KEGG   Trichosurus vulpecula (common brushtail): 118846485
Entry
118846485         CDS       T10126                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
tvp  Trichosurus vulpecula (common brushtail)
Pathway
tvp01521  EGFR tyrosine kinase inhibitor resistance
tvp01522  Endocrine resistance
tvp01524  Platinum drug resistance
tvp04010  MAPK signaling pathway
tvp04012  ErbB signaling pathway
tvp04020  Calcium signaling pathway
tvp04066  HIF-1 signaling pathway
tvp04151  PI3K-Akt signaling pathway
tvp04510  Focal adhesion
tvp04520  Adherens junction
tvp04530  Tight junction
tvp05200  Pathways in cancer
tvp05205  Proteoglycans in cancer
tvp05206  MicroRNAs in cancer
tvp05212  Pancreatic cancer
tvp05213  Endometrial cancer
tvp05215  Prostate cancer
tvp05219  Bladder cancer
tvp05223  Non-small cell lung cancer
tvp05224  Breast cancer
tvp05226  Gastric cancer
tvp05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:tvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118846485 (ERBB2)
   04012 ErbB signaling pathway
    118846485 (ERBB2)
   04066 HIF-1 signaling pathway
    118846485 (ERBB2)
   04020 Calcium signaling pathway
    118846485 (ERBB2)
   04151 PI3K-Akt signaling pathway
    118846485 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118846485 (ERBB2)
   04520 Adherens junction
    118846485 (ERBB2)
   04530 Tight junction
    118846485 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118846485 (ERBB2)
   05206 MicroRNAs in cancer
    118846485 (ERBB2)
   05205 Proteoglycans in cancer
    118846485 (ERBB2)
   05230 Central carbon metabolism in cancer
    118846485 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    118846485 (ERBB2)
   05226 Gastric cancer
    118846485 (ERBB2)
   05219 Bladder cancer
    118846485 (ERBB2)
   05215 Prostate cancer
    118846485 (ERBB2)
   05213 Endometrial cancer
    118846485 (ERBB2)
   05224 Breast cancer
    118846485 (ERBB2)
   05223 Non-small cell lung cancer
    118846485 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118846485 (ERBB2)
   01524 Platinum drug resistance
    118846485 (ERBB2)
   01522 Endocrine resistance
    118846485 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tvp01001]
    118846485 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:tvp04147]
    118846485 (ERBB2)
   04090 CD molecules [BR:tvp04090]
    118846485 (ERBB2)
Enzymes [BR:tvp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     118846485 (ERBB2)
Protein kinases [BR:tvp01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   118846485 (ERBB2)
Exosome [BR:tvp04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   118846485 (ERBB2)
CD molecules [BR:tvp04090]
 Proteins
