Ursus arctos (brown bear): 113246291 Help Entry 113246291         CDS       T05909                                  Symbol SYNE2 Name (RefSeq) nesprin-2 isoform X1   KO K19346   nesprin-2 Organism uah  Ursus arctos (brown bear) Pathway uah04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:uah00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     113246291 (SYNE2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:uah03036]     113246291 (SYNE2) Chromosome and associated proteins [BR:uah03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     113246291 (SYNE2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  CH Spectrin_SYNE1 KASH Spectrin SYNE1 CAMSAP_CH Motif Other DBs NCBI-GeneID:  113246291 NCBI-ProteinID:  XP_026342626 LinkDB All DBs Position Unknown AA seq 6903 aa AA seqDB search MASSPVPPTEDEHVSLGIDDRHISLQAEQEDTQKKTFTCWINSQLAKHTPPSVVSDLFAD IKKGHVLLDLLEVLSGQQLPRDRGSNTFQCRINIEHALTFLKHRSIKLINIHVTDIIDGN PSIILGLIWTIILHFHIEELARTLSCNYNQPSLDSVSVADSSPTSSPPAKKCSRAQERWQ MSAKKALLLWAQEQCAPCESVSVTDFKSSWRNGMAFLAVIHALRPDLVDMKSVKHRSNKA NLKEAFRIAEQEFKIPKLLEPEDVDVVNPDEKSIMTYVAQFLQYSKDAAEAVERAQGKMK DAVVWLNLQEQKLRKVLKDSENETYSKKYESLLSFLESFNEEKKPFLDILPIRRNLDELN EDRLQLREAWDGLTYQIDVWKTELNHALPSPLHQIEAWLQEIEELIDEDLPASQDYCEAM ALIQEKMTLIKNLMDKCDCHWSTLLAFDNRDEQHLPLVPPKKLEEMKGRINNILGKKFIP RLEFHYYKCSVLGLLDEVKLKLDVWNIKYGNKESVELLLEDWHKFIEEKEFLAQLEASFQ KCEEIHKSLAGEYQDISKEYTTVEYNICMYRKKIYNVKSTLQKVLTCWATYVEKLRLLKA CFEETKKEQIKEVPFETLSQWNVEHTALNEVGNFLIQVSTDEVGSSVSKELRRLNKRWRK FITKTQLEMNLPLIKKQDQPNFDNYENIQLSKEGKPTVDFSTSMSVELPENHNQNIKAGE EHEKENEFTGQLQMAEEVENLIGQMEIWEAETESLLELLRPEEGVDASMEEALQHLIAKG SMYEELVSRTEDTLQMDVQNISSRESLQRVLTVGLQTKIQEAKEKVQINMIKLVAVLKNS ADDSPNLDVRLKVEESQKELDSYMTRAEQLLGQKESPSGLISKYKEALIILNSKSLVKYL KAVEELKNTVSEDVKLSLEDKSRGVCAKWESLHHEMSLYIQQLKIDIEKEKLSDTISKLE KQINKEKKLIRRGRTKGLIKEHEACFSEEGSLYQLNHHMDVLRELCEELTSQKSQQEVRR ALKDYEQKIERLRKCASEIRMTLQPTMGGSLKNKETVNTSENGGRGVHSEVPSAESQDRP STEKAMGSIKNFNLESKLKPQQEESSMQKYEKDQNAALSSLQERYDTHRENLELYLENNK FRIISDFSGDEERSSACLQGKLADLQVLKNETDACWKEFEITSLKLEELDSDIKKPFISN MRGRLKEKEREFQMTLNTRMESLETALKIVLPVEKESLLLCGSDLLLHEIAIQEFHLIDA DGIYQNLKNIQDSIAKQIEICNNLEQSGDAAFKELHPLDLRAAQSIMLKHRTQLEEANHK VQRSKDALRALEEFLTSLRTAELSFELVTDLSASDTQVVRENTVTVEDKEREISLMKDQA RHLDKRLKMLGISLNDAEQGDDTCDKLLVALSRKLFETRGCGGQEELTEENKLLETCIFK NNELLKNIQDVYDQISKISLKDPTVPAVKQRKKSLMRLDKDLDEYEEEKKCLQEMVDSLP QFEDGREKPLNQQFQNTALLWESTKASVTECLDQCERVLELLKQYQNFKGVLTALIQKEE NVISLQASYMGKENLKKRIAEIEIVKEEFSEHLEVVDKINQICRNLQFHLNKMRIFEEPP FEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKVLRKMELNQLA EEEREKLKEELQTHEQKSSEFSKRVAKIQFLLQSSEIPLELQVMESSVLNKIENVKTQLI GESICSALSGNTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKH SMMLLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIT MNLKECFESSETKKSVEQKLQNLSDFLTLEGRGSKIQQVGTVLNHVKKHLPKAHVKELNS WIINQEIELEKMESVCQARAKELNDCLQELLRLQDDHRNLSKWLTSQEEKWKEMEKSGEK TELFCEAVARKREQFESLAQLNSSLKEYGLTEEEEIIVESTHLIDRYQTFLRQLCEIDEE AKLPPTEDQSFNDLAHDAIHWIAGIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDA KIQTIMSQAESSKAPLAPKTLTDIKNEWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLR LMLTELKKKQEVGFALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGSYLLECTKN PSFSERPWLEIKHLHESLLQQLQDSVEKLEGHVQEHHSYQLCVTDLNATLDDISKEFASF SDKPVDQTAVEEKLQKLQELENRLHLQDGTLKKILALAKSIKQNTSSVGQKIIKDDIKSL KCKQKDLENRLESATQETENCLNSILKSTHSTEQREKFTLPGREEEVTPDGQEPTQDSAA LEKFEEDRDTNTNSAVEVVLSKQLSLDIQESMKNTEDEQKVNELQNQPLELDVMLRNEQL KEIEELYAQLEAKKTAIEPLEQTEYLHKAETSALALHDRGHSGQHLDDLLQALITLKKNK ESQYYLLNDFQEHLASVESSVKALLTEKESLKVGPLDSATYLDKIKKFLASVEKEKASLS KMKIEWENLSNCLTDMDKKFLESQIKQLAHSWEQVKQLAQKKYSQQAVEHEELTLLMRKI QDLDISLQQQRQALQLGLNSPEEEEGSARVVAMATELGTIKHRFSVVKGQAEFQMKRIWG