Ursus arctos (brown bear): 113241474
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Entry
113241474 CDS
T05909
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X2
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah00220
Arginine biosynthesis
uah00330
Arginine and proline metabolism
uah01100
Metabolic pathways
uah04020
Calcium signaling pathway
uah04022
cGMP-PKG signaling pathway
uah04066
HIF-1 signaling pathway
uah04071
Sphingolipid signaling pathway
uah04151
PI3K-Akt signaling pathway
uah04370
VEGF signaling pathway
uah04371
Apelin signaling pathway
uah04611
Platelet activation
uah04915
Estrogen signaling pathway
uah04921
Oxytocin signaling pathway
uah04926
Relaxin signaling pathway
uah04931
Insulin resistance
uah04933
AGE-RAGE signaling pathway in diabetic complications
uah05415
Diabetic cardiomyopathy
uah05417
Lipid and atherosclerosis
uah05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
113241474 (NOS3)
00330 Arginine and proline metabolism
113241474 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
113241474 (NOS3)
04371 Apelin signaling pathway
113241474 (NOS3)
04066 HIF-1 signaling pathway
113241474 (NOS3)
04020 Calcium signaling pathway
113241474 (NOS3)
04071 Sphingolipid signaling pathway
113241474 (NOS3)
04022 cGMP-PKG signaling pathway
113241474 (NOS3)
04151 PI3K-Akt signaling pathway
113241474 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
113241474 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
113241474 (NOS3)
04921 Oxytocin signaling pathway
113241474 (NOS3)
04926 Relaxin signaling pathway
113241474 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
113241474 (NOS3)
05418 Fluid shear stress and atherosclerosis
113241474 (NOS3)
05415 Diabetic cardiomyopathy
113241474 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
113241474 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
113241474 (NOS3)
Enzymes [BR:
uah01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
113241474 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
113241474
NCBI-ProteinID:
XP_026334936
LinkDB
All DBs
Position
Unknown
AA seq
1201 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTSSEPSRAPAPAPPPALDRSPPLTRP
PDGPKFPRVKNWEVGSITYDTLSAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQDPPPPEQ
LLSQARDFINQYYSSIKRSGSQAHEQRLQEMEAEIAAKGTYQLRESELVFGAKQAWRNAP
RCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFR
IWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPEL
FVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEI
GTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDRAAVEINLAVLHSYQLAKVTIVDHHA
ATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPDPWKG
SATKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLF
RKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPR
PEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCA
FARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARD
IFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILVR
LDTGGQEALQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGPPP
SWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESSEQQELESLSQDPRRYEE
WKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAY
RTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFR
GFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSREPD
SPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDEA
GDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDTPS
P
NT seq
3606 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggaacccgggcccccctgcggcctggggctgggc
ctgggcctggggctgtgcggcaagcagggccctgcctccccgacctcctctgagcccagc
agggcaccggcacccgcgcccccaccagcactggaccgcagccccccgctcacccggccc
