Ursus arctos (brown bear): 113252535
Help
Entry
113252535 CDS
T05909
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah00562
Inositol phosphate metabolism
uah01100
Metabolic pathways
uah01521
EGFR tyrosine kinase inhibitor resistance
uah04012
ErbB signaling pathway
uah04014
Ras signaling pathway
uah04020
Calcium signaling pathway
uah04062
Chemokine signaling pathway
uah04064
NF-kappa B signaling pathway
uah04066
HIF-1 signaling pathway
uah04070
Phosphatidylinositol signaling system
uah04072
Phospholipase D signaling pathway
uah04360
Axon guidance
uah04370
VEGF signaling pathway
uah04380
Osteoclast differentiation
uah04517
IgSF CAM signaling
uah04611
Platelet activation
uah04613
Neutrophil extracellular trap formation
uah04625
C-type lectin receptor signaling pathway
uah04650
Natural killer cell mediated cytotoxicity
uah04662
B cell receptor signaling pathway
uah04664
Fc epsilon RI signaling pathway
uah04666
Fc gamma R-mediated phagocytosis
uah04670
Leukocyte transendothelial migration
uah04722
Neurotrophin signaling pathway
uah04750
Inflammatory mediator regulation of TRP channels
uah04919
Thyroid hormone signaling pathway
uah04933
AGE-RAGE signaling pathway in diabetic complications
uah04935
Growth hormone synthesis, secretion and action
uah05167
Kaposi sarcoma-associated herpesvirus infection
uah05169
Epstein-Barr virus infection
uah05170
Human immunodeficiency virus 1 infection
uah05171
Coronavirus disease - COVID-19
uah05200
Pathways in cancer
uah05205
Proteoglycans in cancer
uah05206
MicroRNAs in cancer
uah05214
Glioma
uah05223
Non-small cell lung cancer
uah05225
Hepatocellular carcinoma
Module
uah_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
113252535 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
113252535 (PLCG2)
04014 Ras signaling pathway
113252535 (PLCG2)
04370 VEGF signaling pathway
113252535 (PLCG2)
04064 NF-kappa B signaling pathway
113252535 (PLCG2)
04066 HIF-1 signaling pathway
113252535 (PLCG2)
04020 Calcium signaling pathway
113252535 (PLCG2)
04070 Phosphatidylinositol signaling system
113252535 (PLCG2)
04072 Phospholipase D signaling pathway
113252535 (PLCG2)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
113252535 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
113252535 (PLCG2)
04613 Neutrophil extracellular trap formation
113252535 (PLCG2)
04625 C-type lectin receptor signaling pathway
113252535 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
113252535 (PLCG2)
04662 B cell receptor signaling pathway
113252535 (PLCG2)
04664 Fc epsilon RI signaling pathway
113252535 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
113252535 (PLCG2)
04670 Leukocyte transendothelial migration
113252535 (PLCG2)
04062 Chemokine signaling pathway
113252535 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
113252535 (PLCG2)
04919 Thyroid hormone signaling pathway
113252535 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
113252535 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
113252535 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
113252535 (PLCG2)
04380 Osteoclast differentiation
113252535 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113252535 (PLCG2)
05206 MicroRNAs in cancer
113252535 (PLCG2)
05205 Proteoglycans in cancer
113252535 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
113252535 (PLCG2)
05214 Glioma
113252535 (PLCG2)
05223 Non-small cell lung cancer
113252535 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
113252535 (PLCG2)
05171 Coronavirus disease - COVID-19
113252535 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
113252535 (PLCG2)
05169 Epstein-Barr virus infection
113252535 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
113252535 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
113252535 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uah04131
]
113252535 (PLCG2)
Enzymes [BR:
uah01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
113252535 (PLCG2)
Membrane trafficking [BR:
uah04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
113252535 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
113252535 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF_HAND_2_PLCG
C2
SH3_1
PH
SH3_9
PH_12
EF_HAND_1_PLCG
SH2_1
PH_14
SH3_2
Motif
Other DBs
NCBI-GeneID:
113252535
NCBI-ProteinID:
XP_026351093
