Tachysurus vachellii: 132862807 Help Entry 132862807         CDS       T09596                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism tvc  Tachysurus vachellii Pathway tvc04020   Calcium signaling pathway tvc04260   Cardiac muscle contraction tvc04261   Adrenergic signaling in cardiomyocytes tvc04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tvc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132862807 (ryr2a)    04020 Calcium signaling pathway     132862807 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     132862807 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     132862807 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tvc04040]     132862807 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:tvc04990]     132862807 (ryr2a) Ion channels [BR:tvc04040]  Voltage-gated cation channels   Ryanodine receptor    132862807 (ryr2a) Domain-containing proteins not elsewhere classified [BR:tvc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132862807 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  132862807 NCBI-ProteinID:  XP_060751069 LinkDB All DBs Position 2:complement(7027639..7187970) Genome browser AA seq 4964 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGSGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSTHARSLWRLETLRVAWSGSHIRWGQSFRLCHVTTGKYLSLLDDK GLLLMDKEKADVKSTAFCFRSSKEKLDFGQRKEVDGMGVPDIKYGDSVCYIQHVDTGLWL TYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRG LDTLSKKGKTSMLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQNLFQEE GMINLVLECIDRLHVYSSAAHFADVAGREAGEAWKSILNSLYELLAALIRGNRKNCAQFS SSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNYVSSMRPNIFLGVNEGSAQYKK WYYELIVDNVEPFVTAEATHLRIGWASTPGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLCADDVVSCCLDLSAPSISFRINGQPVQGMFENFNTDGLFFPVV SFSAGVKVRFLLGSRHGEFKFLPPTGYAPCFEAVLPREKLRVEHNQEYKHDHGVTRDLLG PTPSLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGVVRDDNK RQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGMADERAMEKVKRLKLSAKYML SSGYKPAPMDLSHIKLASTQEAMVDRLAENAHNVWARDRIRQGWTYGIQQDVKNKRNPRL VPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADINNVSAERFRIFRAEK TYCVNTGKWYFELEVVTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKAQRWHQGNEHF GRSWLPGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVWEGFIPVCSLGVSQL GRMNFGKDVSTLKFFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFIPVPQGYEHIEVTR IDGTVESPPCLKVTQRSFGSQNSNTDIVFYRLSMPIECAEGFTKPAGGTLPANGSFFSPK KDLEDFETVSDFEVLMKSSHSHMSSNGPDKEKDEFNNHKDYNQEKPSKLKQRFMLKKSKP DFSTSNSSARLSEEVMADERDDYEFLMQTCTYYYSVRIFPGQEPSSVWVGWVTSDFHQYD PAFHLDKIRTVTVTLGDEKGKVHESIKRSNCYMVWAGESNNPGQGRNNNGLEIGCMVDTA SGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSE RKNAVSQCPPRMHVQFLTPVLWSRVPNQFLRSEVTRVNERHGWMVQCTEPLQFMALHIPE ENRSVDILELTEQRELLQFHYHTLRLYSAMCALGNHRVAAALCSHVDESQLLSAIQNKSM AGLLRTGYYELLIDIHLSSYATARLMMNNEYIVPMTDETKSITLFPDEQKKRHGLPGIGL STSLRPRMHFSSPNFISAVTTGNGSGGSDRFQYSPEFPLETLKSRTMEMLTEAVQEGSLH VRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLRAILQLIEPSVFSQDSGEQGRAISPD