Ursus arctos (brown bear): 113264823 Help Entry 113264823         CDS       T05909                                  Symbol MDN1 Name (RefSeq) midasin isoform X1   KO K14572   midasin Organism uah  Ursus arctos (brown bear) Pathway uah03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:uah00001]  09120 Genetic Information Processing   09122 Translation    03008 Ribosome biogenesis in eukaryotes     113264823 (MDN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03009 Ribosome biogenesis [BR:uah03009]     113264823 (MDN1) Ribosome biogenesis [BR:uah03009]  Eukaryotic type   Pre-60S particles    Other pre-60S particles     113264823 (MDN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AAA_5 AAA_lid_7 AAA_lid_5 AAA_16 AAA AAA_3 AAA_7 AAA_22 TsaE nSTAND3 Sigma54_activ_2 ABC_tran Sigma54_activat AAA_14 MDN1_4th AAA_6 Mg_chelatase AAA_2 Dynein_heavy DUF815 AAA_25 PduV-EutP ResIII VWA Pus10_N_euk Motif Other DBs NCBI-GeneID:  113264823 NCBI-ProteinID:  XP_026367593 LinkDB All DBs Position Unknown AA seq 5596 aa AA seqDB search MEHLFLEVAATPLRLLAAKNEKSRSELGKFLAKQVWTPQDRQCILNTLAQLLLDKDCTVL VGRQLRPLLLDLLERNAEAIKAGGQVNHDLHERLCVSMSKLIGNHPDVLPFALRYFKDTS PVFQRLFLESSDANPVRYGRRRMKLRDLMEAAYKFLQQEQSVFRELWDWSVCVPLLRSHD TLVRWYTANCLALVTCMNEEHKLSFLKKIFNSEELIHFRLRLLEEAQLQDLEKALVLANP ETSLWRKEKELQYLQGHLVTADLSSRVTAVCGVVLPGQQPVPGERASNRSSSREQELAFR SYVLVDSICKNLQTLAMAVASQNAVLLEGPIGCGKTSLVEHLGAMTGRRKPPELLKVQLG DQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAATKGHWILLEDIDYAPLDVVSVLIPLLEN GELLIPGRGDCLKVAPGFQFFATRRLLSCGGNWYRPLNSHATLLDKYWTKIHMDNMDKTE LNEVLQNRYPSLLAVTDHLLDIYIQLTGEKHLSQSDSSVTCEQAPEEVSEARRENKRLSL EGRELSLRDLLNWCNRIVHCFDSLSSSASLNIFQEALDCFTAMLSKHTSKLKMAEIIGSK LNISKKKAEFFCQLYKPEIVINELDVQVGRVRLLQKQSEAVHIQREKLTFAPTRPSSVLI EQLAVCVSKGEPVLLVGETGTGKTSTVQYLAHITGHRLRVVNMNQQSDTADLLGGYKPVD HKLIWLPLREAFEELFAQTFSKKQNFTFLGHIQTCYRQKRWHDLLRLMQHVHKSAVNKDG KESETGLLLKEKWEAFGLRLNHAQQQMKMTENALLFAFVEGTLAQAVKKGEWILLDEINL AAPETLECLSGLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRN RFTELYVEELESKEDLQILIVDYLKGLSVNKTTVQGIISLYTALRKDSGTKLVDGTGHRP HYSLRTLCRALRFAASNPCSNIQRSLYEGFCLGFLTQLDRASHPVVQKLICQHIVSGNVK SLLKQPIPEPKGGRLIQVEGYWISVGDKEPTIDETYILTSSVKLNLRDIVRVVSAGTYPV LIQGETSVGKTSLIRWLAAASGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLID AMRKGYWIILDELNLAPTDVLEALNRLLDDNRELLITETQEVVKAHPRFMLFATQNPPGL YGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSYRRSS SVFAGKQGFITLRDLFRWAERYRLAEQTEKEYDWLQHLANDGFMLLAGRVRKQEEIDVIQ EVLEKHFKKKLCPQSLFSKENVLKLLSKLSTQVSTLESTFSHIVWTEGMRRLAMLVGRAL EFGEPVLLVGDTGCGKTTICQVFAGLANQKLYSVNCHLHMETSDFLGGLRPVRQKPKDKE EIDTSRLFEWHDGPLVLAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLAEKGSVE DKDNEVELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTNREDLIQVISH NLRPGLSLGRIDHKGTDIAEVMLDFIDWLTHQEFGRRCVVSIRDILSWVNFMNTMGEEAA LKRPETISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFLIKKLSKIVRLTE CQKNELKIYDRLKAKEFTGMDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNAQRLL RATKLNKPILLEGSPGVGKTSLVGALAKASGNILVRINLSEQTDITDLFGADLPVEGGKG GEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRGEIYVPELGMSFQVQHE KTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVIDMEFIASTLFPAIDKNIVKKM VAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLMLVDQSPGCYDPGQHVFLVYGER MRTKEDKEKVIAVFKDVFNSSSNPYMGTRLFHITPYDVQLGYSVLSRGSYVPLLSRRPLS LLHQSLRSLESIMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTE LLGGFEQVDLTRPWRQLLEKVEGTVRALLRDSLLISADDAEVVLRAWSHFLLTYKPKCLG DGGKGITMEIVNKLEAVLLLMQRLNNKINSYSKTEFAKLVEEFRNFGVKLLQSTSGHSHG TFEWVDSMLVQALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTLSERGMVDGSTPTI TPNPNFRLFLSMDPVHGEISRAMRNRGLEIYISGEGDGNIPDDLDLKVLLHSLGLVGDSV CDSLLALHTEIQSTIVGSPASSISTLIQTALLIVQYLQRGLSLDKAFSEVCWEAYVRSQH SPANQKLVKTLLEKHVSSLRAHETWGNSILAMGLWPDSLPSALFATEDSHLSIVRSDGQI LVYCLNRMSMKTSSWARIQPLTLPDLEKIMQSSNPESLKFSSVEVDTYWIDEPDVLAMAV KLLIERATNQDWMLRVKWLYHLAKNIPQGLESIQIHLEANAASLRNFYSNSLSAGVSNVI KILQPNITDEFVIPLDPRWNMQALDIIRNSMDFDPQMDQPEQLFALLESVANKTIIYLDR EKRIFTEANLVSVGGKKLRNSVLRMSFEFHKDPESYHSLPHEIVVNLAAFFEFCDALILL WVQSSQGMVSDASVIEILESLRWRDRLWTVADTVKVDAPGLALLALHWHWVLKHLVRQIP QLLVNHEDKYFKEVQTVSEHIQNCLGSPTGGFTGIKKLQKFLGRPFPFKNKLVVECFSQL KVLNKVLAIRERMPALGESGWCEDINRLQVVASEWTLKKSLLQAWGLVLRANVLEDANAD ELKNLVNAHCLELKAKGISLGFLEKKHNEASSLFQLDFTSLIQLTRNVQLWPAMEYLAML WQYKVTADFMTQACLRRSSKNQQPQIDEEISHHITFCLKHTPVAPQELRDLWFLLHCKKV STEEVISLWSDLFHSAFMSFWSSTVTTNPEYWLMWSPLPGVQQREVPKSLLDSTLKGPGS LSRAVFSKCCFEVLTSSCRASPWDVSGFPILSSSHVTLGEWVERALQLRDISLVLWTNMA VPSVAEFRRTDSQLQGLVLCRHLAGLAELLPESQRQEYMQNCEQLLLGDSQAFQHVGQTL GDMAGQEALPKELLCLLLTSLRHFGEGDSKRDLPEPARRGSLWVSLGLLQIQTWLPQARF DPAVKREYKLKYAKEELHQLQCEWKTRNLSSQLLTGRDLEDEVIIHYSHPHIRLLRQRID HLENLICSLSKKQAFRPQVPVYESLVQEIHHYVTSIAKAPAVQDLLTRLLQALHMDGPRS AQVAQNLLKEEASWQQSHHQFRKRLAEEYALYPDSVAPLQASILQLQHGMRLVASEVYAS FQRSVVCADRLGTLATSLLAFPSVGPAFPTYYAHADALCSVKSEEVLRGLGRLILKRSGG KELEGKAQRPCPTREQLLMNALLYLRSHVLCKGELDQRALQLFRHVCQEIINEWDEQERI AQEKAEQESSLYRCRSRNSRTALSEEEEEEREFRKQFPLHEKDFADILVEPTLEEKKGAS DGQEEGATTDPALLSQSSMQAVMLIHQQLCLSFARSLWYQQTVPPHETKHYLGLFLSCYQ TGASLVTHFYPLMGAELNDQLLGSQLLACTLSHNTLFGEAVSDLMVKPDGPYDFYQHPNV PEARHCQPVLQGFSEAVSQLLQDWPEHPALEQLLVVMNRIRSFPLSSPISKFLNGLEILL AKAQDWEENASRALSLRKHLDLVSQMIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWFSI YQMLEKHMQEQTEEQEDDKQMTLMLLVSTLQAFIEGSSLGEFHVRLQMLLVFHCHVLLMP QVEGKDALCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELKEFVKISKWNDVSFWSIKQ SVEKTHRTLFKFMKKFEAVLSEPCRSSLVESDKEEQPDFLSWPAATSEASPVQSLNKALK ETLLARPAAAQAVIPEQCQGAPFSSEGELLRRLPKLMKRMRKMCLTLMKESRLPHLVEGL DHFTGEVISCVSELQSLKVEPSAEKEKQRSEAKHILLRKQRALADLFQHLAKTGLSYRKG LAWARSKNPQEMLHLHPLEIRSALSIVSSTQEADSGLLTEISSSWDGCQKYFFRSLARHA RLSAALAAPAKELGMSNVERCRGFSAHLMKMLIRQRRSLTTLTEQWILLRNLLGCVQEIH GRLTGPLVYPVAFPPQDGVQQWTERLQHLAMQSQVLLEQLSWFLQCCPCAGPTPGQGEAQ AQGQPSAPYPEGPELTKGWLSGAAQDLIPSELSYPSPVPRNQLPSGCRMRKQDQLWQQST TRLTEMLKTIKTVKADVDKIRQQSCETLFHSWKDFEVCSSGLSCLSQMSVHLQGLESLFV IPGREVKQTDQQMALVQSLEYLRGEINKATDEFTAWKTHLLALGSQGGNQMLEEGFVEDF SERVEAAIRAILCAIQNLAERNSKKTEENTDQTGPREEDEAAGCERLQSGHLTKLLEDDL WADVSALHVQKIISAVSELLERLKSYGEDGIAAKNTVFSQSCCLLVRLVPMLSRYSDLVL FFLTMSLATHRSTAKLLSVLAQVFTELAQEGFCLPKEFMEDSAGEGATEFHDYEGGGIGE GEGVKDVSDQIEHEDQAEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGEL EEQEEDDGKSDSEGRDLDKQMGDLNGEEADKLDERLWGDDDEEEDEEEEDSKTEETGPGM DEEDCGLVAKDDNLDAGKSNRDKNQDKKEEKEEAEVADDGQGQDKINEQIDEREYDENEV DPYHGNQEKLPEPEALDLPDDLNLDSEDKNGSEDTDHEEGEENPLEIKEKPMDTEEAGRE AEEIKEEIEADHSEGQSQHEAEEGSSEEEKGEGEEEMDTGADDQDKDTAEHPEENSDDER QSLEDKDKEASEDSAENGVPVDQGLQPQKQEEEEGGENSDPEEQVPEATERKEHASCGQT GVESVQSAQAVELAGTAPEKEQGKEEHGSGAADANQAEGHESSFIARLASQKQTRKNTQS FKRKPGQADNERSVGDHNEHVHKRLRTVDVESQAEQGPAQPPARVEDADAFEHVKEGSGP YDAQTYDVASKEQQQSAKDSSRDQEEEIEDTFADVEEEELRAADVEQLKPEVVTSGTTAS PGLDEMEVETQAVKTEDQDPRTNLSHEETEKEKPERSRDSTIHTAHQFLMDTVFQPFLKD IGELRQELERQLEMWQPHESGNPEEEKAAAEMWQSYLALTAPLSQQLCEQLRLILEPTQA AKLKGDYRTGKRLNMRKVIPYVASQFRKDKIWLRRTKPSKRQYQICLAIDDSSSMVDNHT KQLAFESLAVIGNALALLEAGQIAVCSFGESVKLLHPFHEQFSDSSGSQILRLCKFQQKK TKIAQFLESVARMFAAAQQPSQNASPETAQLLLVVSDGRGLFLEGKDRVLAAVRAARNAN IFVIFVVLDNPSSRDSILDIKVPIFKGPGEMPEIRSYMEEFPFPFYIILRDVNALPETLS DALRQWFELVAASDHP NT seq 16791 nt NT seq  +upstreamnt  +downstreamnt atggagcaccttttcctggaggtggcggccacgccgctgcgtttgctcgctgccaagaac gagaagagccgcagcgaactgggcaagttcttggccaaacaggtgtggacacctcaagat cgccagtgtatcctcaataccttagcccagttacttctggataaagactgtactgtgttg gttggtcgccagctgcgccctcttcttttggatttgttggaaaggaatgctgaggccatt aaagccggaggccaagtcaatcacgatctacacgaacggctctgtgtgtcaatgagcaaa ctcatcggtaaccatcctgatgtcctcccgtttgccctgaggtatttcaaggacacttct ccagtctttcaaagactcttcctagagagttcagatgctaatccagtccgctacgggcgc aggcggatgaagctccgggacctaatggaagcagcttataagtttctgcagcaagagcag tctgtgttccgggagctctgggactggagtgtgtgtgtccctctcctcagaagccatgac accttggtccgctggtacacagccaattgtcttgctctggtcacctgtatgaatgaagag cacaagttatcattccttaagaagatttttaatagtgaggaactgatccatttcaggttg aggttactagaagaggcccagctgcaggacttggagaaggccttggttttggctaatcca gaaacctccctttggcgtaaggagaaggagctgcagtacttacagggacatcttgttaca gctgacctctcttccagagtgactgctgtctgtggtgtggtgctgcctgggcagcagccg gtccctggagagcgggctagtaataggagttcttctcgtgaacaggagctggcctttagg tcttatgtgctggttgattcaatctgcaaaaatcttcagacactggctatggcagtggct tctcaaaatgccgtgttgttggaaggaccaataggatgtggcaaaacttccttagttgaa cacctaggtgcaatgacaggtagacggaagccccctgaacttcttaaagtccagcttgga gatcagaccgacagtaagatgctgttgggaatgtatcgctgcacagatgtcccaggagag tttgtgtggcaacctggtactcttacacaggcagccacaaaaggacactggatccttctg gaggatattgactatgcccccttagacgtggtttccgtgctgatccctctcttggagaat ggagagctcttgattcctggccgaggtgactgtctgaaagtggctcctggatttcagttc tttgcgactaggagactcttgagctgtggaggaaattggtatcgacctctaaatagtcac gctactctgctagacaaatactggacgaaaattcacatggataacatggataagacagaa ctgaatgaggttcttcagaacagatatcccagcctcttggcagtaacggatcacctgctt gacatttacatccaacttactggagagaaacatctctctcaaagtgatagttctgttaca tgtgaacaggcacctgaggaagtttcagaagctagaagagaaaacaaaagactaagcctc gagggaagagaattatctctaagggatctactgaattggtgtaataggattgtccattgt tttgatagtctgtcttcatcagcatccttaaatatttttcaagaggctctggactgtttc acagcaatgctttctaagcatacaagcaaactgaaaatggcagaaatcattggaagcaaa ttgaacatttccaagaaaaaggccgaattcttctgtcagctttataaaccggaaattgtg atcaatgagctagatgtgcaagtgggtcgagtgcggcttctacagaaacaaagtgaggct gtccacatacagagggagaagctcacttttgctcctacgaggccatcctctgttcttatt