EKEKNTLEDAMDNLQKQLEALEPLNIQVENQIKKGEIRNKMKEITLWVKNLLGELTPTIS LLPDDILSQIRKCKVTHDGILDKQQVVESLVEEVKNNIPNLKADESNDLNHLLQDLQSQY QMLVLKSTERSQQLEFKLEERNRFIAAIEKVQLSLQENEALITPEMRAASTEMELEQERV ALTSSQKELLEAQGVIAAHLQEQTNVCKDLSVFERLFLDDQLKNLKTRANRTQRFIQNKC NDVEHKIRFYREFHETGAALQKEVDHIQRSDLLRNQERNEDVKEELYSLKDRITGIQSSI LQALKLKEVFDSVGLNWDCSQLDQLQILVSEKEKELEEKIRQLDVFMAEHGKYQASLSQL KAMDLQIKKRAEGVLGVPHPSPESSLLSAHILEWRIEKAMCLCQEIIKKLNESKAFDDSF KEKEILRIKLYAEENDKLHKILQNGVLKSQPKEMDEKNLQDKLENYLRVLNQIKSQLEQP LLINLDIEHIQKEKENCEAFHEQVQAEMDSMNAVTLMEKQREENSSDTCDMGTKLQDIED LHAQLNTSIDLRIDVLNDAYESMTRYNEAVTRAMGTFTAREAIVASHKIDLDNPEGPLET PGWKQEELQSTIADIQDLTEKLGTISSPEAKQQLQCTLQELVSKDSAIRGAAKVKESEIE RCLENYKCYRKMKEKVCANLSQMEAVLGQSMFPLPASYKEALERLEQSKALGSNLLSTKE ELMKLRQVLRHLRPACTESDDTCLLRTTAALWDKWLSLLEAAKEWEIWCEELKWEWKFVS EEIEREAIILDNLQEDLPEISKTKEAATTEELCELQDSLCRYQENVEKQQLLLTLLLHRM RSIQNVPKSLEAIETISAFQEITSMQERCNKLFQKAQENKELMESEIQERHSFTKEIITL KNLFRQTATSFQNMDLQDHPEKAEQFEELQSIFKKGKLTFENIMEKLRIKYSEMYTLVPA EIESQVEECRKALEDIDEKISNEVLKSSPSYTMSRKIDEINNGLHNVEKMLQQKSKNIEK AQEIQKKMWDELDLWRSRLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAES RTSQLNKATVKMEEYHDLLRSTEAWVENTSRLLANPADYDSSKALSQHASTLQMALEDSE QKHNLLHSIFTDLEDLSIIFETYDLAQSVQELSRQVAALQQKIMESLPQIQRVADDVVAV ETEVKSIEKKVSKIKAILLSKEIFDFSPEEHLKHGEVILENIRPMKKAVAELVSYQVELR WPQTGMKRLPAFQRTNQLLQDVKLLERVTQEQNELLKIVIKQTNECNEDIENLKHILNNY SAEFSHECLSPDQAANLTQVQGDVEGMEKQILSLKQKKENLLVDLKAAILALHQHVQQDQ QAFEPEMPSARAAEEEGEAERDSQWKGNKTGGLSFLPALTEEAEESSLKSENGDKKAEPS SGSWSSLWKPDRDMGEDGASSSSGTIVQEAAEKISTCENPMAQILAPDSLSPSQTEEGAT PPLKAAAPGFSDEQGAFEATVEKSRPKPAEILHACKTQVAELELWLHQANVAFEPETLNA DMQQLVEQQLVGCQAMLTQIEHKVASLLESCKDRGPGDSGATQQEAEALSVKLKTVKCNL EKVQIMLQEKYSEDQHSATLKKPSEHQKDLQPDNPSALESVVTERPQFSRHKDFQQQQVL ELKPMEQKDFIKFIEFNAKNMWPQHCQPDKDTTQKSSESSRASSPENDAPGSVLWARGRS GDKWRYLHHGLSAGLGLPLPEQVQPQVATNMSVLPSVSVYNFRYPTTEELRTYTTQLEDL RQEARNLTQENMTEETYINLDKKLFDLFLTLSQCLGSVGEMLRTPGLFREDVCAQQVHCE TLALELKKLYLAMGDKKNDLVKAMTWPGRNPSLFPECFDNLQVYLEHTQATAASKSKSLK AGLDYNRSYQNEIKRLYDQLIKNKTSLQQSLNEISGQSIDEQLQKADAYTVELQNSESRV AKLRDEGERLHLPYVLLQEVYKLEDVLDSMWGILRARYAELSSPFITESQQDALLRGLAE LVDIGKEKLAHDHLQQTKSKAALQAQIQNHKVFFQKLVADMLLIQTYSNKMLPSLLQKRE TFWAEQIKEVKFLEEKSHQCGIKLQSLLQKWEEFDENYTSLEKDLEILVSTLPSVSLVEE TEERLVERISFYQQIKRNIDEKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLALN KKIDHELHRLQTLLKHLVSYNRDSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNIN NFFEFSKELDNKSSLKAAVVGTGSQLLHLKAADTATLRASLAQLEQKWTMLITQLPDIQE KLHQLQMEKLPSRKAITEMISWMNNVEHQTADEDTERSLSSASQVRNLLQKYKEFRMEMD YKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLL ESITENENKIQILNNWMEAQEERLKTLQKPGSVISVQKMLLDCQDIENQLAIKSKALDEL RQSYLTSESGTMPLLEDTASRIDGLFQKRSSVINQVNELKTSMHSVLQEWKVYDKLYEEV TMMTIRFWYCMEHSKPVVLSLEALRCQVQNLQSLQDEAENSEESWEKLQEVIGKLKDRCP SVAEIIKEKCQETHARWTQVNQDLADQLQKAQSLLQLWKAYNSAHTEAAARLAQQEAKYQ QLENINMSGNNLAEILTPALQDVKELQRDVQKTKEDLLQNSTLLDRLPQLPEASAHVPLS KQLHSLQRASYLEKMLLMKANEFEFVLSQFKDFGDQLESLKGLIVHEEENLDKLNHQEKE ANPDLFLNHVLAMTAQSPDVEHLNEVSLKLPLSDIAVKTLQNVNRRWIRATATALERCSE LQGIGLNEKFLYCCEKWVQLLEKIEETLKVNVADSLPALLEQQKTYEMLEAEVSINQTIA DSYVTQCLQLLDTTEVEKRPEFISKFTKLKDQWQSATQSIRQRKSDIDGLVGQWRYFTTS VEDLLRFLTDTCHLLSAVKSQDCYSLQQTRRLIRELKSKEIHFQRRQTTFELTLEAGEKL LNTANLETEELIDKKIGQLGDKWKDTQLQVGEVMKQLQSNIETWDQCEKKIKELKSRLQV LKAQSRDPLPELHEDLHRQKELIKELEKSLGNWTQNLKELHTLKTDLTQHILVEDVMVLE EQTEHLHRQWEDLCFRVAVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKTRAAEIEDKLNKVNDRWQHLFD VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQD LQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR MKIEETWRLWQKFLDDYSRFEDWLKSAERTAAYPNSSEVLYTSAKEELKRFEAFQRQIHE RLTQLELINKQYRRLARENRTDTASRLKQMAHEGNQRWDTLQRRVTAVLRRLRHFTNQRE EFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGE QLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSHAPGLEEEKEASENETDME DPREIRADSWRKRRESEEPSSPQSLCHLVPPAPGPERSGCETPVSVDSIPLEWDHTGDVG GSSSHEDDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSLPEDHSWHVPDSPSCP KHRYKQMGGDRNVQTIPSDASTPYKPAYVKLLLPPGTDGGKGGSRVSNGSSRQEDEGLAA LSGQQSGAFDRWELMQAQELHNQLRINQSLQQLNSEITDITTWLKEMEAELEMLKTAEPP SDIREMELRVKRLKEILKAFDTYKALVVSVNMSSKDFLQTESAESSELQGRVGQLGLRWD TAQGAVESWREGLRQSLLQCQDFHELSQDLLLWLASAESRRQKARVTDPDADPQVLLECR EELMQLERELVERQPQVNTLQEISDSLLIKGHGEDYIEAEEKVHVIEKKLRQLLEQVSQD LVSLQGRQNPDPSLPSLDEVDAGEQPPAASVPTPQAKFEAERMTTDKHKTDSRVPGPGSS RPRRSFVSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGP PPT NT seq 20712 nt NT seq  +upstreamnt  +downstreamnt atggcatctagtcctgtgccgcccaccgaggatgaacacgtttccttgggcatcgatgat cgccatatttcactgcaagctgaacaggaagacactcagaagaaaacctttacctgctgg atcaactcacagttggcaaagcacacgcctccctcggttgtatcagacctgtttgcagac attaaaaaggggcatgttctcctagacctgctggaggtactctcggggcaacagttgcct cgagacagaggatctaatacattccagtgtagaatcaatatagagcatgccctgacattc ctgaaacaccgatcaatcaagctaataaatattcatgttactgatattatagatggaaac ccatccattattcttggcctaatttggacaattatactacactttcatattgaggagctt gcccggactctttcttgcaattacaatcagccttccctggacagtgtgagtgtggccgac tcatctcctacctcaagtcctccagctaagaagtgctccagagcccaagaaagatggcag atgtctgcaaagaaggctcttctcctgtgggctcaggagcagtgtgccccgtgtgagtcc gtcagtgtgacagattttaagtcaagctggagaaatgggatggcttttttggctgtcatt catgccttgcgaccagacctagttgacatgaagagtgtaaagcacaggtccaacaaagcc aatctgaaagaggccttcagaattgcagaacaagaatttaaaatccccaaattgctagaa ccagaagatgtggatgttgtcaatcccgacgaaaagtcaatcatgacctatgtggcacaa tttctacaatattcgaaggatgcagctgaggctgtagagagagctcagggaaagatgaaa gatgctgtggtctggttaaatctgcaagagcaaaaactacggaaagtgctaaaggattca gaaaatgagacctactctaaaaagtatgaaagtctgctgtcctttttggagtcattcaat gaagaaaaaaagccctttttggacatcctgccgatcagaaggaatctggatgagctgaat gaagatcggttacagttgcgagaagcctgggacggcctcacctaccagattgatgtgtgg aaaacagagctgaatcatgccttgccctcaccgctgcatcaaatcgaagcctggctccag gagatagaggagcttatagacgaagatttgccagcttcccaggattactgcgaagccatg gctctcatacaagagaagatgactttaatcaagaatctgatggataaatgtgattgtcat tggagtactcttctggcatttgacaatagagacgaacaacatttgcccctggttccacct aagaaattggaggaaatgaaaggacgaatcaacaacattttggggaaaaaattcattcca cgtctagaatttcattactataagtgctcagttcttggtttgctagatgaagtgaaatta aagttggatgtttggaacatcaaatatgggaacaaagaatctgtggaattgttgctggaa gactggcataaatttattgaagaaaaagagttcctagctcaacttgaagcttcctttcag aaatgtgaagaaatccataagagtttagctggagaatatcaggatattagcaaagaatat accacggtggaatataatatttgtatgtatagaaaaaaaatatataatgtgaaatccact ctacaaaaagttctgacatgttgggctacttatgtggaaaaacttcgcttactcaaggct tgttttgaggagacaaagaaggaacagattaaagaggtccccttcgagacactgtcccag tggaatgtggaacatactgctttaaatgaagtggggaatttcctaattcaagtcagtact gatgaagttggatcatctgtttctaaagaactgagaaggctgaataaaagatggagaaaa tttattacaaaaactcaacttgagatgaacctgccacttataaaaaaacaggatcagccc aattttgacaattatgaaaatattcagctatctaaagaaggaaaaccaactgttgatttt tcaacatctatgtcagtagaacttcctgaaaatcataatcagaatataaaggctggggaa gaacatgagaaagaaaatgaattcacagggcaacttcaaatggctgaagaggttgaaaac ctcattggacaaatggaaatctgggaggcagagaccgaatcccttttggagcttctgaga cctgaagagggtgtagatgcctcaatggaagaagctttacagcatcttattgccaaaggc tctatgtatgaagagcttgtgtctagaactgaagataccttacaaatggatgtacagaat atttcaagccgggagtcacttcaacgtgttctcacggttgggcttcagacaaagattcaa gaagccaaagagaaagttcagatcaatatgataaaattagttgcagtgttaaaaaactca gctgatgattcaccaaacctggatgtcaggctgaaggtggaagagtcacagaaggagctt gactcctacatgacaagggctgagcaattacttggacaaaaagagagcccgagtggacta atttcaaaatataaggaagcgctaataattcttaattctaaaagtctggtcaagtatctg aaagctgttgaagaactgaaaaatactgtatctgaggatgtaaagctgtctttggaagac aagagtagaggtgtttgtgccaagtgggagtctcttcatcatgagatgtctttatatatt caacaactgaaaatagacattgaaaaagagaaactcagtgacactatttcaaaactcgaa