Tachysurus vachellii: 132851950 Help Entry 132851950         CDS       T09596                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism tvc  Tachysurus vachellii Pathway tvc04020   Calcium signaling pathway tvc04260   Cardiac muscle contraction tvc04261   Adrenergic signaling in cardiomyocytes tvc04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tvc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132851950 (ryr2b)    04020 Calcium signaling pathway     132851950 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     132851950 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     132851950 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tvc04040]     132851950 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:tvc04990]     132851950 (ryr2b) Ion channels [BR:tvc04040]  Voltage-gated cation channels   Ryanodine receptor    132851950 (ryr2b) Domain-containing proteins not elsewhere classified [BR:tvc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132851950 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 KRAB Motif Other DBs NCBI-GeneID:  132851950 NCBI-ProteinID:  XP_060734910 LinkDB All DBs Position 10:3291311..3403865 Genome browser AA seq 4915 aa AA seqDB search MAMDPTDAEDDVQFLRTSDELVLRCCLAAPLQQKLCLAAEGFGSRLCFLESTSNSKNVPA VLSLCVFVLDRCVSVRALQEMLAKHEDLHTGSAETAGHRTLLYGQALLLRHAHSNMYLSC LTSSGLLADKLAFDVGLQEDVAGETCWWTVHPASKQRSEGEKVRVGDDLIFVSVSSERYL HVSWGTGVYEECMNTSVDASFQLTLWTVAPVSSLSTQAQGHLRGGDCLRLLHGHTDECLT VSPAGHTVDERRSVGFEGGCVSSQARSLWRIEMLRVSWSGSHIRWAEQFRLYHVTTGKYL GLTPDRGLLLLDREHADVISTAFCLRPSKDSGQEFPLCVRKKDGMGTPEIKYGDSVCLVQ HVDSALWLTYRTSDSKRTKETQPRKQAILHSEGHMDDGLTLSRSQMEECKAASLIRSSTL LFTLFKRRLDELDHRANIPAPGLPIETLRSSLCDLIGYFRLPDNRWSHEIRQSSSRALKN RQNMFQEEGVITLVLDCIDHLHLYNSAAHFGKAAGKEAGDAWEDILTSFYELLAAMIRGN PYNCSQFSSSLDWLISRLDRLEVSSGILEVLHCVLMESPEALNFIKKEHIRSIITLLDKH GRNHKILEVLSSLCVCHGTAVRSNQHLISDTLLPERDLLLQSRLVNYITCVRPNIFLYMG DDSSQYRKWYYEVVVERAEPFVTPEPTHLRVGWACSAGHRPSLTGGHCWGANGVGDNLQS YGFDGLHLWTGGVGRRVSSANQRLLSEDDVVSCCLDLSAPCISFRVNGQPVQGMLENFNT DALMFPVVSFSAGVRVRVLLGAQHGEFKFLPPAGFSPCIEALLPRGRCRLELCEEVTRGS SQRELLGPAVFTEPVVFTPTPVDTKQVTLPPQLELIRETLAENLHELWLLEKTESGWKHG HVRDDSKQLHPGLVEFSKLPDQEKLVKLQAAEHTLRSLLALGAHIGLSDDHTEEKVKFVR LSNKFELWNGYRPTPVDQSGVHLNAAQEALVEALAENEHNIWSREQIRQGWSYAPQQDIK GKRSPQLLPFLLLDERSRRCHLESARDVLGSLLGFGYTVEASEQRRYLGPDTKAASEERP RIFRVEHTFAVRDGKWYFEFEAVTAGEMRVGWARVGCQPDTELWSDEQSFVFDGSKGQWW HGSTVPFGHVWQKGDVIGCLLDLTRRTMMVTLNGELQLNTYGSEIASKGFSTTGGFVPVC GLGVNQVGRLNLGQKVDSLKYFSVCGLQEGYQPFALNMSKDPPLWMSCREPLFVQIPEDH PHLKVSYIDGTVGHLPSLKVSQRSVGIPDSLSTHVEFYRLSLPIECAQVFSKPVDGAVPP ASSGTCHIKEPEEGEDSDFEMLMKSAHRHTGSRDELNNQKDHAQEKPSRLKQRFLLKKKP ELVSSGSSARLLEDVLAIERDSDNQLANCTKYYFSVKILDGQDPSFVWVGWVTSNFNCYD