Ursus arctos (brown bear): 113242759
Help
Entry
113242759 CDS
T05909
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X6
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah00310
Lysine degradation
uah01100
Metabolic pathways
uah05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
113242759 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
113242759 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
uah03036
]
113242759 (DOT1L)
Enzymes [BR:
uah01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
113242759 (DOT1L)
Chromosome and associated proteins [BR:
uah03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
113242759 (DOT1L)
HMT complexes
Dot1-containing complex
113242759 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
113242759
NCBI-ProteinID:
XP_026336760
LinkDB
All DBs
Position
Unknown
AA seq
1707 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSTTTTPTKVP
ESKAAVPADTPMDSGAEEEKAGATAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKSQTALDLLHAQAAAQTAAPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRTQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSAHLRGKGALGRELEADAGRLHLDLDCSKFSLPHFSSTSPELSINGHAATY
EVCSALSRPSSKQNTPQYLASPLDQEVIPCTPSHSSRSRLEKMSGLALPDYTRLSPAKLV
LRRHLSQDHAASGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGGEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESSSALEKQMGTNAHSAGSKSLAPAPAGFYAGSVAVSGALAGSPAPLAPGAE
PSAFDEVSSSGSLFVSMGSCSSTPQHPPLLPQSRGSGAASPAHPLCASPRLSSAAQGPLP
EASKGDLPSEAGFSDPEGEAKRRIVFTISAGSSSAKQSPPSKPSPLPTGARGDSSQGHGP
DSRKRGRRKRAAAGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEIT
AISSPESLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIER
KIATISLESKSPPKTLESGGSLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQ
AGSALSQNSLFTFRPPLEEPGLADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGG
LAADLSLHSFSDGASLSHKVPEAASLGAPLSFPAPRGKEGSATEPGAFVNKRQLDGLGGP
KGREAGELVLPACGPPDKASLTHSKPGKGRDREPDLKNGHNLFISAATVPPGSLLSGPGL
ATAASSAVSAAPSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLV
HVSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSL
TPLQAVASAPASSFQAPPPPPPGQPALPAPPPPNAALPPAPALLPANSEPVLLQNLASLP
ANQAFLPASSAASLRPANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQAS
STGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5124 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccgatgggtctgtgaagagatcccggacctcaagcttgcgatggagaattacgttctc
atcgactacgacaccaaaagctttgaaagcatgcagaggctctgtgacaaatacaaccgc
gccatcgacagcatccaccagctgtggaagggaaccacgcagcccatgaaactgaacacg
cggccgtccaacgggctcctgcggcacatcctgcagcaggtctacaaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
tttgacttggtcgcgcagatgatcgatgagatcaagatgaccgaggatgacctgtttgtg
gacctgggcagtggagtgggccaggtcgtgctgcaggtcgccgcagccaccaactgcaag
catcactatggcgtggagaaagccgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcggaagagtggagagagcggattgccaacacaagtgttatatttgtg
aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggtggcagaatcgtttcctcgaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagtgacatcggcaccatcatgcgcgttgtggagctctcgcccctgaaa
ggctcggtgtcctggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaggaggca
gctcggcgcaggcagcagcgagagaacaagagcaccacgaccactcccaccaaggtgccc
gaaagcaaggctgccgtgcccgcggacaccccgatggattccggggccgaggaagaaaag
gctggggcgactgccatcaaaaagccgtccccctccaaagcccggaagaagaagctgaac
aagaaggggcggaagatggccggccggaagcgcgggcgtcccaagaagatgagcactgcg
aaccccgagcgtaagcccaagaagagccaaactgcactggacctcctgcacgcccaggcc
gcggcgcagacggcagcgccctcgccgcaggatgcgtacaagtcacctcatagcccgttt
taccagctacctcccagtgtgcagcggcacccccccgaccagctgctgctggcacccacc
ccgcccgcactgcagaagctgctagaatccttcaagattcagtacttgcagttcttggcg
tataccaagaccgcccagtacaaggccagcctgcagcagctgctggaccaggagaaggag