aaacaaataaataaagaaaagaagctaattcgtagagggaggaccaagggtctcatcaag gaacatgaggcctgcttttctgaggaaggcagtctgtaccagctaaaccaccacatggac gtcttgcgggagctgtgtgaagagctgacgtcacagaagagtcaacaagaagtgaggaga gcgctcaaagattacgaacaaaagatagaaagacttcggaaatgtgcttccgagattcgt atgacactgcaacccacgatgggaggctcgttgaaaaacaaggagaccgtgaacacatct gagaacggaggaaggggtgtccacagtgaagtgccatctgcagaatcacaggatcggcca tcaactgaaaaggcaatgggatcgattaagaattttaacctggaatccaagttaaagcct caacaggaagaaagctctatgcagaagtatgaaaaggatcagaatgcagccctcagtagt ttacaagaaaggtatgatacgcacagagaaaatcttgagctgtacctggaaaacaacaaa ttcagaattatttctgatttctccggtgacgaggaaaggagtagtgcttgtctgcagggt aaactggcagacctgcaggtcttaaaaaatgaaaccgatgcttgctggaaagagtttgaa atcacctccttgaagttagaagagcttgacagtgacataaagaagccttttataagtaac atgagaggcagattaaaggaaaaagaaagagagtttcagatgactcttaataccagaatg gaatctctggagaccgcactgaagatcgtgttacctgtggagaaggagtcacttctactc tgtggctcggacctgcttctccatgaaatagccattcaagaatttcatctcattgatgct gatggcatttatcaaaacctgaagaatatccaagattccatagccaagcagattgaaata tgtaacaacctggaacagtcgggcgacgctgcgttcaaggaattacacccacttgatcta cgtgcagcgcagtctattatgctgaagcacagaacacaactcgaagaagcgaaccacaag gtacagaggagcaaagatgccctcagagctctggaggagtttctgacttctctgagaaca gctgaactctcttttgagcttgtaacggacctttcagcctcagatacccaggtagtacga gaaaacactgtgacggtagaagataaagaaagagaaattagtctgatgaaggaccaggcc agacatttggataaacgtttgaagatgctcggcataagcttgaacgatgctgaacagggt gacgacacctgtgacaaactccttgttgctttgtcgagaaagttgtttgagacacgtggc tgcggcgggcaggaagagctcaccgaagaaaacaaattactagagacttgtattttcaaa aataatgaactcctgaaaaacattcaggacgtgtacgatcaaatcagcaaaatcagtctt aaggatcccacggttccagctgtaaaacaacggaaaaaatcactaatgagactggataag gatctagatgaatatgaagaagagaagaaatgcttgcaagagatggttgattctcttcca caatttgaagatggcagagaaaaacctctgaatcaacagttccaaaacacagcacttttg tgggagagtacaaaagcttcggtcactgaatgccttgaccaatgtgaacgagttttggag ctcttaaaacaatatcagaattttaaaggtgtcttgactgctttgattcaaaaagaagag aatgtcatctcccttcaggcttcctacatgggaaaagagaacctgaagaaaaggatagcg gagattgaaattgttaaagaagaatttagtgaacatttagaagttgtagacaagattaac cagatctgcagaaatctacaatttcatctaaataaaatgagaatttttgaagagcctcct tttgagaaagaagctaatattattgtggatagatggcttgatataaatgaaaagacagaa gactactatgaaaatcttggtcgagctctagcattatgggacaaactttttaacttaaaa aatgtcatcgatgagtggactgaaaaggtccttcgaaaaatggaattaaatcaactggct gaagaagaaagagaaaagctgaaggaagagcttcaaacccatgaacaaaaatcttcagag ttctctaaaagagtggctaaaatacagtttctccttcaaagcagtgaaataccccttgaa ttgcaggtcatggagtcctctgttttaaacaagatagaaaatgtaaagacgcagttaata ggagaatccatctgctctgcgcttagtggcaacacagctgagctcagggaggacctcgac caagccaagacccagattggaatgactgagtcgctcttaaaagccctgtctccttccgac agcttagagatcttcactaaactggaggaaatacagcagcaaatcctgcagcaaaagcac agcatgatgttacttgagaatcaaataggttgtctgactcctgaactctctgaattaaaa aagcaatatgaaagcgtcagtgatttatttaataccaaaaaaagtgttttgcaagatcac ttttctaagttattgaatgatcagtgcaagaactttaatgactggtttggcaacattaca atgaaccttaaagagtgttttgaatcttcagaaacaaaaaagagtgtggaacaaaagcta caaaacctttctgatttcttgactcttgaaggaagaggcagtaaaatacagcaggtggga actgtactgaatcatgtgaagaagcacctgcccaaagcacatgttaaggagcttaacagt tggattataaatcaagaaattgaattagaaaaaatggagtccgtttgccaggcacgagca aaggagctcaatgactgcttgcaggagctactgagactccaggatgaccacagaaatctg agcaagtggttgactagtcaagaagagaaatggaaagaaatggaaaaatcaggagagaaa actgagctattttgtgaagctgtagccagaaagagggaacagtttgaatctctggcccag ttgaacagctctttgaaggaatatgggcttactgaagaagaggaaatcatagtggaatca acacatttgattgatagataccagacatttttgagacaattatgtgaaattgatgaagag gctaagttacctcctacagaggaccagagctttaatgatcttgcacatgatgcaattcac tggatagcagggattaaagagtcccttatggttttgaattcatctgaaggcaaaatgccg cttgaggaaagaatccaaaaaataaaggaaatcattttactgaagcctgaaggggacgct aaaatacagaccatcatgagtcaggctgagagcagcaaggctccattggctccaaagacc cttactgatatcaagaacgagtgggacaacacactccatttagccaacacatatctaagc