RTFDMERVCSVTVTLGDQWGKVLESDKCSCCYMVCAAEGSSLSNSRSKLKLEIGCLVDTA TGFLTFTANGKEMGIFYQVKPGTKLYPAVFAKATSSDVFQFELGRIKGALPLSAGLFRSE RKNMEPHCHPRLNVQFLIPTRWTRLPDNAPQVELTRLEERHGWRAKCTESLQVMALHIPE EDRCIDILELSELANLLKFHDHTLRLFSALCAHGNIPVSHALCSYIDQSQILFALRCFRL PGNLRAGFYDLLMTAYLSAHSGARQTTTHEYIVPMTDAMRTIKLFENNRKHPGFPGNSIS TSLQPRMHFSSPCFVRACRNSFDNRSNKSEDGSCQYSPEFPLDVLKVITTSMLKEAVHSV GKNIRDPVGGNIELLLVPLLQLLHTLLLMGVYHHSDLRQVLSLIIPSPYIRENDAGQLMD GDEENDYDIEQEGKEGRALVEQKTLLQMKLPDAVKLQLCHLLQYLCDCQLRHRVEAIVNF SAEIVGHLQSNQRSRYMDVMEALNMSAALTARKTKEFRSPPQEQMNMLLNFRDKEKDCPC SEKIRELFWDFHLDLRSHCGVETGENLLTEGDENQPIRNRLRNLMDKMSRLKRRMSGVVE EDVKAKHVSLQWLISDTVMRWAHEGPLEDPVLVRSAFGLLRCQYAGLAGKMSSALQKTYC ITENSIEDTLGLQEALGRIRSLLTARMGKEEEELMIQGLGDVMNNKVFYQHPNLMRALGM HETVMEVMVNVLGTRESKEIRFPKMVAHCCRFLCYFCRISQHNQKSMFDHLSYLLDHSSV GLASPSMRGSTPLDVAAASVMDNYELALALTEPDLEKVVQYLAGCGLQSCMLLLSKGYAD IGWNPVEGERYLDLLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRVEGGNGLLATI EEAIRLSEEESGECFSKAYQSSSTLDILDDEADDVIHMGHAIMTFYSALIDLLGRCAPEM HLIETGKCEAVRIRAILRSLIPLKDLEGVISIPFLLPFLDKDDCVMEPDMSRCFCPDHKA SMVLFLDRVYGVQKQTFLLHLVEKGFLPDLHAAVSMDNSGLGGTDMALALNRYLCGSVLP LLSKCSSLLRDLPLISTGTVDDFLQVLYRLSKASSLTKAQQDAIQACLLSVCGRLKPSLL QPLLRHLTVDVSQLSENTKMPLKLLTDHYEQNWKYYYTSGGRGGFNAAFEEELQLSRKLF WHVFRALNKKLYDAELFELPIGCLVAVSGAIPPNHIHLTCTSGLDSHSSLGDSEGHFCPQ PLDTSNVIIPEGLEHLVNKYAEHTHEKWSLEKFSNGWVYGEQMCESSKVHPLLKPYRALS ERDKENYRVAIKETVKSMLVLGWTIERSKEGDARDLHHLSRRISQSPQLSFEGTSMFSPK PADTSRVMLTWDQYSMAEQLAENYHNIWTKRKLKELQAEAGGTHTLLVPYGSLSGREQNR IRERVQEMLKFFHINGYSVWRERKPTESDCPSVSGRFAYRLLQQALSCTKHVQEKMLEFE VAQARGQMGKSEKVCDEQQIRFFIKVFLPLIDQYFKNHHLYFLPSLMSSLSSTAHASNKE REVVSSLFCKLAAVARRRISVFGEDAQSVVSCLQILARSLDVKVVMKMSVECRHSALRNF FETAAVDLELAVNSVTPGVIQIRGDGGLLTYTITALLPVLTSVFQHTAHCQSSADLMVDE VQASCYRILCSLYTLGTCSNTFVESRRSSVGECLAALSAAFPVCFLEISLDYTSKAEREE VGVSTVAEDLSRPLPSLQEALSEVEDMLEAESAARHVLLSRVMEVTVPLLCSYVCRWGEE DARGFEGQNGASCSSLTPSHTNTLLGQILTIIHAHMGRHECSWMKRIAAFVQPLVRKSEP GLLTSHFLPLMEKLKKRAESVVQEEERMKTERRGDVAEMELAVQEKFAVLVQDIYAFYPL LILFVERHRILWLRQKSVDADRLFTLVADVFTFWAKSHNFKWEEQNFVVQNDINNTTYLV NSRNSHMTKRVCDEERRKVKRSKDERYSAHTSLIVASLKKLISVGLNRCCQGDRGLEIVT LAKNRFSEKDTEEEVRAFINLQQVSQSLLDECLVESILAVARVLFYLDQVESPQGSKRTV WQKLLSKQRKRAVVACFRMTPLYNLPQHRAVNLFLQSYRKLWVEPEDDLYEQKLIEDLAK AGDGGSAVEEEGWSEGTVQGKKIDPLHQLITLFHQSALTERSRLEEDGLYLAYADIMAKS CQAEDEDGHDEVKSFEEKELEKQRLLYQQARLHDHGAAEMVLQRLSARRGITGPSVEATL KLGIAILNGGNTDVQQKMLDYLREKRDVGFFHSLASLMQSCSVLDLNAFERQMKAEGLGT AAEGKAGDKVMADEALICDLFRFLQLLCEGHNADFQNYLRTQTGNNTTVNIIISTVDYLL RLQESISDFYWYYSGKDVIDEHGQRNFSKAIRVAKQVFNTLTEYIQGPCTGNQQSLAHSR LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLLKDMVVMLLSMLEGNVVNGTIGKQM VDMLVESSSNVEMILTFFDMFLKLKDLVSSVAFKEYDPEGQGLISKKDFQKAMEGYKRYT