RETDYGERRTDGGPGGEEEESGKRKVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAVVAFSDDFVDNLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLSFKDE KQECPCPEDIRDQLLQFHEDLMTHCGIEIDDDKLGEGDSDFTIRGRLMSLVEKVSYLKKK MTDMPKKKKAKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRAL PKTYTINAVSVEDTINLLDSLGQIRSLLSVRMGREEEKLMIRGLSDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEIAFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCLMLVS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIKISEDPSRDGPSPTSEDSKTLSDMMDDEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIYAGKGEAIRIRAILRSLIPIQDLEGVISLPFHMPTLAKDGSVVEPDMSAGF CPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKL RPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDEELHL TRKLFWGIFDALSRKKYDAELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGN FNPQPVDTSNVNVPEKLDHFINKYAEHSHEKWSMEKFANGWVHGEQLCDASKIHPLLKAY KGLSDKDKEVYRWPIRETLKTMLSWGWSIERMRESDSASLHTRTRRISLTSQLSVEGAHG FSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAKKKKHELEAKGGGSHPLLVPYDTLTAK EKSKDREKAQDILKFLQINGYTVSRAMKEQELDTPSIEKRFAYTFLQQLITYVDEAHEHM LEFDVTTRQKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAIRPISSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKAALRAF FDNAAEDLERTMENLRQGQFTHTRTQSRGVTQIINYTTVALLPVLSSLFEHIGQNLFGED LILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPHLNNYNS FSIYNTKGSRERTACGLPAQVEEVCPLVPSLEKALEEIMELAESGMRYTQMPHVMEVVLP MLCSYMSHWWEHGPESNPERADTCCTSLTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIISKARPQLLKTHFLPLMEKLKKKAATVLLDEEHMKAEGRGEMSESELLILDEFT ILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSMQTSLIVAALKRLLPVGLNI CAPGDQELITLAKNRFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKEMPNRSED TSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLP RHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKSGGEEPSEEDEGVKHIDPLHQLIQLF SRTALTEKCKLEEDSLYMAYADIMAKSCHDEEEDDEEEVKSFEEKEMEKQKLLYQQARLH DRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQS LAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNS DFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINV AKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIDLLKELM DLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTF KEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAK DIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEI SESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGER SASKEENEREKPEEETPDMGFFSISTVCSALFALRYNVMLLMKVLSMKSLKKQLKKAKKM TVKDLVTTVAAFCWSVLMGLLHFAFSVARGFFRIIYSSFLGGGLVEGAKTMKVSELLANM PDPTQDEVRGESEEVERKHAEKTSPEEDLADLAVAAEDTDLLSDIFGLDLRREGGQYKLM PHNPNASLTDVLNTPTPPPPTPSPELRRRHTVKGSSSSTDEKEATEETKTVSEKAEGEDG EKKEKKKEVQKKKKPQLYRSSKSDEPDQQESAFWKKIIAYQRKLLNYFARNFYNMRMLAL FVAFAINFILLFYKVSTSSAVKEEKRVVYSASSLDSGLRWDTQGDSSNDRPVTVHFVLEE SSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSE DDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGNDRISELLGMDKAALDFSDAH EKKKPKKDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPD MKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVM YLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14895 nt NT