gaacagctcgcagtgtgcgttagcaaaggggaacctgtgttgctggtgggagagaccggg actggcaaaacctctactgttcagtacttggctcacattacaggccaccgtttgagggtt gtcaatatgaatcaacaaagtgacactgcagacttgcttgggggttacaaaccggtggac cataagcttatttggctgcccttacgggaggcatttgaagaactctttgcccagacattc tccaagaagcaaaactttacattcttggggcacattcagacctgttacaggcagaaacgg tggcatgatctcctcagactaatgcagcatgtgcataagtcggctgtcaacaaggatgga aaagaaagtgaaactgggttactcctaaaagagaaatgggaagcatttggtcttagactc aaccatgctcaacaacagatgaaaatgactgaaaatgctctattgtttgcatttgtagag ggtactctagctcaggccgtgaagaagggagaatggatcttgttggatgagattaatctg gctgctccagaaacattagaatgtctcagtggtttacttgaaggttcctctggctccctt gtgttactggatcgaggagatacagaaccactggttcgtcatcctgacttccgtttattt gcctgtatgaacccagcaacagatgtgggcaaaagaaatctcccaccaggaataagaaac aggttcacagaactttatgtagaagaattggaaagtaaagaagatttacaaattcttatt gtggattatctgaaaggactgagtgtgaataagaccacagtgcaaggaatcatcagcttg tacacagctctacggaaagactctgggacaaaattggtggatggaactggccatagacct cactacagccttcggactctttgcagagctctgcgatttgcagcttccaatccctgtagc aacatccagcgctcgctctatgagggcttttgtttgggtttcttaacacagcttgacagg gcatcacacccagtagttcagaagctcatttgtcaacacattgtctctggcaacgtaaaa agtctgctgaagcagcctattccagaaccaaaaggaggccggcttatccaggtcgaagga tactggatttcggtgggagacaaggaacctacaatagatgagacctacattcttacatct tctgttaagctaaacctgagagacatagtccgagtggtttctgcaggaacctatccagtg ttgattcagggagagacatcagttggtaaaacaagccttatccggtggctggcagcagct tctggtaaccattgtgtgcgtattaacaatcacgaacacacggatattcaggagtacatt ggttgttatacatctgactcttcagggaagcttgtatttaaagaaggtgttcttattgat gctatgagaaagggctactggattattttagatgaattaaatttggcccctactgatgtg ctagaggcactgaacagattgctggatgataaccgtgaattgctcatcacagaaacacaa gaagttgttaaagctcaccctcggttcatgctttttgctacccagaatcccccaggactt tatggaggcagaaaggtgctttctagagccttcaggaatcggtttgtggaattgcatttt gatgaattgcctagttctgagttggaaacaatcttgcataagcgctgtagtttgccaccc tcctattgtagcaagttggttaaagtcatgctggaccttcagtcctatcgcagaagttct tcagtgtttgctggaaaacagggcttcatcactcttcgtgatctgtttcggtgggctgaa agatacagattggctgaacagaccgagaaagagtatgactggctacagcatttagccaac gatggatttatgcttctcgcaggccgagtcaggaagcaggaggagattgatgtgattcaa gaagtccttgaaaaacatttcaagaaaaaattgtgtcctcaatccctcttctccaaggaa aatgtcctaaaattactgagtaaattgtccactcaggtatccacactggagtctacgttc agccacattgtgtggactgagggcatgcggaggttggcgatgctggtgggaagggcgctg gaatttggtgaaccagtgctgctggttggagacactgggtgtgggaaaactacgatctgt caggtgtttgcaggcttggcaaatcagaaactatactctgtcaactgccacttacacatg gagacatcagacttcctggggggactgcggccggtgagacagaagccaaaggacaaggaa gaaattgatacatcaagactttttgagtggcatgatggtcctcttgttctggccatgaaa gaagatggcttttttctcttggatgagatctcactggctgacgactctgtcctggaaaga ctcaatagtgtccttgaagtggaaaagtccctggtattagctgaaaaaggcagtgtagag gacaaggataatgaggtagagctgttgactgctgggaaaaagttccgtatcttagcaacc atgaaccctgggggcgactttggaaaaaaagagctgtctcctgccttaagaaaccggttt acggaaatatggtgcccacaaagcacaaatcgtgaagatttaattcaggttatcagccat aatcttcgtccaggattgtctctgggcagaatagatcataaagggactgacatagctgag gtgatgctggatttcattgattggctgacccaccaggaatttggccgaaggtgtgtggtc agtatcagagatatcctgtcctgggttaacttcatgaacacaatgggggaggaagctgct ttgaaaaggccagagaccatctccactgtgacatcatttgtccatgctgcatgcctggtg tacatagatggaataggttcaggggtaacttcctcagggtttggtacagccctcttggct