catcaagaaaagcttctacttgaaggagagaagtatttgcaaagtaaggaggatctgaga ttaatgctcacagaactaaaaaagaaacaggaagtgggctttgctctgcagcatggcttg caggagaagaaagctcagttaaaaatttataagaaattccttcagaaagcacaagatttg acatccttgctaaaagagttaaaatctcaaggaagttacctcttagagtgcactaaaaat cccagcttcagtgaaaggccttggctggaaataaagcatctacacgaaagtcttctccaa cagctacaggattctgtggaaaaattggaaggtcatgttcaagaacaccactcataccag ctttgcgtcacagacctgaatgccacattggatgatatctccaaggaatttgccagtttt tctgataagcctgtggatcaaacagcagttgaggaaaaactgcagaaactgcaggaacta gagaatagactccatttacaagatggcacattaaagaagattttagctttagcaaaatcc atcaagcaaaatacatcttcagtaggacagaagattattaaagatgatataaaatcactt aagtgtaaacaaaaggatttggaaaacagacttgaatctgctacgcaggagacagaaaat tgtctcaatagcattctcaaatcaacacactcaacagaacagagagaaaagtttactctg ccaggcagagaggaggaggtcactcctgatggtcaggagcccactcaggactccgctgcg ctggaaaagtttgaggaagaccgggacacaaacacgaattcagctgtggaagtggttttg tcaaaacaactttctctggatattcaagaaagcatgaaaaacactgaagatgagcagaaa gtcaatgagctgcaaaatcaacctttagaattagatgttatgttaagaaatgaacaatta aaagagatagaggaattatatgcccagttggaagcaaagaaaacagccattgaaccacta gaacaaactgagtatctccataaagcagaaacaagtgccttggctcttcacgatagggga cattcggggcagcacttggacgatctgcttcaggcactaattactttgaagaaaaataag gaaagccaatattatctccttaatgattttcaggaacaccttgcttcagttgaatcctca gtgaaagccttattgacggaaaaggaaagtcttaaagtggggcctctggacagtgccacc tatctggacaaaattaaaaaattcctggcatccgtcgaaaaagagaaagcttccttaagc aagatgaaaatcgaatgggaaaacttatctaactgcctgaccgacatggataagaagttt ttggaaagccagatcaagcagctcgcacacagctgggaacaggtgaaacagctggctcaa aagaagtattctcagcaagcagtagaacatgaggagttgacacttctcatgaggaagatc caagacctggacatctctctgcagcagcagcggcaggctctacagttagggctcaactct cccgaagaagaggaggggagcgctcgcgtagttgccatggccaccgaactcgggaccatc aagcatcgattttccgtggtaaaggggcaagctgaatttcagatgaagaggatctgggga gaaaaagaaaagaatactttggaagatgcaatggataatttgcagaagcaattagaagcc ttggagccgttaaacatccaggtggaaaatcagatcaagaagggcgaaataaggaacaag atgaaagagattaccctgtgggtcaagaacctgctgggtgaactcactcccaccatttcc cttctcccagacgacattctttcacagatcagaaaatgcaaggtgacacacgatggcatc ctggataagcagcaggtggtggagtcattggttgaagaggtcaaaaataacattcctaac cttaaggcagatgagagcaatgatttaaatcacctcctacaggacttacagagtcaatac caaatgctagttttaaaatcgacggaaagatcgcagcaactagaatttaagttggaagaa agaaacaggtttattgcagccatagagaaggtgcagctttcacttcaagagaatgaagca ctgataactcccgagatgagagcagcctctacagagatggaactagagcaggagcgagtt gcgttgacgagttctcagaaggagctgctggaagctcagggtgtcatcgcagcccacctt caggaacaaacaaatgtctgtaaggatctaagtgtgtttgaaagattatttctggatgac caactgaaaaatcttaagacgagagccaacagaactcaaagattcattcagaacaaatgt aatgatgtagaacacaagatacgtttttacagagaattccatgaaacaggagctgcgctt cagaaggaggttgaccacatacagcgcagtgacctgctacgaaatcaagaaagaaatgaa gacgttaaagaggagctctacagtcttaaagaccgaatcactggtattcagtctagtatc ctccaggcactgaaactcaaagaagtgtttgactctgtaggactaaactgggattgttcc cagcttgaccaattacaaatcctagtatctgaaaaagaaaaggaactcgaagaaaaaatt aggcagttggacgtatttatggcagaacatggcaagtatcaagcgtcactaagtcaattg aaggctatggatttgcaaattaagaaaagggctgaaggagtattaggagtgccccatcca tcacccgaaagcagtctgctcagtgctcacattttggagtggagaattgagaaagccatg tgcttgtgtcaagagataataaagaaattaaatgaaagtaaggcctttgatgactccttc aaagagaaagaaatactccgaataaagctgtatgcagaagaaaatgacaagttacacaag attctccaaaacggggtactaaaatcccaaccaaaagagatggatgaaaagaaccttcag gacaaactggaaaattacttacgtgttttgaatcagataaagtctcagttagagcagcct ttacttataaatttggacattgaacatattcaaaaagaaaaggagaattgtgaagcgttt cacgagcaagttcaggcggaaatggatagcatgaacgctgtgacccttatggagaagcaa agagaagaaaattcttctgacacttgtgatatggggacgaaattgcaggacatcgaagac cttcacgcgcagcttaatacaagcattgatttgcgcatagatgttttgaatgatgcttat gaaagtatgacacgctataatgaggcagtcaccagggcgatgggaacctttactgcccgt gaagccattgttgcctcccataaaatagaccttgataacccagaaggaccactggagacg cctggctggaaacaagaggagttgcaatccacaatagcagatatccaggacctcactgag aaactggggactatctccagccctgaagccaaacaacaactccagtgtactctacaggaa