seq  +upstreamnt  +downstreamnt atggccgagggcggagaaggcgaggacgaaatccagtttttacgcaccgatgatgaggtg gtgttacagtgttctgctacactgcataaggagcagcagaagctctgtctggctgccgag ggctttgggaacagactctgctttctggagtccacctctaattcaaagaatgttcctcca gacctgtcgatatgcacatttgtgctggagcagtcgttatccgtgcgtgctcttcaggag atgttggccaacacagaggagaaggcagaagggacagcacagggtggaggtcatcgcact cttctctacggccatgctgtcttactcaggcactcctacagtggaatgtacctctgctgt ctgtccacttcacgctcatcgactgataaacttgcctttgatgtaggacttcaagaggac acgacaggtgaagcatgctggtggactatacatcctgcctctaagcaaagatcagaaggg gaaaaggtgcgtgtaggtgatgacctcattctggtcagtgtgtcatccgagcggtacctg cacttgtcgtatggcagtggcagtttacatgtggatgctgccttccagcaaacactgtgg agcgtagcaccaatctgctcgggtagcgaggtcgctcagggtttcctgattggtggtgac gtcttgaggttgttgcatggtcacatggacgagtgtctaactgttccatcaggagagcat ggtgaggagcagcgcaggacggtgcactacgagggtggagccgtatccacccatgctcgt tctctgtggaggctggaaactctcagagtggcttggagtggcagtcacattcgatggggt cagtcattccgcttatgtcatgtgaccactggaaagtacctcagcctgctggatgataaa ggtcttctgctgatggataaggaaaaggctgacgtcaaatccactgccttctgtttccgc tcctcaaaggagaagcttgatttcggccagaggaaagaagtggatggcatgggtgtaccc gacattaaatatggcgactctgtttgctacatccagcatgtggacacaggtctgtggctc acttaccaatcagtggatgccaagtgtgcacgtatgggcggagtccagaggaaggctatt atgcaccatgagggtcacatggatgatggtttgaccctctcacgctcccaacacgaggag tctcgcactgccagagtcatccgcagcacagtcttcctgttcaaccgctttattaggggt ttggacacccttagtaaaaagggaaaaacctctatgcttgatctgccaatagagtcggtc agcctgagtctgcaggatctgattggctacttccagccccccgatgagcacttagaacat gaggacaagcagaatcgactccgagcactgaagaacagacagaacctctttcaggaggag ggaatgataaacttggtcctggagtgtatcgaccgattgcatgtgtatagcagtgcagct catttcgctgatgtggcaggacgggaggcaggagaggcctggaaatccatcctcaactct ctctatgagctcctggctgctctgatcaggggtaacaggaagaactgtgctcagttttcc agctcgctggattggctaataagtcgtttagagagactggaggcctcatcagggatcctg gaggtgttgcactgtgtactggtggagagtcctgaagccctaaacataatcaaagaagga catatcaagtccatcatctcactgctggataagcatggacgcaaccacaaggttctggat gtgctgtgttctctgtgtgtgtgtcacggggtggcagttcgctccaaccaacacctcatc tgtgataatctgctcccggggagagacttgttactgcagacgcgcttggtcaactacgtg agcagcatgaggccaaacatcttcctgggggtgaatgaaggctcagcgcagtacaagaaa tggtattatgagctgattgtggacaatgtggagccgtttgtgacagcagaggcaactcat ttgaggataggatgggcatctacacccgggtactcgccttatccaggagggggcgagggc tgggggggcaatggagtcggagacgacctttactcttatggttttgatggcctacacctg tggtcaggctgcattgctcggacagtcagctcccccaatcagcacctactctgtgctgac gatgtggtgagctgttgtctggatctcagcgctcccagcatctcgttccgcatcaacggg cagccagttcagggcatgtttgagaacttcaacacagacggccttttctttcccgtagtc agcttctctgctggagtcaaagtgcgcttccttttgggcagtcgacatggagagtttaag ttcctccctccaacaggttatgcaccatgttttgaggctgtgttaccacgagagaagctc agagtggaacacaatcaagagtacaaacatgaccatggtgtgacccgagaccttctgggg ccaacacccagcctgtcccaggctgcatttacccccacacctgtggataccagccagatt gtgttgccccctcaccttgagcgaatccgagagaagttagccgagaacatccatgagctc tgggtcatgaacaagatcgagctgggctggacatatggagtggtaagggatgacaataag aggcagcacccgtgtctagtggagttctccaaactgccagaacaggagcgcagctacaat ctacagatgtctctggagacgctgaagactctgttggcgttgggttgccatgtcggaatg gcagatgaacgagccatggagaaagtcaaacgtctcaagctctcggctaaatacatgctg tccagtggctacaaacctgcacctatggatctgagccacatcaaactggcctctacacag