KEGG   Ursus arctos (brown bear): 113258346
Entry
113258346         CDS       T05909                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
uah  Ursus arctos (brown bear)
Pathway
uah00562  Inositol phosphate metabolism
uah01100  Metabolic pathways
uah04015  Rap1 signaling pathway
uah04020  Calcium signaling pathway
uah04022  cGMP-PKG signaling pathway
uah04062  Chemokine signaling pathway
uah04070  Phosphatidylinositol signaling system
uah04071  Sphingolipid signaling pathway
uah04072  Phospholipase D signaling pathway
uah04081  Hormone signaling
uah04082  Neuroactive ligand signaling
uah04261  Adrenergic signaling in cardiomyocytes
uah04270  Vascular smooth muscle contraction
uah04310  Wnt signaling pathway
uah04371  Apelin signaling pathway
uah04540  Gap junction
uah04611  Platelet activation
uah04613  Neutrophil extracellular trap formation
uah04621  NOD-like receptor signaling pathway
uah04713  Circadian entrainment
uah04720  Long-term potentiation
uah04723  Retrograde endocannabinoid signaling
uah04724  Glutamatergic synapse
uah04725  Cholinergic synapse
uah04726  Serotonergic synapse
uah04728  Dopaminergic synapse
uah04730  Long-term depression
uah04742  Taste transduction
uah04750  Inflammatory mediator regulation of TRP channels
uah04911  Insulin secretion
uah04912  GnRH signaling pathway
uah04915  Estrogen signaling pathway
uah04916  Melanogenesis
uah04918  Thyroid hormone synthesis
uah04919  Thyroid hormone signaling pathway
uah04921  Oxytocin signaling pathway
uah04922  Glucagon signaling pathway
uah04924  Renin secretion
uah04925  Aldosterone synthesis and secretion
uah04926  Relaxin signaling pathway
uah04927  Cortisol synthesis and secretion
uah04928  Parathyroid hormone synthesis, secretion and action
uah04929  GnRH secretion
uah04933  AGE-RAGE signaling pathway in diabetic complications
uah04934  Cushing syndrome
uah04935  Growth hormone synthesis, secretion and action
uah04961  Endocrine and other factor-regulated calcium reabsorption
uah04970  Salivary secretion
uah04971  Gastric acid secretion
uah04972  Pancreatic secretion
uah04973  Carbohydrate digestion and absorption
uah05010  Alzheimer disease
uah05016  Huntington disease
uah05017  Spinocerebellar ataxia
uah05022  Pathways of neurodegeneration - multiple diseases
uah05142  Chagas disease
uah05143  African trypanosomiasis
uah05146  Amoebiasis
uah05163  Human cytomegalovirus infection
uah05200  Pathways in cancer
uah05415  Diabetic cardiomyopathy
uah05417  Lipid and atherosclerosis
Module
uah_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:uah00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    113258346 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    113258346 (PLCB4)
   04310 Wnt signaling pathway
    113258346 (PLCB4)
   04371 Apelin signaling pathway
    113258346 (PLCB4)
   04020 Calcium signaling pathway
    113258346 (PLCB4)
   04070 Phosphatidylinositol signaling system
    113258346 (PLCB4)
   04072 Phospholipase D signaling pathway
    113258346 (PLCB4)
   04071 Sphingolipid signaling pathway
    113258346 (PLCB4)
   04022 cGMP-PKG signaling pathway
    113258346 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    113258346 (PLCB4)
   04081 Hormone signaling
    113258346 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    113258346 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113258346 (PLCB4)
   04613 Neutrophil extracellular trap formation
    113258346 (PLCB4)
   04621 NOD-like receptor signaling pathway
    113258346 (PLCB4)
   04062 Chemokine signaling pathway
    113258346 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    113258346 (PLCB4)
   04922 Glucagon signaling pathway
    113258346 (PLCB4)
   04929 GnRH secretion
    113258346 (PLCB4)
   04912 GnRH signaling pathway
    113258346 (PLCB4)
   04915 Estrogen signaling pathway
    113258346 (PLCB4)
   04921 Oxytocin signaling pathway
    113258346 (PLCB4)
   04926 Relaxin signaling pathway
    113258346 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    113258346 (PLCB4)
   04918 Thyroid hormone synthesis
    113258346 (PLCB4)
   04919 Thyroid hormone signaling pathway
    113258346 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    113258346 (PLCB4)
   04916 Melanogenesis
    113258346 (PLCB4)
   04924 Renin secretion
    113258346 (PLCB4)
   04925 Aldosterone synthesis and secretion
    113258346 (PLCB4)
   04927 Cortisol synthesis and secretion
    113258346 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    113258346 (PLCB4)
   04270 Vascular smooth muscle contraction
    113258346 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    113258346 (PLCB4)