VSETEFLLSCAETNESKLLDYRAFVARFHEPAKDIGFNVAVLLTNLSEHMPHDTRLHNFL ELADSVLRYFQPHLGRIEIMGSGKRVERVYFEISESSRMQWEKPQVKESKRQFIFDIVNK GGEKEKMELFVNFCEDTIFEMQLAAQISASDRDEEVLGTEDDGADAMKDKDKNPVTNNND TEGGQKVFSSTPMMERLLLAPLCGLMMITWLLSIRNVKRHIKRMSIKSLVLAIVRFFQKV ASAIFRTVSGSICFILHVLYLVFLSGCIIKFAKETKLCDFFRDLPEPTLDDVTGENKGVT HKVRGPTRTLASRGDLNAVTLDLSAVSRNPQLLTEIFGLQLRKEGSQYMLLSRDSVASVG EVMNPSIHQAALSEEEDEEEGKHSETEKAEGEDNEKKQPRKEDEEKRRFRRMSFHKATES EVQESSTWKIINSQKTKLLNYFARNFYNMRVLALCVAFSINFILLFYKVSSGEAESVSLS DLSDENSESVCFILEENGYMKPLLHFLAVLHTLISFGSIIGYYCLKVPLVVFKREKELAR KLEFDGLYVTQRPADDDIRGQWDRLVINTPSFPSNYWDKFVKRKVMAKYGEMYGSERISE LLGLDKKTLDFSYEARKGRRAAREILNSVHIKYQIWKLGVVFTDNSFLYLAWYMLLSVLG HYNNFFFAAHLLDVAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNYFRKF YNKSEDGQTPDMKCDDMLTCYLFHMYVGVRAGGGIGDEIEDPAGDESEFYRVVFDITFFF FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDAVPHGFESHTLHE HNLANYLFFVQYLINKDVTEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLG NT seq 14748 nt NT seq  +upstreamnt  +downstreamnt atggcgatggatcccacagacgcagaagatgacgttcagttccttcgtacatcagatgag ttggtactgcgctgttgcttggctgctcctctccagcagaagctctgtttggctgcagaa ggttttggaagtcggctgtgtttcctcgagtccacttcaaactccaagaatgttccggca gttctgtcgctgtgtgtgtttgtgctggacaggtgtgtgtcggtcagagctctgcaggaa atgctggccaaacacgaggacttacacacagggtcagctgagaccgccggccatcgcact ctcctttacggccaggcgctgctgctcagacatgcccacagcaacatgtatctgagctgt ctgacatcttcaggcctcttggctgataagctggcgtttgacgttggacttcaggaggat gtagcaggtgagacgtgttggtggacggtccatccagcttccaagcagaggtcagaaggc gagaaggtcagagtgggggatgacctcatctttgtcagcgtttcctctgagagatacctg catgtctcctggggtactggtgtatatgaggagtgtatgaacacgagcgtggacgcatct ttccagttgactctatggaccgtggctcctgtttcttctctctcgactcaggctcaaggt cacctacggggaggagactgtctccgtctcctacatggccacacagatgagtgtttgacc gtttcacctgctggacacaccgtggacgagcgcagatctgttggttttgaaggtggctgc gtctcgtctcaagctcgctctctgtggaggatcgagatgttacgtgtgtcttggagtgga agccatatacgttgggcggagcaattccgtctgtatcacgtgaccacaggaaaatacctg ggcctgaccccggaccgtggcctgctgctactggacagagagcatgcggatgtcatatcc accgccttctgtctccgcccatcaaaggactctggtcaagaattcccactttgtgtccgg aagaaagacgggatgggaacgccggagatcaaatacggagactctgtctgtttagtccag catgtggactccgctttatggctcacctaccggaccagcgactcgaagaggacgaaggag acgcagccacgtaaacaggccatcctccattcagagggtcacatggatgatggactcaca ctctctcgctcgcagatggaagagtgtaaagctgccagtctcattcgaagctcaactctc ctgtttacactctttaaacggagattagatgagctcgatcacagagctaacattccagcc ccgggtcttccgatagaaacgctgcgttcgagtttgtgtgacctgatcggttatttccgg ctgcctgacaatcgctggagtcacgagatcagacagagcagcagcagagcgctgaagaac agacagaatatgttccaggaagagggtgtaattacgttggttctagactgcatcgatcat ctgcacctgtataacagtgcagcacattttggcaaggctgctgggaaagaggccggagat gcttgggaggacattttaacctccttctatgagcttctggcggcgatgatccgggggaat