KEGG   Tupaia chinensis (Chinese tree shrew): 106736453
Entry
106736453         CDS       T02978                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup00562  Inositol phosphate metabolism
tup01100  Metabolic pathways
tup01521  EGFR tyrosine kinase inhibitor resistance
tup01522  Endocrine resistance
tup01524  Platinum drug resistance
tup04012  ErbB signaling pathway
tup04014  Ras signaling pathway
tup04015  Rap1 signaling pathway
tup04024  cAMP signaling pathway
tup04062  Chemokine signaling pathway
tup04066  HIF-1 signaling pathway
tup04068  FoxO signaling pathway
tup04070  Phosphatidylinositol signaling system
tup04071  Sphingolipid signaling pathway
tup04072  Phospholipase D signaling pathway
tup04081  Hormone signaling
tup04140  Autophagy - animal
tup04145  Phagocytosis
tup04150  mTOR signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04152  AMPK signaling pathway
tup04210  Apoptosis
tup04211  Longevity regulating pathway
tup04213  Longevity regulating pathway - multiple species
tup04218  Cellular senescence
tup04360  Axon guidance
tup04370  VEGF signaling pathway
tup04380  Osteoclast differentiation
tup04510  Focal adhesion
tup04517  IgSF CAM signaling
tup04518  Integrin signaling
tup04550  Signaling pathways regulating pluripotency of stem cells
tup04611  Platelet activation
tup04613  Neutrophil extracellular trap formation
tup04620  Toll-like receptor signaling pathway
tup04625  C-type lectin receptor signaling pathway
tup04630  JAK-STAT signaling pathway
tup04650  Natural killer cell mediated cytotoxicity
tup04660  T cell receptor signaling pathway
tup04662  B cell receptor signaling pathway
tup04664  Fc epsilon RI signaling pathway
tup04666  Fc gamma R-mediated phagosome formation
tup04668  TNF signaling pathway
tup04670  Leukocyte transendothelial migration
tup04722  Neurotrophin signaling pathway
tup04725  Cholinergic synapse
tup04750  Inflammatory mediator regulation of TRP channels
tup04810  Regulation of actin cytoskeleton
tup04910  Insulin signaling pathway
tup04914  Progesterone-mediated oocyte maturation
tup04915  Estrogen signaling pathway
tup04917  Prolactin signaling pathway
tup04919  Thyroid hormone signaling pathway
tup04923  Regulation of lipolysis in adipocytes
tup04926  Relaxin signaling pathway
tup04929  GnRH secretion
tup04930  Type II diabetes mellitus
tup04931  Insulin resistance
tup04932  Non-alcoholic fatty liver disease
tup04933  AGE-RAGE signaling pathway in diabetic complications
tup04935  Growth hormone synthesis, secretion and action
tup04960  Aldosterone-regulated sodium reabsorption
tup04973  Carbohydrate digestion and absorption
tup05010  Alzheimer disease
tup05017  Spinocerebellar ataxia
tup05020  Prion disease
tup05100  Bacterial invasion of epithelial cells
tup05132  Salmonella infection
tup05135  Yersinia infection
tup05142  Chagas disease
tup05146  Amoebiasis
tup05160  Hepatitis C
tup05161  Hepatitis B
tup05162  Measles
tup05163  Human cytomegalovirus infection
tup05164  Influenza A
tup05165  Human papillomavirus infection
tup05166  Human T-cell leukemia virus 1 infection
tup05167  Kaposi sarcoma-associated herpesvirus infection
tup05168  Herpes simplex virus 1 infection
tup05169  Epstein-Barr virus infection
tup05170  Human immunodeficiency virus 1 infection
tup05171  Coronavirus disease
tup05200  Pathways in cancer
tup05203  Viral carcinogenesis
tup05205  Proteoglycans in cancer
tup05206  MicroRNAs in cancer
tup05207  Chemical carcinogenesis - receptor activation
tup05208  Chemical carcinogenesis - reactive oxygen species
tup05210  Colorectal cancer
tup05211  Renal cell carcinoma
tup05212  Pancreatic cancer
tup05213  Endometrial cancer
tup05214  Glioma
tup05215  Prostate cancer
tup05218  Melanoma
tup05220  Chronic myeloid leukemia
tup05221  Acute myeloid leukemia
tup05222  Small cell lung cancer
tup05223  Non-small cell lung cancer
tup05224  Breast cancer
tup05225  Hepatocellular carcinoma
tup05226  Gastric cancer
tup05230  Central carbon metabolism in cancer
tup05231  Choline metabolism in cancer
tup05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tup05415  Diabetic cardiomyopathy
tup05417  Lipid and atherosclerosis
