Tupaia chinensis (Chinese tree shrew): 102492903 Help Entry 102492903         CDS       T02978                                  Symbol PLCB2 Name (RefSeq) phospholipase C beta 2   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00562   Inositol phosphate metabolism tup01100   Metabolic pathways tup04015   Rap1 signaling pathway tup04020   Calcium signaling pathway tup04022   cGMP-PKG signaling pathway tup04062   Chemokine signaling pathway tup04070   Phosphatidylinositol signaling system tup04071   Sphingolipid signaling pathway tup04072   Phospholipase D signaling pathway tup04081   Hormone signaling tup04082   Neuroactive ligand signaling tup04261   Adrenergic signaling in cardiomyocytes tup04270   Vascular smooth muscle contraction tup04310   Wnt signaling pathway tup04371   Apelin signaling pathway tup04540   Gap junction tup04611   Platelet activation tup04613   Neutrophil extracellular trap formation tup04621   NOD-like receptor signaling pathway tup04713   Circadian entrainment tup04720   Long-term potentiation tup04723   Retrograde endocannabinoid signaling tup04724   Glutamatergic synapse tup04725   Cholinergic synapse tup04726   Serotonergic synapse tup04728   Dopaminergic synapse tup04730   Long-term depression tup04742   Taste transduction tup04750   Inflammatory mediator regulation of TRP channels tup04911   Insulin secretion tup04912   GnRH signaling pathway tup04915   Estrogen signaling pathway tup04916   Melanogenesis tup04918   Thyroid hormone synthesis tup04919   Thyroid hormone signaling pathway tup04921   Oxytocin signaling pathway tup04922   Glucagon signaling pathway tup04924   Renin secretion tup04925   Aldosterone synthesis and secretion tup04926   Relaxin signaling pathway tup04927   Cortisol synthesis and secretion tup04928   Parathyroid hormone synthesis, secretion and action tup04929   GnRH secretion tup04933   AGE-RAGE signaling pathway in diabetic complications tup04934   Cushing syndrome tup04935   Growth hormone synthesis, secretion and action tup04961   Endocrine and other factor-regulated calcium reabsorption tup04970   Salivary secretion tup04971   Gastric acid secretion tup04972   Pancreatic secretion tup04973   Carbohydrate digestion and absorption tup05010   Alzheimer disease tup05016   Huntington disease tup05017   Spinocerebellar ataxia tup05022   Pathways of neurodegeneration - multiple diseases tup05142   Chagas disease tup05143   African trypanosomiasis tup05146   Amoebiasis tup05163   Human cytomegalovirus infection tup05200   Pathways in cancer tup05415   Diabetic cardiomyopathy tup05417   Lipid and atherosclerosis Module tup_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102492903 (PLCB2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102492903 (PLCB2)    04310 Wnt signaling pathway     102492903 (PLCB2)    04371 Apelin signaling pathway     102492903 (PLCB2)    04020 Calcium signaling pathway     102492903 (PLCB2)    04070 Phosphatidylinositol signaling system     102492903 (PLCB2)    04072 Phospholipase D signaling pathway     102492903 (PLCB2)    04071 Sphingolipid signaling pathway     102492903 (PLCB2)    04022 cGMP-PKG signaling pathway     102492903 (PLCB2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102492903 (PLCB2)    04081 Hormone signaling     102492903 (PLCB2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     102492903 (PLCB2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102492903 (PLCB2)    04613 Neutrophil extracellular trap formation     102492903 (PLCB2)    04621 NOD-like receptor signaling pathway     102492903 (PLCB2)    04062 Chemokine signaling pathway     102492903 (PLCB2)   09152 Endocrine system    04911 Insulin secretion     102492903 (PLCB2)    04922 Glucagon signaling pathway     102492903 (PLCB2)    04929 GnRH secretion     102492903 (PLCB2)    04912 GnRH signaling pathway     102492903 (PLCB2)    04915 Estrogen signaling pathway     102492903 (PLCB2)    04921 Oxytocin signaling pathway     102492903 (PLCB2)    04926 Relaxin