gaggccatggtggacagactggctgagaacgctcacaacgtgtgggccagagaccgcatt cgccaagggtggacctacggcatccagcaggatgtgaagaacaagaggaacccacggctg gtgccttatgctcttctggacgaaagaaccaagaaatcaaacaaggacagtctgcgagag gctgtgcgcactttactaggttacggatacaacttggaggctcccgaccaagaccatgca gctcgagcggacattaacaacgtatctgcagagcgtttccggatcttccgggctgaaaag acgtactgtgtgaatactgggaagtggtactttgagctggaggtggtgacggcgggtgag atgagggtgggctgggcccgtccaggctgcctgccagaccaggagctgggttccgatgac caagccttcgtgtttgatggatttaaggctcagaggtggcatcaggggaacgagcacttt gggcgttcatggctgccaggagatgttgtaggctgcatggtggatttgaatgagcacacc atgatgttcacactgaatggagaggtgctgctggatgactcaggatctgaacttgcattc aaggactttgaagtctgggaaggttttatcccggtgtgcagtctgggcgtgagtcagtta ggccggatgaactttgggaaagatgtgagcacactgaagttcttcaccatctgcggcctg caggagggctacgagccattcgctgtcaatatgaaccgagacgtcaccatgtggctcagc aagagactgcctcagtttatacctgtaccacagggctacgagcacattgaggtcacgaga attgatggcacagtggagagtccaccttgcctaaaggttacacagaggtcatttggatcc cagaacagtaacacagacattgtgttttaccggttgagtatgcccatcgagtgcgctgag ggattcactaaacccgctggtgggactttaccagcaaacggcagcttcttctctccgaag aaagatctggaagattttgagacagtctcagactttgaggtgctgatgaagagttctcac agccacatgagctctaacggcccggataaagaaaaggacgagtttaacaaccacaaggac tacaaccaggagaaaccatcaaaactgaaacagaggttcatgttgaaaaagtctaaaccg gatttcagcacaagtaactcatcagctcgtctgtctgaagaggtgatggccgacgagaga gatgattatgagttcctgatgcagacatgcacgtactactactcggtacggatttttcca ggccaggagccttccagtgtgtgggtaggctgggtgacctctgacttccaccagtacgac ccggcctttcaccttgacaagatccggactgtcacagtcaccctcggggatgagaaagga aaagttcatgagagcattaagcgcagtaactgctacatggtgtgggccggtgagagtaat aaccctgggcagggccgtaacaataatggactagagatcggctgcatggtggacactgcc agtggcctgctcactttcacagccaatggcaaagagctcagcacttactaccaggtggag ccgagtaccaaactgttccctgcagtgtttgctcaggccaccagccccaacgtcttccaa tttgaactgggacgaatcaagaatgtgatgccattatcagccgggctgtttaagagcgag cggaagaacgcagtgtctcagtgtccaccccgcatgcatgtccagttcctcacacccgtg ctctggagccgagtgcccaatcagttcctcaggtcagaggtcaccagggtcaatgagagg cacggctggatggtgcagtgcacagaaccgctgcagttcatggccctgcatatacctgag gagaacaggtcggtggatatcctggaactcacagaacagcgggagctgttgcagtttcac taccacacactgcgtctgtactcagccatgtgtgctctggggaaccaccgtgtggcagca gcgctctgcagccatgtggacgagtctcagctgctgtcagctattcagaacaaaagtatg gcgggcctgcttcgcaccggctactatgagctgctcatcgacatccatctgagcagctat gccacagcccggctcatgatgaacaacgagtacattgtgcccatgactgatgagaccaag agcatcacactctttcctgacgagcagaagaagcgccacggcctgccaggaattggcctg agcacctcactgagaccacgcatgcacttctcctctccgaatttcatcagtgctgtcacc acaggcaatggcagcggcgggagcgaccgtttccaatacagcccagagttcccgctggag actctgaagagccgcacgatggagatgctcacagaggcagtacaggagggcagccttcat gttcgagaccctgtagggggaagcacagagtttctttttgtgcctcttatcaagctcttt tatacattgctcatcatgggcatcttccacaatggggacctgagggctatcctgcaactc atcgagcccagtgtattctcacaggactctggggaacaggggcgggccatcagtccagac agagaaactgattacggagagagaaggactgacggaggcccaggaggagaggaggaagag agtggaaagaggaaagtgcctaaagaaggcctgcttcagatgaagctgcctgaacctgtt aaactgcagatgtgccaccttctgcagtatctgtgtgactgtcaggtccggcaccggatc gaggcggtagtggccttctctgatgactttgtagacaacctgcaggataaccaacgtttc cgctataacgaggtgatgcaggcactcaacatgtctgctgccctcactgctcgcaaaacc aaagagttccgctcaccgcctcaggaacagattaacatgctgctcagcttcaaggatgag