ccgtataactgctctcagttctccagctctctggactggctgatcagcagactggacaga ctcgaggtctccagtggaattcttgaagttctgcactgtgtattaatggaaagtccagaa gcactgaattttattaaaaaagaacacattcgctccatcatcactctgttagacaaacac ggacgcaaccacaagatcttggaggtcctgagttcactgtgtgtgtgtcatggtacagca gtgcgctctaatcagcacctgatctctgacacactgctgcctgagagagatttactgctg cagagccgtctggtcaactacatcacctgtgttcgtccaaacatcttcctctacatggga gacgattcctcccagtacaggaagtggtattacgaggtggtggtggagagggcggagcct tttgtgacacctgagccgactcacctgagggtgggttgggcctgtagcgcaggtcaccgc ccctctctgacaggaggtcattgctggggggcaaacggagttggagataacctgcaatcg tacgggttcgacggcctgcacctgtggacaggtggcgtaggtcgcagggtcagctcggcc aatcagaggctgctgagtgaggatgatgtcgtcagctgctgcctggacctcagtgcgccg tgtatttcgttccgagtcaacgggcagccagtgcagggcatgttggagaacttcaacacc gacgcactcatgttccctgtggtcagcttctccgctggagtcagggtgcgagtgctgtta ggagctcagcacggggagtttaaattcttgcctcctgctggattctcgccgtgtattgag gctttactccccagggggcgctgcaggctggagctgtgtgaggaggtcacacggggaagc agccagcgggaacttttaggcccggctgtattcactgagccggtggtcttcacccctaca ccagtggacaccaagcaggtaacgctgcctcctcagctcgagttgatcagagagacactg gctgagaacctgcatgagctctggctgctggagaaaactgagagcggctggaaacacgga catgtgagagatgacagtaaacagcttcacccaggactggtggagttttctaaacttcca gatcaggagaaactcgtcaagctccaggctgctgaacacacgctgaggtctctgttggct ctcggagctcacatcggtctgtctgatgaccacacagaggagaaggtgaagttcgtccgg ctttcaaacaagtttgagctgtggaacggttacagaccgactccagtggatcagtctgga gttcatctgaacgcagctcaggaagctctggtagaagctctggctgagaacgagcacaac atctggagcagagagcagatcagacagggctggagctacgcaccacaacaggacattaag gggaagagaagccctcagctgctgccgttccttctgttggatgaaagaagcagacgttgt catttagagtcagcgagggacgtgttaggaagtctgcttgggttcggatacaccgtagaa gcatcagagcaacggcggtacctgggccctgacacgaaggctgcgagtgaggaaaggcct cgcatattccgtgtggagcacacttttgcagtgcgtgatgggaaatggtatttcgagttt gaagcagtcactgctggtgagatgagagtgggctgggctcgagtgggatgtcaaccggac acggagttgtggtcagacgagcagagctttgtgtttgatggctcaaagggtcagtggtgg catggaagcactgtcccatttggtcatgtttggcagaagggggatgtgattggatgtttg ttggatttgactcggagaaccatgatggtcactttaaatggagagctacagctgaacact tatggctctgaaattgcttccaaagggttcagtacaaccggtggctttgttcctgtctgt ggtttgggtgtaaatcaggttggacgattaaatctgggccaaaaggttgactcactaaaa tatttcagtgtttgtgggcttcaggagggctaccagccttttgccttgaacatgagcaaa gatcctccactctggatgagttgtagagagcctttatttgtacagataccagaggaccat cctcacttaaaggttagttatattgatgggacagttggccacctaccatctctgaaggtc tcccagcgttcagtgggaatacctgacagtcttagcactcatgttgagttctatcgcctg agcttgcccatagagtgtgcacaagtgttcagcaaacccgtagatggtgcagtacctcca gctagcagtggaacatgtcacattaaggaaccagaagaaggggaggactccgactttgaa atgctgatgaagtcagctcacagacacacaggaagtagagatgaactaaacaatcaaaag gatcatgctcaagaaaagccttccagacttaaacaaaggtttcttttaaagaagaaacca gaattggtgtctagtggctcttcagcccggctactggaagacgtgctggcaatcgagagg gacagcgataaccaacttgccaactgcactaagtactacttttctgtgaagatcctggat