   04971 Gastric acid secretion
    113258346 (PLCB4)
   04972 Pancreatic secretion
    113258346 (PLCB4)
   04973 Carbohydrate digestion and absorption
    113258346 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    113258346 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    113258346 (PLCB4)
   04725 Cholinergic synapse
    113258346 (PLCB4)
   04728 Dopaminergic synapse
    113258346 (PLCB4)
   04726 Serotonergic synapse
    113258346 (PLCB4)
   04720 Long-term potentiation
    113258346 (PLCB4)
   04730 Long-term depression
    113258346 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    113258346 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    113258346 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    113258346 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    113258346 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113258346 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    113258346 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    113258346 (PLCB4)
   05142 Chagas disease
    113258346 (PLCB4)
   05143 African trypanosomiasis
    113258346 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113258346 (PLCB4)
   05016 Huntington disease
    113258346 (PLCB4)
   05017 Spinocerebellar ataxia
    113258346 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    113258346 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113258346 (PLCB4)
   05415 Diabetic cardiomyopathy
    113258346 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    113258346 (PLCB4)
   04934 Cushing syndrome
    113258346 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uah04131]
    113258346 (PLCB4)
Enzymes [BR:uah01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     113258346 (PLCB4)
Membrane trafficking [BR:uah04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    113258346 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    113258346 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 113258346
NCBI-ProteinID: XP_026358819
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESTAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTVALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKTCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQSPN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gctgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcgcctgggagccaccccaaaggatcccaaaatcctg
gccgctcttgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacggatctggtgaacatcagtttcacatacatggtggctgaaaatccggaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaagcactggatgaaattggcgtttatgaccaacaca
aacggtaaaattccagttaggagcattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctacagcctttacatacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagac
ttgaagaaaaaaggcctcatatcaagcgacgggttttgcagatatctgatgtccgatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcccctggcc
cactacttcatcagttcttcccacaacacctatctcacgggccgacagtttggcgggaaa
tcttcagtagaaatgtacagacaggtgctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacgtcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggacctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaagctttgaaaagcatg
atggaagctggagaatccactgccccagttagcatcctagaggacgataatgaagaggag
atagaaagtgctgaccaagaggaggaggctcacccggaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgccaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtcactgtggaagatgaacaggcatgg
atggcatcgtataaatacgtaggtgctaccactaatatccatccgtatttgtctacaatg
atcaactatgcacagcctgtgaagttccaaggtttccatgtggctgaagagcgcaatatc
cattataacatgtcttcttttaatgagtccgtcggtctgggctatttgaagacacacgcg
attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtacctcctcaaaccagatttcatgagacggccggatcgaacattcgat
cccttctctgaaactcctgttgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtacggg
ttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtaatcctccctgacctggcg
gtcttgagaatagcagtgtatgatgacaacaacaggctgataggccagaggattcttcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgacggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag
agcagctccgagctcagaccaaccaccacggtggccctggggtctggcgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgcaaag
gagcacagcacaatgcagaagttgcactgcacgcaagttgacaaaattgtggcccagtat
gacaaagagaagtcaacgcatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaaccgaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagagatccgggacctccacctcagccagcagtgtgag
ctcctgcgaaagctactgatcagtgcccacgagcagcaaacccagcagctcaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gaattaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctcgagttcctagag
aaacagaatgaacagctattgaaaacctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccagagcccaaactga

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