tup05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tup00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    106736453
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    106736453
   04014 Ras signaling pathway
    106736453
   04015 Rap1 signaling pathway
    106736453
   04370 VEGF signaling pathway
    106736453
   04630 JAK-STAT signaling pathway
    106736453
   04668 TNF signaling pathway
    106736453
   04066 HIF-1 signaling pathway
    106736453
   04068 FoxO signaling pathway
    106736453
   04070 Phosphatidylinositol signaling system
    106736453
   04072 Phospholipase D signaling pathway
    106736453
   04071 Sphingolipid signaling pathway
    106736453
   04024 cAMP signaling pathway
    106736453
   04151 PI3K-Akt signaling pathway
    106736453
   04152 AMPK signaling pathway
    106736453
   04150 mTOR signaling pathway
    106736453
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    106736453
   04517 IgSF CAM signaling
    106736453
   04518 Integrin signaling
    106736453
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    106736453
   04140 Autophagy - animal
    106736453
  09143 Cell growth and death
   04210 Apoptosis
    106736453
   04218 Cellular senescence
    106736453
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    106736453
   04550 Signaling pathways regulating pluripotency of stem cells
    106736453
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    106736453
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106736453
   04613 Neutrophil extracellular trap formation
    106736453
   04620 Toll-like receptor signaling pathway
    106736453
   04625 C-type lectin receptor signaling pathway
    106736453
   04650 Natural killer cell mediated cytotoxicity
    106736453
   04660 T cell receptor signaling pathway
    106736453
   04662 B cell receptor signaling pathway
    106736453
   04664 Fc epsilon RI signaling pathway
    106736453
   04666 Fc gamma R-mediated phagosome formation
    106736453
   04670 Leukocyte transendothelial migration
    106736453
   04062 Chemokine signaling pathway
    106736453
  09152 Endocrine system
   04910 Insulin signaling pathway
    106736453
   04923 Regulation of lipolysis in adipocytes
    106736453
   04929 GnRH secretion
    106736453
   04915 Estrogen signaling pathway
    106736453
   04914 Progesterone-mediated oocyte maturation
    106736453
   04917 Prolactin signaling pathway
    106736453
   04926 Relaxin signaling pathway
    106736453
   04935 Growth hormone synthesis, secretion and action
    106736453
   04919 Thyroid hormone signaling pathway
    106736453
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    106736453
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    106736453
  09156 Nervous system
   04725 Cholinergic synapse
    106736453
   04722 Neurotrophin signaling pathway
    106736453
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    106736453
  09158 Development and regeneration
   04360 Axon guidance
    106736453
   04380 Osteoclast differentiation
    106736453
  09149 Aging
   04211 Longevity regulating pathway
    106736453
   04213 Longevity regulating pathway - multiple species
    106736453
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106736453
   05206 MicroRNAs in cancer
    106736453
   05205 Proteoglycans in cancer
    106736453
   05207 Chemical carcinogenesis - receptor activation
    106736453
   05208 Chemical carcinogenesis - reactive oxygen species
    106736453
   05203 Viral carcinogenesis
    106736453
   05230 Central carbon metabolism in cancer
    106736453
   05231 Choline metabolism in cancer
    106736453
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106736453
  09162 Cancer: specific types
   05210 Colorectal cancer
    106736453
   05212 Pancreatic cancer
    106736453
   05225 Hepatocellular carcinoma
    106736453
   05226 Gastric cancer
    106736453
   05214 Glioma
    106736453
   05221 Acute myeloid leukemia
    106736453
   05220 Chronic myeloid leukemia
    106736453
   05218 Melanoma
    106736453
   05211 Renal cell carcinoma
    106736453
   05215 Prostate cancer