cgcaaagaatgtctgaaattcttaatcaagaaactttccaagatagtgcgtcttacagag tgtcagaaaaacgaattgaagatttatgacagactcaaggccaaagaatttactggaatg gataacctttggggaattcatccattttttataccaaggggacctgtccttcacaggaat aatattgccgactatgcactcagtgcaggcaccacagctatgaatgcccagaggctctta agagctacaaaactgaacaaacccattctcctggagggctctcctggtgtgggcaagaca agtttggtgggagcattagcaaaggcttcaggcaacatccttgttcgaatcaacttgtca gagcagacggacatcacagacttgtttggagcagatctccctgttgaaggtggcaaggga ggagagtttgcctggcgggatggccccttgctggcggctctgaaggcaggccattgggtt gtgttggatgagctcaacctggcatctcagtctgtattggaaggactcaacgcttgtttt gaccacagaggagaaatctacgttcctgagttaggaatgagttttcaagtacagcatgaa aagacgaagattttcgggtgtcaaaatccttttagacaaggaggtgggaggaaaggcttg ccgaggtctttccttaacagattcactcaggtctttgtggatccccttacagtaattgac atggagttcattgccagtactctgtttccagccattgacaaaaatattgttaagaagatg gtggctttcaacaaccaaattgatcatgaagtgactgttgagaagaaatgggggcaaaaa ggaggaccctgggaattcaaccttcgggaccttttccgctggtgtcagttgatgctagtt gaccagtcccctgggtgttatgatcctggtcagcatgtgtttttggtctatggtgagaga atgagaaccaaggaagacaaagaaaaggtcattgctgtattcaaggatgtgttcaattca agttccaacccatacatgggaaccagactatttcacatcactccctatgatgttcagctg ggctactcagtcctttcccgtggcagttacgttcctctcctgtcccgccgtcccctgtca ctcctgcaccagtcattacggtccctggagtctattatgaagtgtgtgcagatgagctgg atggtcatccttgtggggccagcttctgtgggcaagaccagcctggtccagctcctggca caccttactggtcatacattaaagatcatggcaatgaacagtgcaatggacactacagag cttctgggtggatttgagcaggttgatcttacacggccgtggaggcagctgcttgaaaag gtggagggcactgtaagggcactgttaagagacagcctccttatcagtgctgatgatgcg gaagtagtgctacgagcctggagtcacttccttctgacctataagcccaagtgtcttgga gatggtggtaaaggtatcacaatggagattgtcaataagctggaagcggtattattgctt atgcagcgactcaacaataaaatcaactcctactccaagacagagtttgccaaacttgtg gaagagttccgaaattttggggtgaagcttctgcagtccaccagtggtcacagccatgga acatttgaatgggttgacagcatgttggttcaggctctgaagtctggagattggcttttg atggacaatgttaacttctgcaacccatcagtgctggatcgtttgaatgctttgcttgaa cccggaggtgttctcactcttagtgagagaggaatggtagatggatccactcccaccata acaccaaatcccaatttcagactttttctctcgatggatcccgttcatggagaaatatcc cgagctatgaggaatcgtggacttgaaatctacatttcaggagaaggggatgggaacatc ccagatgacctggatctgaaagttctgctgcacagccttgggttggtgggggatagtgtg tgcgacagcctcttggctctacacacagagatccaaagcactatagtaggttctccagcg tcctctatttcaactctaatccagacagccttactcattgtgcagtacctacagcgaggg ctgagtttagacaaagccttttctgaagtatgctgggaagcgtatgtccgctcccagcat tcaccggcaaaccagaagctcgtgaagactttactggagaaacatgtttcttctctgcga gcacatgaaacctggggtaactccatccttgccatgggcctgtggccagattctctgccc tcggctctctttgctacagaagattctcacctgtctatcgtccgaagtgatggacagatc ttagtatattgcctcaacaggatgagcatgaaaaccagcagctgggccaggattcaacct cttaccttgccagacttagagaaaatcatgcagtcttctaaccctgagagcttgaaattc agttcagttgaagtggatacttactggatcgatgaaccagatgttctggccatggctgtt aaattgcttatagaaagagcaaccaatcaagattggatgctcagagttaaatggctttat catttagccaagaatataccgcaggggctggaatcaatacagattcatttggaagccaat gctgcatctcttaggaatttttactcaaattctctctcagctggggtcagtaatgtcatc aaaatattacaaccaaatataacagatgaatttgtgatccctttggacccccgatggaat atgcaggctttggacatcattagaaattcgatggactttgacccacaaatggaccagcct gagcagctctttgcccttttagagtctgttgcaaacaagacaatcatatatcttgaccgg