ttggtttctaaggattcagccattaggggggcagccaaagtaaaggaaagtgaaatagaa aggtgtcttgagaattacaaatgctatagaaaaatgaaagagaaagtttgcgctaacctc agccaaatggaggcagttcttgggcagtccatgttcccgttgccggcatcttacaaagaa gctttagagcgcttggaacagagcaaggctttggggtcaaatcttctgtcaaccaaagaa gagttaatgaaactacgtcaggtcctcaggcatctgagacccgcgtgcacagagagtgat gacacctgtttgctcagaaccacggcagctctgtgggacaaatggttgagtttgctggag gctgctaaagaatgggagatatggtgtgaggaactgaagtgggagtggaaatttgtcagt gaagaaattgaacgagaagcaattattttagataatcttcaagaagatctccctgaaatt tcgaaaacaaaagaggcggccactacagaggagctctgtgagctgcaagactctttatgc cgttaccaggaaaatgtggagaagcagcagctgttactgaccttacttcttcatcgcatg agaagtatccagaatgttcccaaaagcttagaagctatagaaacaatttcagcatttcaa gagattacctcgatgcaagaacgatgcaacaagctttttcagaaagctcaagaaaataag gaattgatggagagtgaaatccaagaaagacattctttcacaaaagaaataattactttg aagaatttatttcgacagactgcaacttctttccaaaatatggacttacaagatcaccca gaaaaggcagaacagtttgaggagcttcaaagcatttttaagaaagggaagctaactttc gagaatattatggaaaaactgcgaatcaagtattctgaaatgtacacgctagtccctgca gagattgaatcccaggtggaagagtgcagaaaagctttagaagacatagatgagaagata agcaacgaagttttgaaaagctcaccctcatatacaatgagtagaaaaatagatgaaatt aacaatggcctccacaatgttgaaaagatgttgcagcagaaaagcaaaaatattgagaaa gctcaagaaattcagaagaaaatgtgggacgagctagacctctggcgttccaggctcaat gagctggattccgaagtgcaggacattgttgaacaggatcccggacaggctcaagaatgg atggataacctgatgattcctttccagcaatatcagcaagtctcacagagagcagaatct agaacctcacagctgaataaggccacagtcaagatggaggaatatcacgaccttttgagg agtacagaggcctgggtagaaaacaccagccgtctgctggctaatcctgcggactatgat tcttcgaaggcgctgagtcagcacgccagcacccttcagatggctttggaagattcagaa cagaaacacaatcttttgcattcaattttcacggatctagaagacttgtcaataattttt gaaacctatgatttagcacagtctgtacaagagttaagtcgtcaagtagcagctttacaa caaaaaatcatggaaagccttccacagattcagcgggtggctgatgatgtggttgctgtc gaaactgaagtaaaatcaatagagaaaaaagtttcaaaaatcaaagctatcctcttatca aaagaaatatttgatttttcaccggaagaacatcttaagcatggggaggtcatacttgaa aacatacgtcccatgaagaaagccgttgctgaactcgtgtcttaccaagtggaactgcgg tggccccagacaggaatgaaacgtctgcctgcatttcagcggacaaatcagcttctacaa gatgtaaaactgttggaaagggtgactcaggaacaaaatgaattattaaagatcgtcata aaacagaccaacgaatgcaatgaagacatagaaaatttgaagcacatcttaaataattat tcagctgagttctcccatgaatgtctatcaccagaccaagctgccaacctgacacaagta cagggagatgtcgaaggtatggaaaagcagattctgagtttgaagcagaagaaggagaac ctgctggtggacctgaaggcggccatactggcccttcaccagcacgtacagcaagatcag caggcattcgagccagaaatgccgtcagcccgagcagcagaagaggagggagaggctgag agggattctcagtggaaggggaacaaaaccggtggcctgtccttcctgccggcgctcacg gaagaggcggaagagagctccctgaagagcgaaaatggagataagaaagcagagccgtct tctgggtcttggtcttcactctggaagcctgacagggacatgggggaagatggagcatcc tcgtcctctggaaccatcgttcaggaagcagctgagaaaataagcacatgtgaaaatcct atggcacaaattcttgcaccagattcactgagtcccagccaaacagaggagggtgccacg cctcctctcaaggctgccgctccgggcttttccgacgagcaaggagcttttgaggccacg gtggagaaatcgaggcccaagcctgcggaaatcctccatgcctgcaagacccaggtggcc gagctggagctgtggctgcaccaagccaacgtggcattcgagccggaaacattaaatgca gacatgcagcagttggtggaacagcagctggtagggtgccaggctatgctaacacagatc gagcacaaggttgcttctctgctggagagctgcaaagatcgggggccaggagacagtggg gccactcagcaggaggctgaagctctttccgtgaaattaaagactgtgaagtgcaatttg gaaaaagtccagatcatgcttcaggagaaatacagcgaagaccagcattctgccactcta aagaaaccttcagagcatcagaaggatctccaaccagataacccttctgcattggaatct gttgtaaccgaaaggccacagttcagcagacacaaagatttccagcagcaacaggttctg gagttaaagccaatggaacagaaagatttcatcaaattcatcgaatttaatgccaagaac atgtggccccagcattgccaacctgataaagatacaactcagaaatcatctgaaagcagt agggcgtcaagccccgagaacgatgctccaggctctgtcctgtgggctcggggccggagt ggagataagtggcggtacctacatcacggactctcagcaggactcgggctgccgctccct gagcaggtgcagcctcaggttgccacaaatatgagtgttctgcccagtgtgagtgtgtat aacttcagatacccgacaactgaagaactgagaacatacaccacacagctggaagacctg cgtcaggaagcgaggaatctgacccaggaaaacatgacagaagaaacatacataaatttg gataaaaaattatttgacctatttctgaccctcagtcagtgccttggcagtgtgggcgag