signaling pathway     102492903 (PLCB2)    04935 Growth hormone synthesis, secretion and action     102492903 (PLCB2)    04918 Thyroid hormone synthesis     102492903 (PLCB2)    04919 Thyroid hormone signaling pathway     102492903 (PLCB2)    04928 Parathyroid hormone synthesis, secretion and action     102492903 (PLCB2)    04916 Melanogenesis     102492903 (PLCB2)    04924 Renin secretion     102492903 (PLCB2)    04925 Aldosterone synthesis and secretion     102492903 (PLCB2)    04927 Cortisol synthesis and secretion     102492903 (PLCB2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102492903 (PLCB2)    04270 Vascular smooth muscle contraction     102492903 (PLCB2)   09154 Digestive system    04970 Salivary secretion     102492903 (PLCB2)    04971 Gastric acid secretion     102492903 (PLCB2)    04972 Pancreatic secretion     102492903 (PLCB2)    04973 Carbohydrate digestion and absorption     102492903 (PLCB2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     102492903 (PLCB2)   09156 Nervous system    04724 Glutamatergic synapse     102492903 (PLCB2)    04725 Cholinergic synapse     102492903 (PLCB2)    04728 Dopaminergic synapse     102492903 (PLCB2)    04726 Serotonergic synapse     102492903 (PLCB2)    04720 Long-term potentiation     102492903 (PLCB2)    04730 Long-term depression     102492903 (PLCB2)    04723 Retrograde endocannabinoid signaling     102492903 (PLCB2)   09157 Sensory system    04742 Taste transduction     102492903 (PLCB2)    04750 Inflammatory mediator regulation of TRP channels     102492903 (PLCB2)   09159 Environmental adaptation    04713 Circadian entrainment     102492903 (PLCB2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102492903 (PLCB2)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     102492903 (PLCB2)   09174 Infectious disease: parasitic    05146 Amoebiasis     102492903 (PLCB2)    05142 Chagas disease     102492903 (PLCB2)    05143 African trypanosomiasis     102492903 (PLCB2)   09164 Neurodegenerative disease    05010 Alzheimer disease     102492903 (PLCB2)    05016 Huntington disease     102492903 (PLCB2)    05017 Spinocerebellar ataxia     102492903 (PLCB2)    05022 Pathways of neurodegeneration - multiple diseases     102492903 (PLCB2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102492903 (PLCB2)    05415 Diabetic cardiomyopathy     102492903 (PLCB2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102492903 (PLCB2)    04934 Cushing syndrome     102492903 (PLCB2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tup04131]     102492903 (PLCB2) Enzymes [BR:tup01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102492903 (PLCB2) Membrane trafficking [BR:tup04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102492903 (PLCB2)  Endocytosis   Macropinocytosis    Phospholipase C     102492903 (PLCB2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 Gp58 Motif Other DBs NCBI-GeneID:  102492903 NCBI-ProteinID:  XP_006158762 LinkDB All DBs Position Un AA seq 1197 aa AA seqDB search MSLLNPVLLPPKVPAYLSQGERFIKWDDETAIASPVILRVDPKGYYLYWTYQSKEMEFLD ITSIRDTRFGKFAKMPKSQKLREVFNMEFPDNNFXXXXXKTLTVVSGPDMVDLTFHNFVS YKENVGKNWAEDVLALVKHPLTANAPRSTFLDKILVKLKMQLNPEGKIPVKNLFQMFLLX XXXLPADRKRVEAALSACHLPKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSYHS KAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEG MVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL SGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPVILSFENH VDSPRQQAKMAEYCRTMFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGP AAPSKEAGGEAEGSCPPSAPASEDTVWAGEEGTEPEEEEVDEEEEEEESGSLDEEEIKKM QSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKAS VQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFN GQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFG LPGDPKRRYRTKMSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNRFLGHRIIP INALSSGYHHLCLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKK SVKLKEAMGGLPEKPFSPRSPVLDQVNGALAPMSNGSAAAGAKAKEEATKKTDEPRTASL QEVRELKAAVKLQRRHEKELRELERRCARRWEELLQRGAAQLAELAPPGAGVGGGGRKLC