KEGG   Tupaia chinensis (Chinese tree shrew): 102497488
Entry
102497488         CDS       T02978                                 
Symbol
RAF1
Name
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup01521  EGFR tyrosine kinase inhibitor resistance
tup01522  Endocrine resistance
tup04010  MAPK signaling pathway
tup04012  ErbB signaling pathway
tup04014  Ras signaling pathway
tup04015  Rap1 signaling pathway
tup04022  cGMP-PKG signaling pathway
tup04024  cAMP signaling pathway
tup04062  Chemokine signaling pathway
tup04068  FoxO signaling pathway
tup04071  Sphingolipid signaling pathway
tup04072  Phospholipase D signaling pathway
tup04140  Autophagy - animal
tup04150  mTOR signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04210  Apoptosis
tup04218  Cellular senescence
tup04270  Vascular smooth muscle contraction
tup04360  Axon guidance
tup04370  VEGF signaling pathway
tup04371  Apelin signaling pathway
tup04510  Focal adhesion
tup04540  Gap junction
tup04550  Signaling pathways regulating pluripotency of stem cells
tup04613  Neutrophil extracellular trap formation
tup04625  C-type lectin receptor signaling pathway
tup04630  JAK-STAT signaling pathway
tup04650  Natural killer cell mediated cytotoxicity
tup04660  T cell receptor signaling pathway
tup04662  B cell receptor signaling pathway
tup04664  Fc epsilon RI signaling pathway
tup04666  Fc gamma R-mediated phagocytosis
tup04720  Long-term potentiation
tup04722  Neurotrophin signaling pathway
tup04726  Serotonergic synapse
tup04730  Long-term depression
tup04810  Regulation of actin cytoskeleton
tup04910  Insulin signaling pathway
tup04912  GnRH signaling pathway
tup04914  Progesterone-mediated oocyte maturation
tup04915  Estrogen signaling pathway
tup04916  Melanogenesis
tup04917  Prolactin signaling pathway
tup04919  Thyroid hormone signaling pathway
tup04921  Oxytocin signaling pathway
tup04926  Relaxin signaling pathway
tup04928  Parathyroid hormone synthesis, secretion and action
tup04929  GnRH secretion
tup04935  Growth hormone synthesis, secretion and action
tup05010  Alzheimer disease
tup05022  Pathways of neurodegeneration - multiple diseases
tup05034  Alcoholism
tup05132  Salmonella infection
tup05152  Tuberculosis
tup05160  Hepatitis C
tup05161  Hepatitis B
tup05163  Human cytomegalovirus infection
tup05164  Influenza A
tup05165  Human papillomavirus infection
tup05167  Kaposi sarcoma-associated herpesvirus infection
tup05170  Human immunodeficiency virus 1 infection
tup05200  Pathways in cancer
tup05205  Proteoglycans in cancer
tup05206  MicroRNAs in cancer
tup05207  Chemical carcinogenesis - receptor activation
tup05208  Chemical carcinogenesis - reactive oxygen species
tup05210  Colorectal cancer
tup05211  Renal cell carcinoma
tup05212  Pancreatic cancer
tup05213  Endometrial cancer
tup05214  Glioma
tup05215  Prostate cancer
tup05218  Melanoma
tup05219  Bladder cancer
tup05220  Chronic myeloid leukemia
tup05221  Acute myeloid leukemia
tup05223  Non-small cell lung cancer
tup05224  Breast cancer
tup05225  Hepatocellular carcinoma
tup05226  Gastric cancer
tup05230  Central carbon metabolism in cancer
tup05231  Choline metabolism in cancer
tup05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tup00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102497488 (RAF1)
   04012 ErbB signaling pathway
    102497488 (RAF1)
   04014 Ras signaling pathway
    102497488 (RAF1)
   04015 Rap1 signaling pathway
    102497488 (RAF1)
   04370 VEGF signaling pathway
    102497488 (RAF1)
   04371 Apelin signaling pathway
    102497488 (RAF1)
   04630 JAK-STAT signaling pathway
    102497488 (RAF1)
   04068 FoxO signaling pathway
    102497488 (RAF1)
   04072 Phospholipase D signaling pathway
    102497488 (RAF1)
   04071 Sphingolipid signaling pathway
    102497488 (RAF1)
   04024 cAMP signaling pathway
    102497488 (RAF1)
   04022 cGMP-PKG signaling pathway
    102497488 (RAF1)
   04151 PI3K-Akt signaling pathway
    102497488 (RAF1)
   04150 mTOR signaling pathway
    102497488 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102497488 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    102497488 (RAF1)
   04218 Cellular senescence
    102497488 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102497488 (RAF1)
   04540 Gap junction
    102497488 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102497488 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102497488 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102497488 (RAF1)
   04625 C-type lectin receptor signaling pathway
    102497488 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    102497488 (RAF1)
   04660 T cell receptor signaling pathway
    102497488 (RAF1)
   04662 B cell receptor signaling pathway
    102497488 (RAF1)
   04664 Fc epsilon RI signaling pathway
    102497488 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    102497488 (RAF1)
   04062 Chemokine signaling pathway
    102497488 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102497488 (RAF1)
   04929 GnRH secretion
    102497488 (RAF1)
   04912 GnRH signaling pathway
    102497488 (RAF1)
   04915 Estrogen signaling pathway
    102497488 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    102497488 (RAF1)
   04917 Prolactin signaling pathway
    102497488 (RAF1)
   04921 Oxytocin signaling pathway
    102497488 (RAF1)
   04926 Relaxin signaling pathway
    102497488 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    102497488 (RAF1)