    106736453
   05213 Endometrial cancer
    106736453
   05224 Breast cancer
    106736453
   05222 Small cell lung cancer
    106736453
   05223 Non-small cell lung cancer
    106736453
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106736453
   05170 Human immunodeficiency virus 1 infection
    106736453
   05161 Hepatitis B
    106736453
   05160 Hepatitis C
    106736453
   05171 Coronavirus disease
    106736453
   05164 Influenza A
    106736453
   05162 Measles
    106736453
   05168 Herpes simplex virus 1 infection
    106736453
   05163 Human cytomegalovirus infection
    106736453
   05167 Kaposi sarcoma-associated herpesvirus infection
    106736453
   05169 Epstein-Barr virus infection
    106736453
   05165 Human papillomavirus infection
    106736453
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106736453
   05135 Yersinia infection
    106736453
   05100 Bacterial invasion of epithelial cells
    106736453
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    106736453
   05142 Chagas disease
    106736453
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106736453
   05017 Spinocerebellar ataxia
    106736453
   05020 Prion disease
    106736453
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    106736453
   05418 Fluid shear stress and atherosclerosis
    106736453
   05415 Diabetic cardiomyopathy
    106736453
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    106736453
   04932 Non-alcoholic fatty liver disease
    106736453
   04931 Insulin resistance
    106736453
   04933 AGE-RAGE signaling pathway in diabetic complications
    106736453
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106736453
   01524 Platinum drug resistance
    106736453
   01522 Endocrine resistance
    106736453
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tup04131]
    106736453
Enzymes [BR:tup01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     106736453
Membrane trafficking [BR:tup04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    106736453
SSDB
Motif
Pfam: PI3K_C2 PI3K_rbd PI3K_p85B PI3Ka Ig_NOMO
Other DBs
NCBI-GeneID: 106736453
NCBI-ProteinID: XP_014448864
LinkDB
Position
Un
AA seq 582 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKISHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWSEWLNYDMYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQ
NT seq 1746 nt   +upstreamnt  +downstreamnt
atgcccccacggccgtcgtcgggtgagctgtggggcatccacttgatgcccccaagaatc
ctcgtggaatgtttactaccaaacgggatgatagtgactttagagtgcctccgtgaggcc
acgctggtgaccataaagcatgagctgtttaaagaagcaagaaagtaccccctccaccag
cttctgcaagatgagtcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgagacaagacgactttgcgaccttcggctttttcaaccgtttttaaaa
gtaatcgaacctgtaggcaaccgtgaagagaagatcctcaaccgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagacccagaagtgcaggacttccgg
agaaacatcctgaacgtctgtaaagaagccgtggaccttagggacctcaattcacctcac
agtagggccatgtatgtctaccctccaaatgtggagtcttcgccagaactgccgaagcac
atttataataaactagacaaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaaacagaagtatactctgaagatcagccacgactgcgtgccagagcaggtc
attgctgaagcgatccggaagaaaactcgaagtatgctgctgtcctctgaacagctaaaa
ctctgcgtcttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaataccctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagagagtctttactcccaactgcccatggac
tgctttaccatgccgtcctactccaggcgcatctccacagccacgccgtacatgaacgga
gagaccgccacgaaatccctctgggttatcaacagcgcactcagaataaaaattctctgc
gctacatacgtgaatgtaaacattagagacatcgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaatacccagagagtaccttgttccaat
cccaggtggagtgagtggctgaattatgacatgtacattcctgaccttcctcgcgctgct
cgactgtgtctctccatttgctctgttaaaggccgaaaaggtgctaaagaggagcactgc
ccattggcctggggaaatataaacctgttcgattacaccgacactctcgtatctggaaag
atggctttgaatctttggccagtccctcatgggttagaagacttgctgaaccctattggt
gttactgggtcaaacccaaataaagaaactccctgcttagagctggagtttgactggttc
agcagtgttgtgaagtttccggatatgtctgtgatcgaagagcatgccaactggtctgtg
tcccgcgaggcaggatttagttactcccacgcaggactgagtaacagacttgctagagac
aatgagttaagagaaaatgacaaagaacagctccgagccatctgtacccgagaccccctc
tctgaaattacggagcaagagaaagatttcctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gcccag

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