Ursus arctos (brown bear): 113242985
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Entry
113242985 CDS
T05909
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X2
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah04217
Necroptosis
uah04380
Osteoclast differentiation
uah04620
Toll-like receptor signaling pathway
uah04621
NOD-like receptor signaling pathway
uah04630
JAK-STAT signaling pathway
uah04658
Th1 and Th2 cell differentiation
uah04659
Th17 cell differentiation
uah05145
Toxoplasmosis
uah05160
Hepatitis C
uah05161
Hepatitis B
uah05162
Measles
uah05164
Influenza A
uah05165
Human papillomavirus infection
uah05167
Kaposi sarcoma-associated herpesvirus infection
uah05168
Herpes simplex virus 1 infection
uah05169
Epstein-Barr virus infection
uah05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
113242985 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
113242985 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
113242985 (TYK2)
04621 NOD-like receptor signaling pathway
113242985 (TYK2)
04658 Th1 and Th2 cell differentiation
113242985 (TYK2)
04659 Th17 cell differentiation
113242985 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
113242985 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
113242985 (TYK2)
05160 Hepatitis C
113242985 (TYK2)
05171 Coronavirus disease - COVID-19
113242985 (TYK2)
05164 Influenza A
113242985 (TYK2)
05162 Measles
113242985 (TYK2)
05168 Herpes simplex virus 1 infection
113242985 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
113242985 (TYK2)
05169 Epstein-Barr virus infection
113242985 (TYK2)
05165 Human papillomavirus infection
113242985 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
113242985 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113242985 (TYK2)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
113242985 (TYK2)
Protein kinases [BR:
uah01001
]
Non-receptor tyrosine kinases
JAK family [OT]
113242985 (TYK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
Kinase-like
RA_2
Kdo
FERM_C_FAK1
ABC1
Motif
Other DBs
NCBI-GeneID:
113242985
NCBI-ProteinID:
XP_026337159
LinkDB
All DBs
Position
Unknown
AA seq
1182 aa
AA seq
DB search
MPLCHWGATTRDSRPDGDGTQPMATRGGLKVLLHWAGPGGGDPWVTFSEATLTAEEVCIH
IAQKVGITPSCLNLFALFDAQAQVWLPPNHVLEISRDMSLTLYFRMRFYFRNWHGTNPQE
PAVYRCGPPGAKSSSEQAEQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHF
KNESLGMAFLHLCHLALCHGVPLEKVAKKISFKDCIPRSFRLQIRRHNALTRLRLRNIFR
RFVRAFQPGHVSQQVIMVKYLATLEQLAPRFGTERVPVCRLQLPAQAGGEPYYIRDGGQP
PPDPGPELAPGPPTHEVLVTGTGGIQWRPVQAEGPRGDGSSRNPHAGPSGKKTKAPEVVD
QPADRPREAPWAYFCDFRDITHVVLKERHVSIHCQDNKSLELTLPSRAAALSLVSLVDGY
FRLTADSSHYLCHEVAPPRLVMSIQEGIHGPLLEPFVLAKLRPEDGLYLVHWSASHLNRL
ILTVAQREQAPGTQHVHLRKFPIELQAGVFTLEGWDRSFPSVRELRAALQGCSLRAGDDC
FSLRRCCLPRPGEISNLIVMRGPRASTGPPNLSQLSFHRVCRDDITQLSHLGQGTRTNVY
EGILRVGGRSPEEGMADGEDPPTPSGDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
SHVHLAFVHGICVHGSENIMVTEYVEHGPLDVWLRREKGHTPVAWKVVVAQQLASALSYL
EDKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERAERIPWIAPECLS
GAANSLTTAADQWGFGATLLEICFDGEAPLQGRGPSEKECFYQKQHRLPQPSCPELATLT
SQCLTYEPAQRPSFRTILRDLTQLQPQNLADVLAVNPDSPASDPTVFHKRYLKKIRDLGE
GHFGKVSLYCYDPTNDGTGEMVAVKALKADCSPQLRTGWRREIDILRTLYHKHIVKYRGC
CEDPGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHGQHYVHRDLA
ARNVLLDNDRLVKLGDFGLTKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVW
SFGVTLYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPRPERCPCEIY
LLMKNCWEAEASFRPTFQNLIPILKTAQEKYQGQAASVFNVC
NT seq
3549 nt
NT seq
+upstream
nt +downstream
nt
atgcctctgtgccattggggtgccaccaccagggacagcaggcctgatggcgatggaact