gggcaggatccgtcctttgtctgggttggatgggtaacttcaaacttcaactgttatgac cgaacgtttgacatggagagagtgtgtagtgtgactgtcacacttggggaccaatggggc aaagttcttgagagtgacaaatgcagttgctgttacatggtatgtgctgcagagggaagt agtctctctaacagccgcagtaaattaaagctggagattggctgtctggttgacactgca actggatttcttacctttactgctaatggaaaggagatgggaatcttctatcaggtcaag ccaggcactaaattgtacccagcagtttttgccaaagccaccagttctgatgtctttcag tttgaacttggacgaattaagggtgcattgccattgtctgctggtttgtttcggagtgaa aggaaaaacatggagccgcactgtcatcccaggcttaatgtccaattcctgatacccacg aggtggacacggcttcccgataatgctccgcaggtagagctgacacggcttgaggaaagg catggctggagggctaagtgcaccgagagcctacaggttatggccctgcacattcctgag gaagacaggtgcatagacattcttgaactctctgaactggccaatcttctcaagttccat gaccacactctccgactcttttctgccctctgtgcccatggaaacatacctgtaagccat gccttgtgcagctacatcgatcagtcgcagattctgtttgcactgcgctgttttagactg cctgggaatctgcgagcaggtttctatgacttattaatgactgcctacctaagtgctcat agcggtgctagacagaccaccacccacgagtatattgtgcccatgactgatgccatgcgg actattaaactttttgaaaacaacagaaagcatcccggcttcccaggcaatagcatcagc acctctctgcaaccaagaatgcattttagctcaccttgttttgttagagcttgcagaaac agttttgataataggtccaataagtctgaagatggatcctgtcaatatagtcctgaattc ccactggatgtgcttaaagttataacaacatccatgttgaaggaggcagtccactcagta gggaagaatatccgggaccctgtgggcggcaacatagagctactgcttgttcctcttctc caacttcttcacacactccttctcatgggtgtatatcatcactcagatctgcggcaagtg ctttcccttatcattccctctccttacataagggaaaatgatgcagggcaattgatggat ggagacgaagagaatgattatgatatagagcaagaggggaaagaaggaagagctcttgtt gaacaaaaaactttattgcaaatgaagctaccagatgcagttaaactacagttatgtcac ctgctgcagtatctgtgtgactgtcagttgcgtcacagggtcgaggccatagtgaacttt tctgctgaaattgtgggccatcttcagagtaaccagcgttctcgttacatggatgtaatg gaagcactcaacatgtctgctgctctcactgcccgcaagaccaaggagtttcgctctcca cctcaagaacagatgaacatgttgctaaactttcgggacaaggagaaggactgcccctgc tctgagaagataagagagctcttctgggatttccatctggacctcaggagccattgtgga gttgaaactggtgaaaacctgcttactgaaggtgatgagaatcagcctatcaggaatcga ttaaggaacctgatggataaaatgtctcgtctgaaaaggaggatgtctggtgtggttgaa gaggatgttaaagctaaacatgtttctcttcagtggctaatctcagacactgtgatgcgt tgggctcatgaggggccgctcgaggacccggttctggtacggtctgcgtttggacttctg cgctgccagtatgctggcctggctggcaaaatgtcctctgcattgcaaaaaacttactgc atcactgagaactctatagaggacacacttggcctgcaggaggctctgggacggatccgc tcactacttacagccagaatgggcaaagaagaagaggaactcatgatccaaggacttggt gatgtcatgaataataaagtgttctaccagcacccgaacctgatgagggccctgggtatg cacgagactgtcatggaggtgatggttaatgtcctgggcacccgggagtccaaggaaatc aggtttccaaagatggtggcccactgctgtcgtttcctgtgttatttttgtcgaatcagc caacacaatcagaaatccatgtttgatcacctgagctacctgttggaccacagcagcgtt ggacttgcatccccctccatgcgaggctcgactcctctggacgtggccgcggcttctgta atggacaactacgagctggcgttagcgcttacagagccagatctggagaaggttgtacag tatttagcaggctgtggtttgcagagttgtatgttgctgctctctaaaggatacgcagat atcggctggaatcctgtcgaaggcgagagatacctggacttgctgcgctttgccgtcttc