| Entry |
|
| Symbol |
PLCB3
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
|
| KO |
|
| Organism |
uah Ursus arctos (brown bear)
|
| Pathway |
| uah04070 | Phosphatidylinositol signaling system |
| uah04072 | Phospholipase D signaling pathway |
| uah04261 | Adrenergic signaling in cardiomyocytes |
| uah04270 | Vascular smooth muscle contraction |
| uah04613 | Neutrophil extracellular trap formation |
| uah04621 | NOD-like receptor signaling pathway |
| uah04723 | Retrograde endocannabinoid signaling |
| uah04750 | Inflammatory mediator regulation of TRP channels |
| uah04919 | Thyroid hormone signaling pathway |
| uah04925 | Aldosterone synthesis and secretion |
| uah04927 | Cortisol synthesis and secretion |
| uah04928 | Parathyroid hormone synthesis, secretion and action |
| uah04933 | AGE-RAGE signaling pathway in diabetic complications |
| uah04935 | Growth hormone synthesis, secretion and action |
| uah04961 | Endocrine and other factor-regulated calcium reabsorption |
| uah04973 | Carbohydrate digestion and absorption |
| uah05022 | Pathways of neurodegeneration - multiple diseases |
| uah05163 | Human cytomegalovirus infection |
|
| Module |
| uah_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:uah00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
113244175 (PLCB3)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
113244175 (PLCB3)
04310 Wnt signaling pathway
113244175 (PLCB3)
04371 Apelin signaling pathway
113244175 (PLCB3)
04020 Calcium signaling pathway
113244175 (PLCB3)
04070 Phosphatidylinositol signaling system
113244175 (PLCB3)
04072 Phospholipase D signaling pathway
113244175 (PLCB3)
04071 Sphingolipid signaling pathway
113244175 (PLCB3)
04022 cGMP-PKG signaling pathway
113244175 (PLCB3)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
113244175 (PLCB3)
04081 Hormone signaling
113244175 (PLCB3)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
113244175 (PLCB3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
113244175 (PLCB3)
04613 Neutrophil extracellular trap formation
113244175 (PLCB3)
04621 NOD-like receptor signaling pathway
113244175 (PLCB3)
04062 Chemokine signaling pathway
113244175 (PLCB3)
09152 Endocrine system
04911 Insulin secretion
113244175 (PLCB3)
04922 Glucagon signaling pathway
113244175 (PLCB3)
04929 GnRH secretion
113244175 (PLCB3)
04912 GnRH signaling pathway
113244175 (PLCB3)
04915 Estrogen signaling pathway
113244175 (PLCB3)
04921 Oxytocin signaling pathway
113244175 (PLCB3)
04926 Relaxin signaling pathway
113244175 (PLCB3)
04935 Growth hormone synthesis, secretion and action
113244175 (PLCB3)
04918 Thyroid hormone synthesis
113244175 (PLCB3)
04919 Thyroid hormone signaling pathway
113244175 (PLCB3)
04928 Parathyroid hormone synthesis, secretion and action
113244175 (PLCB3)
04916 Melanogenesis
113244175 (PLCB3)
04924 Renin secretion
113244175 (PLCB3)
04925 Aldosterone synthesis and secretion
113244175 (PLCB3)
04927 Cortisol synthesis and secretion
113244175 (PLCB3)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
113244175 (PLCB3)
04270 Vascular smooth muscle contraction
113244175 (PLCB3)
09154 Digestive system
04970 Salivary secretion
113244175 (PLCB3)
04971 Gastric acid secretion
113244175 (PLCB3)
04972 Pancreatic secretion
113244175 (PLCB3)
04973 Carbohydrate digestion and absorption
113244175 (PLCB3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
113244175 (PLCB3)
09156 Nervous system
04724 Glutamatergic synapse
113244175 (PLCB3)
04725 Cholinergic synapse
113244175 (PLCB3)
04728 Dopaminergic synapse
113244175 (PLCB3)
04726 Serotonergic synapse
113244175 (PLCB3)
04720 Long-term potentiation
113244175 (PLCB3)
04730 Long-term depression
113244175 (PLCB3)
04723 Retrograde endocannabinoid signaling
113244175 (PLCB3)
09157 Sensory system
04742 Taste transduction
113244175 (PLCB3)
04750 Inflammatory mediator regulation of TRP channels
113244175 (PLCB3)
09159 Environmental adaptation
04713 Circadian entrainment
113244175 (PLCB3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113244175 (PLCB3)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
113244175 (PLCB3)
09174 Infectious disease: parasitic
05146 Amoebiasis
113244175 (PLCB3)
05142 Chagas disease
113244175 (PLCB3)
05143 African trypanosomiasis
113244175 (PLCB3)
09164 Neurodegenerative disease
05010 Alzheimer disease
113244175 (PLCB3)
05016 Huntington disease
113244175 (PLCB3)
05017 Spinocerebellar ataxia
113244175 (PLCB3)
05022 Pathways of neurodegeneration - multiple diseases
113244175 (PLCB3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
113244175 (PLCB3)