atgctgcggacacccgggctcttcagagaggatgtctgtgctcagcaggtgcactgcgag acactggctcttgaattgaaaaaactttacttagctatgggtgacaagaagaatgacctt gtaaaagccatgacttggcctgggaggaaccccagcttgtttcctgaatgttttgacaac ctccaagtctacctggagcacacccaggccacagctgcctctaaaagcaagtccctgaaa gctggtctcgactataaccgcagttatcagaatgaaataaagcgactgtatgatcaactt attaagaacaaaacatctttacaacagtctttgaatgaaattagtggccagagtattgat gaacagcttcagaaagcagatgcgtatacagtggagctgcagaactccgagagccgggtg gcaaagctgagagacgaaggggagaggcttcatttgccttatgttttattgcaagaggtt tacaaattagaggatgtacttgacagcatgtggggaatcctgagagcccggtacgcagaa ctcagcagccctttcatcactgagagccagcaagacgccttgctgcgaggcttggcagag ctagtagatatcgggaaggagaagcttgctcatgaccacttacaacaaaccaagagtaaa gctgccttacaggctcaaatacaaaatcacaaggttttttttcagaagcttgttgctgat atgctgttgatccagacatactccaacaaaatgcttccttctttattgcaaaagagagag acattttgggcagaacaaataaaagaagttaaattcctggaggaaaagtcacaccaatgt ggaataaagctgcagagcttgctacagaaatgggaagaatttgatgaaaactatacatct cttgaaaaggatctggaaattctggtatctacattgccctctgtgagtttggtggaagag acagaggaaagattagtggaaaggatttcattttaccagcaaataaaaagaaacattgat gaaaagcatgcccggctctaccaaactctgaatgaaggcaaacagctggtggcatccgtg agctgtcccgaactagagggccagattgcaaagctagaagagcagtggttggccctgaac aaaaaaatcgaccatgaactgcacagactacaaacacttctcaagcatctggtcagttat aacagagattcggatcagttaaccaaatggttggaatcttctcagcaaactctgaattac tggaaagaacaatccctcaatgtgtctcaggacttggatacaatcagaagcaacataaac aacttttttgagttttcaaaggaactcgacaacaagtcttccttgaaggccgcagtcgtg ggaaccgggagccagcttctccacctgaaagcggccgatacggccacgctgagggcttcc ttagcgcagttggaacaaaaatggacaatgctcataactcaacttccagatattcaagaa aaacttcaccagcttcagatggagaaactgccgtctcgtaaagcaatcacggaaatgatt agctggatgaacaatgtggaacatcagaccgcagatgaggacactgagcgttcactgagt tctgcgtctcaagtgagaaatcttcttcagaagtacaaggagttcagaatggaaatggac tataaacagtggatcgttgattttgttaaccagtcattacttcagttaagcacctgtgat gtagaaagtaagcgctatgagagaacagagtttgcagagcacctgggagagatgaaccgc caatggcagcgggtacatggaaccctaaatagaaagatacagcacttagaacaacttttg gaaagtatcactgagaatgaaaacaaaatacagattttgaacaactggatggaggcacaa gaggagagactgaaaactttacaaaaacctggcagtgtgatctcggtgcagaagatgctc ctggactgtcaggatatagaaaatcaacttgcaattaaatccaaagccctggatgagttg agacaaagttacctgacttcggagagtgggacgatgccactgttagaagacacagcatcc agaattgatgggttatttcaaaaaaggagcagtgttatcaaccaggtcaatgagctcaag acctccatgcactcagttttacaggagtggaaggtttatgataaactgtatgaggaagtg acaatgatgacaatccgattctggtactgcatggagcacagcaagcctgtggttttgtca ttagaagccttaagatgccaggtgcagaaccttcagtctcttcaggatgaagccgagaac agtgaagaaagttgggagaaactgcaggaggtgattggaaaactcaaagatcgctgcccc tcagttgctgagataatcaaagagaaatgccaagagacgcatgccaggtggacccaggta aaccaagacctcgcagaccagttgcagaaggcccagagtctgctgcagctctggaaggcc tataacagtgctcacacggaagccgcagcaaggctggcgcagcaggaagcaaagtaccaa cagcttgaaaacatcaacatgtctggaaacaacctggcagagatcctgaccccagccctg caggatgtaaaggagctgcagcgtgatgtacagaagaccaaagaagaccttctccagaat tccactctcctggatcgacttccgcagctcccggaggccagcgcccacgtgcccctctcc aaacaactgcactccctccagagggcttcttacttggaaaagatgctgctcatgaaggct aatgaatttgagtttgttctgtcacagttcaaggattttggggaccagttggaatcttta aaaggtctcattgtgcatgaagaagagaatttggataaactcaaccatcaagagaaagaa gccaaccctgacttattcctgaaccatgtgctggcaatgacagcccaatcacctgatgtt gaacatttgaatgaagtaagcctcaagctcccacttagtgacatagccgtaaagacattg caaaacgtgaaccggcggtggattcgggccacagcaactgccctggaacgctgcagtgag cttcagggaattggattgaatgaaaagtttctttattgctgtgaaaaatgggtccagctt ttggagaagatagaagagacactcaaggtgaatgttgccgacagcctcccagctctcctg gagcagcagaaaacatacgagatgttagaagctgaagtttctataaaccagacaattgct gattcttatgtcacccagtgcttacaactcttggacacaacggaagtagagaagagaccg gaatttatttcaaagttcacaaaactgaaggaccagtggcagagcgccacccagagcatc cggcagaggaagagtgacatcgatgggctggtggggcagtggcggtacttcaccacctcc gtggaggacttgctccgcttcctcacggacacctgccacctgctgtctgcagtgaagagc