tgcaacggtgagagcgttgaagagaacgcatacgtcgttgtccggctcctgattcgccgc cccgaatgcttcggccccgctctcagagtagagggtggaaacggtctcttagcaaccata gaggaagccatcaggctctcagaagaggagagtggagagtgtttttctaaagcctaccag tccagtagcactcttgacatccttgatgatgaagctgatgatgtcatccacatgggacac gctatcatgactttttactcggctcttatagacctactgggccgctgtgctccagagatg cacctgatagaaaccggtaaatgtgaggctgtgcgtataagagccatcttgagatctctg atccctctgaaagacctggaaggagtcatcagcatccctttcctgctcccttttctggac aaagatgattgtgtcatggagccggatatgtccaggtgcttctgtccagatcacaaagca tccatggtgctgtttctggaccgagtctatggtgtccagaaacaaacctttctgctccac cttgttgagaaaggcttcctgccagatctgcatgctgctgttagcatggataatagtgga ctgggcggtacggacatggcactggctctgaatcgttatttgtgtgggtcggtgctgccg ttgttgagtaagtgctcgtcgctgcttcgcgaccttcctctcattagcacaggaacagtg gacgacttcctacaagtgctgtatcgtctttctaaagccagcagcctcactaaagcccag caagatgccattcaggcctgcctgctgtctgtgtgtggaagactgaagccatccctcttg cagcctctactgcgacatctcaccgtcgacgtctcacagctctctgagaacaccaagatg ccacttaagcttctgaccgaccactatgagcagaactggaagtactactacacatctgga ggacgtggtgggtttaacgccgcctttgaggaggagcttcagctcagcaggaagctgttt tggcatgttttcagagcattaaacaaaaagctgtatgacgccgagctgttcgagctgccc atcggatgtctggttgccgtgtctggtgctattcctcctaatcacatccatctgacctgc acatctggactggactcacactcctcactaggggactcagagggacacttctgtcctcaa cctctggacacgtccaatgtaataatacctgagggattggagcatctggtgaataaatac gcagaacacacacatgagaagtggtcactagagaagttttctaatggttgggtttacgga gagcagatgtgcgagagctctaaagtccatccgctcctgaagccttacagagccctatca gaacgagataaagagaactaccgagtggccattaaagagacagtaaaaagcatgctggtc ttgggctggaccatcgagaggtcaaaagagggggatgccagggacctccatcacctatcc aggaggatctcacagtctccccagctgtcgtttgagggaacctccatgttcagtcccaaa cctgcagacaccagcagagtcatgctgacctgggatcagtattctatggcagaacagctg gcagaaaactaccataacatctggaccaagaggaaactgaaggaactgcaggctgaagca gggggcactcacacactgctggtgccctatgggtctctgagtggccgagagcagaaccga atcagagagagagtgcaggaaatgctgaaattcttccacatcaacggatactccgtgtgg agagaaagaaaaccgacagagtctgattgtccatctgtctcaggccggtttgcataccgt ctccttcagcaggcgctctcctgtaccaaacatgtccaggaaaaaatgctagagtttgag gttgctcaggctagagggcaaatgggaaagtcagagaaagtgtgtgacgagcagcagata cgtttcttcatcaaggttttcttgcctctaattgatcagtattttaaaaatcatcatctc tacttcctgcccagtttgatgtcgtctctcagcagcactgctcatgcttccaataaagaa cgagaggtggtttctagtttgttctgtaagctggctgctgtcgccagacgcaggatttct gtcttcggtgaagatgctcagtctgtggtgagctgtctgcagatcctggcacgctcgctg gatgtgaaggttgtgatgaagatgtcggtggagtgcagacattcagctctgcgcaacttc ttcgagactgcggcggtggacttggagctggcggtgaacagcgtgacccctggggtcata cagattcgaggagatggaggactgctgacctacaccatcactgctctcctcccagtcctg acatctgtgtttcaacatacagctcactgccagagctcagccgacctcatggtggatgaa gtgcaggcctcgtgttacaggatcctctgcagtctgtacacactcggcacttgcagtaac acttttgtggaaagtcggaggtcttcagtaggcgagtgccttgctgccttgtcagctgcc ttccctgtgtgtttcctggagatttcgctggactacacgagtaaagcagagcgagaagaa