05415 Diabetic cardiomyopathy
113244175 (PLCB3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
113244175 (PLCB3)
04934 Cushing syndrome
113244175 (PLCB3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:uah04131]
113244175 (PLCB3)
Enzymes [BR:uah01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
113244175 (PLCB3)
Membrane trafficking [BR:uah04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
113244175 (PLCB3)
Endocytosis
Macropinocytosis
Phospholipase C
113244175 (PLCB3)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Unknown
|
| AA seq |
1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSSYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPNS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGPEKPSLEPQKSLGE
DGLPRGPDALGSADREDEEEEEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQSQQL
GSQLTPNPTPSPLDTSPRRPPGPVTSPTSPSLSSPGQRDDLIASLLSEVAPTPLDELRGH
KALVKLRSRQERELRELQKKHQRKAVALTRRLLDGLAQARTEGRCRQRPGVLGGENEKEE
EEEVRRYQEFQKRQVQSLLELREAQVDTEAERRLEHLRQAQQRLREIVLDFHTTQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGDTPEGLGDGRL
VACASNGHAPGSGGHLSGADSESQEENTKL |
| NT seq |
3693 nt +upstreamnt +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactcgaatggcttctttctgtactggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacggggcgttacgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgcccggctggag
gagaagttgatgacggtggtggctgggccagacccagtgaatacaacattcttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgaaaagcatacacaaagctg
aagctgcaagtgaaccaggacggacggatcccggtgaagaatatcctgaagatgttttca
gcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggccggacgaattttccttggaaatcttcgagcggttcctgaataagttg
tgtttgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccgtac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaagtgctgtacccacccctgcggccctcgcaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaacggcatcctgcctctggaggccctggatctgagcacagacatgacc
cagccgctgagctcctacttcatcaactcctcgcacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccgccaggcgctgctgtggggctgccgctgc
gtggagctggatgtgtggaaagggcggccgcccgaggaggagcccttcatcacccacggc
ttcaccatgaccaccgaggtgccgctgcgagatgtgctcgaggccatcgcggaaaccgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgttccatctttggggacgcgctgctcattgac
ccactggacaagtacccgctggccccaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaaaaagcgacaccggcccagcactggtgtccccaacagc
tctgtgcgtaagcggccgctggagcagagcaactcggccctgagcgagagctctgccgcc
accgagccctcctcacctcagctcgggtcccccagttctgacagctgcccaggcctgagc
aacggggaagaggtgggcccggagaagcccagcctggagcctcaaaagtctctgggcgag
gacgggctaccgaggggccctgatgctcttgggtctgctgaccgtgaggacgaggaggaa
gaggaggaagaggaggaacagacagatcctaaaaagccgaccacagatgagggcactgct
agcagtgaggtcaatgccaccgaggaaatgtcaacactcgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatccttc
gtggaaaccaaggccatggagcagctgaccaagagccccatggagtttgtggaatacaat
aagcagcagctcagccggatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaacgtcggctgccagcttgtcgcgctcaacttccagaccctggac
gtggcgatgcagctcaacgcgggcgtgttcgagtacaacgggcgcagtggctacctgctg
aagcccgagttcatgcggcggccagacaagtccttcgatcccttcaccgaggtcatcgtg
gacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgttcggcctccccgtggacacgcggcgc
aagtaccgcactcggacctctcaggggaactccttcaatcctgtgtgggacgaggagccc
tttgacttccccaaggtggtgctgcccacactggcttcgctgcgcatcgcggcctttgag
gagggcggcaagtttgtggggcatcggattctgcccgtctctgccatccgctcaggatac
cactacatctgtctgcggaacgaggccaaccagccactctgcctgccggccctgctcatc
tacaccgaagcctctgactacatccctgatgaccaccaggactacgccgaggccctgatc
aaccccatcaagcacgtcagcctgatggaccagagagccaagcagttggccgccctcatt
ggggagagcgaggctcaggccggcccagagacctgccaggagactcagtctcagcagctg
gggtcccagctgaccccaaaccccacacccagccctctggacacctccccgcgccggccc
ccaggccctgtcacgtcccctaccagcccctcgctcagcagtccagggcagcgggacgac
ctcatcgccagtctcctgtcagaggtggccccgaccccgctggatgagctccgaggccac
aaggcgctggtgaagctccggagccggcaggagcgagagctgcgggagctgcagaagaag
caccagcgaaaggccgtcgccctcacgcgccggctcctcgacggcctggctcaggcgcgg
acagagggcaggtgccgccagcggccgggggtcctaggcggggaaaacgagaaggaggag
gaggaagaggtgaggcggtatcaagagttccagaagagacaggtgcagagtctgctggag
ctgagggaggcccaggtagatacagaggctgagcggaggctggagcacctgagacaggct
cagcagcggctcagggagattgtcctggattttcacacaactcagttcaagaggctgaag
gagatgaacgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaac
agtatctcagaggccaagacaagggagaaacataagaaggaggcggaactgacagagatt
aaccggcggcatatcaccgagtcggtcaactccatccgccggctggaggaggcccagaag
cagcggcatgagcgccttgtggccgggcagcagcaggtcctacagcagctggcagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggcgaggctgccc
caggagatccgccggagcctgctgggcgacacgccggaggggctgggggacgggcgtctg
gtggcctgtgccagcaacggtcacgcacccgggagcggcgggcacctgtctggcgctgac
tcggagagccaagaggagaatacgaagctctga |