443 nt NT seq  +upstreamnt  +downstreamnt atggacgacgtggctgtcgtgaaggagggctggctacacaaacgaggggagtacatcaag acctggcggccgcgctacttccttctcaagagcgacggcagcttcattggctacaaggag cggccgcaggacgtggaccagcgcgaggcccccctcaacaacttctccgtggcgcagtgc cagctgatgaagacggagcggccgcggcccaacaccttcatcatccgctgcctgcagtgg accacagtcatcgagcgcaccttccacgtggagacgcccgaggaacgggaggagtggacc actgccattcagacggtggcagacgggctcaagaagcaagaggaggaggggatggacttc cggccaggctcgcccagtgacagctcgggggccgaggacatggaggtgtcactggccagg cccaagcaccgtgtgaccatgagcgagttcgagtacctgaagctgctgggcaagggcacc tttgggaaggtgatcctggtgaaggagagggccaccgggcgctactacgccatgaagatc ctcaagaaggaggtcatcgtggccaaggacgaggtggcccacacgctcacagagaaccga gtcctgcagaactccaagcaccccttcctcacggccctgaaatactccttccagacccac gaccgcctctgcttcgtcatggagtacgccaacgggggcgagctcttcttccatctgtcg cgggagcgtgtgttctccgaggaccgggcccgcttctacggcgcagagatcgtgtcggcc ctggactacctgcactcggagaagaacgtggtgtaccgcgacctcaagctggagaacctc atgctggacaaggacggccacgtgaagatcacggacttcgggctgtgcaaggagggcata aaggacggcgccaccatgcggaccttctgcgggacgcccgagtacctggcgcccgaggtg ctggaggacaacgactacggcagggccgtgggctggtgggggctgggcgtggtcatgtac gagatgctctgcggccgcctgcccttctacaaccaggaccacgagaagctcttcgagctc atcctcatggaggacatccgcttcccgcgcaccctcggccccgaagccagggcgctgctc gctgggctgctcaagaaggacccccggcagaggctcggcgggggccccgaggacgccaag gagatcatgcggcaccgcttcttcgccaacatcgtgtggcaggacgtgtacgagaagaag ctcagcccgcccttcaggcctcaggtcacgtctgagacggacaccaggtacttcgatgag gagttcaccgcccagataatcaccatcacgccacctgaccaagatgacagcatggagtgt gtggacagcgagcggaggccccacttcccgcagttctcctactccgccagcggcacggcc tga

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