aagcaggaatgtccctgtccagaggacatccgagaccagctgctgcagttccatgaagat ctcatgacacactgtggtatagagattgatgacgataagctgggggaaggagacagcgat ttcacgatcagagggcgtcttatgtccctggtggaaaaagtgtcttacttgaagaagaaa atgactgacatgccgaagaaaaaaaaagccaagaagcccagcactctgcagcagttgatt tcagagacgatggttcgctgggctcaggagtctgtgatagaggaccctgagctagtcagg gccatgtttgtgctgctacacagacagtatgatggaatcggcgggcaggtgcgtgctctg ccaaaaacatacaccatcaatgctgtctctgtggaggacaccatcaacctgttagactcg cttggacagatccgttcactgctcagcgtccgcatgggccgcgaggaagaaaaactcatg atccgaggcctcagcgacatcatgaacaataaggtgttctatcagcacccaaacctgatg agagctttggggatgcatgaaacagttatggaggtcatggttaatgtgctgggtggagga gagtccaaggaaatcgcatttcctaagatggtggccaactgctgtcgctttctgtgttac ttctgccggatcagccgtcaaaaccagaaggccatgtttgatcacctgagctatttgctg gagaacagcagcgtgggtctcgcgtctccatcaatgcgtggctccacaccactggacgta gctgctgcttctgtgatggataataacgaactggcgctggccctcagagaaccagacctg gaaaaggtggtgcagtatcttgcaggctgtggtctgcagagctgtttaatgttggtgtct aagggttatcctgatattggctggaaccctgtggagggagagcgatatctcgacttcctc cgcttcgctgtattctgcaacggtgagagtgtggaagagaatgctaatgtggtggtgcgc ctattgattcgccggccagagtgttttggccccgccttgcgtggtgagggtggaaatggg ttgctggcagcgatggaggaggctattaaaatatctgaagatccaagcagagatggaccc tcacctacatcagaggacagcaagacacttagcgatatgatggatgacgaggaggatgac actatacacatgggtaatgccatcatgaccttctatgccgctctgatagatcttttgggc cgctgtgctccagagatgcacctgatctatgctggaaaaggagaggcgattcgtatccgg gccatccttcgctctctcattcccattcaggacctggagggagtgatcagcctccccttt cacatgcccacactcgctaaagacggttctgtggtggagccagacatgtcggctgggttc tgtccagaccacaaagcagccatggttctttttctagaccgcgtttatggaatcgaggac cagaacttcctactccatctgctggaggtcggctttctgcctgatctgagagctgctgcc tcattggatacagctgctctgagtgccacagacatggcgctggctctaaaccgttacttg tgtactgctgttctacccttgctgacaaaatgcgcacctctattcgcgggcacagagccg tttgcctcactcatcgactcgctcctccacactgtgtaccgcctgtccaagggctgctgc ctcaccaaagcccagagagacgccatcgaagagtgcctgctcgctgtgtgtgggaaactg aggccatctatgatgcagcatctgctgagacgtctggtgtttgatgttcctctgctgaat gaacacaccaaaatgcctttaaagcttttgaccaatcactacgagcgatgctggaagtac tactgtctgtcaggggggtggggaagctttggtgcagcgtcagacgaggagctccacctc acaagaaaactcttctggggaatctttgatgctttatccagaaagaagtatgatgctgag ctgtttaagctggctttaccgtgtctgagtgctgttgctggcgctctacctccagactac atggagtctaactatgtggcgatgatggagaaacagtcgtccatggatgcagagggcaac tttaatcctcagcctgttgacaccagcaatgtgaatgttcctgagaagctggatcacttt atcaacaagtacgctgaacactcacacgagaaatggtccatggagaagtttgctaatggc tgggttcatggtgagcagttgtgtgatgcctccaaaattcatccattgctaaaggcttac aagggactctcggacaaggataaagaggtgtaccgttggcccatcagagagactctgaag accatgttgtcttggggctggagcatcgaaaggatgagggagagcgactcggccagttta cacacccggacacgcaggatctccctcaccagccagctttctgtagagggcgctcatgga ttcagccctcgcccagtggacatgagcaatgtcaccctgtcccgggatctgcattccatg gcagagctgcttgcagagaactatcataatatttgggccaagaagaagaagcatgaactg gaagccaaaggagggggaagccatccactgctggttccctatgacactctaactgccaaa gagaaatccaaagacagagaaaaagcacaagacatcctcaagttccttcagattaatgga tacaccgtatcacgggctatgaaggagcaagagctggacacaccctctatagagaaacgg tttgcttacacgtttctacagcagctcatcacatatgtggatgaagctcatgagcacatg ctggaattcgacgttactacacgacaaaaaggagagaaaattcctcacgagcagcagatg aagttctttggaaaggttgttctgccactggttgaccagtactttaagaaccatcggctc