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTALVNVDTLPEYEKSQIKRALELGTVMTVFSFRKYTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTVLYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFLEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLTKVRERMTKFIHDTVRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLMKPTEASADQLPSPSQLRERIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
ASAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYF
LTDNLTFTSIYALIQHYRETHLRCTEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTFDGEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKQFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAATQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccgccctggtcaacgtggacacccttcctgagtacgagaagagtcagatcaagaga
gcgctggagctgggcacggtgatgacggtgttcagtttccgcaagtacaccccagagcgg
aggaccgtccaggtgatcatggagacgcgccaggtggcctggagcaagacagccgacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgcccagggaagaactccaag
gactttgagcgtgccaaagctgtccgccagaaggaagactgctgctttaccgtcctgtac
ggcacccagtttgttctcagcacgctcagcttggcagccgactccaaagaagatgcgact
aagtggctgtctggcttgaaaatcttacaccaggaagcaatgagcgcctccacacccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcagcctccgagagctgaagacaatcttacccctggtcaacttcaaagtgaacagtgcc
aagttcctcaaagataagtttctggaaatcggcgcgcacaaagatgaactcagcttcgag
cagttccacctgttctacaaaaaccttatgtttgagcaacaaaagtcgattcttgacgaa
ttcaaaaaagattcttctgtgttcatcttgggcaacaccgaccggccggacgcctctgct
gtttacctgcacgacttccagcgctttctcttacacgagcagcaggagctttgggctcag
gatctgaccaaagtccgtgagcggatgactaagtttatccacgacaccgtgagggaaact
gctgagcccttcttatttgtcgatgagttcctcacgtacctgttctcgcgggagaacagc
atctgggatgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtcgcat
tactggatctcctcttcgcataacacgtacctcaccggtgaccaactgcggagcgagtca
tccacggaagcgtacgtccgctgcctgcggatgggctgtcgctgcattgagctggactgc
tgggatgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacttcaagcttccca
gtgatcctgtccatcgaggagcactgttgcgttgaacagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgaccagctgctgatgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaggataatcatcaagcataagaagctgggcccg
cgaggtgacgtggatgtcaacatggaggataagaaagatgagcacaaacaacagggtgaa
ctgtacatgtgggattccatcgaccagaagtggactcggcactactgtgccatcgctgat
gccaagctgtcgttcagcgacgacattgaacagactgcagaagaggaactgccccaggac
ataccccctacggagctgcactttggggaggagtggttccacaagaaggtggagaagagg
gcgagtgccgagaagctgctgcaggaatactgtgcggagacagggggcaaggatgggacc
ttcctggtgcgggagagcaagaccttccccaacgactacacgctgtccttctggcggtcc
ggccgggtccagcactgccggatccgttccaccatggagggcgggaccatgaagtacttc
ctgacagacaacctcacgttcaccagcatctatgccctcatccagcactaccgcgagacg
cacctgcgttgcacagagtttgagctccggctcaccgaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgatgggctgagccgcggggaagcagaggacatgctc
atgagggttccccgggatggcgccttcctgatccggaggcgggagggcaccgactcctac
gccatcaccttcagggccaggggcaaggtaaagcactgtcgcattcaccgggacggccgg
cactttgtgctggggacctcggcctactttgagagcctcgtggagctcgtcagctactac
gagaagcacgcgctctaccggaagatgcggctgcgctaccccgtgacgccggagctcctg
gagcgctacaatatggaaagagacataaactccctctatgacgtcagcagaatgtatgtg
gatcccagcgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggaaccctggggctggtggaaaggagactatgggaccagaatccagcagtacttccca
tccaattacgtcgaggacatttcaacattcgacggggaggagatggagaagcagattatt
gaagacaatcccttagggtctctttgtaggggaatattggatctcaacacctataacgtc
gtgaaagccccccaggggaaaaaccagaaacagttcgtgtttatcctggagcccaagaag
caaggcgaccccccagtcgagtttgccacggacaaggtggaggagctcttcgagtggttc
cagagcatccgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtagtttactgcaagccaacc
agcaagaccaaggataatctagaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggcggacagtgtcgtcaggcagaaacccatcgacctcctgaagtacaatcagaag
ggcctgacccgtgtttacccaaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaacttccagacgccagacaagtac
atgcagatgaatcacgccttgttctcactcaacgggcggacgggctacgtcctccagcct
gagagcatgaggtccgagaagtatgaccccatgccaccggagtcccagaggaagatcctg
atgactctgtcagtcaaggttctcggggctcgccatctccccaagcttggacgaagtatt
gcgtgtccctttgtggaggtggaaatctgcggagccgaatatgacaacaacaagtttaag
acaacagttgtgaatgacaatggcctaagtcctgtttgggctgcaacacaggagaaagtg
acctttgaaatttacgaccccaacctggcatttctgcgctttgtggtctacgaggaagat
atgttcagtgatcccaatttcctcgcccacgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagcgaagaggagctgtactcctcctgc
cgccagctgcgacggcggcaggaagaactgaacaaccagctcttcctgtacgacacgcac
cagaacttgcgcaacgccaaccgggatgccctcgtgaaagagttcaacgtcaatgagaac
cagctccagctctatcaggagaagtgcaatcggaggttgagagagaagagggtcagcaac
agcaggttttactcctag
DBGET
integrated database retrieval system