aagaacgcgcggttgctaggcgctgcccagcagctgttcggccactgccaggcccagaaa
gaggagatcaagaggcttttccagcagaaactggatgagctgggagtgaaggcgctgacc
tacaatgacctgatccaggcgcagaaggagatctcggctcacaaccagcagctgagggag
cagacggagcagctgcagaaggacaacagggagctgaggagccagagcctgcagctgctc
aaggctcggtgtgaggagctgaagctggactggtccacgctgtccctggagaacctgctg
aaggagaagcaggccctgcggacccagatctccgagaagcagaggcactgcctggagctg
cagataagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgcgtgccgccggacgatgccctgtcggcacacctgcgcgggaaaggcgccctgggc
cgggagctggaggccgacgccggccggctgcacctcgacctggactgctccaagttctct
ctgccccacttcagcagcacgagcccagaactctccataaacggccacgcagccacctat
gaggtctgcagtgcgctgagccggccctcgtccaagcagaacaccccccagtacctggcc
tcccccctggaccaggaagtcataccctgcacgcccagccacagcagccgctcgaggctc
gagaagatgtcgggcctggccttgcccgactacacccggctctccccagccaagctagtg
ctgaggcgtcacctgagccaggaccatgcggccagtggcaagactgcggctggcgagctg
cacccgcgagctgagcatgccaaggagaacggccttccgtaccagagccctggcatcgca
aatggcatcaagctgagccctcaggaccctcgaccttcatcccccgtggccttacagatg
acaggggagaggggcggcgagaagggtttgaaggagcgtgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagccaagcaagctgcct
gtcagcatccctctggccagtgtggtgctgcccagccgcgccgagaaagtgagaagcacc
cccagccccgtaccgcagacccgagagtcctcgtccgcacttgaaaagcagatgggcacg
aacgcccacagtgctggaagcaaaagcctcgccccagctcctgcaggcttctacgcgggc
tcagtggccgtcagtggggccctggcaggcagcccagccccccttgctcctggagccgag
cccagcgccttcgacgaggtctccagctcaggaagcctgttcgtcagcatggggtcctgc
agctctaccccacagcacccgccactgctgccgcagtcccgcggctccggcgcagcctca
cctgcccatccactctgcgccagcccccggctcagcagtgccgcccagggcccgctcccc
gaggccagcaaaggggaccttccgtctgaggccggcttctcagaccccgagggcgaagcc
aagaggaggatcgtctttaccatctcagctggcagcagcagtgccaagcagtcacctccc
agcaaacccagccctctgcccacgggtgcccgcggggacagcagccagggccacgggccg
gacagtcgcaagcggggcaggaggaagcgggcagcagccgggacccccagcctgagttct
ggcgtgtcgcccaagcgtcgcgccctgccatccgttgccggcctcttcacgcagtcgtca
gggtccccactgaacctcaactcgatggtcagcaacattaatcagcctttggaaatcacg
gccatctcgtcccccgagagcctgaagagctcccctgtcccctaccaggacaacgaccag
ccgcccgttctcaagaaggagaagcccttgagccagaccaacggggcccactactcccca
ttgacctcagacgaggagcaaggctccgaggacgagccgggcagcgccagaatcgagaga
aaaattgcaacaatttccttagaaagcaaatctcctccgaaaaccttggaaagtggtggt
agcctggccggcaggaagccgacccctgccggtgagcccgccaacagcagcaagtggaaa
tccaccttctcgcccatctccgacctcggcctggccaaatgcgccgacagcccgctgcag
gccggctctgccctgagccagaactccctgttcactttccggccccccctagaggagccc
ggcttggccgatgccaagctggctgcccaccccaggaaaagctttcccggtgcgctgtcg
ggggccggtgggctgagccccagcagcaaccctcccaacggcttcgccttcagcgggggc
ctggccgccgacctcagtttacacagcttcagcgatggtgcttctctctcccacaaggtc
cccgaggccgccagcctgggcgcccccctgagcttccccgccccgcggggcaaggagggc
agtgccacagagcccggcgcctttgtgaacaagaggcagctggacggactgggaggccca
aagggcagggaggcaggcgagctggtcctgccggcgtgcgggcccccagacaaggcctcg
ctgacgcacagcaagccaggcaagggccgggaccgtgagcccgacttgaagaacggccac
aacctcttcatttctgccgccactgtgcctcccgggagcctcctcagcggcccgggcctc
gccacggcggcgtcctcggcagtcagcgcggccccctctgcccagactcaccgccccttc
ctgggcacctttgcccccggcccgcagtttgccctgggtcccatgtccctgcaggccaat
ctgggctcgtccgtgctacagtccttgttcagctccgtgccagccgctgccggcctggtg
cacgtctcgtctgccgcgaccagactgaccaactcgcacgccatgggcagcttctcctcc
ggggtggcaggcggcgctgttggaggtgtctttaaccacgcggtgccttccgcctccgct
catccgtttggagccagtttcggcagcggggctgcgtgtcgcagcgccacgctgagctta
accccgctgcaggcggtggccagcgcccctgcgtcttcctttcaggccccgcccccgccc
cctccggggcagcccgccctccccgcaccccctccccctaacgccgccttgcctcctgcc
cccgcgctgctcccggctaactctgagcctgtgcttctgcagaacctcgcgtccctcccg
gctaaccaggctttcttacccgcctcttctgccgcctctctgcggcccgctaacgcctct
ctgtccatcaagctcgcctccctcccgcacaaggccccccgcccctccttcacggtgcac
caccagcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggccagc
tccacggggccgtctgccgtgtgggtttcccttggcatgccgcctccgtatgccgcgcgc
cttgcgggggttaagccaagataa
DBGET
integrated database retrieval system
