Tupaia chinensis (Chinese tree shrew): 102495986 Help Entry 102495986         CDS       T02978                                  Symbol NOS3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00220   Arginine biosynthesis tup00330   Arginine and proline metabolism tup01100   Metabolic pathways tup04020   Calcium signaling pathway tup04022   cGMP-PKG signaling pathway tup04066   HIF-1 signaling pathway tup04071   Sphingolipid signaling pathway tup04151   PI3K-Akt signaling pathway tup04370   VEGF signaling pathway tup04371   Apelin signaling pathway tup04611   Platelet activation tup04915   Estrogen signaling pathway tup04921   Oxytocin signaling pathway tup04926   Relaxin signaling pathway tup04931   Insulin resistance tup04933   AGE-RAGE signaling pathway in diabetic complications tup05415   Diabetic cardiomyopathy tup05417   Lipid and atherosclerosis tup05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     102495986 (NOS3)    00330 Arginine and proline metabolism     102495986 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     102495986 (NOS3)    04371 Apelin signaling pathway     102495986 (NOS3)    04066 HIF-1 signaling pathway     102495986 (NOS3)    04020 Calcium signaling pathway     102495986 (NOS3)    04071 Sphingolipid signaling pathway     102495986 (NOS3)    04022 cGMP-PKG signaling pathway     102495986 (NOS3)    04151 PI3K-Akt signaling pathway     102495986 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102495986 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     102495986 (NOS3)    04921 Oxytocin signaling pathway     102495986 (NOS3)    04926 Relaxin signaling pathway     102495986 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102495986 (NOS3)    05418 Fluid shear stress and atherosclerosis     102495986 (NOS3)    05415 Diabetic cardiomyopathy     102495986 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     102495986 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     102495986 (NOS3) Enzymes [BR:tup01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      102495986 (NOS3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  102495986 NCBI-ProteinID:  XP_006150279 LinkDB All DBs Position Un AA seq 1203 aa AA seqDB search MGNLKSVTQEPGPPCGLGLGLGLGLCGKQGPASPASEPSRAPASPPPPQPAPDHSPPLTR PPEAPRFPRVKNWEVGSIAYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPPTSPPPPE QLLSQARDFIHQYYSSIKRSGSQAHEQRLQEVETEVTATGTYQLRESELVFGAKQAWRNA PRCVGRIQWGKLQVFDARDCRSAQEMFTCLCNHIKYATNRGNLRSAITVFPQRCPGRGDF RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE LFTLPPELVLEVPLEHPKLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHH VATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK GSGAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQGYAQQLGRL FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAAR DIFSPKRSWKRQRYRLSTQAEGLQLLPGLSHVHRRKMFQATILSVENLQSSKSTRATILV RLDTGGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPAEPPVAVEQLEKGSPGGP PPGWARDPRLPPCTLRQALTFFLDITSPPSPRLLQLLSTLAEEPSEQQELEALSQDPRRY EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGELHLTVAVL AYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP FRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE PDSPKTYVQDILRTELAAEVYRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELD AAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWALEPPGTDI LSQ NT seq 3612 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagcgtgacccaggagcccgggccaccctgcggcctggggctgggg ctgggcctcgggctgtgcggcaagcagggtccagcttccccggcaagcgagcccagccgg gctccagcatccccgcccccaccccaacccgcgccagaccacagccccccactaacccgg