Ursus arctos (brown bear): 113258943 Help Entry 113258943         CDS       T05909                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism uah  Ursus arctos (brown bear) Pathway uah04020   Calcium signaling pathway uah04024   cAMP signaling pathway uah04260   Cardiac muscle contraction uah04261   Adrenergic signaling in cardiomyocytes uah04371   Apelin signaling pathway uah04713   Circadian entrainment uah04911   Insulin secretion uah04921   Oxytocin signaling pathway uah04972   Pancreatic secretion uah05020   Prion disease uah05022   Pathways of neurodegeneration - multiple diseases uah05410   Hypertrophic cardiomyopathy uah05412   Arrhythmogenic right ventricular cardiomyopathy uah05414   Dilated cardiomyopathy uah05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113258943 (RYR2)    04020 Calcium signaling pathway     113258943 (RYR2)    04024 cAMP signaling pathway     113258943 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     113258943 (RYR2)    04921 Oxytocin signaling pathway     113258943 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     113258943 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     113258943 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     113258943 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     113258943 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     113258943 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     113258943 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     113258943 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     113258943 (RYR2)    05414 Dilated cardiomyopathy     113258943 (RYR2)    05415 Diabetic cardiomyopathy     113258943 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:uah04040]     113258943 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:uah04990]     113258943 (RYR2) Ion channels [BR:uah04040]  Voltage-gated cation channels   Ryanodine receptor    113258943 (RYR2) Domain-containing proteins not elsewhere classified [BR:uah04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    113258943 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  113258943 NCBI-ProteinID:  XP_057164468 LinkDB All DBs Position Unknown AA seq 4975 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDPGARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKMVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSVNNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILRLIEPSVFKEATTLDEE TDALEKEPSPEDARPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDAEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPRGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNV YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALSSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRRGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQD DEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYY SGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEM ILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAET DENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNF CEDTIFEMQLAAQISESDLNERSANKDESEKEKPEEQGPRMGFFSILTVKSALLALRYNI LTLMRMLSLKSLKKQMKKVKKMTVKDMVTAAFSSYWSIFLSLLHFVASVSRGFFRIVCSL LLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRKPMEAALPSEDLTDLKELTEE SDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKAKEDEKEEK EENKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLL NYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVSSLDSSSP RIMAVHYVLEESSGYMEPTLKILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEF DGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGM DKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLG HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKF YNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFF FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQE HNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14928 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggagagggcgaggacgagatccagttcctgcgaactgacgacgaggtg gtcctgcaatgcaccgctaccatccacaaggaacaacagaaactgtgtttggccgcagaa gggtttggcaaccgactctgtttcttggagtccacttcgaattccaagaatgtcccccca gacctctccatctgcaccttcgtgctggaacagtctctctctgtccgcgccctgcaggag atgctggctaacaccgtggagaagtcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagaccgctcaaggtggtggtcatcgaacactcctctacggacacgccatattg ctgcgccattcctatagtggcatgtatctgtgctgcctgtccacctcccggtcttcaact gataaactggcttttgatgttggcttgcaagaggacacaacaggggaggcctgttggtgg accatccatcctgcctcaaagcagcggtcagaaggagagaaggtgcgagttggagatgac ctcatcttggtcagcgtgtcctcggagaggtacctgcacctgtcttatggcaacggcagt ttacacgtggacgcggctttccagcagactctctggagcgtggcccccatcagctcagga agcgaagccgcccaagggtatctcattggtggtgacgtcctcaggttgctgcacggacac atggacgagtgcctcactgtcccttcaggagaacacggggaagagcagcggagaactgtt cactatgaaggtggtgctgtatccgtccatgcacgttccctgtggagactagagacgcta agagttgcgtggagtggaagccacataagatggggccagcctttccgactacgccacgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aaggctgatgtaaaatcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggagtgagaaaagaagtcgatggcatggggacatctgaaataaaatacggagactcagta tgctatatacagcatataaatacaggcctatggcttacttaccagtctgtggatgtgaaa tcagtgagaatggggtccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatttatctagatctcagcatgaagaatcacggactgcacgtgtcatccgg agtacagtcttccttttcaatagatttataaggggccttgatgcactcagcaaaaaagtg aaggcttccacggtggacctccctatagaatctgtgagtctaagtctgcaggacctgatt ggctactttcatcccccagatgaacatttagagcatgaagacaagcagaacagattacga gctctaaagaaccggcagaatctcttccaggaagagggaatgatcaacctcgtgctcgaa tgtatagacaggctgcacgtgtacagcagtgcggcccactttgctgacgtcgccgggaga gaagccggcgagtcctggaagtcaattctgaattctctctatgagttgctagcggcacta attagaggaaatcgtaaaaactgtgctcagttttctggctcccttgactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagta gaaagtccagaagctctaaatattattaaggaaggacacattaaatccataatctcactt ttagacaagcatgggagaaaccacaaggtcctggacgtcttgtgctccctgtgtgtctgc catggagtggcagtccgttctaaccagcatctcatctgtgacaatctgctgccaggaaga gatctactgttgcagacgcgtcttgtgaaccatgtcagcagcatgagacccaatattttt ctgggcgtcagtgaaggctccgctcagtacaagaagtggtactatgagctgatggtggac cacacggagccgttcgtgaccgccgaagccacgcacctgcgggtgggctgggcttccacc gaagggtactctccctacccaggaggcggtgaggagtggggtggaaacggagttggagac gatctcttctcctacggattcgacggccttcacctctggtcaggctgtattgctcgtact gtcagctcaccaaaccagcatctgctgagaaccgatgacgtcatcagttgctgtctagat ctcagtgccccgagcatctcattccgaattaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattcctcccgccacctgggtatgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagccgagagtac aagcaagaaagaacgtacacacgggacctgctgggccccacagtctccctgacgcaggcc gccttcacgccgatcccggtggataccagtcagattgtgttgcctcctcatctagagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacaacacccatgtctggtggag ttctccaagctgcccgaacaggagcgcaattacaacttgcagatgtcgcttgagaccctg aagactttgctggcactaggatgtcatgtgggtatctcagatgagcatgctgaagaaaag gtgaaaaaaatgaagcttcccaagaattaccagctgacaagtgggtataagcctgcccca atggacctgagcttcattaaactcaccccatctcaggaagcgatggtggacaagttggca gaaaatgcccataatgtgtgggcccgggatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacaggagaaaccctcgcctggtgccctacgcccttctggatgac cgcaccaagaaatccaataaggacagcctccgtgaggctgtgcgcacgctgctggggtat ggctacaacctggaggcaccagatcaggatcccggggccagagccgaagtgtgcagcggc accggggagaggttccgaatcttccgcgccgagaagacctatgctgtcaaggcaggaagg tggtattttgagttcgaggccgtcactgccggcgacatgagggttggctggagcaggcct ggctgtcaacctgatcaagagcttggctccgacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggtaacgaacactacgggcgctcttggcaagcgggcgac gttgtggggtgcatggtagatatgacagagcacaccatgatgttcacgctgaatggtgaa atccttcttgacgattcgggctcagagctggcattcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaagtgggcaggatgaactttggaaaagat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccgtttgct gttaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccatcaaatcatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaggtgactcagaagtccttcggttctcagaacagcagcacggacatcatg ttctatcgcctgagcatgcccatcgagtgcgcagaagtgttctccaagatggtggccggg ggactcccaggcgctggcctctttgggcccaagaatgatctggaggactacgatgcagat tccgactttgaggttctaatgaagacggctcatggccatctggtgccagatcgcgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattacgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccggattacagcacaagc cattctgcaagactcactgaagacgtgcttgcagatgatcgggatgattacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgctaac gtctgggtaggctggattacatcagatttccatcaatatgatacaggctttgacttggac agagttcgcacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgtgcgggtgagagcatgagcccggggcaaggacgc aacaacaatggcctggagatcgggtgcgtggtggatgccgccagtgggctgcttacattc accgccaacggcaaggagctgggcacatactaccaggtggaaccaagtacaaaattattt cctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaatgtgatgcctctgtcggcgggattattcaagagcgagcacaaaaaccctgtgcca cagtgtccgccgcgtctccacgtgcaatttctttcccatgtcctatggagcaggatgcct aaccagttcttgaaggtagatgtctctcgaatcagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctcttcatatcccagaggagaacagatctgtcgac atactggaattgacagagcaggaggagctgctaaaattccactatcacactctccgcctt tactccgccgtctgcgctcttgggaaccaccgggtggcacatgccttgtgcagccacgtg gatgagcctcagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgcgcc ggctactatgacctgctgatcgacatccaccttagctcctacgccacggccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcacccttttccct gatgagaacaaaaaacatggcctcccggggattggcctcagcacctcccttaggccacgg atacagttttcctcccccagttttgtaagcgttaacaatgaatgttaccagtatagtcca gagttcccgctggacatcctcaaggccaaaaccattcagatgttgacagaagctgttaaa gagggcagccttcatgcccgggaccccgttggggggaccactgagttcctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgaggacttgaaa cacatcttgcgattgatagagcccagtgtgttcaaggaagccaccactctggatgaggag acagacgcgctggagaaagagcccagcccagaagatgccagaccagaaggagctggtgaa gaagaagccaaagggggtaagaggcccaaggaaggcctgctccagatgaaactgcctgag ccagttaaattgcagatgtgcctgctgcttcagtacctctgtgactgtcaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagcaaagctccaagacaatcag cgcttccgatacaacgaagtgatgcaagccttaaacatgtcagctgccctcaccgccagg aaaacgaaggaatttagatcaccacctcaagagcagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgtgaccaactcttagattttcat gaagatttgatgacacattgtggaattgagctggatgaagatgggtctttagatggaaac agtgacttaacaattcgaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgagaaaccagttgagagtgactccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaagaccctgaattg gtgagggccatgtttgtgttgctccatcggcagtatgatggcattggtggtctggtccgg gctctgccaaagacctacactatcaatggtgtctccgtggaggataccatcaacctgctg gcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtgttttaccagcaccctaat ctcatgagggcccttgggatgcatgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgtttcctt tgttacttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatctcagctat ttattggagaatagcagtgttggccttgcctcaccagctatgaggggctcaacaccactg gatgtggcagctgcctcggtgatggataataacgaactggccttagcactgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagctgccagatgctg gtgtctaagggttatccagacattggatggaatccagttgaaggagagagatatcttgac tttctccgatttgctgtcttctgtaatggggagagtgtggaagagaacgctaatgtcgtg gtgaggttgcttatccggaggcccgagtgttttggtcctgctttgagaggggaaggtggg aacggtctgctcgcagccatggaggaagccataaaaatagctgaggatccttctcgagat ggtccctcaccaactagcggatccagtaaaacacttgatgcagaagaggaggaggatgac actatccacatggggaatgccatcatgaccttttacgcagccttgattgacctgttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tccattttgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtt caagatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgct tctttagacacggctgctctgagtgctacagacatggccttggccctcaatcggtacctt tgcacagccgtgctgcctctgttaacgagatgtgcccctctttttgcgggcacagagcac catgcctctctcattgactccttacttcacactgtgtacagactctctaagggctgctct cttaccaaagctcagcgggatgccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcaacacttgctccgaagattagtatttgatgtcccattattaaat gaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaactttggagctgcctcagaggaagagcttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatatcacaattcctgagaagttggaatacttc attaacaaatatgcggaacattctcatgacaagtggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcaaccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggcctatcaaagagtctttaaaa accatgctggcgtggggttggaggattgagagaacgcgggagggagacagcatggcactc tataaccggactcgtcgcatttctcagacaagccaggtttctgtagatgccgcgcatggc tatagcccccgagccattgacatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatttgggccaagaaaaagaaaatggaactg gaatccaaaggaggtggaaaccatcccctgctggttccctatgacacgctcacagccaaa gagaaagccaaggatagggagaaagcacaggacatcctcaagttcttgcagatcaatggc tatgcggtgtccagaggattcaaggacctggagttggacacaccttccattgagaaacga tttgcctatagcttccttcagcaactcattcgctatgtggatgaagcccatcagtacatc ctggagtttgatggtgggagtagaagcaaaggagagcatttcccttacgaacaagaaatc aagttcttcgctaaagttgtgcttcctctaattgaccagtacttcaaaaaccatcgctta tacttcttatctgcagcaagcagacctctctgctctggaggacatgcatcaaacaaggag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgccttcacattttgggtcagactttg gatgccaggactgtgatgaagactggcctcgagagtgttaaaagtgcactccgagctttt ctggacaacgccgcggaggatctggagaagaccatggagaatctcaagcaaggccagttc acccacacccgaaaccaacccagaggtgtcactcagattatcaattacaccacggtggct ctgttgccgatgctgtcgtcattatttgagcacattggccagcatcagtttggagaagat ctaatattggaagatgtacaggtgtcatgttacagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtctcgcg gcttttgcgggtgcctttcctgtagcgtttttggaaactcatctcgacaaacataatgtt tactctatctacaatactaagtcctcacgagaaagagcagctctcaatttgccaactaat gtggaagatgtttgcccaaatataccctctttggagaagctcatggaagaaattgtggaa ctagccgagtctggtattcgatacacacaaatgccacatgtaatggaagtcatactgccc atgctttgcagctacatgtcccgttggtgggagcacggacctgaaaacaacccggagagg gccgagatgtgctgcacagcgctgagctctgagcacatgaacacactcctggggaacata ctgaaaatcatctataataacttgggaattgatgagggcgcctggatgaagaggttagca gttttctcgcagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggttgtgtctgaggaggaccatctg aaggccgaggccaggggggatatgtccgaggcagaacttctcattcttgatgagttcacc acgctggccagagatctctatgccttctacccactcttgattagattcgtggattataac agggcaaagtggctaaaagagcctaacccagaagcagaggacctgttccgcatggtggcc gaagtgtttatctactggtcgaaatcccataatttcaaaagagaagagcagaacttcgtg gtacagaatgaaatcaacaatatgtctttccttatcactgacaccaagtcaaagatgtca aaggcggctgtttctgaccaggaaaggaagaaaatgaagcgcagaggagatcggtactcc atgcagacttctctaatagtggcagctctgaagcgactgctgcccatcgggttgaacatc tgtgccccgggggaccaggagctcattgctctggccaaaaaccgattcagtatgaaagac acggaggatgaagtacgagatataatccgcagtaatattcacttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccgaacaggactgaagat acatcagatccggagaagactgtggaaagagtattagacatagcgaatgtgctttttcat ctcgagcagaaatctacatgtatgcgccggagatattacagtctggtggagcacccacag agatcgaagaaggcagtatggcacaagctgttgtccaagcagaggaagagggcggtggtc gcctgcttcaggatggctcctttatacaatctgccaaggcatcgggctgtcaatctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactattttgaagataaactg atagaagatttagcaaagcctggagccgaccctccagaagaagaggaaggcacgaagaga gttgatcccctccatcagctcatccttctgtttagtcgaacagctttaacagagaaatgc aaactggaggaagattttttatacatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggagaaagaaatggaaaagcaaaagcttctctaccagcaagccaggctgcac gaccgcggggctgctgagatggtgctgcagaccatcagcgccagcaaaggtgatactgga ccaatggtagctgcgactttgaaacttggaattgctatcttaaatggtgggaactccaca gtccagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttctttcagagt ctggctggcctgatgcagtcatgtagtgtcctcgacctaaatgcatttgagcgccaaaac aaagctgaaggacttggaatggtgaccgaggaaggatcaggagaaaaggttctccaggat gacgagttcacttgcgacctcttccgcttcctacaactgctttgtgagggacacaactca gattttcaaaattatctgagaactcagaccggcaataacacaaccgtcaacataatcatc tctaccgtagactacctcctgagagtccaggaatccattagtgatttctattggtattat tctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagcaattcaagta gcaaagcaagtctttaacactctcacggagtatattcagggtccttgcactgggaatcag cagagcttggcccatagcaggctgtgggatgcggttgtgggctttcttcatgtatttgcc cacatgcagatgaagctgtctcaggattccagtcaaattgagctattaaaagaattaatg gatcttcagaaggatatggtggtcatgctgctgtccatgttagaaggtaatgttgttaat ggaaccattggcaaacagatggtcgatatgctcgtggaatcttccaacaatgtggagatg attctcaagttttttgacatgttcttaaaactaaaggatttgacatcctctgacacgttt aaggaatacgatcccgatggcaagggagtcatttccaagagggacttccataaagcgatg gaaagccataagcactacacacagtcggaaaccgagtttcttctgtcctgtgcagagacc gatgaaaatgagaccctcgactatgaggagtttgtcaaacggttccatgagcccgcaaag gacatcggcttcaacgtcgccgttctcctgaccaacctgtccgaacacatgcccaatgac acgcgactgcagactttcctggagttggcagagagcgtgctgaattacttccagcccttt ctgggccgcatcgagatcatgggcagtgccaaacgcatcgagagggtttatttcgaaatc agtgagtccagccgcacccagtgggagaagccccaggtcaaggagtccaaacggcagttc atatttgacgtggtcaatgaagggggagaaaaggagaagatggagcttttcgtcaacttc tgtgaggacaccatatttgaaatgcagctggcggcacagatctcagagtcggatctgaat gaaaggtcagcgaataaggacgaaagtgagaaggagaagcccgaagagcagggacccagg atgggtttcttttccattctgacggtcaagtcggccctgctggctctcaggtacaatatc ttgaccctcatgcggatgctaagcctgaagagcctgaagaaacagatgaagaaggtgaag aagatgaccgtgaaggatatggtcacagccgccttttcatcctactggagtatattcctg agcctcctgcatttcgtggccagcgtttccagaggctttttccgcattgtttgcagcctg ctgctggggggcagcctggtagaaggagcaaaaaagatcagagtggcagagctcttagcc aacatgccggaccccactcaggatgaggtgaggggggacggcgaggagggggacaggaag cccatggaagccgccctgccctcggaagacctgacggacctaaaggaactgacagaggaa agtgaccttctttcggacatatttggcttggatctaaagagagaaggaggacagtacaaa ctcattcctcataacccaaacgctggcctcagtgacctcatgagcaacccggtccccatt cctgacgtgcaagaaaaattccaggaacagaaggcgaaagaggacgaaaaggaggaaaaa gaagaaaacaaatctgaaccagaaaaggccgagggagaagatggagaaaaagaagaaaaa gccaaagaagataagggtaaacagaagttgaggcagctccacacgcacagatacggagag cccgaagttcccgagtcagcgttctggaagaagatcatagcgtatcaacagaaacttcta aactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgca atcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggag ctccccactcgcagttcgagtgaaaatgccaaagttagcagcctagacagcagctcgccc agaatcatggcggttcactacgtcctggaggagagcagtggctacatggagcccacgctg aagatcttagctattctgcacacggtcatttctttcttctgcatcatcggatactactgc ttgaaagtcccactggttatttttaagcgagaaaaggaagtagctcgaaaattggaattt gatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggataga cttgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaag gttatggacaagtacggagagttctatggccgggacagaatcagcgagctcctgggtatg gacaaagccgctctggacttcagcgatgcccgggagaagaagaagccgaagaaagacagc tccctatcggccgtactgaactctatcgacgtaaagtatcagatgtggaaactaggagtc gtcttcaccgacaactccttcctctacctggcctggtatatgactatgtccgttcttgga cactataacaactttttttttgctgctcatcttcttgacattgctatgggattcaagacg ctaagaaccatcttgtcatcggtaacgcacaatggcaagcagcttgtattaactgttggc ttattagctgttgtcgtatacctatatactgtggtggcattcaattttttccgaaaattc tacaataaaagcgaagacggtgacactccagatatgaaatgtgatgacatgctaacgtgc tatatgttccacatgtacgtcggggtacgtgccggagggggtatcggtgatgaaatcgaa gacccagcaggcgacgaatatgagatctatcgaatcatctttgacatcaccttcttcttc tttgtgattgtcattctcttggccataatacaaggtttaattattgatgctttcggagaa ctgagagaccagcaggagcaagtcaaagaagacatggagaccaaatgcttcatctgtggg atagggaacgattacttcgacacagtgccacatggctttgaaacccacactttacaggaa cacaacctggccaattacctgttttttctgatgtatcttataaacaaagatgaaacagag cacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgttgggaatttttc ccagcaggggactgtttccggaaacagtatgaggaccagctaaattag

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