  118846485 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Haspin_kinase ABC1 PDGLE CcmD
Other DBs
NCBI-GeneID: 118846485
NCBI-ProteinID: XP_036610986
LinkDB
Position
4:complement(185448509..185478734)
AA seq 1255 aa
MDLSGCCCWGLLLVLLPPAVWGTQVCTGTDMKLQYPASIENHLDTLRHLYQGCQVVQGNL
ELTYLPADANLSFLQDIQEVQGYVLIAHSLVKSFPLQRLRIIRGTQLYEDKYALVVLDNG
NPLGTAPPTPQGLPGLRELQLRSLTEILKGGVLILNNPQLCHQDTVLWTDIFHKNNYLAT
TSIDTNRSRTCSPCSSSCKSGKCWGEGHDNCQSLTSTICASGCARCKGPLPTDCCHEQCA
AGCTGPKHSDCLACLHFNHSGICEQHCPPLVIYNSDTFESMPNPDGRYTFGSSCVKSCPY
NYLATDVGSTSCTLVCPLHSQEVTAEDGTHRCEKCSKACPKVCYGLGMGHLRSVRAVNST
NIQDFAGCKKIFGSLAFLPETFTGDLATNTSPLMPEDLKVFENLEEITGYLYISAWPDSF
PDLSIFQNLRVIRGRVLHNGVYSLTLEHLGIGWLGLRSLRELGSGLALIHHNAHLCFVHT
VPWNQLFRNTRQALLYSANRPADECAREGLACYSLCAQGHCWGPGPTQCLNCSQFLRGQE
CVEECRVMQGYPREYVKERRCFPCHEECQPQNGTETCFGSEADKCVACAHFKDPPACVAR
CPSGVKSDLSFIPIWKYPDDEGICQTCPTNCTHSCTVLDDKGCPAEQKLSPVTSIIAGVV
GVLLALIIGLIIGILIKRRKQKERKHTMRRLLQETELVEPLTPSGALPNQAQMRILKETE
LRKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS
PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLCSQDLLNWCVQIAKGMNYLEEV
RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILCRRF
THQSDVWSYGVTVWELMTFGAKPYEGIPAREIPDLLEKGDRLPQPPVCTIDVYMIMVKCW
MIDSECRPRFRELVTEFSRMARDPQRFVVIQNEDSGPASPLDSTFYRSLLEEDDMGDLVD
AEEYLVPQQGFFCPDPPLAPGPGGTAHRRHRSSSTRSGGELPGGLEGSEDDTPQTSTEPW
EGTGSDVFDGDPGGSPKGLQGLPPRDLSPLQRYTEDPTGTLPPEMDGYIVPPVCGPLPEY
VNQPEVHLPPPSPLEGTLTPPHPSSSTLERPKLPPPGKNGVVKDTFTFGAAVENPEYLAP
HGGGPLHLSPTAFSPAFDNLYYWDQDPPDRGAAPNGFAATPTAENPEYLGLDMTV
NT seq 3768 nt   +upstreamnt  +downstreamnt
atggacctgtcgggctgctgctgttgggggctccttctggtccttctgcccccagcagtc
tggggaacccaagtgtgcacaggcacagatatgaagctgcagtatcctgccagtattgag
aatcaccttgacacactgagacacctgtaccaaggatgccaggttgtacagggcaacttg
gaactcacttacctgcctgctgatgccaacctctccttcctccaggacatccaggaagtg
caggggtatgtgctgattgcccacagcctggtgaagagcttcccgctgcagaggctacgc
atcatacgaggcacacagctctatgaggacaaatatgccctggttgttctggacaatggg
aatccccttgggactgcccctcccacaccacagggcctccctggccttcgggagctgcaa
cttcgaagcctcacagagattctgaaaggtggggtcctgatcctgaacaaccctcagcta
tgtcaccaggacacagtgctatggaccgacatcttccataagaacaactacttggctacc
acctccatcgacacaaaccgcagccgaacttgcagcccttgttcttcatcatgtaaatcc
ggcaaatgctggggggaaggacatgacaactgtcagagcttgaccagcacaatctgtgcc
agtggctgtgcccgctgcaaggggcccctccccacagactgctgccatgaacagtgtgct
gctggctgcactggccccaagcattctgactgcctggcctgcctccacttcaaccacagt
ggcatctgtgagcagcactgcccaccgctggtcatctacaactcagacacctttgagtca
atgcctaatcctgatgggcgatacacctttgggtccagttgtgtgaaatcatgtccctat
aactacctggctacagacgtgggctccacctcctgcacccttgtgtgtcccctccacagc
caggaggtgactgccgaggatgggacccatcggtgtgagaagtgcagcaaggcctgtccc
aaagtgtgttatgggctgggcatggggcacttgcggtcagtgagagctgtcaacagtacc
aacatccaggactttgccgggtgcaagaagatctttggaagcctggccttcttgcctgaa