ccggacgggcccaagttccctcgcgtgaagaactgggaggtggggagcatcacctacgac
accctgagtgcccagtcacagcaggatgggccctgcacccccagacgctgcctgggctct
ctggtatttccacggaaactgcagagccggccgtctcaggaccctccaccccctgagcag
ctgctgagccaggccagggacttcatcaaccagtactatagctctatcaagaggagcggc
tcccaggcccacgagcagaggcttcaggagatggaagctgagatagcggccaagggcacc
taccagcttcgggagagcgagctggtgttcggagccaagcaggcctggcgaaatgctccc
cgctgcgtaggccggatccaatgggggaagctgcaggtgttcgatgcccgggattgcagc
tctgcccaggagatgttcacctacatctgcaaccacatcaagtatgccaccaaccggggc
aacctccgctcggccatcacagtgttcccccagcgtgccccaggccgcggagacttccga
atctggaacagccaactggtgcgctacgcgggctacaggcagcaggacggctcggtgcgg
ggggacccagccaacgtggagatcacagagctctgcattcagcacggctggaccccagga
aacggccgctttgacgtgctacccctactgctccaggccccagatgagcccccagaactc
tttgttctgccccctgagctggtcctcgaggtgcccctggagcaccccacgctggagtgg
tttgcggccttgggcctgcgctggtatgccctcccagcggtgagcaacatgctgctggaa
attgggggactggagttccctgcggcccctttcagcggctggtacatgagcactgagatt
ggcacgcggaacctgtgtgaccctcaccgatataatatcctggaggatgtggcggtctgc
atggacttggatacccggacaacctcatccctgtggaaagacagggccgcggtggagatc
aacttggccgtgctgcacagttaccagctggccaaagtgaccatcgtggaccaccatgct
gccactgcctccttcatgaagcacctggagaacgagcagaaggctagggggggctgccct
gccgactgggcctggatcgtgccccccatctctggcagcctcacccctgtcttccatcag
gagatggtcaactatgtcctgtccccggccttccgctatcagccagacccatggaagggg
agtgcaaccaagggtgccggcatcaccaggaagaagacctttaaggaagtggccaatgcg
gtgaagatctctgcctcactcatgggcactgtgatggcaaagcgagtgaaggcgactatc
ctgtatggctccgagaccggccgggcccagagctacgcacagcagctggggagactcttc
cggaaggctttcgacccccgggtcctgtgcatggatgagtacgatgtggtgtcccttgaa
catgagacactggtgttggtggtgaccagcacatttgggaatggtgatcccccagagaac
ggagagagttttgcggcggccctgatggagatgtccggcccctacaacagttcccctcgg
ccagaacagcacaagagttacaaaatccgcttcaacagcgtctcctgctcagacccgctg
gtgtcctcctggaggcggaagagaaaggagtccagtaacacagacagcgcaggggccctg
ggcaccctcaggttctgtgtgttcgggctgggatcccgggcatacccccacttctgcgcc
tttgctcgtgcggtggacacacggctggaggagctgggtggggagcggctgctgcagctg
ggccagggagatgagctgtgtggccaggaggaggccttccgtggctgggcccaggccgcc
ttccaggcctcctgtgagactttctgcgtgggagaggatgccaaggccgccgcccgggat
atattcagccccaaacggagctggaagcgccaaaggtaccggctgagtgcccaggctgag
ggcctccagctgctgccaggcctgatccacgtgcacaggaggaaaatgttccaggctacg
gtcctctcagtggaaaacctgcaaagcagcaagtccacccgggccacgatcctggtgcgc
ctagacactggaggccaggaggcgctgcagtaccagcccggcgaccacataggcatctgc
ccgcccaaccggcccggccttgtggaggcgctgctgagccgtgtggaggatccgcctcca
ccaggagagccagtggcagtggagcagctggagaagggcagccctggtggcccgcccccc
agctgggttcgggacccccggctgcccccatgcacactgcgccaggctctcaccttcttc
ctggacatcacttccccgcccagccctcaactccttcgactgctcagcaccctggccgaa
gagtccagcgaacagcaggagctcgagagcctcagccaggacccgcggcgctacgaggag
tggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccctccgtggca
ctacctgcccccctgctcctcacccagctgcccctgctccagccccggtactactcggtc
agctcagcacccagcgcccacccaggagagatccacctcacggtagccgtgctggcatac
aggacgcaggatggactgggcccccttcattatggagtctgctccacatggctaagccaa
ctgaaggccggagatcctgtaccctgcttcatcaggggggctccctccttccggctgccg
cctgatcccagcttgccctgcattctagtgggccctggcacaggcattgcccccttccgg
ggattttggcaggagcggctgcatgacattgacagcaaagggctgcagcccgcccccatg
actttggtgttcggctgccgatgctcccagctcgaccacctttaccgcgacgaggtgcag
gatgcccagcagcgcggagtttttgggcgcgtcctcaccgccttctcccgggagcccgac
agccctaagacctacgtgcaagacatcctgcggacggagctggctgctgaggtgcaccgc
gtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggcaaccagc
gtcctgcagacggtgcagcgaatcctagcgacggagggcgacatggagctggacgaggcc
ggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttcgggctc
acactgcgcacgcaggaagtgacaagccgcatacgcacccagagcttttccttgcaggag
cgacatctgcggggcgcagtgccctgggcgttcgacccgcccggcccggacactcccagc
ccctga
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integrated database retrieval system