gaaaaacggatttttactgaagcaaatttagtttctgttggtggcaaaaagttaagaaat agtgttttgagaatgtcctttgagttccataaagatccagagagctatcacagcctgccc catgaaattgtggtcaatcttgctgctttttttgaattttgtgatgcactaatcctgctc tgggtccagtcctctcaggggatggtgtctgatgccagtgtcattgagatcttggagtct ctgcggtggcgggaccggttatggacggtggctgacacagtaaaagtggatgccccaggc ctggccctgcttgcccttcactggcactgggttttaaaacatttggtccgccagatcccc caactcctagtgaaccacgaagacaaatatttcaaagaggttcagacggtctcagaacat attcagaattgcttggggagcccgactggtggcttcactggtataaagaagttgcaaaag ttcctgggacgaccatttccttttaagaacaagctggtggtggagtgtttttctcaactg aaagtccttaacaaagtgcttgccatcagagagcggatgcctgcccttggggaaagtgga tggtgtgaagacattaatcggctccaagtggttgcttctgaatggactttaaagaaaagt ctcttgcaggcctggggattggtcctcagagctaatgttctggaagatgccaacgcagat gagttgaagaatcttgtgaatgcccattgtttagaactaaaagccaaaggaatttcactt ggttttctggagaaaaagcacaatgaagcttcctcgctgttccaactagactttacctcc ctaatccagctcaccaggaatgttcaattgtggcctgcaatggagtacctggctatgctt tggcagtacaaagtgacagctgattttatgacacaggcttgtctaagaaggtccagcaaa aatcagcaaccccagatagatgaagagataagtcatcacatcacattttgtcttaagcac acaccagttgctccgcaagagcttcgagacctttggttcttattgcactgtaagaaggtg tctactgaagaagttatctccttgtggtctgacttatttcattccgcatttatgtctttt tggagcagtactgtgactacaaatccagagtactggctaatgtggagccctctgcctggt gtacagcagagggaggtgcccaagtcccttttggactccacattgaagggccctggcagt ctcagtagagccgtattctccaagtgctgctttgaagtcttgaccagcagctgcagagca agtccctgggatgtgagcggcttccccatcctgtcctcctcacatgtcaccctgggagag tgggttgagagagccctgcagctccgggacatcagcctggtactttggaccaacatggct gtgccttcagtcgcagaattcagacgcacggattcgcagctccaggggcttgtgctgtgc cgacacctggcaggtttggcagagctgctccctgagtcccagcggcaggagtacatgcag aactgcgagcagctgctgctcggggacagccaggccttccagcatgtgggccagactctt ggggacatggccgggcaggaggccctgcccaaagagctgctgtgcctcttgctcacctcc ctgcgccactttggggaaggggacagtaaacgggaccttcctgagccagcccgccgtggg agcctctgggtgagccttggcttgctccagattcagacgtggcttccgcaggcacggttt gaccctgcagtgaagagggaatacaagctcaagtatgctaaggaagagttacaccagttg cagtgtgagtggaagacccgaaacctctcgtcccagctactgactggaagagacctggaa gatgaagtcattatccattactctcatcctcacatcagactacttcgccaaagaattgat catctggagaacttaatctgcagcctgtcaaagaagcaggccttcagaccccaagtgcct gtctatgagtcactggtgcaggagatccaccactacgtcaccagcattgccaaggcccct gctgttcaggatctgctcacacggctcctgcaggccctccacatggatgggcctcggtct gcccaggtggcccagaaccttctgaaggaggaagcttcctggcaacaatcccaccaccag ttcaggaagcggctggccgaggagtacgccctgtatccggactctgtggccccactgcag gcatccatcctgcagttgcagcatggcatgaggctggtggcatctgaggtctacgcttca ttccaacgcagtgtggtctgtgcagacaggctgggtaccctggccacatccctgttggct tttccatcggtgggccctgccttccccacttactatgctcatgcagacgctttatgctca gtgaagtcagaggaggttcttcgaggccttgggaggttgatccttaagcgctcaggagga aaggagctggaaggcaaggcccagagaccttgccccacccgagagcagctgctgatgaac gccctcctttacctgcgctcccatgtgctgtgcaagggagagctggaccagagggccctg cagctcttcagacatgtgtgccaggaaattatcaatgagtgggatgaacaggaacgcata gcccaagagaaggctgagcaggaaagcagcctttacagatgcaggagcaggaactccagg acagccctgagcgaggaggaggaggaagaacgggagttcagaaagcagttcccacttcat gaaaaggattttgcagatattctggtagaaccaacactggaagagaagaagggagcttca gatggacaagaagagggagcaaccacagaccctgccctcctctcccagagctcaatgcag gctgtgatgctgattcaccagcagctgtgcctcagcttcgctcggtccctctggtaccaa