cagcccatggccaccaggggaggcctgaaggttcttctgcactgggctggccctggtggc
ggggacccatgggtcaccttcagcgaagccacactgaccgcagaggaggtctgcatccac
attgcacaaaaagttggtatcactccatcctgcctcaatctctttgctctcttcgatgcc
caggctcaggtctggctgcccccaaaccatgtcttggagatctccagagacatgagcctg
acattgtatttccgcatgaggttttatttccggaactggcatggcacaaaccctcaggaa
ccggctgtgtaccgctgtgggcccccaggggccaagtcttcctcagaacaggcagagcag
gggatgcaattgctggacccagcctcctttgagtacctctttgagcagggcaagcatgag
tttgtgaatgacgtggcgtcactgtgggagctgtcgagcgaggaggagatccaccatttt
aagaacgagagtctgggcatggcctttctgcacctctgccacctggctctctgccatggc
gtccccctggagaaggtggccaagaagatcagcttcaaggactgcatcccgcgctccttc
cggctgcagatccggcggcacaacgcgctgacgaggctacgcttgcggaacatcttccgc
aggttcgtgcgggccttccagccgggccacgtctcgcagcaggtcatcatggtcaagtac
ctggccacgctcgagcagctggcaccccgcttcggcacggagcgcgtgcccgtgtgccgc
ctgcagctaccggcccaggccggtggggagccctactacatccgggacggcgggcagcct
cccccagatcctgggccggagttggcccccggaccccccactcatgaggtgctggtgacg
ggcacgggtggcatccagtggcggccggtacaggcagagggtcccagaggcgatggcagc
agcaggaatccccatgctggcccatctgggaagaaaaccaaggccccagaggtggtcgac
cagccagcagacaggcctcgggaagcgccatgggcctacttctgtgacttccgggatatc
acgcacgtggtgctgaaagaacgccacgtcagcatccactgtcaggacaacaagagcctg
gagctgaccctgccttcccgggccgcggccctgtccttggtgtcgctggtggacggctat
ttccgccttaccgccgactcgagccactacctgtgccacgaggtggctcctccgcggctg
gtgatgagcatccaggagggtatccacggacccctgctggagccgtttgtgctggccaag
ctgcggccggaggatggcctctacctcgtccactggagcgccagccacctcaaccgcctc
atcctgaccgtggcccagcgtgagcaggcaccgggcacacagcacgtgcacctgcgtaaa
ttccccattgagctgcaggcgggggtcttcacgctggagggctgggaccggtccttcccc
agcgtgcgcgagctgcgagctgccctgcagggttgctccctgcgggctggcgatgactgt
ttctccctgcgccgctgctgcctgccgcggccgggagagatctccaacctcatcgtcatg
cgggggcctcgggccagcacgggcccccccaacctcagccagctcagcttccaccgggtc
tgccgggatgacatcacccagctctcccacttgggccaaggcacaaggaccaatgtgtat
gagggcatcttacgagtggggggcagaagccccgaggagggcatggcagatggtgaggac
ccccccacgcccagtggggaccgtgggcaagagctccgagtggtactcaaggtgctggac
cccagtcaccatgatatcgccctggccttctacgagacagccagcctcatgagccaggtg
tcccacgtgcacctggccttcgtgcacggcatctgcgtgcacggctctgagaacatcatg
gtgacggagtacgtggagcacgggcccctggatgtgtggctgcggcgagagaagggccac
acgcctgtggcctggaaggtggtggtggcccagcagctggccagcgccctcagctacctg
gaagacaagaacctggttcatggtaatgtgtgtggccggaacattctgctggcacgactg
gggctggcggagggcaccagccccttcatcaagctgagcgaccccggtgtgggcctgggc
gccctttccagggaggagcgggcggagcggatcccctggatagcccccgagtgtctctct
ggtgcggccaacagcctaaccaccgcagccgatcaatggggctttggcgccaccctcctg
gagatctgcttcgacggggaggcccctctgcagggccgtggcccctctgagaaagagtgt
ttctaccagaagcagcaccggcttcctcagccctcctgcccggagctggccacactcacc
agccagtgcctgacctatgaaccagctcagcggccctccttccgcaccatcctgcgtgac
ctcactcaactgcagccccagaatcttgctgacgtcttggctgtgaaccccgactcgcct
gcgtcagaccccaccgttttccacaagcgctatttgaaaaagatccgggatctgggcgag
ggtcatttcggcaaggtcagcctgtactgctacgaccccacgaacgacggcactggggag
atggtggccgtgaaggccctcaaggcggactgcagcccccagctgcgcaccggctggagg
cgggagatcgacatcctgcgcacgctctaccacaagcacatcgtcaagtacaggggctgc
tgcgaggacccaggagagaagtcggtgcagctcgtcatggagtacgtgcctctgggaagc
ctgcgcgactacctgccgcggcacagcgtcggactcgcgcagctgctgctcttcgctcag
cagatctgtgagggcatggcctaccttcacggacagcactacgtgcaccgagacctggct
gcccgcaacgtgctgctggacaacgacaggctggtcaaacttggggactttggcctgacc
aaggctgtgcctgagggccatgaatactaccgcgtgcgcgaggacggggacagccccgta
ttctggtatgccccagagtgcctgaaggagtgtaagttctactatgcgtccgacgtctgg
tccttcggggtcaccctctacgagctgctgacctactgtgactccagccagagccccccc
tcgaaattcatcgagctcataggcctcacccaggggcagatgacggtgctgaggctcact
gagctgctggaacgaggggagaggctgccccggccagagagatgtccttgtgagatctat
ctcctcatgaagaactgctgggaggcagaggcttcattccgtcccaccttccagaacctc
atacccattctcaagaccgcccaggagaaataccaaggccaggccgcctcagtgttcaat
gtgtgctga
DBGET
integrated database retrieval system