cccccagaggcacccaggttcccccgtgtgaagaactgggaagtgggcagcatcgcctac gacacgctcagcgcacaggcccaacaggatggaccctgcaccccaagacgctgcctgggc tccctcgtatttccacggaagctgcagagccggccccccacgagccctccgccccctgag cagctgctgagtcaggcccgggatttcatccaccagtactacagctctatcaagaggagc gggtcccaggcccatgagcagcgtcttcaggaggtggagacagaggtgacagccacaggc acctaccagcttcgggagagtgagctggtgttcggggccaagcaggcctggcggaatgcc ccgcgctgcgtgggccggatccagtgggggaagctgcaggtgttcgatgcgcgggattgc agatctgcccaggagatgttcacctgcctctgcaaccacataaaatatgccaccaaccga ggcaacctccgctcggccatcacagtgttcccccagcgctgcccgggccgcggagacttc cggatctggaacagccagctggtgcgctatgcaggctacaggcagcaggacggctctgtg cgcggggacccggccaacgtggagatcaccgagctctgcattcagcacggctggacccca gggaacggccgcttcgacgtgctgcccctgctgctccaggcccccgacgaacccccggag ctcttcaccctgccccccgagctggtcctcgaggtgcccctggagcaccccaagctggag tggttcgcggccctgggcctgcgctggtacgcactgccggccgtgtccaacatgctgctg gagatcgggggcctggagttccccgcggcccctttcagcggctggtacatgagcacggag atcggcacgcgcaacctgtgtgacccgcaccgctacaacatcctggaggacgtggctgtc tgcatggacctggacacccggaccacctcgtccctgtggaaagacaaggctgcagtggag attaacctggccgtgctgcacagctaccagctggccaaagtgaccattgtggaccaccac gttgccaccgcatccttcatgaagcacctggagaacgagcagaaggcccggggcggctgc cctgccgactgggcctggatcgtgccccccatctcgggcagcctcactcctgtcttccat caggagatggtcaactacttcctgtcccctgccttccgctaccagccggacccctggaag gggagtggagccaagggcaccggcatcaccaggaagaagacctttaaggaagtggccaat gcggtgaagatctcggcctcgctcatgggcacagtgatggcaaagcgagtgaaggcgacc atcctgtacggctctgagaccggccgggcccagggctacgcgcagcagctggggaggctc ttccggaaggctttcgacccccgggtcctgtgcatggatgaatacgatgtggtgtctctc gagcacgagacgctggtgttggtggtgaccagcacatttgggaatggggaccccccggag aatggagagagcttcgcagcagccctgatggagatgtccggcccctacaacagctccccc cggcctgagcagcacaaaagttacaaaatccgcttcaacagcgtctcctgctcagaccct ctggtgtcctcttggcggcgaaagaggaaggagtccagtaacacagacagtgcaggggcc ctgggcaccctcaggttctgtgtgttcgggctggggtcccgggcatacccccacttctgc gcctttgcccgagcggtggacacgcggctggaagagctgggcggggagcggctgctgcag ctcggccagggcgacgagctgtgtggccaggaggaggccttccgcggctgggcccaggcc gccttccaggcctcctgtgaaactttctgtgtgggagaggatgccaaggccgccgctcga gacatattcagccccaaacgaagctggaagcgccagcggtaccggctgagtacacaggcc gagggcctgcagctgctgccaggcctcagccacgtgcacaggcggaagatgttccaggct accatcctctcagtggaaaacctgcaaagcagcaagtccacccgggccacgatcctggtg cgcctggacactggaggccaggaggggctgcagtaccagccgggggaccacataggcatc tgcccgcccaaccggccgggcctggtggaggcactgctgagccgcgtggaggacccgccc ccgcctgcagagcctcctgtggcagtggagcagctggagaagggcagccctggcggccct cctcccggctgggcgcgggatccccggctgcccccgtgcacgctgcgccaggctctcacc ttcttcctggacatcacctccccgcccagcccgcggctcctgcagctgctcagcaccctg gccgaggagcccagcgagcagcaggagctggaggccctcagccaggacccccggcgctac gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccatcc gtggccctgccggccccactgctcctcacccagctgcccctgctccagccccggtactac tcggtcagctctgcgcccagcgcccacccgggagagctgcacctcactgtggccgtgctg gcatacaggacccaggatgggctgggccccctgcactacggagtctgctccacgtggctg agccagctgaaggccggagaccctgtgccctgcttcatcagaggggctccctcctttcgc ctgcctcctgaccccagcttgccctgcattctggtgggtcctggcaccggcatcgccccc ttccggggattctggcaggagcggctgcacgacattgagagcaaaggactgcagcccgcc cccatgactttggtgttcggctgccgctgctcccagctcgaccacctctaccgcgacgag gtgcaggacgctcagcagcgcggggtgttcggccgcgtcctcaccgccttctcccgggag cctgacagccccaagacctacgtgcaggacatcctgaggactgagctggcagctgaggtg taccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcaccatggca acaagcgtcctacagacagtgcagcgaatcctggcgacggagggcgacatggagctggac gcggcgggagatgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttc gggctcacgctgcgcacccaggaagtgacaagccgcatacgcacccagagcttttcgctg caggagcggcagctgcggggcgcagtgccctgggcgttggagcctcctggcacagacatc cttagccagtga

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