tacttcctgtccactgccatccgtccaatcagcagtggaggccatgcttccaataaagag aaggagatggtgaccagtcttttctgcaaactgggagttcttgtgagacataggatatct ctgtttgggaatgatgccacttctatcgtgaactgccttcacatacttgggcagacatta gatgccaggacagttatgaagacgggtctagagtcggtaaaggcagcattgcgggcattt ttcgataatgccgccgaggatctggagaggacaatggagaatctacggcagggtcagttc acacacactcgaactcagtccagaggagtcacccagatcatcaactacaccaccgtggct ctgctgcccgtcctgtcctcactgtttgagcacatcggtcaaaacctttttggagaggac cttatattggatgatgtccaggtttcctgttacaggatcctaaacagcctctactcactt ggcaccagtaaaagtatctacgtagaaaggcagcggcctgctctgggcgagtgtctggca gcattttctggtgcgttccccgtagccttcctggaacctcatcttaacaattacaacagc ttctccatctacaacactaaaggctccagagagaggacagcatgtggtctcccagctcag gtggaagaagtgtgtcccttagtcccttccttggagaaagctctggaagagatcatggag ctggctgagtcaggcatgcgctacactcagatgccccatgtgatggaggtggtgctgcct atgctgtgcagctacatgtctcattggtgggagcacgggccagagagcaacccagagcgt gctgatacgtgctgcacttcgctcacctctgagcacatgaacacccttctgggcaacata ctcaagatcatctataacaacttgggtattgacgaaggtgcctggatgaagaggctcgct gttttctctcagcccatcatcagtaaagcccggccacagctgttaaagacacacttcctg ccgctgatggagaagctgaagaagaaggcggccactgtgcttttggacgaagaacatatg aaggcagaaggccgcggtgagatgtccgagtctgagctgctcattctggacgagttcacc atcttggtgcgcgacctgtacgccttctatccactcctcatccgctttgtcgattataac agagcaaagtggctgaaagaaccgaaccctgaggctgaggaactgttccgcatggttgca gaggtcttcatcttctgggccaaatcacataatttcaaacgggaggaacagaactttgtt gttcagaacgagataaacaacatgtcgttcctcatcactgacaccaagtccaaaatgtcc aagggggcagtgtcggaccaggagagaaagaagatgaagaagagaggagatcgttattcc atgcaaacatctctgattgttgctgctctcaagaggctgcttcctgttggtctaaatatc tgtgctcccggagaccaggaactcatcaccctcgccaagaaccgctttactcagaaagac acagaggatgaagttcgggagatcatccgtaataatcttcacctgcagggaaagctggag gaccctgccattcgctggcagatggctctgtataaggaaatgcctaaccgcagtgaggac acctcagacccagagaagactgtagagagagtgctggacatcgctcatgtgctcttccat ctggaccaggtggaacatcctcagaggagtaaaaaagctgtgtggcacaagcttctgtcc aaacagaggaaacgtgcagtggtggcatgcttcaggatggcgcctctttataacctgccc agacaccgagccgtgaacctgttcctgcagggatatgagaaatcctggattgagacagag gagcattattttgaagataagctcatagaggatttggctaagtctggtggagaggagcca tcagaagaggatgaaggggttaaacacattgaccctctgcaccagctcattcagctcttc agcaggactgcgctcacagagaaatgtaaactggaggaggacagcctttacatggcctac gctgacatcatggccaagagctgccatgatgaggaggaagacgatgaagaggaagtgaag agttttgaagagaaggagatggagaagcagaaattgctctatcagcaggctcggctccat gatcgtggtgcagctgagatggtgctgcagaccatcagtgccagcaaaggtgagatgggg ccgatggtggcatctacactcaagctgggcatcgctatacttaatggtggaaattccaca gtacagcagaaaatgctggattacctgaaggataaaaaggacgtcggattcttccagagc ctggcaggacttatgcagtcttgcagcgttctagacttgaatgctttcgagaggcagaat aaagctgagggtctgggcatggtgacggaagaaggctcaggcgaaaaggtgatgcaggat gacgagttcacctgtgacctgttccgcttcctgcagctgctctgtgaaggacacaactcg gatttccagaactacctgagaacacaaacaggaaacaacacgactgtcaacatcatcatc tccactgtggactacctactaagggtacaggaatccatcagtgatttttactggtactat tcagggaaggatgtgattgatgagcagggtcaacgtaatttctccaaagctataaatgtg gctaagcaggtcttcaatactcttacggagtatattcagggtccttgtacagggaaccag cagagcctagcgcacagtcgcctgtgggatgcggtggttgggttcctccatgtttttgca cacatgcagatgaagctctcacaggattcaagtcagattgaccttctgaaagagctcatg gatctgcagaaggacatggtggtaatgcttctctccatgttagaggggaatgttgtgaat