accttcacaggggacttggccaccaatacttctccactaatgcctgaagatctcaaggtc
tttgagaacctggaggagatcacaggctatctatacatctcagcctggcctgacagcttc
cctgacctcagcatctttcagaacctaagggtgatcaggggaagggtgctgcacaatggt
gtctactccctgacactggagcatctgggtattggctggctggggctgcggtcactgaga
gagcttggcagtgggctggcactcatccatcacaatgcccacctatgctttgtccacacg
gtgccttggaaccagctcttccgcaatacccgccaggccctactctacagtgccaaccga
cctgctgatgagtgtgcaagggagggactagcatgctactccctgtgtgctcaggggcac
tgctggggccccggaccaactcagtgtctcaactgcagccaatttctccgagggcaggag
tgtgtggaggagtgccgggtcatgcaggggtacccccgagaatatgtaaaggagaggcgc
tgcttcccatgccatgaggagtgccagccacagaatggcactgagacctgctttggatcg
gaggctgacaaatgtgtagcctgtgcacatttcaaggatccccctgcctgtgtggcccga
tgccccagtggggtgaagtctgacctctccttcatacctatctggaagtacccagatgat
gagggcatttgccagacctgccccaccaactgtacccactcctgtactgtattggatgac
aaaggctgtcctgctgagcagaaactcagccctgtgacctccatcattgctggggtggtc
ggggtgctcctagccctcatcataggcctgatcattggcatcttgattaagcgtcggaag
cagaaggaacgcaaacacactatgaggaggctgctacaggagacggagctggtggagccc
ctgacgcccagcggggcattgcccaaccaagctcagatgcgaatcctaaaagagacggag
ctgaggaaagtgaaggttctcggttctggggctttcggcacagtctacaagggtatttgg
atccccgatggtgaaagtgtgaagattccagtggctatcaaggtgttgagggaaaacaca
tcccccaaagccaacaaggagatcttggatgaagcatacgtgatggcaggtgtcggctct
ccatatgtgtctcgccttctgggcatctgtctgacatctacggtgcagctggtgacccag
cttatgccctatggctgcctcctggaccatgtgcgtgaaaaccgagggcgactctgctcc
caggacctcctcaattggtgtgtgcagattgccaaggggatgaactacctggaggaggtt
cggctagtacacagagacctagcagccagaaatgtgctggtcaaaagtcccaaccacgtc
aagattaccgactttggactcgcaaggctcttggacattgatgagacagagtaccacgca
gatgggggcaaggttcccatcaagtggatggcactggagtccattctctgccgaagattc
acccatcagagtgatgtgtggagctatggggtgacagtgtgggaactgatgacctttggg
gctaaaccatatgaggggattcctgcccgagagattcctgacctgctggagaaaggggac
cgactgccccagccccccgtctgcaccatcgatgtctacatgatcatggtcaaatgttgg
atgattgactctgagtgtcggcctcggttccgggagctagttactgaattctcacgaatg
gcccgagaccctcagcgctttgtggtcatccagaatgaggattctggcccagccagcccc
ctggacagcactttctaccgctcactgttggaagaagacgacatgggagacttggtggat
gcagaagaatacctggtgccccagcaaggcttcttctgccctgaccctcccctggctcca
ggtcctgggggcactgcccacagaagacacagaagttcttctacaaggagtggcggggag
cttccaggcggactggaaggctcagaagatgacactccccaaacttcaacagagccttgg
gaagggactggttcagatgtgtttgatggggaccctggagggagccctaaggggctacag
gggctcccccctcgagacctcagccccctgcagcgctacactgaggatcccacagggaca
ctgccccctgagatggatggctacattgtcccacctgtctgtggccccctgccagaatac
gtgaaccagccagaggtgcacctaccacccccttcacctctggaggggaccctgactccc
cctcacccatccagctccaccctggaacgccccaagttgcctcctccagggaagaacgga
gtggtgaaggacacatttacctttggtgcagctgtggagaaccctgagtacttggcccca
catggaggcggtccccttcatctttccccaactgccttcagcccagcctttgacaacctc
tactactgggaccaggatccccctgaccgaggggctgctcctaatggctttgcagcgacc
cccacagctgagaaccctgagtacttgggtctggatatgactgtgtga

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