PGKGSRKKRSQPGEEPAGTALGEGSEGTDARVKELRDRLELELLQLGGEQCESVLKRKEQ HVAEQISKMMELAREKQAAELKTLKETSETDTKEMKKKLEAKRLERIQAMTKATTDKMAQ ERLKREINNSHIQEVVQVIKQLTESLERQQEKLEEKQAACLEQIQEMEKQFQQEVQSEYE ARMKGLEAEVKESVRACLRACFLPEAEDKPERPCEASREQSEQDPLTAKADAQESHL NT seq 3594 nt NT seq  +upstreamnt  +downstreamnt atgtctctgctcaaccctgtcctgctgcctcccaaggtgccggcctatctgagccaaggg gagcgcttcatcaaatgggacgatgaaacggcaatagcctccccagtaatcctccgtgtg gatcccaagggctattacttatactggacatatcagagtaaggagatggagtttctggat atcaccagcatccgggatacccgctttgggaagtttgccaagatgcccaagagccagaag ctccgagaggtcttcaacatggagtttcctgacaacaacttcnnnnnnnnnnnnntgaag accctcacggtggtgtccggccctgacatggtggacctcaccttccacaacttcgtctcc tacaaggagaacgtgggcaagaactgggctgaggacgtgctggccctggtcaagcaccca ctgacagccaatgccccccgcagcaccttcctggacaagatcctggtgaagctcaaaatg cagctcaacccagaagggaagattcctgtgaagaatcttttccagatgtttcttctgnnn nnnnnnnggttgcctgctgaccgcaagcgggtggaagctgctctcagcgcctgccacctc ccgaaaggcaaaaacgatgccatcaatcctgaggacttcccagaatctgtctacaagagt ttcctcatgaacctctgtcctcggccagaaatagacgagatctttacttcctaccattct aaggccaagccctacatgaccaaggagcacttgaccaaattcatcaaccagaaacagcga gactcaagactcaactccctgctgttcccgccagcacggcctgaccaggtgcaaggtctc atcgacaagtacgagcccagtggcatcaatgtgcagaggggccagctgtcacctgagggc atggtctggtttctctgtgggccagagaacagtgtgctggcccaggacaagctgctactc caccacgacatgacgcagcccctcaatcattacttcatcaactcctcacataacacctac ctgacagccggccagttctcaggcctttcctcggcggagatgtaccgccaggtgctgctg tctggctgccgttgtgtggagctggactgctggaaggggaagccccccgacgaggagccc atcatcacccacggcttcaccatgaccacagacatcttcttcaaggaagccatcgaagct attgcagagagtgccttcaagacctccccctatcccgtcatcctgtcctttgaaaaccac gtggactcaccccgccagcaggctaagatggctgagtactgccgaaccatgtttggggac atgctccttacagagcccctggaaaagttcccactgaaacctggagtcccgctgcccagc ccagaggatctccggggcaagatcctcatcaagaacaagaagaaccagttttctggtcca gcagcccccagcaaggaggctgggggagaggctgagggcagctgcccacccagtgcccct gccagcgaggacacagtgtgggctggcgaggaagggactgagccagaggaggaggaggta gacgaggaggaggaggaggaagagtcaggaagcctggatgaagaagagataaagaagatg cagtcggacgagggcaccgcgggcctagaggtgacagcttacgaggagatgtccagccta gtcaattacattcagcccaccaagttcatctccttcgagttctctgcccagaagaaccga agttacgtcatctcctccttcacagagctcaaggcttatgatctgctttccaaggcctca gtgcagtttgtggactacaacaagcgccagatgagccgcatctaccccaagggtacccgc atggactcctccaactacatgccccagatgttctggaatgccggatgccagatggtcgcc ctgaacttccagacaatggacctgcccatgcaacagaacatggcgctgtttgagttcaac gggcagagtggctacctcctcaagcatgagttcatgcgccgtccggacaagcagttcaat cccttctcggtggaccgcatcgacgtggtggtggccaccaccctttccattacggtaatc tctgggcagttcctgtcagaacgcagtgtacgcacctatgtggaagtggagctgtttggc cttcctggggacccgaagaggcgctatcgcaccaagatgtcacctagtacgaactccatc aatcctgtatggaaagaggagccctttgtcttcgagaagatcttgatgcctgagctggcc tccctcagggtggctgtcatggaggaaggcaacaggttcctcggacaccgcatcatcccc atcaatgccctcagttccgggtaccaccacctgtgcttgcacagcgagagcaacatgccc ctcaccatgcccgcgctctttgtcttcctggagatgaaggactatgtacctgacacctgg gcagatctcaccgtggccctggccaaccccatcaagttcttcagtgcccatgataagaag tcggtgaagctcaaggaagccatgggcggtctccctgagaagcccttctcacccaggagc ccagttctggaccaggtcaatggggcactggccccgatgagtaatgggtcagcagcagct ggggccaaggccaaggaggaggccacaaaaaaaactgacgagccacggaccgccagcctg caggaggtgcgggagctgaaggcagctgtgaagctgcagcggcggcacgagaaggagctg cgggagctggagcggcgctgcgcgcggcgctgggaggagctgctgcagcgaggcgcagcg cagctggcagagctcgcgcctccgggcgcgggggtcggcggcgggggccgcaagctctgt cccggcaagggatcgcgcaagaaaagaagccagcctggcgaggagcctgctgggaccgca ctgggcgagggctccgagggcacagacgcgcgcgtgaaggagctgagggacaggctggag ctggagctgctgcagctcggcggggagcagtgtgagagcgtcctgaagcgcaaggagcag cacgtggctgagcaaatctccaaaatgatggagctggccagggagaaacaggcggcagaa ctgaaaaccctcaaggaaacctcagagactgacaccaaagagatgaagaaaaagctggaa gccaagaggctggagcggatccaagccatgaccaaagccaccacagacaagatggcccag gagaggttgaagagagagattaacaactcccacatccaggaagtggtacaggtcatcaag cagctgacagagagcctggagaggcagcaggagaagctggaagagaagcaggcggcctgc ctggaacagatccaggagatggaaaagcagttccagcaggaggtgcagtcagagtacgag gccaggatgaagggcctggaggccgaggtgaaggagtcagtgagggcctgcctcagagcc tgcttcctccctgaggccgaggacaagccagagagaccctgtgaggcctccagggagcag agtgagcaggacccactcacagcaaaggcggatgcccaggagagccacctctga

DBGET integrated database retrieval system