cagactgtgccaccacacgagacaaagcattaccttggcctgtttctgtcctgctatcaa accggggcatctcttgtaacacacttctaccctctcatgggagccgagctgaatgaccaa ctcttgggcagccaacttttggcctgcaccctctcccataacactctctttggtgaggca gtctcagatctgatggtgaagcctgatgggccctatgacttctaccagcaccccaatgtc ccagaagcaaggcattgtcaacctgtgcttcaaggtttctcagaggctgttagtcagctg ctgcaggactggccggaacacccggcccttgaacagctgctggttgtaatgaatagaatt cgtagttttccactttccagtcccatctcaaagttcctgaatggcttagagatccttctg gcaaaggcacaggattgggaagagaatgcgagtcgagctctgtctctgcggaaacatctt gatttggtcagtcagatgatcattcgttggcgtaaactggagctgaactgctggtcaatg agtttggataataccatgaagcgccatactgagaaatccaccaagcactggttctccatc taccagatgcttgagaagcacatgcaggaacaaacagaggagcaggaagatgacaaacag atgaccctgatgttgctggtcagcacgttacaagcatttattgaaggatcctcactggga gaattccacgtacgacttcagatgttactggttttccattgtcatgtcttgttgatgcct caagttgaaggaaaggatgcactttgcagcgttctgtggaatctgtaccattattacaag caattctttgaccgggtccaagccaaaattgtggaacttcgttcgccccttgaaaaagaa cttaaagaatttgttaaaatatccaagtggaatgatgtcagcttctggtccattaaacaa tctgtggaaaagacacacaggactctctttaaattcatgaagaaatttgaagctgttctg agtgaaccttgccggtcatccttggtggagagtgacaaggaggaacagcctgattttttg tcgtggccagcagccaccagtgaggcatcccctgttcagagtctgaacaaggcactgaag gagaccctgctagcccggccggcagctgcacaggctgtgattccagaacagtgtcagggt gctcctttctcctcggagggggagctgctgcgtcgcttgccgaagctcatgaaacgaatg aggaagatgtgcctgacactgatgaaggaaagccgcctgcctcacctagtggagggcctt gaccacttcaccggcgaagtcatttcctgtgtgagcgagctacagagcttaaaggtggag ccctccgcagagaaggagaagcagcggtcagaagccaagcacattctcctgcggaagcag cgagctttagcagacctctttcaacaccttgcaaaaactggtttgtcatatcgcaaaggt cttgcctgggcccgttcaaaaaaccctcaagagatgcttcatcttcacccgttagaaatc cggagtgcattgtctatagtcagcagcactcaggaggctgattctgggctgcttacagaa atctcatcgtcatgggatggatgccagaaatatttctttcgctctcttgcacggcacgcc aggcttagtgcagccttagcagctcctgccaaggagttgggcatgagcaacgttgagcga tgcagagggttctcggcacatttgatgaagatgcttatccgacagcggcgctccctgacc acgctgactgagcagtggattctcctcaggaacctcctcggctgtgtgcaggagattcac ggcaggctgactggcccactggtctaccccgtggccttcccccctcaggatggtgtgcag cagtggacagagaggctgcagcacctggccatgcagagccaggtcttgcttgagcagctc tcctggttcctccagtgctgcccctgtgcagggccaactcccggccaaggcgaggcccag gcacagggtcagccttctgccccttacccagagggaccagagctcaccaaggggtggctt tccggagcagcacaggacctcatcccatcagaactgagttacccatccccagtacctcga aatcagctgccctctggctgccggatgcggaaacaggaccagctttggcaacagtcaact acgagattaacagagatgctgaaaaccattaaaacagtgaaagctgacgttgacaaaatc aggcagcagtcttgtgagactctctttcattcttggaaggattttgaagtttgctcttct gggctgagttgcctgtcccagatgtcggttcatttgcaaggcctggagtccttgttcgtt attccagggagggaggttaaacaaacagatcaacaaatggcattagttcagagcctggaa tatttaagaggagaaatcaataaagccacggatgagtttactgcctggaagacacatcta cttgctttaggcagccaaggcggaaaccaaatgttggaggaagggtttgtggaagatttt tcagagcgagtggaagctgccatccgggccatcctttgtgccatccagaacttagcagaa agaaacagtaaaaagacagaggagaacactgaccaaacaggaccacgagaagaggatgag gcagcaggctgtgagagactgcagtcaggacatctaacaaaactcttagaggatgacctg tgggcggacgtgagtgctctgcatgtgcagaagataatctctgctgtctctgagctgttg gagcggctgaaatcttatggcgaggatggcatagcagcgaagaacacggtcttcagccag tcctgctgcttgctggtgcgtctggtgcccatgctctccaggtactcagacctcgttctc