ggcaccattggaaagcagatggtcgacatgttagtggagtcttccaacaacgtggagatg attctcaagttcttcgacatgttcctcaaactaaaagatctgacgtcgtcagataccttc aaagagtatgacccagacgggaagggggtcatctccaagagagacttccacaaagccatg gagagtcacaagcattacacgcagtccgagacagagttcctactgtcgtgtgctgaaacg gacgagaacgagctgctcgattacgaagaatttgtagagcgatttcatgagccggccaag gatatcggcttcaacgtggccgtgctactgactaacttgtccgagcacatgcctcacgac tcgcgcctgcagacgttcctggagctggccgaaagtgtgctcaattacttccagccttac ctgggccgcatcgagatcatgggcagcgccaaacgcatcgagcgggtgtactttgagatc agtgagtcgagccgcacacagtgggagaagccacaggtgaaagagtccaagcgccagttc atctttgatgttgtcaatgagggtggtgaaaaagagaagatggagctgtttgttaatttc tgtgaagacaccatatttgagatgcagctggctgcacagatgtctgacgccggagagcgc tcggcgagcaaagaagagaacgagcgggagaaacctgaagaggaaacccctgacatgggc ttcttctctatcagcactgtttgctcagcactgtttgccctccgctacaacgtcatgctt ctgatgaaggtgctgtccatgaaaagtctgaagaagcagctgaagaaggctaagaagatg accgtgaaggacttggtgaccacagtggctgctttctgctggagcgtgctcatggggctg cttcactttgctttcagcgtggcccgcggcttcttccgaatcatatacagcagcttcctg ggtggaggcctggtggagggagccaagaccatgaaggtgtctgagctgctggccaacatg cccgatccaacgcaggacgaggtgagaggagagagtgaggaggtggagaggaaacatgca gagaaaacatcacctgaggaagacttagccgacctcgcagtggctgcggaagacacggac ctgctgtctgatatatttggactggatttgaggagggaaggaggacaatacaaactcatg cctcataaccccaacgccagcctgacagacgtgctcaatacacccacgccaccgccccct acgccctcgcccgaactccgcagaagacacacggtgaagggttcatcttcatcaactgat gagaaagaagctacagaagaaaccaagacagtgtctgagaaagcagaaggggaggacgga gagaaaaaggaaaagaagaaggaagtacaaaagaaaaagaagcctcagctttatcggtcc tccaaatcagatgagccagatcaacaggagtctgccttctggaagaagatcatcgcttac cagcgcaagctgctaaactattttgcacggaatttctacaacatgagaatgctggctctg ttcgtggcctttgcaatcaacttcatcttgctgttctacaaggtttccacttcctctgca gtaaaagaggaaaagcgggtggtgtacagtgcatcatcactggacagtggactgcggtgg gacacgcaaggcgactcttccaacgatcggccagttaccgtgcattttgttctagaggag agtagcggctacatggagcccacactgcgtatcctagccatcctacacaccatcatctct ttcttctgcatcatcggatattactgcctcaaggttcccctggtgatctttaagagggag aaggaagtggctaggaagctggagtttgatgggttgtatattacagagcagccatcagag gatgacattaaaggccagtgggacagactggtcatcaacacacagtcctttccaaacaac tactgggataaatttgtaaagagaaaggtgatggataaatatggggaattttacggtaat gaccgaatcagtgagcttctggggatggacaaagctgcactggactttagtgatgcccat gaaaagaaaaagcccaagaaagacagctcactagctgctgtactgaactctgttgatgtg aaatatcagatctggaagttgggagttgtcttcacagataattctttcctctacctagcc tggtacatgacgatgtccatactgggccactacaataacttcttcttcgctgctcatctg ctagacattgctatgggctttaagacactgaggactatactgtcttctgttactcacaat ggcaaacagcttgtgttgacagtgggcttgctggcagtggtagtctacctctacactgtg gtggccttcaacttcttccgcaagttctacaacaagagcgaggacggagaatctccggac atgaagtgtgacgacatgttaacgtgttacatgttccacatgtacgtgggcgtacgcgcg ggcggtggcatcggcgatcagattgaggatcctgcaggtgacgaatatgagatttaccgc atcatcttcgacatcacctttttcttctttgtcatcgtcatcctcctcgccataattcag ggtcttatcattgatgcatttggtgagctaagagaccagcaagaacaagtgaaggaggac atggagaccaagtgcttcatctgtgggattggaaacgactatttcgacaccgtccctcac ggcttcgaaacacacaccttacaggagcacaacttggcaaactatctattttttgtgatg tatctcataaataaggatgaaacggagcacacaggccaggagtcctacgtttggaaaatg taccaggaacgctgctgggaatttttcccggccggagactgcttccgtaaacaatacgag gaccagctcaactga

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