gtaggcgtgtccactgtagcagaggatttgtccaggcccctcccctccctgcaggaagct ctgtcagaagtggaggacatgctggaggcggagtcagcggctcgtcacgtccttctgtcc agggtcatggaggtaactgttcctctgctgtgcagctacgtgtgtcgatggggtgaagag gatgctcgggggtttgaggggcagaatggggcatcatgctcctctctcacaccctcacac accaacaccctactggggcaaatcctcaccatcatccatgcccacatgggcagacacgaa tgcagctggatgaaacggattgcagcattcgtccagccgctggtccgtaagtcagagccc ggtctcctgacgagtcacttcctgcctctgatggagaagctgaagaagagggcagagtca gtggtgcaggaggaggagcgcatgaagacggagaggcgtggagatgtggcggagatggag ttggctgtgcaggagaagtttgctgtgttggtgcaggacatctatgctttttatcccctc cttatattgtttgtagaacgtcacaggattctgtggctgaggcagaagagcgtcgacgct gacagactcttcactctggtcgctgacgtgttcactttctgggccaaatctcacaatttt aagtgggaggagcagaactttgtcgtacagaatgacatcaacaacacaacctacctggtg aacagcaggaacagccacatgacaaagagagtgtgtgacgaggagaggaggaaggtgaag aggagcaaagacgagcgttactccgcccacacttctcttatcgtggcctctctgaagaag ctcatctccgtcggactgaatcgatgctgtcaaggagatcgaggcctcgagatcgttact ctcgccaagaaccgcttctctgagaaagatacggaggaggaagttcgagcgttcatcaac cttcaacaggtttctcagtctttactggatgaatgtcttgttgaaagtatccttgctgtg gcccgtgtgctcttctatctggatcaggtggagtctcctcagggcagtaagagaactgtg tggcagaagctgctctctaaacagagaaaacgagccgttgtggcctgcttcaggatgact ccattatacaacctgccacagcacagggcggtgaacttgtttctacagagctacaggaag ctgtgggtggagccagaagatgacttgtatgagcagaagcttattgaagatttagctaaa gcgggagatggagggagtgctgtggaggaggagggatggagtgagggaacagtgcaaggc aaaaagatcgaccctcttcatcagctcattactctcttccaccaaagcgccctgacagag aggagcaggctggaggaagacggactgtacctggcctacgctgacatcatggccaagagc tgccaggccgaggacgaggacggtcacgatgaggtgaaatcctttgaagagaaagagctg gagaaacagagactcttatatcaacaggccagactacatgatcatggagctgcagagatg gttctccagaggctcagtgccagaagaggtattacgggcccctctgtggaggccactctt aaactgggcatcgccatcctgaacggaggaaacacggacgtacagcagaaaatgttggac tatctgagagagaaaagagacgttggattcttccacagcctggcgagcctcatgcagtcc tgcagcgttttggacctgaacgcattcgagaggcagatgaaagccgaaggtttgggaaca gcggccgaaggcaaggcaggtgataaggttatggcagacgaagcgctgatttgtgatctc ttccgcttcctccagttgctttgcgaaggacataatgcagattttcagaactatctgaga actcagacaggaaacaataccacagtaaacattatcatctccactgtggactaccttctc cgactgcaggagtccatcagcgacttttactggtattactctgggaaagatgtcatcgac gaacacggccagcggaacttctccaaagccatcagagtggccaaacaggtcttcaacacc ctcacagagtacatccagggtccctgcactggaaaccagcagagtttggcacacagtcgg ttgtgggacgccgtggtcggcttcctccacgttttcgcccacatgcagatgaagctttct caggattcgagtcagatcgagctgctgaaggaactgatggatctgctgaaagacatggtg gtgatgctgctgtctatgcttgaagggaacgttgtgaacggaaccatcgggaaacagatg gtggacatgctggtggagtcgtccagcaacgtcgaaatgatcctgacgttctttgacatg ttcctgaaactcaaagatctcgtatcctctgttgccttcaaagaatatgaccctgaagga caggggcttatctccaagaaggactttcaaaaggccatggaaggctacaaacgctacacc gtatctgaaaccgaatttctgttgtcttgcgcagaaacgaatgagagcaaactcctggac tatcgtgcgtttgtggctcgttttcatgaaccggccaaagacatcggtttcaacgtggct