ttcttcctgaccatgtctttggcgactcaccgtagcactgcaaagctgctgtctgtgctt gcccaggtcttcacagagctcgcccaggagggattttgcctgcccaaagaattcatggaa gattcagcaggagagggagcaactgagttccatgactatgagggaggtggaattggggaa ggtgagggcgtgaaagatgtgagtgaccagatagaacatgaagaccaggcagaagataca tttcagaaaggtcaagaaaaggataaagaggatcctgactcaaaatcagacattaaaggc gaggataatgccattgagatgtcagaagactttgatgggaaaatgcatgatggagaactt gaagaacaagaagaggatgatgggaaatcggacagtgagggcagagacctggataaacag atgggcgatctgaatggtgaggaagctgacaaactagatgagaggctttggggtgatgac gacgaggaggaagatgaggaggaagaagacagtaaaactgaagagacaggaccaggaatg gatgaggaagattgtggacttgttgccaaagatgacaacttggatgctgggaagtcaaac agagataaaaaccaagataagaaggaagaaaaggaagaagcagaagttgctgatgatgga caaggccaggacaaaattaatgaacaaatagatgagagagaatatgatgagaatgaggta gacccttaccatggcaatcaggagaagctgccagaacctgaggccttggaccttccggac gacttgaatctagacagtgaagacaagaacggtagtgaggacacagaccatgaagaagga gaagaaaatcctttggaaattaaagaaaagccaatggatactgaggaagcaggtcgtgaa gctgaggaaataaaggaagagatcgaggctgaccacagtgaaggtcagagtcaacatgaa gctgaggaaggctccagtgaagaggagaagggggagggggaggaagagatggacacagga gctgatgaccaagacaaagatactgctgaacatcctgaagaaaactccgacgatgagcgg cagtctctggaggacaaggacaaggaagccagtgaggacagtgcagaaaatggcgttcct gttgaccaaggtctccagccccagaagcaggaagaagaagaaggcggggagaactctgac ccagaggagcaggtgccagaggccacggagaggaaagagcacgcctcctgcgggcaaact ggggtggagagtgtgcagagcgcacaggctgtggagctggctgggaccgcgcctgagaag gagcaggggaaggaggaacacgggagtggagctgcggacgcaaaccaggcagaaggccac gaatccagcttcatcgcccggttggcttcccagaaacagaccaggaaaaacacacagagt tttaagaggaaacctgggcaggccgacaacgaacgctccgtgggtgaccacaatgagcat gtgcacaagcggctgaggactgtggatgtggagagccaggccgaacaggggccagcccag cccccggcccgggtggaggatgcagatgcgtttgagcacgttaaagaaggcagtggcccc tacgatgcacagacgtacgatgtggccagcaaggagcagcaacagtctgcaaaagattcc agcagggatcaagaagaggagatagaggataccttcgcggacgtggaggaggaggagctc cgagcagcagacgtggaacagctgaagccagaggtcgtcacgtcggggaccacagcgagc cctggccttgatgagatggaggtggagacccaagctgttaaaacagaagaccaagatccc aggaccaacctgtcccacgaggagacagagaaggagaaaccagagagaagccgagattca accattcacacagcccatcagttcctcatggacacagttttccagccctttttaaaagac atcggtgagctaagacaagagctggagagacagttggaaatgtggcagccacatgaatct ggaaacccagaagaagagaaggctgcagctgagatgtggcagagttacctggccttaacc gcgcctctttcacaacagttgtgtgagcagctccgtctcatattagagcctacccaggca gccaagctgaaaggagactatcgcactgggaagcggctgaacatgcggaaggtcattcca tacgttgctagtcagtttcggaaagacaagatttggcttcgaaggaccaagcccagtaaa cgccagtatcagatttgtttggccatcgatgactcttctagcatggtggacaaccatacc aaacagctggcatttgaatctttggctgtgatcggaaatgctctagccctcctggaagcg ggtcagattgctgtgtgcagttttggagagtctgtaaagttgttacatccattccatgaa cagttcagtgattcctcagggtcccagattctgcgactctgcaaattccaacaaaagaaa accaagattgctcagtttctcgagtccgtagcccgcatgtttgcagctgcccagcagccc tcacagaacgccagtccagaaacagcacagctcctcctggtggtctctgatggacgtggc cttttccttgaggggaaagacagagtcctggcggcagtccgggctgcccgaaatgctaac atctttgtcatttttgttgtattggacaatcccagttcccgggattctatcttggacatt aaagtaccaatatttaaaggaccgggagagatgcccgaaatccgatcctacatggaagag ttcccattcccattctatatcattcttcgcgatgtgaatgcgctccccgagacgctcagc gatgccctgaggcagtggtttgagttggtggcagcctccgaccacccctag

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