caggactgctacagcctccagcaaaccagaaggctgatccgtgagctgaagagtaaagaa attcattttcagagacggcaaactacctttgaactaacattagaagctggggagaagtta ctgaatacagctaacctggaaactgaagagttgattgacaagaaaatcggtcaacttggg gacaagtggaaggacacgcagctccaagtaggagaggtgatgaaacagttgcagagcaac atagagacctgggaccagtgtgaaaagaaaatcaaggagttgaaaagcaggctgcaagtt ttaaaggcacaaagtagagaccctcttccagaacttcatgaggacctccacagacaaaaa gagctgattaaggaactagaaaagtctttgggcaactggacgcagaacttgaaagaactt cacactctgaagaccgacttaacccagcacattcttgtggaggacgtgatggttttggag gagcaaacagagcatttgcacagacaatgggaggacctctgcttccgagtggctgtccgc aaacaggagattgaagatagactcaattcatggattgtgttcaatgaaaaaaataaagag ttgtgcgcatggctggtgcagatggaaaacaaagtgctccagacggcagatattagtatc gaagaaatgattgagaagttacagaaggactgcatggaagaaataaacttgtttagtgaa aacaagttacagttaaagcagatgggtgaccagttgatcaaggccagcaacaagacaaga gcagctgagatcgaggacaagctcaacaaagtcaacgaccgttggcagcatctctttgac gtcattggatcacgggtgaagaagctgaaggagacctttgcttttattcagcagttagac aaaaacatgagcaaccttcgtacctggttggctcgaattgagtcagagctctctaagcct gtcgtgtatgacgtctgtgacgatcaagagatccagaagaggctcgccgagcagcaggac ctgcagcgagacatcgaacaacacagcgcgggcgtggagtctgtgtttaacatctgtgat gtcctcctgcatgactctgatgcctgtgccaacgagaccgagtgcgactccatccagcag accaccagaagcttggacagacgctggaggaacatctgcgccatgtcgatggaacggcga atgaaaatcgaggagacttggcgcctgtggcagaaatttctagatgattactcccgcttc gaggactggctcaagtccgccgagaggacggcagcctatccgaattcctcagaggtgttg tacacgagtgccaaagaagagctgaagaggttcgaggccttccagcggcagatccacgag aggctgacgcagctcgagctcatcaacaagcagtaccggcggctggcgcgcgagaaccgc accgacacggccagcaggctgaagcagatggcgcacgagggcaaccagcgctgggacacc ctccagaggcgggtcacggccgtgctgcggagactcagacatttcaccaaccaaagggag gaattcgaggggaccagggagagcattctggtgtggctcacggagatggacctgcagctg accaacgtggagcacttctcggagagcgacgccgatgacaagatgcgccagctgaacggt ttccagcaggaaattacactgaacaccaacaagatcgatcagctcattgttttcggggag cagctgatccagaagagcgagccgctggacgccgtgctgatcgaggacgagctggaggag ctgcaccggtactgccaggaagtcttcggccgcgtctcccgcttccaccgcaggctcacc tcccacgccccgggcttggaagaggaaaaagaggcctcagagaatgaaacggacatggag gaccccagagagatccgggccgactcctggcgtaaaaggagagagagcgaggagccctcg tctcctcagtccctttgtcatctggtgcccccggcgccggggcccgagcggtctggctgc gagacccctgtcagcgtggactccatccctctggagtgggatcacacgggggacgtgggg ggctcgtcctcccatgaagatgacgaggaaggcccgtactacagcgcactgtcagatgta gaaatccctgaaaatcctgaggcatatcttaaaatgaccacaaaaactttgaaagcgtct tctggtaaatcccttcctgaagaccactcgtggcatgttcctgacagcccttcctgcccc aagcatcgctacaaacaaatgggaggtgataggaatgtacagaccatcccctcagatgcc agcaccccttataagccagcctatgtaaagctgctgttacccccgggcactgatggtggc aaaggaggctccagagtctcgaacggcagctcacggcaggaagacgaaggcctggccgct ctcagcgggcagcagtcaggtgcctttgacagatgggagctgatgcaagcccaggaactt cacaatcagctcagaataaaccaaagcttgcaacagctgaactctgagatcaccgacatc accacttggctgaaagaaatggaagcagagctagaaatgttgaagacggcagagcctccc tctgatatccgggaaatggagctccgcgtgaagcgactcaaggaaatcttaaaagccttt gacacctacaaggctttagtggtctctgtcaacatgagcagcaaggactttctgcagacc gagagcgcggagtccagcgagctccagggtagagtcggccagctggggctgcgctgggac acggcccagggcgcggtggagagctggcgagagggcttacggcagtccctcctacagtgc caggacttccacgagttgagtcaagatctgttactgtggttggcgagtgctgagagccgg aggcagaaggctcgggtcacggacccagacgcagacccccaggtcctcctggaatgccgg gaagaactgatgcaactggaaagggaacttgtggaacgtcaacctcaagtaaacacctta caagagatttcagacagccttcttattaaggggcatggagaagactatattgaggctgaa gagaaagtgcatgttattgagaagaagctcagacagctactcgagcaagtgtcccaagac ttagtgtccttgcagggacgccagaacccagacccatctctgcccagcttggacgaagta gacgccggagagcagccgccagccgcatccgtgccaactccccaagcaaagttcgaagca gagagaatgacaacagacaagcacaagacagacagcagggtgcccggccccggcagctcc cggccccgccgctccttcgtgtcccgggtgatcagggccgcgctgcccctgcagctgctt cttctgctgctgctgctcctggcctgcctgctgccctcctccgaagaggactacagctgc actcaggccaacaactttgccaggtccttctaccccatgctgaggtacaccaacgggccc ccccccacctag

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