   04919 Thyroid hormone signaling pathway
    102497488 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    102497488 (RAF1)
   04916 Melanogenesis
    102497488 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102497488 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    102497488 (RAF1)
   04720 Long-term potentiation
    102497488 (RAF1)
   04730 Long-term depression
    102497488 (RAF1)
   04722 Neurotrophin signaling pathway
    102497488 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    102497488 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102497488 (RAF1)
   05206 MicroRNAs in cancer
    102497488 (RAF1)
   05205 Proteoglycans in cancer
    102497488 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    102497488 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102497488 (RAF1)
   05230 Central carbon metabolism in cancer
    102497488 (RAF1)
   05231 Choline metabolism in cancer
    102497488 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102497488 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102497488 (RAF1)
   05212 Pancreatic cancer
    102497488 (RAF1)
   05225 Hepatocellular carcinoma
    102497488 (RAF1)
   05226 Gastric cancer
    102497488 (RAF1)
   05214 Glioma
    102497488 (RAF1)
   05221 Acute myeloid leukemia
    102497488 (RAF1)
   05220 Chronic myeloid leukemia
    102497488 (RAF1)
   05218 Melanoma
    102497488 (RAF1)
   05211 Renal cell carcinoma
    102497488 (RAF1)
   05219 Bladder cancer
    102497488 (RAF1)
   05215 Prostate cancer
    102497488 (RAF1)
   05213 Endometrial cancer
    102497488 (RAF1)
   05224 Breast cancer
    102497488 (RAF1)
   05223 Non-small cell lung cancer
    102497488 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102497488 (RAF1)
   05161 Hepatitis B
    102497488 (RAF1)
   05160 Hepatitis C
    102497488 (RAF1)
   05164 Influenza A
    102497488 (RAF1)
   05163 Human cytomegalovirus infection
    102497488 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102497488 (RAF1)
   05165 Human papillomavirus infection
    102497488 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102497488 (RAF1)
   05152 Tuberculosis
    102497488 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102497488 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    102497488 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    102497488 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102497488 (RAF1)
   01522 Endocrine resistance
    102497488 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tup01001]
    102497488 (RAF1)
Enzymes [BR:tup01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102497488 (RAF1)
Protein kinases [BR:tup01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102497488 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 RBD Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 102497488
NCBI-ProteinID: XP_006160711
LinkDB
Position
Un
AA seq 573 aa
MSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVP
LTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLL
FPNSIVGDGGAPALPSLTMRRMRESVSRLPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ
RSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKALVPAQ
RERAPGPGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVK
ILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV
QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR
WSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRD
QIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK
INRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1722 nt   +upstreamnt  +downstreamnt
atgagcttgcacgactgccttatgaaagctctcaaggtgaggggcctgcaaccggagtgc
tgtgcggtgttcagacttctccaggagcacaaaggtaaaaaagctcgtttagattggaat
actgatgctgcctctttgattggagaagaacttcaagtagatttcctggatcacgttccc
ctcacaacacataactttgctcggaagacgttcctgaaacttgccttctgtgacatctgc
cagaaattcctgctcaatggatttcgatgtcagacttgcggctacaaatttcatgaacat
tgtagcaccaaagtacctactatgtgtgtggactggagtaatatcagacagctcttgtta
tttcccaattccatcgtcggcgatggtggggcccccgcactaccttccttgacaatgcgc
cggatgcgagagtctgtctcgcggttgcctgtcagttcccaacacagatattccacaccc
catgccttcacgttcaacacctccagcccctcctccgagggctccctgtcccagaggcag
aggtcgacgtccacacctaatgtccacatggtcagcaccaccctgcctgtggacagcagg
atgattgaggatgcaattcgaagccacagcgaatcagcctcaccttcagccctgtccagc
agtcccaacaacctgagcccaacgggctggtcacagcccaaagccctcgtgccagcacaa
agggagcgtgcaccgggacctgggacccaggagaaaaacaaaattaggcctcgcggacag
agagattccagctactactgggaaatagaagccagcgaagtgatgctttccactcggatt
gggtcaggctcctttggaactgtctacaagggcaagtggcatggagacgttgcagtaaaa
atcctaaaggtggtcgacccaactccggagcagttccaggcgttcaggaatgaggtggcc
gtcctgcgcaaaacgcggcatgtgaacatcctgctgttcatgggctacatgacgaaagac
aacctggccatcgtgacccagtggtgtgagggcagcagcctctacaaacacctgcatgtc
caggagaccaagttccagatgttccagttaattgacattgcccggcagacggctcagggg
atggactatttgcatgcgaagaacatcatccacagagacatgaaatccaacaatatattt
ctccacgaaggcttaacagtaaaaattggagattttggcctggcaacagtgaagtcgcgc
tggagtggctctcagcaggtggaacagcccactggctctgtcctgtggatggccccagag
gtgatccgaatgcaggataacaacccgttcagcttccagtctgacgtctactcctacggc
atcgtgctgtacgagctgatgacgggggagctgccgtactcccacatcaacaaccgcgat
cagatcatcttcatggtgggccgagggtatgcctctccggatctcagtaagctgtacaag
aactgccccaaggcaatgaagaggctggtggccgactgtgtgaagaaggttaaggaagag
aggcccctttttccccagatcctgtcttccatcgagctgctccaacactctctaccgaaa
atcaaccggagtgcttctgagccatccctgcaccgggcagcccacactgaggacatcaac
gcctgcacgctgaccacgtccccgaggctgcctgtcttctag

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