gtccttttgaccaacctgtcagagcacatgcctcatgatacacgattacataattttctg gagttagctgacagcgtgctcaggtatttccagcctcacctgggcaggattgagatcatg ggcagcgggaagcgggtcgagagggtctatttcgaaatcagcgagtcgagccggatgcag tgggagaagccacaggtgaaggagagcaagcgtcagttcatcttcgacattgtgaacaag gggggtgagaaggaaaagatggagctcttcgtaaacttctgcgaggacactatcttcgag atgcagctggctgcccagatctctgcctccgaccgtgacgaggaagtgctgggaacagaa gatgatggagcagatgcaatgaaggacaaagataaaaaccctgttacgaataacaacgac accgaaggaggacagaaagtcttttcctcgacgccgatgatggaacggctcctcctggcc cctctctgtggcctgatgatgataacttggctcctgtccataaggaatgtgaagaggcac ataaaaaggatgagcataaagagtcttgttctggccattgtccgcttcttccagaaggtt gcatcggccatttttcgtaccgtttcaggctccatctgctttatcctacacgtcctttat ctcgtctttctcagtggttgcattatcaagtttgccaaagagaccaaactctgtgatttt tttagagatctgccagaacccacgctggatgatgtcacaggggaaaacaaaggggtaacc cacaaggtccgaggtccaacacggaccttagcctcccggggtgaccttaacgcagtgaca ctggacttatcagctgtgtccagaaaccctcagctacttactgaaatatttggtctccag ttaagaaaggaaggaagccagtatatgctgcttagtcgagattccgttgctagcgttggt gaagtaatgaatccttctatacatcaggcagctttgtctgaggaggaggacgaagaggag gggaaacattcagagactgaaaaagcagaaggtgaagacaacgagaagaagcagccgagg aaggaagatgaggagaaacgcagatttaggaggatgagcttccataaagcgactgagtct gaagttcaagaatcatccacgtggaaaataatcaactctcagaagacaaaactgctcaat tattttgccaggaatttctacaacatgcgagtgctggccctgtgtgtggccttcagcatc aacttcattcttctgttctacaaggtttcctctggcgaagctgaaagtgtgtccttatct gacctcagcgatgagaactctgagagtgtgtgttttattctggaagagaacggttacatg aagccgctcctccactttctggctgtattacacactcttatctccttcggctccatcatc ggctactactgtctgaaggttcctttagtagtgtttaaacgtgagaaggagttggcgcgt aagctggagtttgacggcttgtacgtcacacagcgacctgctgatgatgacatcaggggc cagtgggaccgactggtcataaacacgccatcttttccaagtaattactgggacaaattt gtgaagaggaaggtgatggccaagtacggcgagatgtacggctccgagaggatcagcgag ctgctgggtttggataaaaagacactggatttcagttacgaagccaggaaaggaagaaga gcagcccgagaaatactgaactctgtccatataaaatatcagatttggaaactcggagtt gtgtttaccgacaactcgttcctctatctcgcctggtacatgctgctctcagttctcggc cattacaataatttcttcttcgccgctcacctcttggacgtggccatgggctttaagacg ctgcgcaccatcctgtcgtccgtcacacacaacggaaaacagttggttctgactgtaggc ctcttggctgtggttgtgtatctctacaccgtcgtggccttcaattacttccgcaagttt tacaataaaagtgaagatggccaaactccagatatgaagtgtgacgacatgttgacgtgt tacctgttccacatgtatgtgggggtgcgtgccggcggggggatcggtgacgagatcgaa gacccggcaggagacgaatccgagttttaccgcgtggtcttcgacatcaccttcttcttc ttcgtcatcgtcatcctcttggccatcattcagggtctgatcatcgatgcgttcggagag ctgagagaccaacaggagcaggtgaaagaggacatggagacgaagtgttttatctgcggc atcgggagcgaatattttgatgccgtgcctcatgggtttgagtctcacacgctgcatgaa cacaacctggccaactacctgttctttgtgcagtacctcatcaataaagatgtgacggaa cacacagggcaggaatcctacgtatggaagatgtaccaggaacgctgctgggagtttttc ccagtcggagactgtttccgtaaacagtatgaagatcagctgggttaa

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